PDCD4: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Programmed cell death protein 4''' is a [[protein]] that in humans is encoded by the ''PDCD4'' [[gene]].<ref name="pmid9759869">{{cite journal | vauthors = Azzoni L, Zatsepina O, Abebe B, Bennett IM, Kanakaraj P, Perussia B | title = Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells | journal = Journal of Immunology | volume = 161 | issue = 7 | pages = 3493–500 | year = 1998 | pmid = 9759869 }}</ref><ref name="entrez">{{EntrezGene|27250}}</ref> It is one of the targets of an oncomiR, [[MIRN21]].<ref>{{cite journal | vauthors = Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH | title = Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells | journal = The Journal of Biological Chemistry | volume = 283 | issue = 2 | pages = 1026–33 | year = 2008 | pmid = 17991735 | doi = 10.1074/jbc.M707224200 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_PDCD4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ggf.
| PDB = {{PDB2|2ggf}}, {{PDB2|2hm8}}, {{PDB2|2iol}}, {{PDB2|2ion}}, {{PDB2|2ios}}, {{PDB2|2nsz}}
| Name = Programmed cell death 4 (neoplastic transformation inhibitor)
| HGNCid = 8763
| Symbol = PDCD4
| AltSymbols =; H731; MGC33046; MGC33047
| OMIM = 608610
| ECnumber = 
| Homologene = 7879
| MGIid = 107490
| GeneAtlas_image1 = PBB_GE_PDCD4_202731_at_tn.png
| GeneAtlas_image2 = PBB_GE_PDCD4_202730_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PDCD4_212593_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007569 |text = cell aging}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0043508 |text = negative regulation of JNK activity}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27250
    | Hs_Ensembl = ENSG00000150593
    | Hs_RefseqProtein = NP_055271
    | Hs_RefseqmRNA = NM_014456
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 112621555
    | Hs_GenLoc_end = 112649754
    | Hs_Uniprot = Q53EL6
    | Mm_EntrezGene = 18569
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_011050
    | Mm_RefseqProtein = NP_035180
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Programmed cell death 4 (neoplastic transformation inhibitor)''', also known as '''PDCD4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27250| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27250| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
PDCD4 has been shown to [[Protein-protein interaction|interact]] with [[RPS13]]<ref name=pmid12054647>{{cite journal | vauthors = Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY | title = Up-regulation of PDCD4 in senescent human diploid fibroblasts | journal = Biochemical and Biophysical Research Communications | volume = 293 | issue = 1 | pages = 617–21 | year = 2002 | pmid = 12054647 | doi = 10.1016/S0006-291X(02)00264-4 }}</ref> and [[Ribosomal protein L5]].<ref name=pmid12054647/>


