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{{ | '''Transforming acidic coiled-coil-containing protein 2''' is a [[protein]] that in humans is encoded by the ''TACC2'' [[gene]].<ref name="pmid14767476">{{cite journal | vauthors = Gangisetty O, Lauffart B, Sondarva GV, Chelsea DM, Still IH | title = The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases | journal = Oncogene | volume = 23 | issue = 14 | pages = 2559–63 |date=Apr 2004 | pmid = 14767476 | pmc = | doi = 10.1038/sj.onc.1207424 }}</ref><ref name="entrez"/> | ||
}} | |||
'''Transforming | |||
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| summary_text = Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is thought to affect the progression of breast | | summary_text = Transforming acidic [[coiled-coil]] proteins are a [[conserved family]] of [[centrosome]]- and [[microtubule]]-interacting proteins that are implicated in [[cancer]]. This gene encodes a protein that concentrates at centrosomes throughout the [[cell cycle]]. This gene lies within a [[chromosomal region]] associated with [[tumorigenesis]]. [[Gene expression|Expression]] of this gene is thought to affect the progression of [[breast tumor]]s. Expression of this gene is also induced by [[erythropoietin]].<ref name="entrez">{{cite web | title = Entrez Gene: TACC2 transforming, acidic coiled-coil containing protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10579| accessdate = }}</ref> | ||
}} | }} | ||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
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| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Still IH, Vince P, Cowell JK |title=The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. |journal=Genomics |volume=58 |issue= 2 |pages= 165–70 |year= 1999 |pmid= 10366448 |doi= 10.1006/geno.1999.5829 }} | ||
*{{cite journal | *{{cite journal |vauthors=Still IH, Hamilton M, Vince P, etal |title=Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon. |journal=Oncogene |volume=18 |issue= 27 |pages= 4032–8 |year= 1999 |pmid= 10435627 |doi= 10.1038/sj.onc.1202801 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gergely F, Kidd D, Jeffers K, etal |title=D–TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo |journal=EMBO J. |volume=19 |issue= 2 |pages= 241–52 |year= 2000 |pmid= 10637228 |doi= 10.1093/emboj/19.2.241 | pmc=305558 }} | ||
*{{cite journal | *{{cite journal |vauthors=Chen HM, Schmeichel KL, Mian IS, etal |title=AZU-1: A Candidate Breast Tumor Suppressor and Biomarker for Tumor Progression |journal=Mol. Biol. Cell |volume=11 |issue= 4 |pages= 1357–67 |year= 2000 |pmid= 10749935 |doi= 10.1091/mbc.11.4.1357| pmc=14852 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gergely F, Karlsson C, Still I, etal |title=The TACC domain identifies a family of centrosomal proteins that can interact with microtubules |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14352–7 |year= 2001 |pmid= 11121038 |doi= 10.1073/pnas.97.26.14352 | pmc=18922 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Pu JJ, Li C, Rodriguez M, Banerjee D |title=Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells |journal=Cytokine |volume=13 |issue= 3 |pages= 129–37 |year= 2001 |pmid= 11161455 |doi= 10.1006/cyto.2000.0812 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Lauffart B, Gangisetty O, Still IH |title=Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2 |journal=Genomics |volume=81 |issue= 2 |pages= 192–201 |year= 2003 |pmid= 12620397 |doi=10.1016/S0888-7543(02)00039-3 }} | ||
*{{cite journal | *{{cite journal |vauthors=Sadek CM, Pelto-Huikko M, Tujague M, etal |title=TACC3 expression is tightly regulated during early differentiation |journal=Gene Expr. Patterns |volume=3 |issue= 2 |pages= 203–11 |year= 2004 |pmid= 12711550 |doi=10.1016/S1567-133X(02)00066-2 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
*{{cite journal | *{{cite journal |vauthors=Deloukas P, Earthrowl ME, Grafham DV, etal |title=The DNA sequence and comparative analysis of human chromosome 10 |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }} | ||
*{{cite journal | vauthors=Still IH, Vettaikkorumakankauv AK, DiMatteo A, Liang P |title=Structure-function evolution of the Transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms |journal=BMC Evol. Biol. |volume=4|pages= 16 |year= 2004 |pmid= 15207008 |doi= 10.1186/1471-2148-4-16 | pmc=441373 }} | |||
*{{cite journal | | *{{cite journal |vauthors=Dou Z, Ding X, Zereshki A, etal |title=TTK kinase is essential for the centrosomal localization of TACC2 |journal=FEBS Lett. |volume=572 |issue= 1–3 |pages= 51–6 |year= 2004 |pmid= 15304323 |doi= 10.1016/j.febslet.2004.06.092 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }} | ||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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Latest revision as of 13:29, 29 November 2017
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Transforming acidic coiled-coil-containing protein 2 is a protein that in humans is encoded by the TACC2 gene.[1][2]
Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is thought to affect the progression of breast tumors. Expression of this gene is also induced by erythropoietin.[2]
References
- ↑ Gangisetty O, Lauffart B, Sondarva GV, Chelsea DM, Still IH (Apr 2004). "The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases". Oncogene. 23 (14): 2559–63. doi:10.1038/sj.onc.1207424. PMID 14767476.
- ↑ 2.0 2.1 "Entrez Gene: TACC2 transforming, acidic coiled-coil containing protein 2".
Further reading
- Still IH, Vince P, Cowell JK (1999). "The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines". Genomics. 58 (2): 165–70. doi:10.1006/geno.1999.5829. PMID 10366448.
- Still IH, Hamilton M, Vince P, et al. (1999). "Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon". Oncogene. 18 (27): 4032–8. doi:10.1038/sj.onc.1202801. PMID 10435627.
- Gergely F, Kidd D, Jeffers K, et al. (2000). "D–TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo". EMBO J. 19 (2): 241–52. doi:10.1093/emboj/19.2.241. PMC 305558. PMID 10637228.
- Chen HM, Schmeichel KL, Mian IS, et al. (2000). "AZU-1: A Candidate Breast Tumor Suppressor and Biomarker for Tumor Progression". Mol. Biol. Cell. 11 (4): 1357–67. doi:10.1091/mbc.11.4.1357. PMC 14852. PMID 10749935.
- Gergely F, Karlsson C, Still I, et al. (2001). "The TACC domain identifies a family of centrosomal proteins that can interact with microtubules". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14352–7. doi:10.1073/pnas.97.26.14352. PMC 18922. PMID 11121038.
- Pu JJ, Li C, Rodriguez M, Banerjee D (2001). "Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells". Cytokine. 13 (3): 129–37. doi:10.1006/cyto.2000.0812. PMID 11161455.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lauffart B, Gangisetty O, Still IH (2003). "Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2". Genomics. 81 (2): 192–201. doi:10.1016/S0888-7543(02)00039-3. PMID 12620397.
- Sadek CM, Pelto-Huikko M, Tujague M, et al. (2004). "TACC3 expression is tightly regulated during early differentiation". Gene Expr. Patterns. 3 (2): 203–11. doi:10.1016/S1567-133X(02)00066-2. PMID 12711550.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
- Still IH, Vettaikkorumakankauv AK, DiMatteo A, Liang P (2004). "Structure-function evolution of the Transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms". BMC Evol. Biol. 4: 16. doi:10.1186/1471-2148-4-16. PMC 441373. PMID 15207008.
- Dou Z, Ding X, Zereshki A, et al. (2004). "TTK kinase is essential for the centrosomal localization of TACC2". FEBS Lett. 572 (1–3): 51–6. doi:10.1016/j.febslet.2004.06.092. PMID 15304323.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
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