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{{Infobox_gene}}
{{PBB_Controls
'''LIM domain only 2''' ('''rhombotin-like 1'''), also known as '''LMO2''', '''RBTNL1''', '''RBTN2''', '''RHOM2''', '''LIM Domain Only Protein 2''', '''TTG2''', and '''T-Cell Translocation Protein 2''', is a [[protein]] which in humans is encoded by the ''LMO2'' [[gene]].<ref name="pmid2034676">{{cite journal | vauthors = Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH | title = The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 10 | pages = 4367–71 | date = May 1991 | pmid = 2034676 | pmc = 51660 | doi = 10.1073/pnas.88.10.4367 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = LIM domain only 2 (rhombotin-like 1)
| HGNCid = 6642
| Symbol = LMO2
| AltSymbols =; RBTN2; RBTNL1; RHOM2; TTG2
| OMIM = 180385
| ECnumber = 
| Homologene = 4072
| MGIid = 102811
| GeneAtlas_image1 = PBB_GE_LMO2_204249_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4005
    | Hs_Ensembl = ENSG00000135363
    | Hs_RefseqProtein = NP_005565
    | Hs_RefseqmRNA = NM_005574
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 33836701
    | Hs_GenLoc_end = 33870412
    | Hs_Uniprot = P25791
    | Mm_EntrezGene = 16909
    | Mm_Ensembl = ENSMUSG00000032698
    | Mm_RefseqmRNA = XM_001001351
    | Mm_RefseqProtein = XP_001001351
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 103771062
    | Mm_GenLoc_end = 103782713
    | Mm_Uniprot = Q544Z2
  }}
}}
'''LIM domain only 2 (rhombotin-like 1)''', also known as '''LMO2''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
LMO2 encodes a cysteine-rich, two [[LIM domain]] protein that is required for yolk sac [[erythropoiesis]].<ref name="pmid8033210">{{cite journal | vauthors = Warren AJ, Colledge WH, Carlton MB, Evans MJ, Smith AJ, Rabbitts TH | title = The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development | journal = Cell | volume = 78 | issue = 1 | pages = 45–57 | date = Jul 1994 | pmid = 8033210 | doi = 10.1016/0092-8674(94)90571-1 }}</ref> The LMO2 protein has a central and crucial role in [[haematopoiesis|hematopoietic]] development and is highly conserved.
{{PBB_Summary
| section_title =
| summary_text = LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis.  The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved.  The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur.<ref name="entrez">{{cite web | title = Entrez Gene: LMO2 LIM domain only 2 (rhombotin-like 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4005| accessdate = }}</ref>
}}


==References==
== Clinical significance ==
{{reflist|2}}


==Further reading==
The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number of [[T-lymphoblastic leukemia/lymphoma|T-cell acute lymphoblastic leukemia]]-specific translocations occur.<ref name="entrez">{{EntrezGene|4005}}</ref>
 
