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{{Infobox_gene}}
{{PBB_Controls
'''Urocortin-3''' is a [[protein]] that in humans is encoded by the ''UCN3'' [[gene]].<ref name="pmid11416224">{{cite journal | vauthors = Lewis K, Li C, Perrin MH, Blount A, Kunitake K, Donaldson C, Vaughan J, Reyes TM, Gulyas J, Fischer W, Bilezikjian L, Rivier J, Sawchenko PE, Vale WW | title = Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 13 | pages = 7570–5 | date = Jun 2001 | pmid = 11416224 | pmc = 34709 | doi = 10.1073/pnas.121165198 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UCN3 urocortin 3 (stresscopin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114131| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Urocortin 3 (stresscopin)
| HGNCid = 17781
| Symbol = UCN3
| AltSymbols =; SCP; SPC; MGC119002; UCNIII
| OMIM = 605901
| ECnumber = 
| Homologene = 49959
| MGIid = 1932970
| GeneAtlas_image1 = PBB_GE_UCN3_gnf1h01252_at_tn.png
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0007189 |text = G-protein signaling, adenylate cyclase activating pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 114131
    | Hs_Ensembl = ENSG00000178473
    | Hs_RefseqProtein = NP_444277
    | Hs_RefseqmRNA = NM_053049
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 5396972
    | Hs_GenLoc_end = 5406169
    | Hs_Uniprot = Q969E3
    | Mm_EntrezGene = 83428
    | Mm_Ensembl = ENSMUSG00000044988
    | Mm_RefseqmRNA = NM_031250
    | Mm_RefseqProtein = NP_112540
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 3940402
    | Mm_GenLoc_end = 3940896
    | Mm_Uniprot = Q0VDY5
  }}
}}
'''Urocortin 3 (stresscopin)''', also known as '''UCN3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UCN3 urocortin 3 (stresscopin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114131| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. It is also expressed by beta cells in the pancreas and is co-released with insulin to promote somatostatin release from neighboring delta cells, which provides negative feedback on insulin secretion.<ref name="pmid26076035">{{cite journal | vauthors = van der Meulen T, Donaldson CJ, Cáceres E, Hunter AE, Cowing-Zitron C, Pound LD, Adams MW, Zembrzycki A, Grove KL, Huising MO | title = Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion | journal = Nature Medicine | volume = 21 | issue = 7 | pages = 769–76 | date = Jul 2015 | pmid = 26076035 | doi = 10.1038/nm.3872 | pmc=4496282}}</ref>  In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.<ref name="entrez">{{cite web | title = Entrez Gene: UCN3 urocortin 3 (stresscopin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114131| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hauger RL, Grigoriadis DE, Dallman MF, Plotsky PM, Vale WW, Dautzenberg FM | title = International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands | journal = Pharmacological Reviews | volume = 55 | issue = 1 | pages = 21–6 | date = Mar 2003 | pmid = 12615952 | doi = 10.1124/pr.55.1.3 }}
| citations =
* {{cite journal | vauthors = Florio P, Torres PB, Torricelli M, Toti P, Vale W, Petraglia F | title = Human endometrium expresses urocortin II and III messenger RNA and peptides | journal = Fertility and Sterility | volume = 86 | issue = 6 | pages = 1766–70 | date = Dec 2006 | pmid = 17074339 | doi = 10.1016/j.fertnstert.2006.05.041 }}
*{{cite journal | author=Hauger RL, Grigoriadis DE, Dallman MF, ''et al.'' |title=International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands. |journal=Pharmacol. Rev. |volume=55 |issue= 1 |pages= 21-6 |year= 2003 |pmid= 12615952 |doi= 10.1124/pr.55.1.3 }}
* {{cite journal | vauthors = Imperatore A, Florio P, Torres PB, Torricelli M, Galleri L, Toti P, Occhini R, Picciolini E, Vale W, Petraglia F | title = Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes | journal = American Journal of Obstetrics and Gynecology | volume = 195 | issue = 1 | pages = 288–95 | date = Jul 2006 | pmid = 16626608 | doi = 10.1016/j.ajog.2005.12.048 }}
*{{cite journal | author=Florio P, Torres PB, Torricelli M, ''et al.'' |title=Human endometrium expresses urocortin II and III messenger RNA and peptides. |journal=Fertil. Steril. |volume=86 |issue= 6 |pages= 1766-70 |year= 2006 |pmid= 17074339 |doi= 10.1016/j.fertnstert.2006.05.041 }}
