SF3B2: Difference between revisions

Jump to navigation Jump to search
Newer edit →
VisualWikitext
WikiBot (talk | contribs)
Bots, Bureaucrats, bureaucrats, interwiki, nocaptcha, Administrators
57,550 edits
m Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Splicing factor 3B subunit 2''' is a [[protein]] that in humans is encoded by the ''SF3B2'' [[gene]].<ref name="pmid8566756">{{cite journal | vauthors = Gozani O, Feld R, Reed R | title = Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A | journal = Genes & Development | volume = 10 | issue = 2 | pages = 233–43 | date = Jan 1996 | pmid = 8566756 | pmc =  | doi = 10.1101/gad.10.2.233 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SF3B2 splicing factor 3b, subunit 2, 145kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10992| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_SF3B2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2do5.
| PDB = {{PDB2|2do5}}
| Name = Splicing factor 3b, subunit 2, 145kDa
| HGNCid = 10769
| Symbol = SF3B2
| AltSymbols =; SAP145; SF3B145; SF3b1; SF3b150
| OMIM = 605591
| ECnumber = 
| Homologene = 6678
| MGIid = 2441856
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}}
| Process = {{GNF_GO|id=GO:0000398 |text = nuclear mRNA splicing, via spliceosome}} {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10992
    | Hs_Ensembl = ENSG00000087365
    | Hs_RefseqProtein = NP_006833
    | Hs_RefseqmRNA = NM_006842
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 65576392
    | Hs_GenLoc_end = 65592958
    | Hs_Uniprot = Q13435
    | Mm_EntrezGene = 319322
    | Mm_Ensembl = ENSMUSG00000024853
    | Mm_RefseqmRNA = NM_030109
    | Mm_RefseqProtein = NP_084385
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 5273932
    | Mm_GenLoc_end = 5295448
    | Mm_Uniprot = 
  }}
}}
'''Splicing factor 3b, subunit 2, 145kDa''', also known as '''SF3B2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SF3B2 splicing factor 3b, subunit 2, 145kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10992| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.<ref name="entrez">{{cite web | title = Entrez Gene: SF3B2 splicing factor 3b, subunit 2, 145kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10992| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
SF3B2 has been shown to [[Protein-protein interaction|interact]] with [[SF3B4]],<ref name=pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name=pmid7958871>{{cite journal | vauthors = Champion-Arnaud P, Reed R | title = The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site | journal = Genes & Development | volume = 8 | issue = 16 | pages = 1974–83 | date = Aug 1994 | pmid = 7958871 | doi = 10.1101/gad.8.16.1974 }}</ref> [[RBM7]],<ref name=pmid12634307>{{cite journal | vauthors = Guo TB, Boros LG, Chan KC, Hikim AP, Hudson AP, Swerdloff RS, Mitchell AP, Salameh WA | title = Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors | journal = Journal of Andrology | volume = 24 | issue = 2 | pages = 204–14 | year = 2003 | pmid = 12634307 | doi=10.1002/j.1939-4640.2003.tb02664.x}}</ref> [[SF3B1]]<ref name=pmid10490618>{{cite journal | vauthors = Das BK, Xia L, Palandjian L, Gozani O, Chyung Y, Reed R | title = Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155 | journal = Molecular and Cellular Biology | volume = 19 | issue = 10 | pages = 6796–802 | date = Oct 1999 | pmid = 10490618 | pmc = 84676 | doi=10.1128/mcb.19.10.6796}}</ref><ref name=pmid12234937>{{cite journal | vauthors = Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R | title = Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein | journal = The EMBO Journal | volume = 21 | issue = 18 | pages = 4978–88 | date = Sep 2002 | pmid = 12234937 | pmc = 126279 | doi = 10.1093/emboj/cdf480 }}</ref> and [[CDC5L]].<ref name=pmid11101529>{{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6569–81 | date = Dec 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Agell N, Aligué R, Alemany V, Castro A, Jaime M, Pujol MJ, Rius E, Serratosa J, Taulés M, Bachs O | title = New nuclear functions for calmodulin | journal = Cell Calcium | volume = 23 | issue = 2-3 | pages = 115–21 | year = 1998 | pmid = 9601606 | doi = 10.1016/S0143-4160(98)90109-9 }}
| citations =
* {{cite journal | vauthors = Champion-Arnaud P, Reed R | title = The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site | journal = Genes & Development | volume = 8 | issue = 16 | pages = 1974–83 | date = Aug 1994 | pmid = 7958871 | doi = 10.1101/gad.8.16.1974 }}
*{{cite journal | author=Agell N, Aligué R, Alemany V, ''et al.'' |title=New nuclear functions for calmodulin. |journal=Cell Calcium |volume=23 |issue= 2-3 |pages= 115-21 |year= 1998 |pmid= 9601606 |doi= }}
* {{cite journal | vauthors = Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M | title = Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex | journal = Nature Genetics | volume = 20 | issue = 1 | pages = 46–50 | date = Sep 1998 | pmid = 9731529 | doi = 10.1038/1700 }}
*{{cite journal | author=Champion-Arnaud P, Reed R |title=The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site. |journal=Genes Dev. |volume=8 |issue= 16 |pages= 1974-83 |year= 1994 |pmid= 7958871 |doi= }}
* {{cite journal | vauthors = Das BK, Xia L, Palandjian L, Gozani O, Chyung Y, Reed R | title = Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155 | journal = Molecular and Cellular Biology | volume = 19 | issue = 10 | pages = 6796–802 | date = Oct 1999 | pmid = 10490618 | pmc = 84676 | doi =  10.1128/mcb.19.10.6796}}
*{{cite journal  | author=Gozani O, Feld R, Reed R |title=Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A. |journal=Genes Dev. |volume=10 |issue= 2 |pages= 233-43 |year= 1996 |pmid= 8566756 |doi=  }}
* {{cite journal | vauthors = Das R, Zhou Z, Reed R | title = Functional association of U2 snRNP with the ATP-independent spliceosomal complex E | journal = Molecular Cell | volume = 5 | issue = 5 | pages = 779–87 | date = May 2000 | pmid = 10882114 | doi = 10.1016/S1097-2765(00)80318-4 }}