== Interactions ==
LMO2 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[GATA1]],<ref name = pmid7568177>{{cite journal | vauthors = Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH | title = Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 21 | pages = 9585–9 | date = Oct 1995 | pmid = 7568177 | pmc = 40846 | doi = 10.1073/pnas.92.21.9585 }}</ref>
* [[GATA2]],<ref name = pmid7568177/>
* [[JARID1A]],<ref name = pmid9129143>{{cite journal | vauthors = Mao S, Neale GA, Goorha RM | title = T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2 | journal = Oncogene | volume = 14 | issue = 13 | pages = 1531–9 | date = Apr 1997 | pmid = 9129143 | doi = 10.1038/sj.onc.1200988 }}</ref>
* [[MLLT4]],<ref name = pmid12067721>{{cite journal | vauthors = Bégay-Müller V, Ansieau S, Leutz A | title = The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL oncogene | journal = FEBS Letters | volume = 521 | issue = 1-3 | pages = 36–8 | date = Jun 2002 | pmid = 12067721 | doi = 10.1016/s0014-5793(02)02814-4 }}</ref> and
* [[TAL1]]<ref name = pmid7568177/><ref name = pmid7957052>{{cite journal | vauthors = Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R | title = Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia | journal = The EMBO Journal | volume = 13 | issue = 20 | pages = 4831–9 | date = Oct 1994 | pmid = 7957052 | pmc = 395422 | doi =  }}</ref><ref name = pmid8078932>{{cite journal | vauthors = Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH | title = The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 18 | pages = 8617–21 | date = Aug 1994 | pmid = 8078932 | pmc = 44657 | doi = 10.1073/pnas.91.18.8617 }}</ref><ref name = pmid16407974>{{cite journal | vauthors = Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T | title = ETO2 coordinates cellular proliferation and differentiation during erythropoiesis | journal = The EMBO Journal | volume = 25 | issue = 2 | pages = 357–66 | date = Jan 2006 | pmid = 16407974 | pmc = 1383517 | doi = 10.1038/sj.emboj.7600934 }}</ref>
{{Div col end}}
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Royer-Pokora B, Loos U, Ludwig WD | title = TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11) | journal = Oncogene | volume = 6 | issue = 10 | pages = 1887–93 | date = Oct 1991 | pmid = 1923511 }}
| citations =
* {{cite journal | vauthors = Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH | title = The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 10 | pages = 4367–71 | date = May 1991 | pmid = 2034676 | pmc = 51660 | doi = 10.1073/pnas.88.10.4367 }}
*{{cite journal | author=Royer-Pokora B, Loos U, Ludwig WD |title=TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). |journal=Oncogene |volume=6 |issue= 10 |pages= 1887-93 |year= 1991 |pmid= 1923511 |doi=  }}
* {{cite journal | vauthors = Boehm T, Spillantini MG, Sofroniew MV, Surani MA, Rabbitts TH | title = Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression | journal = Oncogene | volume = 6 | issue = 5 | pages = 695–703 | date = May 1991 | pmid = 2052354 }}
*{{cite journal | author=Boehm T, Foroni L, Kaneko Y, ''et al.'' |title=The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 10 |pages= 4367-71 |year= 1991 |pmid= 2034676 |doi= }}
* {{cite journal | vauthors = Dong WF, Xu Y, Hu QL, Munroe D, Minowada J, Housman DE, Minden MD | title = Molecular characterization of a chromosome translocation breakpoint t(11;14)(p13;q11) from the cell line KOPT-K1 | journal = Leukemia | volume = 9 | issue = 11 | pages = 1812–7 | date = Nov 1995 | pmid = 7475267 }}
*{{cite journal | author=Boehm T, Spillantini MG, Sofroniew MV, ''et al.'' |title=Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression. |journal=Oncogene |volume=6 |issue= 5 |pages= 695-703 |year= 1991 |pmid= 2052354 |doi=  }}
* {{cite journal | vauthors = Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH | title = Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 21 | pages = 9585–9 | date = Oct 1995 | pmid = 7568177 | pmc = 40846 | doi = 10.1073/pnas.92.21.9585 }}
*{{cite journal | author=Dong WF, Xu Y, Hu QL, ''et al.'' |title=Molecular characterization of a chromosome translocation breakpoint t(11;14)(p13;q11) from the cell line KOPT-K1. |journal=Leukemia |volume=9 |issue= 11 |pages= 1812-7 |year= 1995 |pmid= 7475267 |doi=  }}
* {{cite journal | vauthors = Sánchez-García I, Axelson H, Rabbitts TH | title = Functional diversity of LIM proteins: amino-terminal activation domains in the oncogenic proteins RBTN1 and RBTN2 | journal = Oncogene | volume = 10 | issue = 7 | pages = 1301–6 | date = Apr 1995 | pmid = 7731680 }}
*{{cite journal | author=Osada H, Grutz G, Axelson H, ''et al.'' |title=Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 21 |pages= 9585-9 |year= 1995 |pmid= 7568177 |doi= }}
* {{cite journal | vauthors = Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R | title = Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia | journal = The EMBO Journal | volume = 13 | issue = 20 | pages = 4831–9 | date = Oct 1994 | pmid = 7957052 | pmc = 395422 }}
*{{cite journal | author=Sánchez-García I, Axelson H, Rabbitts TH |title=Functional diversity of LIM proteins: amino-terminal activation domains in the oncogenic proteins RBTN1 and RBTN2. |journal=Oncogene |volume=10 |issue= 7 |pages= 1301-6 |year= 1995 |pmid= 7731680 |doi=  }}
* {{cite journal | vauthors = Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH | title = The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 18 | pages = 8617–21 | date = Aug 1994 | pmid = 8078932 | pmc = 44657 | doi = 10.1073/pnas.91.18.8617 }}
*{{cite journal | author=Wadman I, Li J, Bash RO, ''et al.'' |title=Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. |journal=EMBO J. |volume=13 |issue= 20 |pages= 4831-9 |year= 1994 |pmid= 7957052 |doi= }}
* {{cite journal | vauthors = Wilkinson DA, Neale GA, Mao S, Naeve CW, Goorha RM | title = Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia | journal = Leukemia | volume = 11 | issue = 1 | pages = 86–96 | date = Jan 1997 | pmid = 9001422 | doi = 10.1038/sj.leu.2400516 }}