* {{cite journal | vauthors = Saruta M, Takahashi K, Suzuki T, Fukuda T, Torii A, Sasano H | title = Urocortin 3/stresscopin in human colon: possible modulators of gastrointestinal function during stressful conditions | journal = Peptides | volume = 26 | issue = 7 | pages = 1196–206 | date = Jul 2005 | pmid = 15949638 | doi = 10.1016/j.peptides.2005.01.014 }}
*{{cite journal | author=Imperatore A, Florio P, Torres PB, ''et al.'' |title=Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes. |journal=Am. J. Obstet. Gynecol. |volume=195 |issue= 1 |pages= 288-95 |year= 2006 |pmid= 16626608 |doi= 10.1016/j.ajog.2005.12.048 }}
* {{cite journal | vauthors = Chang CL, Hsu SY | title = Ancient evolution of stress-regulating peptides in vertebrates | journal = Peptides | volume = 25 | issue = 10 | pages = 1681–8 | date = Oct 2004 | pmid = 15476935 | doi = 10.1016/j.peptides.2004.05.022 }}
*{{cite journal | author=Saruta M, Takahashi K, Suzuki T, ''et al.'' |title=Urocortin 3/stresscopin in human colon: possible modulators of gastrointestinal function during stressful conditions. |journal=Peptides |volume=26 |issue= 7 |pages= 1196-206 |year= 2005 |pmid= 15949638 |doi= 10.1016/j.peptides.2005.01.014 }}
* {{cite journal | vauthors = Takahashi K, Totsune K, Murakami O, Saruta M, Nakabayashi M, Suzuki T, Sasano H, Shibahara S | title = Expression of urocortin III/stresscopin in human heart and kidney | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 89 | issue = 4 | pages = 1897–903 | date = Apr 2004 | pmid = 15070962 | doi = 10.1210/jc.2003-031663 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Seres J, Bornstein SR, Seres P, Willenberg HS, Schulte KM, Scherbaum WA, Ehrhart-Bornstein M | title = Corticotropin-releasing hormone system in human adipose tissue | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 89 | issue = 2 | pages = 965–70 | date = Feb 2004 | pmid = 14764822 | doi = 10.1210/jc.2003-031299 }}
*{{cite journal  | author=Chang CL, Hsu SY |title=Ancient evolution of stress-regulating peptides in vertebrates. |journal=Peptides |volume=25 |issue= 10 |pages= 1681-8 |year= 2005 |pmid= 15476935 |doi= 10.1016/j.peptides.2004.05.022 }}
* {{cite journal | vauthors = Chanalaris A, Lawrence KM, Stephanou A, Knight RD, Hsu SY, Hsueh AJ, Latchman DS | title = Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes | journal = Journal of Molecular and Cellular Cardiology | volume = 35 | issue = 10 | pages = 1295–305 | date = Oct 2003 | pmid = 14519439 | doi = 10.1016/S0022-2828(03)00244-X }}
*{{cite journal | author=Takahashi K, Totsune K, Murakami O, ''et al.'' |title=Expression of urocortin III/stresscopin in human heart and kidney. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 4 |pages= 1897-903 |year= 2004 |pmid= 15070962 |doi= }}
* {{cite journal | vauthors = Hsu SY, Hsueh AJ | title = Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor | journal = Nature Medicine | volume = 7 | issue = 5 | pages = 605–11 | date = May 2001 | pmid = 11329063 | doi = 10.1038/87936 }}
*{{cite journal | author=Seres J, Bornstein SR, Seres P, ''et al.'' |title=Corticotropin-releasing hormone system in human adipose tissue. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 2 |pages= 965-70 |year= 2004 |pmid= 14764822 |doi= }}
*{{cite journal | author=Chanalaris A, Lawrence KM, Stephanou A, ''et al.'' |title=Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes. |journal=J. Mol. Cell. Cardiol. |volume=35 |issue= 10 |pages= 1295-305 |year= 2004 |pmid= 14519439 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Lewis K, Li C, Perrin MH, ''et al.'' |title=Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7570-5 |year= 2001 |pmid= 11416224 |doi= 10.1073/pnas.121165198 }}
*{{cite journal | author=Hsu SY, Hsueh AJ |title=Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. |journal=Nat. Med. |volume=7 |issue= 5 |pages= 605-11 |year= 2001 |pmid= 11329063 |doi= 10.1038/87936 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 03:10, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Urocortin-3 is a protein that in humans is encoded by the UCN3 gene.[1][2]