*{{cite journal | author=Neubauer G, King A, Rappsilber J, ''et al.'' |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46-50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700 }}
* {{cite journal | vauthors = Bryant HE, Wadd SE, Lamond AI, Silverstein SJ, Clements JB | title = Herpes simplex virus IE63 (ICP27) protein interacts with spliceosome-associated protein 145 and inhibits splicing prior to the first catalytic step | journal = Journal of Virology | volume = 75 | issue = 9 | pages = 4376–85 | date = May 2001 | pmid = 11287586 | pmc = 114182 | doi = 10.1128/JVI.75.9.4376-4385.2001 }}
*{{cite journal | author=Das BK, Xia L, Palandjian L, ''et al.'' |title=Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 6796-802 |year= 2000 |pmid= 10490618 |doi=  }}
* {{cite journal | vauthors = Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L | title = UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation | journal = The EMBO Journal | volume = 20 | issue = 12 | pages = 3187–96 | date = Jun 2001 | pmid = 11406595 | pmc = 150203 | doi = 10.1093/emboj/20.12.3187 }}
*{{cite journal | author=Das R, Zhou Z, Reed R |title=Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. |journal=Mol. Cell |volume=5 |issue= 5 |pages= 779-87 |year= 2000 |pmid= 10882114 |doi= }}
* {{cite journal | vauthors = Will CL, Schneider C, MacMillan AM, Katopodis NF, Neubauer G, Wilm M, Lührmann R, Query CC | title = A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site | journal = The EMBO Journal | volume = 20 | issue = 16 | pages = 4536–46 | date = Aug 2001 | pmid = 11500380 | pmc = 125580 | doi = 10.1093/emboj/20.16.4536 }}
*{{cite journal | author=Bryant HE, Wadd SE, Lamond AI, ''et al.'' |title=Herpes simplex virus IE63 (ICP27) protein interacts with spliceosome-associated protein 145 and inhibits splicing prior to the first catalytic step. |journal=J. Virol. |volume=75 |issue= 9 |pages= 4376-85 |year= 2001 |pmid= 11287586 |doi= 10.1128/JVI.75.9.4376-4385.2001 }}
* {{cite journal | vauthors = Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ | title = Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis | journal = RNA | volume = 8 | issue = 4 | pages = 426–39 | date = Apr 2002 | pmid = 11991638 | pmc = 1370266 | doi = 10.1017/S1355838202021088 }}
*{{cite journal | author=Brand M, Moggs JG, Oulad-Abdelghani M, ''et al.'' |title=UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. |journal=EMBO J. |volume=20 |issue= 12 |pages= 3187-96 |year= 2001 |pmid= 11406595 |doi= 10.1093/emboj/20.12.3187 }}
* {{cite journal | vauthors = Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R | title = Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein | journal = The EMBO Journal | volume = 21 | issue = 18 | pages = 4978–88 | date = Sep 2002 | pmid = 12234937 | pmc = 126279 | doi = 10.1093/emboj/cdf480 }}
*{{cite journal | author=Will CL, Schneider C, MacMillan AM, ''et al.'' |title=A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site. |journal=EMBO J. |volume=20 |issue= 16 |pages= 4536-46 |year= 2001 |pmid= 11500380 |doi= 10.1093/emboj/20.16.4536 }}
* {{cite journal | vauthors = Warner DR, Roberts EA, Greene RM, Pisano MM | title = Identification of novel Smad binding proteins | journal = Biochemical and Biophysical Research Communications | volume = 312 | issue = 4 | pages = 1185–90 | date = Dec 2003 | pmid = 14651998 | doi = 10.1016/j.bbrc.2003.11.049 }}
*{{cite journal | author=Jurica MS, Licklider LJ, Gygi SR, ''et al.'' |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426-39 |year= 2002 |pmid= 11991638 |doi= }}
* {{cite journal | vauthors = Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Lührmann R | title = The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome | journal = RNA | volume = 10 | issue = 6 | pages = 929–41 | date = Jun 2004 | pmid = 15146077 | pmc = 1370585 | doi = 10.1261/rna.7320604 }}
*{{cite journal | author=Will CL, Urlaub H, Achsel T, ''et al.'' |title=Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. |journal=EMBO J. |volume=21 |issue= 18 |pages= 4978-88 |year= 2002 |pmid= 12234937 |doi=  }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Lin KT, Lu RM, Tarn WY | title = The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo | journal = Molecular and Cellular Biology | volume = 24 | issue = 20 | pages = 9176–85 | date = Oct 2004 | pmid = 15456888 | pmc = 517884 | doi = 10.1128/MCB.24.20.9176-9185.2004 }}
*{{cite journal | author=Warner DR, Roberts EA, Greene RM, Pisano MM |title=Identification of novel Smad binding proteins. |journal=Biochem. Biophys. Res. Commun. |volume=312 |issue= 4 |pages= 1185-90 |year= 2004 |pmid= 14651998 |doi= }}
* {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | date = Jan 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
*{{cite journal | author=Will CL, Schneider C, Hossbach M, ''et al.'' |title=The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. |journal=RNA |volume=10 |issue= 6 |pages= 929-41 |year= 2004 |pmid= 15146077 |doi= }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Ardon O, Zimmerman ES, Andersen JL, DeHart JL, Blackett J, Planelles V | title = Induction of G2 arrest and binding to cyclophilin A are independent phenotypes of human immunodeficiency virus type 1 Vpr | journal = Journal of Virology | volume = 80 | issue = 8 | pages = 3694–700 | date = Apr 2006 | pmid = 16571786 | pmc = 1440437 | doi = 10.1128/JVI.80.8.3694-3700.2006 }}
*{{cite journal | author=Lin KT, Lu RM, Tarn WY |title=The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo. |journal=Mol. Cell. Biol. |volume=24 |issue= 20 |pages= 9176-85 |year= 2004 |pmid= 15456888 |doi= 10.1128/MCB.24.20.9176-9185.2004 }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Ardon O, Zimmerman ES, Andersen JL, ''et al.'' |title=Induction of G2 arrest and binding to cyclophilin A are independent phenotypes of human immunodeficiency virus type 1 Vpr. |journal=J. Virol. |volume=80 |issue= 8 |pages= 3694-700 |year= 2006 |pmid= 16571786 |doi= 10.1128/JVI.80.8.3694-3700.2006 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=10992}}
{{WikiDoc Sources}}

