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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Nucleolar RNA helicase 2''' is an [[enzyme]] that in humans is encoded by the ''DDX21'' [[gene]].<ref name="pmid8614622">{{cite journal | vauthors = Valdez BC, Henning D, Busch RK, Woods K, Flores-Rozas H, Hurwitz J, Perlaky L, Busch H | title = A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease | journal = Nucleic Acids Res. | volume = 24 | issue = 7 | pages = 1220–4  | date = Jun 1996 | pmid = 8614622 | pmc = 145780 | doi = 10.1093/nar/24.7.1220 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DDX21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9188| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
| HGNCid = 2744
| Symbol = DDX21
| AltSymbols =; DKFZp686F21172; GUA; GURDB; RH-II/GU; RH-II/GuA
| OMIM = 606357
| ECnumber = 
| Homologene = 3473
| MGIid = 1860494
| GeneAtlas_image1 = PBB_GE_DDX21_208152_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0004004 |text = ATP-dependent RNA helicase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9188
    | Hs_Ensembl = ENSG00000165732
    | Hs_RefseqProtein = NP_004719
    | Hs_RefseqmRNA = NM_004728
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 70385890
    | Hs_GenLoc_end = 70414835
    | Hs_Uniprot = Q9NR30
    | Mm_EntrezGene = 56200
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_019553
    | Mm_RefseqProtein = NP_062426
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''DEAD (Asp-Glu-Ala-Asp) box polypeptide 21''', also known as '''DDX21''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DDX21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9188| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription.<ref name="entrez">{{cite web | title = Entrez Gene: DDX21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9188| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
DDX21 has been shown to [[Protein-protein interaction|interact]] with [[C-jun]].<ref name=pmid11823437>{{cite journal | vauthors = Westermarck J, Weiss C, Saffrich R, Kast J, Musti AM, Wessely M, Ansorge W, Séraphin B, Wilm M, Valdez BC, Bohmann D | title = The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription | journal = EMBO J. | volume = 21 | issue = 3 | pages = 451–60  | date = Feb 2002 | pmid = 11823437 | pmc = 125820 | doi = 10.1093/emboj/21.3.451 }}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Valdez BC, Henning D, Perlaky L, Busch RK, Busch H | title = Cloning and characterization of Gu/RH-II binding protein | journal = Biochem. Biophys. Res. Commun. | volume = 234 | issue = 2 | pages = 335–40 | year = 1997 | pmid = 9177271 | doi = 10.1006/bbrc.1997.6642 }}
| citations =
* {{cite journal | vauthors = Valdez BC, Wang W | title = Mouse RNA helicase II/Gu: cDNA and genomic sequences, chromosomal localization, and regulation of expression | journal = Genomics | volume = 66 | issue = 2 | pages = 184–94 | year = 2000 | pmid = 10860663 | doi = 10.1006/geno.2000.6209 }}
*{{cite journal | author=Valdez BC, Henning D, Busch RK, ''et al.'' |title=A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease. |journal=Nucleic Acids Res. |volume=24 |issue= 7 |pages= 1220-4 |year= 1996 |pmid= 8614622 |doi=  }}
* {{cite journal | vauthors = Zhu K, Henning D, Valdez B, Busch H | title = Human RNA helicase II/Gu gene: genomic organization and promoter analysis | journal = Biochem. Biophys. Res. Commun. | volume = 281 | issue = 4 | pages = 1006–11 | year = 2001 | pmid = 11237763 | doi = 10.1006/bbrc.2001.4446 }}
*{{cite journal  | author=Valdez BC, Henning D, Perlaky L, ''et al.'' |title=Cloning and characterization of Gu/RH-II binding protein. |journal=Biochem. Biophys. Res. Commun. |volume=234 |issue= 2 |pages= 335-40 |year= 1997 |pmid= 9177271 |doi= 10.1006/bbrc.1997.6642 }}
* {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Curr. Biol. | volume = 12 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
