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{{Infobox_gene}}
{{PBB_Controls
'''Phosphofructokinase, platelet''', also known as '''PFKP''' is an [[enzyme]] which in humans is encoded by the ''PFKP'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PFKP phosphofructokinase, platelet| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5214| accessdate = }}</ref>
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== Function ==
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
The PFKP gene encodes the platelet isoform of [[phosphofructokinase]] (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of [[fructose 6-phosphate]] to [[fructose 1,6-bisphosphate]] and is a key regulatory enzyme in [[glycolysis]]. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle ([[PFKM]]) and liver ([[PFKL]]) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Full tetrameric phosphofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.<ref name="entrez" /><ref name="pmid6451249">{{cite journal | author = Vora S | title = Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system | journal = Blood | volume = 57 | issue = 4 | pages = 724–32 |date=April 1981 | pmid = 6451249 | doi = | url = http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=6451249 }}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Phosphofructokinase, platelet
| HGNCid = 8878
| Symbol = PFKP
| AltSymbols =; FLJ40226; PFK-C; PFKF
| OMIM = 171840
| ECnumber = 
| Homologene = 20579
| MGIid = 1891833
| GeneAtlas_image1 = PBB_GE_PFKP_201037_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003872 |text = 6-phosphofructokinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005945 |text = 6-phosphofructokinase complex}}
| Process = {{GNF_GO|id=GO:0006096 |text = glycolysis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5214
    | Hs_Ensembl = ENSG00000067057
    | Hs_RefseqProtein = NP_002618
    | Hs_RefseqmRNA = NM_002627
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 3099712
    | Hs_GenLoc_end = 3169762
    | Hs_Uniprot = Q01813
    | Mm_EntrezGene = 56421
    | Mm_Ensembl = ENSMUSG00000021196
    | Mm_RefseqmRNA = NM_019703
    | Mm_RefseqProtein = NP_062677
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 6579120
    | Mm_GenLoc_end = 6647970
    | Mm_Uniprot = Q8C605
  }}
}}
'''Phosphofructokinase, platelet''', also known as '''PFKP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PFKP phosphofructokinase, platelet| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5214| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Interactive pathway map==
{{PBB_Summary
{{GlycolysisGluconeogenesis_WP534|highlight=PFKP}}
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| summary_text =
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Meienhofer MC, Lagrange JL, Cottreau D, ''et al.'' |title=Phosphofructokinase in human blood cells. |journal=Blood |volume=54 |issue= 2 |pages= 389-400 |year= 1979 |pmid= 156568 |doi= }}
*{{cite journal  | author=Meienhofer MC |title=Phosphofructokinase in human blood cells |journal=Blood |volume=54 |issue= 2 |pages= 389–400 |year= 1979 |pmid= 156568 |doi=  |name-list-format=vanc| author2=Lagrange JL  | author3=Cottreau D | display-authors=3  | last4=Lenoir  | first4=G  | last5=Dreyfus  | first5=JC  | last6=Kahn  | first6=A }}
*{{cite journal | author=Kahn A, Meienhofer MC, Cottreau D, ''et al.'' |title=Phosphofructokinase (PFK) isozymes in man. I. Studies of adult human tissues. |journal=Hum. Genet. |volume=48 |issue= 1 |pages= 93-108 |year= 1979 |pmid= 156693 |doi=  }}
*{{cite journal  | author=Kahn A |title=Phosphofructokinase (PFK) isozymes in man. I. Studies of adult human tissues |journal=Hum. Genet. |volume=48 |issue= 1 |pages= 93–108 |year= 1979 |pmid= 156693 |doi=  10.1007/bf00273280|name-list-format=vanc| author2=Meienhofer MC | author3=Cottreau D  | display-authors=3  | last4=Lagrange  | first4=JL  | last5=Dreyfus  | first5=JC  }}
*{{cite journal  | author=Morrison N, Simpson C, Fothergill-Gilmore L, ''et al.'' |title=Regional chromosomal assignment of the human platelet phosphofructokinase gene to 10p15. |journal=Hum. Genet. |volume=89 |issue= 1 |pages= 105-6 |year= 1992 |pmid= 1533608 |doi=  }}
