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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''ZW10 interactor''' (Zwint-1) is a [[protein]] that in humans is encoded by the ''ZWINT'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZWINT ZW10 interactor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11130| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ZW10 interactor
| HGNCid = 13195
| Symbol = ZWINT
| AltSymbols =; HZwint-1; KNTC2AP; MGC117174
| OMIM = 609177
| ECnumber = 
| Homologene = 48496
| MGIid = 1289227
| GeneAtlas_image1 = PBB_GE_ZWINT_204026_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000775 |text = chromosome, pericentric region}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007051 |text = spindle organization and biogenesis}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0048015 |text = phosphoinositide-mediated signaling}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11130
    | Hs_Ensembl = ENSG00000122952
    | Hs_RefseqProtein = NP_001005413
    | Hs_RefseqmRNA = NM_001005413
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 57786995
    | Hs_GenLoc_end = 57791042
    | Hs_Uniprot = O95229
    | Mm_EntrezGene = 52696
    | Mm_Ensembl = ENSMUSG00000019923
    | Mm_RefseqmRNA = NM_025635
    | Mm_RefseqProtein = NP_079911
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 72050189
    | Mm_GenLoc_end = 72070263
    | Mm_Uniprot = Q9CQU5
  }}
}}
'''ZW10 interactor''', also known as '''ZWINT''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZWINT ZW10 interactor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11130| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Zwint-1 is clearly involved in [[kinetochore]] function although an exact role is not known. It interacts with [[ZW10]], another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late [[anaphase]]. It has a uniform distribution in the [[cytoplasm]] of [[interphase]] cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: ZWINT ZW10 interactor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11130| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
ZWINT has been shown to [[Protein-protein interaction|interact]] with [[MIS12]].<ref name="pmid15371340">{{cite journal | vauthors = Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A | title = A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension | journal = Genes & Development | volume = 18 | issue = 18 | pages = 2255–68 | date = Sep 2004 | pmid = 15371340 | pmc = 517519 | doi = 10.1101/gad.1234104 }}</ref><ref name="pmid15502821">{{cite journal | vauthors = Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M | title = A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1 | journal = Nature Cell Biology | volume = 6 | issue = 11 | pages = 1135–41 | date = Nov 2004 | pmid = 15502821 | doi = 10.1038/ncb1187 }}</ref>
ZWINT has also been shown to [[Protein-protein interaction|interact]] with [[RAB3C]]<ref name="pmid18625232">{{cite journal | vauthors = van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf PS, Heck AJ, Hoogenraad CC, van der Sluijs P | title = A unique residue in rab3c determines the interaction with novel binding protein Zwint-1 | journal = FEBS Letters | volume = 582 | issue = 19 | pages = 2838–42 | date = Aug 2008 | pmid = 18625232 | doi = 10.1016/j.febslet.2008.07.012 }}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Starr DA, Saffery R, Li Z, Simpson AE, Choo KH, Yen TJ, Goldberg ML | title = HZwint-1, a novel human kinetochore component that interacts with HZW10 | journal = Journal of Cell Science | volume = 113 ( Pt 11) | issue = 11 | pages = 1939–50 | date = Jun 2000 | pmid = 10806105 | doi =  }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Musio A, Mariani T, Montagna C, Zambroni D, Ascoli C, Ried T, Vezzoni P | title = Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes | journal = Gene | volume = 331 | issue =  | pages = 33–40 | date = Apr 2004 | pmid = 15094189 | doi = 10.1016/j.gene.2004.01.028 }}
*{{cite journal | author=Starr DA, Saffery R, Li Z, ''et al.'' |title=HZwint-1, a novel human kinetochore component that interacts with HZW10. |journal=J. Cell. Sci. |volume=113 ( Pt 11) |issue= |pages= 1939-50 |year= 2000 |pmid= 10806105 |doi=  }}
* {{cite journal | vauthors = Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A | title = A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension | journal = Genes & Development | volume = 18 | issue = 18 | pages = 2255–68 | date = Sep 2004 | pmid = 15371340 | pmc = 517519 | doi = 10.1101/gad.1234104 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Wang H, Hu X, Ding X, Dou Z, Yang Z, Shaw AW, Teng M, Cleveland DW, Goldberg ML, Niu L, Yao X | title = Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling | journal = The Journal of Biological Chemistry | volume = 279 | issue = 52 | pages = 54590–8 | date = Dec 2004 | pmid = 15485811 | doi = 10.1074/jbc.M407588200 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M | title = A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1 | journal = Nature Cell Biology | volume = 6 | issue = 11 | pages = 1135–41 | date = Nov 2004 | pmid = 15502821 | doi = 10.1038/ncb1187 }}
*{{cite journal  | author=Musio A, Mariani T, Montagna C, ''et al.'' |title=Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes. |journal=Gene |volume=331 |issue=  |pages= 33-40 |year= 2004 |pmid= 15094189 |doi= 10.1016/j.gene.2004.01.028 }}
* {{cite journal | vauthors = Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T, Patel A, Mills GB, Bast RC | title = Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling | journal = The Journal of Biological Chemistry | volume = 280 | issue = 3 | pages = 2092–104 | date = Jan 2005 | pmid = 15504738 | doi = 10.1074/jbc.M403080200 }}
*{{cite journal | author=Cheeseman IM, Niessen S, Anderson S, ''et al.'' |title=A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. |journal=Genes Dev. |volume=18 |issue= 18 |pages= 2255-68 |year= 2004 |pmid= 15371340 |doi= 10.1101/gad.1234104 }}
* {{cite journal | vauthors = Kops GJ, Kim Y, Weaver BA, Mao Y, McLeod I, Yates JR, Tagaya M, Cleveland DW | title = ZW10 links mitotic checkpoint signaling to the structural kinetochore | journal = The Journal of Cell Biology | volume = 169 | issue = 1 | pages = 49–60 | date = Apr 2005 | pmid = 15824131 | pmc = 1351127 | doi = 10.1083/jcb.200411118 }}
*{{cite journal | author=Wang H, Hu X, Ding X, ''et al.'' |title=Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. |journal=J. Biol. Chem. |volume=279 |issue= 52 |pages= 54590-8 |year= 2005 |pmid= 15485811 |doi= 10.1074/jbc.M407588200 }}
* {{cite journal | vauthors = Lin YT, Chen Y, Wu G, Lee WH | title = Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control | journal = Oncogene | volume = 25 | issue = 52 | pages = 6901–14 | date = Nov 2006 | pmid = 16732327 | doi = 10.1038/sj.onc.1209687 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Obuse C, Iwasaki O, Kiyomitsu T, ''et al.'' |title=A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. |journal=Nat. Cell Biol. |volume=6 |issue= 11 |pages= 1135-41 |year= 2004 |pmid= 15502821 |doi= 10.1038/ncb1187 }}
*{{cite journal | author=Le XF, Lammayot A, Gold D, ''et al.'' |title=Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. |journal=J. Biol. Chem. |volume=280 |issue= 3 |pages= 2092-104 |year= 2005 |pmid= 15504738 |doi= 10.1074/jbc.M403080200 }}
*{{cite journal | author=Kops GJ, Kim Y, Weaver BA, ''et al.'' |title=ZW10 links mitotic checkpoint signaling to the structural kinetochore. |journal=J. Cell Biol. |volume=169 |issue= 1 |pages= 49-60 |year= 2005 |pmid= 15824131 |doi= 10.1083/jcb.200411118 }}
*{{cite journal | author=Lin YT, Chen Y, Wu G, Lee WH |title=Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control. |journal=Oncogene |volume=25 |issue= 52 |pages= 6901-14 |year= 2006 |pmid= 16732327 |doi= 10.1038/sj.onc.1209687 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC genome browser|ZWINT}}
* {{UCSC gene details|ZWINT}}
 