==Further reading==
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Göke R, Gregel C, Göke A, Arnold R, Schmidt H, Lankat-Buttgereit B | title = Programmed Cell Death Protein 4 (PDCD4) Acts As a Tumor Suppressor in Neuroendocrine Tumor Cells | journal = Annals of the New York Academy of Sciences | volume = 1014 | pages = 220–1 | year = 2004 | pmid = 15153438 | doi = 10.1196/annals.1294.024 }}
| citations =
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: A simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Göke R, Gregel C, Göke A, ''et al.'' |title=Programmed cell death protein 4 (PDCD4) acts as a tumor suppressor in neuroendocrine tumor cells. |journal=Ann. N. Y. Acad. Sci. |volume=1014 |issue=  |pages= 220-1 |year= 2004 |pmid= 15153438 |doi= }}
* {{cite journal | vauthors = Shibahara K, Asano M, Ishida Y, Aoki T, Koike T, Honjo T | title = Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death | journal = Gene | volume = 166 | issue = 2 | pages = 297–301 | year = 1995 | pmid = 8543179 | doi = 10.1016/0378-1119(95)00607-9 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Shibahara K, Asano M, Ishida Y, ''et al.'' |title=Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death. |journal=Gene |volume=166 |issue= 2 |pages= 297-301 |year= 1996 |pmid= 8543179 |doi= }}
* {{cite journal | vauthors = Yoshinaga H, Matsuhashi S, Fujiyama C, Masaki Z | title = Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody | journal = Pathology International | volume = 49 | issue = 12 | pages = 1067–77 | year = 1999 | pmid = 10632927 | doi = 10.1046/j.1440-1827.1999.00995.x }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal |pages=113–4 |doi=10.1159/000015408 |title=Assignment<sup>1</sup> of the programmed cell death 4 gene (PDCD4) to human chromosome band 10q24 by in situ hybridization |year=1999 |last1=Soejima |first1=H. |last2=Miyoshi |first2=O. |last3=Yoshinaga |first3=H. |last4=Masaki |first4=Z. |last5=Ozaki |first5=I. |last6=Kajiwara |first6=S. |last7=Niikawa |first7=N. |last8=Matsuhashi |first8=S. |last9=Mukai |first9=T. |journal=Cytogenetic and Genome Research |volume=87}}
*{{cite journal  | author=Azzoni L, Zatsepina O, Abebe B, ''et al.'' |title=Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells. |journal=J. Immunol. |volume=161 |issue= 7 |pages= 3493-500 |year= 1998 |pmid= 9759869 |doi=  }}
* {{cite journal | vauthors = Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY | title = Up-regulation of PDCD4 in senescent human diploid fibroblasts | journal = Biochemical and Biophysical Research Communications | volume = 293 | issue = 1 | pages = 617–21 | year = 2002 | pmid = 12054647 | doi = 10.1016/S0006-291X(02)00264-4 }}
*{{cite journal | author=Yoshinaga H, Matsuhashi S, Fujiyama C, Masaki Z |title=Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody. |journal=Pathol. Int. |volume=49 |issue= 12 |pages= 1067-77 |year= 2000 |pmid= 10632927 |doi= }}
* {{cite journal | vauthors = Chen Y, Knösel T, Kristiansen G, Pietas A, Garber ME, Matsuhashi S, Ozaki I, Petersen I | title = Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis | journal = The Journal of Pathology | volume = 200 | issue = 5 | pages = 640–6 | year = 2003 | pmid = 12898601 | doi = 10.1002/path.1378 }}
*{{cite journal | author=Soejima H, Miyoshi O, Yoshinaga H, ''et al.'' |title=Assignment of the programmed cell death 4 gene (PDCD4) to human chromosome band 10q24 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 1-2 |pages= 113-4 |year= 2000 |pmid= 10640828 |doi= }}
* {{cite journal | vauthors = Yang HS, Cho MH, Zakowicz H, Hegamyer G, Sonenberg N, Colburn NH | title = A Novel Function of the MA-3 Domains in Transformation and Translation Suppressor Pdcd4 is Essential for Its Binding to Eukaryotic Translation Initiation Factor 4A | journal = Molecular and Cellular Biology | volume = 24 | issue = 9 | pages = 3894–906 | year = 2004 | pmid = 15082783 | pmc = 387765 | doi = 10.1128/MCB.24.9.3894-3906.2004 }}
*{{cite journal | author=Kang MJ, Ahn HS, Lee JY, ''et al.'' |title=Up-regulation of PDCD4 in senescent human diploid fibroblasts. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 1 |pages= 617-21 |year= 2002 |pmid= 12054647 |doi= 10.1016/S0006-291X(02)00264-4 }}