Function

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. It is also expressed by beta cells in the pancreas and is co-released with insulin to promote somatostatin release from neighboring delta cells, which provides negative feedback on insulin secretion.[3] In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.[2]

References

  1. ↑ Lewis K, Li C, Perrin MH, Blount A, Kunitake K, Donaldson C, Vaughan J, Reyes TM, Gulyas J, Fischer W, Bilezikjian L, Rivier J, Sawchenko PE, Vale WW (Jun 2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor". Proceedings of the National Academy of Sciences of the United States of America. 98 (13): 7570–5. doi:10.1073/pnas.121165198. PMC 34709. PMID 11416224.
  2. ↑ 2.0 2.1 "Entrez Gene: UCN3 urocortin 3 (stresscopin)".
  3. ↑ van der Meulen T, Donaldson CJ, Cáceres E, Hunter AE, Cowing-Zitron C, Pound LD, Adams MW, Zembrzycki A, Grove KL, Huising MO (Jul 2015). "Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion". Nature Medicine. 21 (7): 769–76. doi:10.1038/nm.3872. PMC 4496282. PMID 26076035.

Further reading

  • Hauger RL, Grigoriadis DE, Dallman MF, Plotsky PM, Vale WW, Dautzenberg FM (Mar 2003). "International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands". Pharmacological Reviews. 55 (1): 21–6. doi:10.1124/pr.55.1.3. PMID 12615952.
  • Florio P, Torres PB, Torricelli M, Toti P, Vale W, Petraglia F (Dec 2006). "Human endometrium expresses urocortin II and III messenger RNA and peptides". Fertility and Sterility. 86 (6): 1766–70. doi:10.1016/j.fertnstert.2006.05.041. PMID 17074339.
  • Imperatore A, Florio P, Torres PB, Torricelli M, Galleri L, Toti P, Occhini R, Picciolini E, Vale W, Petraglia F (Jul 2006). "Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes". American Journal of Obstetrics and Gynecology. 195 (1): 288–95. doi:10.1016/j.ajog.2005.12.048. PMID 16626608.
  • Saruta M, Takahashi K, Suzuki T, Fukuda T, Torii A, Sasano H (Jul 2005). "Urocortin 3/stresscopin in human colon: possible modulators of gastrointestinal function during stressful conditions". Peptides. 26 (7): 1196–206. doi:10.1016/j.peptides.2005.01.014. PMID 15949638.
  • Chang CL, Hsu SY (Oct 2004). "Ancient evolution of stress-regulating peptides in vertebrates". Peptides. 25 (10): 1681–8. doi:10.1016/j.peptides.2004.05.022. PMID 15476935.
  • Takahashi K, Totsune K, Murakami O, Saruta M, Nakabayashi M, Suzuki T, Sasano H, Shibahara S (Apr 2004). "Expression of urocortin III/stresscopin in human heart and kidney". The Journal of Clinical Endocrinology and Metabolism. 89 (4): 1897–903. doi:10.1210/jc.2003-031663. PMID 15070962.
  • Seres J, Bornstein SR, Seres P, Willenberg HS, Schulte KM, Scherbaum WA, Ehrhart-Bornstein M (Feb 2004). "Corticotropin-releasing hormone system in human adipose tissue". The Journal of Clinical Endocrinology and Metabolism. 89 (2): 965–70. doi:10.1210/jc.2003-031299. PMID 14764822.
  • Chanalaris A, Lawrence KM, Stephanou A, Knight RD, Hsu SY, Hsueh AJ, Latchman DS (Oct 2003). "Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes". Journal of Molecular and Cellular Cardiology. 35 (10): 1295–305. doi:10.1016/S0022-2828(03)00244-X. PMID 14519439.
  • Hsu SY, Hsueh AJ (May 2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor". Nature Medicine. 7 (5): 605–11. doi:10.1038/87936. PMID 11329063.


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