*{{cite journal  | author=Morrison N |title=Regional chromosomal assignment of the human platelet phosphofructokinase gene to 10p15 |journal=Hum. Genet. |volume=89 |issue= 1 |pages= 105–6 |year= 1992 |pmid= 1533608 |doi=10.1007/BF00207053 |name-list-format=vanc| author2=Simpson C | author3=Fothergill-Gilmore L  | display-authors=3  | last4=Boyd  | first4=Elizabeth  | last5=Connor  | first5=J.Michael  }}
*{{cite journal | author=Simpson CJ, Fothergill-Gilmore LA |title=Isolation and sequence of a cDNA encoding human platelet phosphofructokinase. |journal=Biochem. Biophys. Res. Commun. |volume=180 |issue= 1 |pages= 197-203 |year= 1991 |pmid= 1834056 |doi=  }}
*{{cite journal  |vauthors=Simpson CJ, Fothergill-Gilmore LA |title=Isolation and sequence of a cDNA encoding human platelet phosphofructokinase |journal=Biochem. Biophys. Res. Commun. |volume=180 |issue= 1 |pages= 197–203 |year= 1991 |pmid= 1834056 |doi=10.1016/S0006-291X(05)81276-8 }}
*{{cite journal  | author=Nakajima H, Noguchi T, Yamasaki T, ''et al.'' |title=Cloning of human muscle phosphofructokinase cDNA. |journal=FEBS Lett. |volume=223 |issue= 1 |pages= 113-6 |year= 1987 |pmid= 2822475 |doi=  }}
*{{cite journal  | author=Nakajima H |title=Cloning of human muscle phosphofructokinase cDNA |journal=FEBS Lett. |volume=223 |issue= 1 |pages= 113–6 |year= 1987 |pmid= 2822475 |doi=10.1016/0014-5793(87)80519-7 |name-list-format=vanc| author2=Noguchi T  | author3=Yamasaki T  | display-authors=3  | last4=Kono  | first4=Norio  | last5=Tanaka  | first5=Takehiko  | last6=Tarui  | first6=Seiichiro  }}
*{{cite journal | author=Eto K, Sakura H, Yasuda K, ''et al.'' |title=Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet. |journal=Biochem. Biophys. Res. Commun. |volume=198 |issue= 3 |pages= 990-8 |year= 1994 |pmid= 8117307 |doi= 10.1006/bbrc.1994.1141 }}
*{{cite journal  | author=Eto K |title=Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet |journal=Biochem. Biophys. Res. Commun. |volume=198 |issue= 3 |pages= 990–8 |year= 1994 |pmid= 8117307 |doi= 10.1006/bbrc.1994.1141 |name-list-format=vanc| author2=Sakura H  | author3=Yasuda K  | display-authors=3  | last4=Hayakawa  | first4=T.  | last5=Kawasaki  | first5=E.  | last6=Moriuchi  | first6=R.  | last7=Nagataki  | first7=S.  | last8=Yazaki  | first8=Y.  | last9=Kadowaki  | first9=T. }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  }}
*{{cite journal  | author=Adam GC, Sorensen EJ, Cravatt BF |title=Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes. |journal=Mol. Cell Proteomics |volume=1 |issue= 10 |pages= 828-35 |year= 2003 |pmid= 12438565 |doi= }}
*{{cite journal  |vauthors=Adam GC, Sorensen EJ, Cravatt BF |title=Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes |journal=Mol. Cell. Proteomics |volume=1 |issue= 10 |pages= 828–35 |year= 2003 |pmid= 12438565 |doi= 10.1074/mcp.T200007-MCP200}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Mahlknecht U, Chesney J, Hoelzer D, Bucala R |title=Cloning and chromosomal characterization of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 gene (PFKFB3, iPFK2). |journal=Int. J. Oncol. |volume=23 |issue= 4 |pages= 883-91 |year= 2004 |pmid= 12963966 |doi= }}
*{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Navarro-Lérida I |title=Proteomic identification of brain proteins that interact with dynein light chain LC8 |journal=Proteomics |volume=4 |issue= 2 |pages= 339–46 |year= 2004 |pmid= 14760703 |doi= 10.1002/pmic.200300528  |name-list-format=vanc| author2=Martínez Moreno M  | author3=Roncal F  | display-authors=3  | last4=Gavilanes  | first4=Francisco  | last5=Albar  | first5=Juan Pablo  | last6=Rodríguez-Crespo  | first6=Ignacio }}
*{{cite journal  | author=Navarro-Lérida I, Martínez Moreno M, Roncal F, ''et al.'' |title=Proteomic identification of brain proteins that interact with dynein light chain LC8. |journal=Proteomics |volume=4 |issue= 2 |pages= 339-46 |year= 2004 |pmid= 14760703 |doi= 10.1002/pmic.200300528 }}