Revision as of 06:12, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Splicing factor 3B subunit 2 is a protein that in humans is encoded by the SF3B2 gene.[1][2]

Function

This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.[2]

Interactions

SF3B2 has been shown to interact with SF3B4,[3][4] RBM7,[5] SF3B1[6][7] and CDC5L.[8]

References

  1. ↑ Gozani O, Feld R, Reed R (Jan 1996). "Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A". Genes & Development. 10 (2): 233–43. doi:10.1101/gad.10.2.233. PMID 8566756.
  2. ↑ 2.0 2.1 "Entrez Gene: SF3B2 splicing factor 3b, subunit 2, 145kDa".
  3. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  4. ↑ Champion-Arnaud P, Reed R (Aug 1994). "The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site". Genes & Development. 8 (16): 1974–83. doi:10.1101/gad.8.16.1974. PMID 7958871.
  5. ↑ Guo TB, Boros LG, Chan KC, Hikim AP, Hudson AP, Swerdloff RS, Mitchell AP, Salameh WA (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". Journal of Andrology. 24 (2): 204–14. doi:10.1002/j.1939-4640.2003.tb02664.x. PMID 12634307.
  6. ↑ Das BK, Xia L, Palandjian L, Gozani O, Chyung Y, Reed R (Oct 1999). "Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155". Molecular and Cellular Biology. 19 (10): 6796–802. doi:10.1128/mcb.19.10.6796. PMC 84676. PMID 10490618.
  7. ↑ Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (Sep 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". The EMBO Journal. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937.
  8. ↑ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=SF3B2&oldid=1414801"