* {{cite journal | vauthors = Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC | title = Robust Phosphoproteomic Profiling of Tyrosine Phosphorylation Sites from Human T Cells Using Immobilized Metal Affinity Chromatography and Tandem Mass Spectrometry | journal = Analytical Chemistry | volume = 76 | issue = 10 | pages = 2763–72 | year = 2004 | pmid = 15144186 | doi = 10.1021/ac035352d }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Göke R, Barth P, Schmidt A, Samans B, Lankat-Buttgereit B | title = Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21Waf1/Cip1 | journal = AJP: Cell Physiology | volume = 287 | issue = 6 | pages = C1541–6 | year = 2004 | pmid = 15317660 | doi = 10.1152/ajpcell.00025.2004 }}
*{{cite journal  | author=Chen Y, Knösel T, Kristiansen G, ''et al.'' |title=Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis. |journal=J. Pathol. |volume=200 |issue= 5 |pages= 640-6 |year= 2003 |pmid= 12898601 |doi= 10.1002/path.1378 }}
* {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nature Biotechnology | volume = 23 | issue = 1 | pages = 94–101 | year = 2004 | pmid = 15592455 | doi = 10.1038/nbt1046 }}
*{{cite journal | author=Yang HS, Cho MH, Zakowicz H, ''et al.'' |title=A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. |journal=Mol. Cell. Biol. |volume=24 |issue= 9 |pages= 3894-906 |year= 2004 |pmid= 15082783 |doi= }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein–protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | displayauthors = 8 }}
*{{cite journal | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
* {{cite journal | vauthors = Palamarchuk A, Efanov A, Maximov V, Aqeilan RI, Croce CM, Pekarsky Y | title = Akt Phosphorylates and Regulates Pdcd4 Tumor Suppressor Protein | journal = Cancer Research | volume = 65 | issue = 24 | pages = 11282–6 | year = 2005 | pmid = 16357133 | doi = 10.1158/0008-5472.CAN-05-3469 }}
*{{cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
* {{cite journal | vauthors = Yang HS, Matthews CP, Clair T, Wang Q, Baker AR, Li CC, Tan TH, Colburn NH | title = Tumorigenesis Suppressor Pdcd4 Down-Regulates Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Expression to Suppress Colon Carcinoma Cell Invasion | journal = Molecular and Cellular Biology | volume = 26 | issue = 4 | pages = 1297–306 | year = 2006 | pmid = 16449643 | pmc = 1367180 | doi = 10.1128/MCB.26.4.1297-1306.2006 }}
*{{cite journal  | author=Göke R, Barth P, Schmidt A, ''et al.'' |title=Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1). |journal=Am. J. Physiol., Cell Physiol. |volume=287 |issue= 6 |pages= C1541-6 |year= 2004 |pmid= 15317660 |doi= 10.1152/ajpcell.00025.2004 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Palamarchuk A, Efanov A, Maximov V, ''et al.'' |title=Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. |journal=Cancer Res. |volume=65 |issue= 24 |pages= 11282-6 |year= 2006 |pmid= 16357133 |doi= 10.1158/0008-5472.CAN-05-3469 }}
*{{cite journal | author=Yang HS, Matthews CP, Clair T, ''et al.'' |title=Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. |journal=Mol. Cell. Biol. |volume=26 |issue= 4 |pages= 1297-306 |year= 2006 |pmid= 16449643 |doi= 10.1128/MCB.26.4.1297-1306.2006 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=27250}}


{{protein-stub}}
{{gene-10-stub}}
{{WikiDoc Sources}}

Latest revision as of 03:33, 11 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene.[1][2] It is one of the targets of an oncomiR, MIRN21.[3]

Function

This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.[2]

Interactions

PDCD4 has been shown to interact with RPS13[4] and Ribosomal protein L5.[4]

References

  1. ↑ Azzoni L, Zatsepina O, Abebe B, Bennett IM, Kanakaraj P, Perussia B (1998). "Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells". Journal of Immunology. 161 (7): 3493–500. PMID 9759869.
  2. ↑ 2.0 2.1 EntrezGene 27250
  3. ↑ Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH (2008). "Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells". The Journal of Biological Chemistry. 283 (2): 1026–33. doi:10.1074/jbc.M707224200. PMID 17991735.
  4. ↑ 4.0 4.1 Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochemical and Biophysical Research Communications. 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.

Further reading


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