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{{Infobox_gene}}
{{PBB_Controls
'''Centrosomal protein of 55 kDa''' is a [[protein]] that in humans is encoded by the ''CEP55'' [[gene]].<ref name="pmid16198290">{{cite journal | vauthors = Fabbro M, Zhou BB, Takahashi M, Sarcevic B, Lal P, Graham ME, Gabrielli BG, Robinson PJ, Nigg EA, Ono Y, Khanna KK | title = Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis | journal = Dev Cell | volume = 9 | issue = 4 | pages = 477–88 |date=Oct 2005 | pmid = 16198290 | pmc =  | doi = 10.1016/j.devcel.2005.09.003 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CEP55 centrosomal protein 55kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55165| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
CEP55 is a mitotic [[phosphoprotein]] that plays a key role in [[cytokinesis]], the final stage of cell division.<ref name="pmid19855176">{{cite journal | vauthors = van der Horst A, Simmons J, Khanna KK | title = Cep55 stabilization is required for normal execution of cytokinesis | journal = Cell Cycle | volume = 8 | issue = 22 | pages = 3742–9 |date=November 2009 | pmid = 19855176 | doi = 10.4161/cc.8.22.10047 }}</ref>
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Centrosomal protein 55kDa
| HGNCid = 1161
| Symbol = CEP55
| AltSymbols =; C10orf3; FLJ10540; URCC6
| OMIM = 610000
| ECnumber =
| Homologene = 10019
| MGIid = 1921357
| Function =
| Component =
| Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55165
    | Hs_Ensembl = ENSG00000138180
    | Hs_RefseqProtein = NP_060601
    | Hs_RefseqmRNA = NM_018131
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 95246379
    | Hs_GenLoc_end = 95278839
    | Hs_Uniprot = Q53EZ4
    | Mm_EntrezGene = 74107
    | Mm_Ensembl = ENSMUSG00000024989
    | Mm_RefseqmRNA = NM_028760
    | Mm_RefseqProtein = NP_083036
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 38120184
    | Mm_GenLoc_end = 38139565
    | Mm_Uniprot = Q9CZP8
  }}
}}
'''Centrosomal protein 55kDa''', also known as '''CEP55''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CEP55 centrosomal protein 55kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55165| accessdate = }}</ref>


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==References==
{{PBB_Summary
{{reflist}}
| section_title =  
 
| summary_text =
==External links==
}}
* {{UCSC gene info|CEP55}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
| citations =
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Deloukas P, Earthrowl ME, Grafham DV |title=The DNA sequence and comparative analysis of human chromosome 10 |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Martinez-Garay I, Rustom A, Gerdes HH, Kutsche K |title=The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody |journal=Genomics |volume=87 |issue= 2 |pages= 243–53 |year= 2006 |pmid= 16406728 |doi= 10.1016/j.ygeno.2005.11.006 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Zhao WM, Seki A, Fang G |title=Cep55, a Microtubule-bundling Protein, Associates with Centralspindlin to Control the Midbody Integrity and Cell Abscission during Cytokinesis |journal=Mol. Biol. Cell |volume=17 |issue= 9 |pages= 3881–96 |year= 2006 |pmid= 16790497 |doi= 10.1091/mbc.E06-01-0015 | pmc=1593165 }}
*{{cite journal  | author=Fabbro M, Zhou BB, Takahashi M, ''et al.'' |title=Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. |journal=Dev. Cell |volume=9 |issue= 4 |pages= 477-88 |year= 2005 |pmid= 16198290 |doi= 10.1016/j.devcel.2005.09.003 }}
*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal  | author=Martinez-Garay I, Rustom A, Gerdes HH, Kutsche K |title=The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody. |journal=Genomics |volume=87 |issue= 2 |pages= 243-53 |year= 2006 |pmid= 16406728 |doi= 10.1016/j.ygeno.2005.11.006 }}
*{{cite journal  | vauthors=Chen CH, Lu PJ, Chen YC |title=FLJ10540-elicited cell transformation is through the activation of PI3-kinase/AKT pathway |journal=Oncogene |volume=26 |issue= 29 |pages= 4272–83 |year= 2007 |pmid= 17237822 |doi= 10.1038/sj.onc.1210207 |display-authors=etal}}
*{{cite journal  | author=Zhao WM, Seki A, Fang G |title=Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesis. |journal=Mol. Biol. Cell |volume=17 |issue= 9 |pages= 3881-96 |year= 2006 |pmid= 16790497 |doi= 10.1091/mbc.E06-01-0015 }}
*{{cite journal  | vauthors=Carlton JG, Martin-Serrano J |title=Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery |journal=Science |volume=316 |issue= 5833 |pages= 1908–12 |year= 2007 |pmid= 17556548 |doi= 10.1126/science.1143422 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | vauthors=Morita E, Sandrin V, Chung HY |title=Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis |journal=EMBO J. |volume=26 |issue= 19 |pages= 4215–27 |year= 2007 |pmid= 17853893 |doi= 10.1038/sj.emboj.7601850 | pmc=2230844 |display-authors=etal}}
*{{cite journal  | author=Chen CH, Lu PJ, Chen YC, ''et al.'' |title=FLJ10540-elicited cell transformation is through the activation of PI3-kinase/AKT pathway. |journal=Oncogene |volume=26 |issue= 29 |pages= 4272-83 |year= 2007 |pmid= 17237822 |doi= 10.1038/sj.onc.1210207 }}
*{{cite journal  | author=Carlton JG, Martin-Serrano J |title=Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery. |journal=Science |volume=316 |issue= 5833 |pages= 1908-12 |year= 2007 |pmid= 17556548 |doi= 10.1126/science.1143422 }}
*{{cite journal  | author=Morita E, Sandrin V, Chung HY, ''et al.'' |title=Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. |journal=EMBO J. |volume=26 |issue= 19 |pages= 4215-27 |year= 2007 |pmid= 17853893 |doi= 10.1038/sj.emboj.7601850 }}
}}
{{refend}}
{{refend}}


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{{centrosome}}
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Latest revision as of 09:35, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Centrosomal protein of 55 kDa is a protein that in humans is encoded by the CEP55 gene.[1][2]

CEP55 is a mitotic phosphoprotein that plays a key role in cytokinesis, the final stage of cell division.[3]

References

  1. ↑ Fabbro M, Zhou BB, Takahashi M, Sarcevic B, Lal P, Graham ME, Gabrielli BG, Robinson PJ, Nigg EA, Ono Y, Khanna KK (Oct 2005). "Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis". Dev Cell. 9 (4): 477–88. doi:10.1016/j.devcel.2005.09.003. PMID 16198290.
  2. ↑ "Entrez Gene: CEP55 centrosomal protein 55kDa".
  3. ↑ van der Horst A, Simmons J, Khanna KK (November 2009). "Cep55 stabilization is required for normal execution of cytokinesis". Cell Cycle. 8 (22): 3742–9. doi:10.4161/cc.8.22.10047. PMID 19855176.

External links

Further reading


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