*{{cite journal | author=Valge-Archer VE, Osada H, Warren AJ, ''et al.'' |title=The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 18 |pages= 8617-21 |year= 1994 |pmid= 8078932 |doi= }}
* {{cite journal | vauthors = Mao S, Neale GA, Goorha RM | title = T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2 | journal = Oncogene | volume = 14 | issue = 13 | pages = 1531–9 | date = Apr 1997 | pmid = 9129143 | doi = 10.1038/sj.onc.1200988 }}
*{{cite journal | author=Wilkinson DA, Neale GA, Mao S, ''et al.'' |title=Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia. |journal=Leukemia |volume=11 |issue= 1 |pages= 86-96 |year= 1997 |pmid= 9001422 |doi= }}
* {{cite journal | vauthors = Osada H, Grutz GG, Axelson H, Forster A, Rabbitts TH | title = LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1 | journal = Leukemia | volume = 11 Suppl 3 | pages = 307–12 | date = Apr 1997 | pmid = 9209374 }}
*{{cite journal | author=Mao S, Neale GA, Goorha RM |title=T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2. |journal=Oncogene |volume=14 |issue= 13 |pages= 1531-9 |year= 1997 |pmid= 9129143 |doi= 10.1038/sj.onc.1200988 }}
* {{cite journal | vauthors = Wadman IA, Osada H, Grütz GG, Agulnick AD, Westphal H, Forster A, Rabbitts TH | title = The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins | journal = The EMBO Journal | volume = 16 | issue = 11 | pages = 3145–57 | date = Jun 1997 | pmid = 9214632 | pmc = 1169933 | doi = 10.1093/emboj/16.11.3145 }}
*{{cite journal | author=Osada H, Grutz GG, Axelson H, ''et al.'' |title=LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1. |journal=Leukemia |volume=11 Suppl 3 |issue=  |pages= 307-12 |year= 1997 |pmid= 9209374 |doi=  }}
* {{cite journal | vauthors = Visvader JE, Mao X, Fujiwara Y, Hahm K, Orkin SH | title = The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 25 | pages = 13707–12 | date = Dec 1997 | pmid = 9391090 | pmc = 28370 | doi = 10.1073/pnas.94.25.13707 }}
*{{cite journal | author=Wadman IA, Osada H, Grütz GG, ''et al.'' |title=The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. |journal=EMBO J. |volume=16 |issue= 11 |pages= 3145-57 |year= 1997 |pmid= 9214632 |doi= 10.1093/emboj/16.11.3145 }}
* {{cite journal | vauthors = Jurata LW, Pfaff SL, Gill GN | title = The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors | journal = The Journal of Biological Chemistry | volume = 273 | issue = 6 | pages = 3152–7 | date = Feb 1998 | pmid = 9452425 | doi = 10.1074/jbc.273.6.3152 }}
*{{cite journal | author=Visvader JE, Mao X, Fujiwara Y, ''et al.'' |title=The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 25 |pages= 13707-12 |year= 1998 |pmid= 9391090 |doi= }}
* {{cite journal | vauthors = Kenny DA, Jurata LW, Saga Y, Gill GN | title = Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 19 | pages = 11257–62 | date = Sep 1998 | pmid = 9736723 | pmc = 21629 | doi = 10.1073/pnas.95.19.11257 }}
*{{cite journal | author=Jurata LW, Pfaff SL, Gill GN |title=The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors. |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3152-7 |year= 1998 |pmid= 9452425 |doi= }}
* {{cite journal | vauthors = Ono Y, Fukuhara N, Yoshie O | title = TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3 | journal = Molecular and Cellular Biology | volume = 18 | issue = 12 | pages = 6939–50 | date = Dec 1998 | pmid = 9819382 | pmc = 109277 }}
*{{cite journal | author=Kenny DA, Jurata LW, Saga Y, Gill GN |title=Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11257-62 |year= 1998 |pmid= 9736723 |doi= }}
* {{cite journal | vauthors = Bach I, Rodriguez-Esteban C, Carrière C, Bhushan A, Krones A, Rose DW, Glass CK, Andersen B, Izpisúa Belmonte JC, Rosenfeld MG | title = RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex | journal = Nature Genetics | volume = 22 | issue = 4 | pages = 394–9 | date = Aug 1999 | pmid = 10431247 | doi = 10.1038/11970 }}
*{{cite journal | author=Ono Y, Fukuhara N, Yoshie O |title=TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. |journal=Mol. Cell. Biol. |volume=18 |issue= 12 |pages= 6939-50 |year= 1998 |pmid= 9819382 |doi= }}
* {{cite journal | vauthors = Vitelli L, Condorelli G, Lulli V, Hoang T, Luchetti L, Croce CM, Peschle C | title = A pentamer transcriptional complex including tal-1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblasts | journal = Molecular and Cellular Biology | volume = 20 | issue = 14 | pages = 5330–42 | date = Jul 2000 | pmid = 10866689 | pmc = 85982 | doi = 10.1128/MCB.20.14.5330-5342.2000 }}
*{{cite journal | author=Bach I, Rodriguez-Esteban C, Carrière C, ''et al.'' |title=RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. |journal=Nat. Genet. |volume=22 |issue= 4 |pages= 394-9 |year= 1999 |pmid= 10431247 |doi= 10.1038/11970 }}
* {{cite journal | vauthors = Davenport J, Neale GA, Goorha R | title = Identification of genes potentially involved in LMO2-induced leukemogenesis | journal = Leukemia | volume = 14 | issue = 11 | pages = 1986–96 | date = Nov 2000 | pmid = 11069036 | doi = 10.1038/sj.leu.2401913 }}
*{{cite journal | author=Vitelli L, Condorelli G, Lulli V, ''et al.'' |title=A pentamer transcriptional complex including tal-1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblasts. |journal=Mol. Cell. Biol. |volume=20 |issue= 14 |pages= 5330-42 |year= 2000 |pmid= 10866689 |doi= }}
* {{cite journal | vauthors = Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, Visvader JE | title = The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity | journal = The Journal of Biological Chemistry | volume = 277 | issue = 10 | pages = 7849–56 | date = Mar 2002 | pmid = 11751867 | doi = 10.1074/jbc.M110603200 }}
*{{cite journal | author=Davenport J, Neale GA, Goorha R |title=Identification of genes potentially involved in LMO2-induced leukemogenesis. |journal=Leukemia |volume=14 |issue= 11 |pages= 1986-96 |year= 2000 |pmid= 11069036 |doi= }}
*{{cite journal | author=Sum EY, Peng B, Yu X, ''et al.'' |title=The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 7849-56 |year= 2002 |pmid= 11751867 |doi= 10.1074/jbc.M110603200 }}
}}
{{refend}}
{{refend}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 21:01, 9 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