*{{cite journal  | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446  |name-list-format=vanc| author2=Jedrychowski M  | author3=Schwartz D  | display-authors=3  | last4=Elias  | first4=JE  | last5=Villén  | first5=J  | last6=Li  | first6=J  | last7=Cohn  | first7=MA  | last8=Cantley  | first8=LC  | last9=Gygi  | first9=SP }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rush J |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046  |name-list-format=vanc| author2=Moritz A  | author3=Lee KA  | display-authors=3  | last4=Guo  | first4=Ailan  | last5=Goss  | first5=Valerie L  | last6=Spek  | first6=Erik J  | last7=Zhang  | first7=Hui  | last8=Zha  | first8=Xiang-Ming  | last9=Polakiewicz  | first9=Roberto D }}
*{{cite journal | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal  | author=Hannemann A |title=Characterization of the human P-type 6-phosphofructo-1-kinase gene promoter in neural cell lines |journal=Gene |volume=345 |issue= 2 |pages= 237–47 |year= 2005 |pmid= 15716112 |doi= 10.1016/j.gene.2004.11.018  |name-list-format=vanc| author2=Jandrig B  | author3=Gaunitz F  | display-authors=3  | last4=Eschrich  | first4=K  | last5=Bigl  | first5=M }}
*{{cite journal | author=Hannemann A, Jandrig B, Gaunitz F, ''et al.'' |title=Characterization of the human P-type 6-phosphofructo-1-kinase gene promoter in neural cell lines. |journal=Gene |volume=345 |issue= 2 |pages= 237-47 |year= 2005 |pmid= 15716112 |doi= 10.1016/j.gene.2004.11.018 }}
*{{cite journal  | author=Beausoleil SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240  |name-list-format=vanc| author2=Villén J  | author3=Gerber SA  | display-authors=3  | last4=Rush  | first4=John  | last5=Gygi  | first5=Steven P }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal  | author=Ewing RM |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948  |name-list-format=vanc| author2=Chu P  | author3=Elisma F  | display-authors=3  | last4=Li  | first4=Hongyan  | last5=Taylor  | first5=Paul  | last6=Climie  | first6=Shane  | last7=McBroom-Cerajewski  | first7=Linda  | last8=Robinson  | first8=Mark D  | last9=O'Connor | first9=Liam }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal  |vauthors=Martínez-Costa OH, Sánchez-Martínez C, Sánchez V, Aragón JJ |title=Chimeric phosphofructokinases involving exchange of the N- and C-terminal halves of mammalian isozymes: implications for ligand binding sites |journal=FEBS Lett. |volume=581 |issue= 16 |pages= 3033–8 |year= 2007 |pmid= 17544406 |doi= 10.1016/j.febslet.2007.05.059 }}
*{{cite journal  | author=Martínez-Costa OH, Sánchez-Martínez C, Sánchez V, Aragón JJ |title=Chimeric phosphofructokinases involving exchange of the N- and C-terminal halves of mammalian isozymes: implications for ligand binding sites. |journal=FEBS Lett. |volume=581 |issue= 16 |pages= 3033-8 |year= 2007 |pmid= 17544406 |doi= 10.1016/j.febslet.2007.05.059 }}
}}
}}
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{{Kinases}}
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Latest revision as of 18:00, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Wikidata
View/Edit Human

Phosphofructokinase, platelet, also known as PFKP is an enzyme which in humans is encoded by the PFKP gene.[1]

Function

The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose 6-phosphate to fructose 1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM) and liver (PFKL) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Full tetrameric phosphofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[1][2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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<imagemap> Image:WP534.png
|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit]]
Glycolysis and Gluconeogenesis edit
  1. ↑ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

References

  1. ↑ 1.0 1.1 "Entrez Gene: PFKP phosphofructokinase, platelet".
  2. ↑ Vora S (April 1981). "Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system". Blood. 57 (4): 724–32. PMID 6451249.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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