*{{cite journal | author=Valdez BC, Wang W |title=Mouse RNA helicase II/Gu: cDNA and genomic sequences, chromosomal localization, and regulation of expression. |journal=Genomics |volume=66 |issue= 2 |pages= 184-94 |year= 2000 |pmid= 10860663 |doi= 10.1006/geno.2000.6209 }}
* {{cite journal | vauthors = Westermarck J, Weiss C, Saffrich R, Kast J, Musti AM, Wessely M, Ansorge W, Séraphin B, Wilm M, Valdez BC, Bohmann D | title = The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription | journal = EMBO J. | volume = 21 | issue = 3 | pages = 451–60 | year = 2002 | pmid = 11823437 | pmc = 125820 | doi = 10.1093/emboj/21.3.451 }}
*{{cite journal | author=Zhu K, Henning D, Valdez B, Busch H |title=Human RNA helicase II/Gu gene: genomic organization and promoter analysis. |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 4 |pages= 1006-11 |year= 2001 |pmid= 11237763 |doi= 10.1006/bbrc.2001.4446 }}
* {{cite journal | vauthors = Valdez BC, Yang H, Hong E, Sequitin AM | title = Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs | journal = Gene | volume = 284 | issue = 1-2 | pages = 53–61 | year = 2002 | pmid = 11891046 | doi = 10.1016/S0378-1119(01)00888-5 }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi= }}
* {{cite journal | vauthors = Henning D, So RB, Jin R, Lau LF, Valdez BC | title = Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production | journal = J. Biol. Chem. | volume = 278 | issue = 52 | pages = 52307–14 | year = 2003 | pmid = 14559904 | doi = 10.1074/jbc.M310846200 }}
*{{cite journal | author=Westermarck J, Weiss C, Saffrich R, ''et al.'' |title=The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription. |journal=EMBO J. |volume=21 |issue= 3 |pages= 451-60 |year= 2002 |pmid= 11823437 |doi= }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Valdez BC, Yang H, Hong E, Sequitin AM |title=Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs. |journal=Gene |volume=284 |issue= 1-2 |pages= 53-61 |year= 2002 |pmid= 11891046 |doi= }}
* {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | year = 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Yang H, Henning D, Valdez BC | title = Functional interaction between RNA helicase II/Gu(alpha) and ribosomal protein L4 | journal = FEBS J. | volume = 272 | issue = 15 | pages = 3788–802 | year = 2005 | pmid = 16045751 | doi = 10.1111/j.1742-4658.2005.04811.x }}
*{{cite journal | author=Henning D, So RB, Jin R, ''et al.'' |title=Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52307-14 |year= 2004 |pmid= 14559904 |doi= 10.1074/jbc.M310846200 }}
* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 14 | pages = 5391–6 | year = 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}
*{{cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal | author=Yang H, Henning D, Valdez BC |title=Functional interaction between RNA helicase II/Gu(alpha) and ribosomal protein L4. |journal=FEBS J. |volume=272 |issue= 15 |pages= 3788-802 |year= 2005 |pmid= 16045751 |doi= 10.1111/j.1742-4658.2005.04811.x }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-10-stub}}

Latest revision as of 18:19, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nucleolar RNA helicase 2 is an enzyme that in humans is encoded by the DDX21 gene.[1][2]

Function

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription.[2]

Interactions

DDX21 has been shown to interact with C-jun.[3]

References

  1. ↑ Valdez BC, Henning D, Busch RK, Woods K, Flores-Rozas H, Hurwitz J, Perlaky L, Busch H (Jun 1996). "A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease". Nucleic Acids Res. 24 (7): 1220–4. doi:10.1093/nar/24.7.1220. PMC 145780. PMID 8614622.
  2. ↑ 2.0 2.1 "Entrez Gene: DDX21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21".
  3. ↑ Westermarck J, Weiss C, Saffrich R, Kast J, Musti AM, Wessely M, Ansorge W, Séraphin B, Wilm M, Valdez BC, Bohmann D (Feb 2002). "The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription". EMBO J. 21 (3): 451–60. doi:10.1093/emboj/21.3.451. PMC 125820. PMID 11823437.

Further reading


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