LIM domain only 2 (rhombotin-like 1), also known as LMO2, RBTNL1, RBTN2, RHOM2, LIM Domain Only Protein 2, TTG2, and T-Cell Translocation Protein 2, is a protein which in humans is encoded by the LMO2 gene.[1]

Function

LMO2 encodes a cysteine-rich, two LIM domain protein that is required for yolk sac erythropoiesis.[2] The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved.

Clinical significance

The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number of T-cell acute lymphoblastic leukemia-specific translocations occur.[3]

Interactions

LMO2 has been shown to interact with:

References

  1. ↑ Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH (May 1991). "The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13". Proceedings of the National Academy of Sciences of the United States of America. 88 (10): 4367–71. doi:10.1073/pnas.88.10.4367. PMC 51660. PMID 2034676.
  2. ↑ Warren AJ, Colledge WH, Carlton MB, Evans MJ, Smith AJ, Rabbitts TH (Jul 1994). "The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development". Cell. 78 (1): 45–57. doi:10.1016/0092-8674(94)90571-1. PMID 8033210.
  3. ↑ EntrezGene 4005
  4. ↑ 4.0 4.1 4.2 Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (Oct 1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proceedings of the National Academy of Sciences of the United States of America. 92 (21): 9585–9. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177.
  5. ↑ Mao S, Neale GA, Goorha RM (Apr 1997). "T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2". Oncogene. 14 (13): 1531–9. doi:10.1038/sj.onc.1200988. PMID 9129143.
  6. ↑ Bégay-Müller V, Ansieau S, Leutz A (Jun 2002). "The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL oncogene". FEBS Letters. 521 (1–3): 36–8. doi:10.1016/s0014-5793(02)02814-4. PMID 12067721.
  7. ↑ Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (Oct 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". The EMBO Journal. 13 (20): 4831–9. PMC 395422. PMID 7957052.
  8. ↑ Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (Aug 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proceedings of the National Academy of Sciences of the United States of America. 91 (18): 8617–21. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932.
  9. ↑ Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T (Jan 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". The EMBO Journal. 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. PMC 1383517. PMID 16407974.

Further reading

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