 
{{gene-10-stub}}

Latest revision as of 01:16, 19 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ZWINT gene.[1]

Function

Zwint-1 is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[1]

Interactions

ZWINT has been shown to interact with MIS12.[2][3] ZWINT has also been shown to interact with RAB3C[4]

References

  1. ↑ 1.0 1.1 "Entrez Gene: ZWINT ZW10 interactor".
  2. ↑ Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
  3. ↑ Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821.
  4. ↑ van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf PS, Heck AJ, Hoogenraad CC, van der Sluijs P (Aug 2008). "A unique residue in rab3c determines the interaction with novel binding protein Zwint-1". FEBS Letters. 582 (19): 2838–42. doi:10.1016/j.febslet.2008.07.012. PMID 18625232.

Further reading

  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Starr DA, Saffery R, Li Z, Simpson AE, Choo KH, Yen TJ, Goldberg ML (Jun 2000). "HZwint-1, a novel human kinetochore component that interacts with HZW10". Journal of Cell Science. 113 ( Pt 11) (11): 1939–50. PMID 10806105.
  • Musio A, Mariani T, Montagna C, Zambroni D, Ascoli C, Ried T, Vezzoni P (Apr 2004). "Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes". Gene. 331: 33–40. doi:10.1016/j.gene.2004.01.028. PMID 15094189.
  • Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
  • Wang H, Hu X, Ding X, Dou Z, Yang Z, Shaw AW, Teng M, Cleveland DW, Goldberg ML, Niu L, Yao X (Dec 2004). "Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling". The Journal of Biological Chemistry. 279 (52): 54590–8. doi:10.1074/jbc.M407588200. PMID 15485811.
  • Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821.
  • Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T, Patel A, Mills GB, Bast RC (Jan 2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". The Journal of Biological Chemistry. 280 (3): 2092–104. doi:10.1074/jbc.M403080200. PMID 15504738.
  • Kops GJ, Kim Y, Weaver BA, Mao Y, McLeod I, Yates JR, Tagaya M, Cleveland DW (Apr 2005). "ZW10 links mitotic checkpoint signaling to the structural kinetochore". The Journal of Cell Biology. 169 (1): 49–60. doi:10.1083/jcb.200411118. PMC 1351127. PMID 15824131.
  • Lin YT, Chen Y, Wu G, Lee WH (Nov 2006). "Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control". Oncogene. 25 (52): 6901–14. doi:10.1038/sj.onc.1209687. PMID 16732327.

External links


Retrieved from "https://www.wikidoc.org/index.php?title=ZWINT&oldid=1414320"