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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''AP-2 complex subunit alpha-2''' is a [[protein]] that in humans is encoded by the ''AP2A2'' [[gene]].<ref name="pmid9700202">{{cite journal | vauthors = Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME | title = Huntingtin interacts with a family of WW domain proteins | journal = Human Molecular Genetics | volume = 7 | issue = 9 | pages = 1463–74 | date = Sep 1998 | pmid = 9700202 | pmc =  | doi = 10.1093/hmg/7.9.1463 }}</ref><ref name="pmid2564002">{{cite journal | vauthors = Robinson MS | title = Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins) | journal = The Journal of Cell Biology | volume = 108 | issue = 3 | pages = 833–42 | date = Mar 1989 | pmid = 2564002 | pmc = 2115374 | doi = 10.1083/jcb.108.3.833 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=161| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_AP2A2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b9k.
| PDB = {{PDB2|1b9k}}, {{PDB2|1gw5}}, {{PDB2|1ky6}}, {{PDB2|1ky7}}, {{PDB2|1kyd}}, {{PDB2|1kyf}}, {{PDB2|1kyu}}, {{PDB2|1qtp}}, {{PDB2|1qts}}, {{PDB2|1w80}}
| Name = Adaptor-related protein complex 2, alpha 2 subunit
| HGNCid = 562
| Symbol = AP2A2
| AltSymbols =; ADTAB; CLAPA2; HIP9; HYPJ
| OMIM = 607242
| ECnumber = 
| Homologene = 5335
| MGIid = 101920
| GeneAtlas_image1 = PBB_GE_AP2A2_211779_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_AP2A2_212159_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_AP2A2_212161_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0008289 |text = lipid binding}}
| Component = {{GNF_GO|id=GO:0005905 |text = coated pit}} {{GNF_GO|id=GO:0030117 |text = membrane coat}} {{GNF_GO|id=GO:0030122 |text = AP-2 adaptor complex}} {{GNF_GO|id=GO:0030130 |text = clathrin coat of trans-Golgi network vesicle}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006897 |text = endocytosis}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 161
    | Hs_Ensembl = ENSG00000183020
    | Hs_RefseqProtein = NP_036437
    | Hs_RefseqmRNA = NM_012305
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 915841
    | Hs_GenLoc_end = 1002240
    | Hs_Uniprot = O94973
    | Mm_EntrezGene = 11772
    | Mm_Ensembl = ENSMUSG00000002957
    | Mm_RefseqmRNA = NM_007459
    | Mm_RefseqProtein = NP_031485
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 141413558
    | Mm_GenLoc_end = 141484333
    | Mm_Uniprot = Q3U7X9
  }}
}}
'''Adaptor-related protein complex 2, alpha 2 subunit''', also known as '''AP2A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=161| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
AP2A2 has been shown to [[Protein-protein interaction|interact]] with [[EPN1]]<ref name=pmid9723620>{{cite journal | vauthors = Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P | title = Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis | journal = Nature | volume = 394 | issue = 6695 | pages = 793–7 | date = Aug 1998 | pmid = 9723620 | doi = 10.1038/29555 }}</ref> and [[SHC1]].<ref name=pmid8617812>{{cite journal | vauthors = Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M | title = Interaction of Shc with adaptor protein adaptins | journal = The Journal of Biological Chemistry | volume = 271 | issue = 9 | pages = 5265–9 | date = Mar 1996 | pmid = 8617812 | doi = 10.1074/jbc.271.9.5265 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kirchhausen T | title = Clathrin | journal = Annual Review of Biochemistry | volume = 69 | issue =  | pages = 699–727 | year = 2000 | pmid = 10966473 | doi = 10.1146/annurev.biochem.69.1.699 }}
| citations =
* {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Research | volume = 9 | issue = 3 | pages = 99–106 | date = Jun 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 }}
*{{cite journal | author=Kirchhausen T |title=Clathrin. |journal=Annu. Rev. Biochem. |volume=69 |issue=  |pages= 699-727 |year= 2000 |pmid= 10966473 |doi= 10.1146/annurev.biochem.69.1.699 }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
* {{cite journal | vauthors = David C, McPherson PS, Mundigl O, de Camilli P | title = A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 1 | pages = 331–5 | date = Jan 1996 | pmid = 8552632 | pmc = 40232 | doi = 10.1073/pnas.93.1.331 }}
*{{cite journal  | author=Robinson MS |title=Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). |journal=J. Cell Biol. |volume=108 |issue= 3 |pages= 833-42 |year= 1989 |pmid= 2564002 |doi=  }}
* {{cite journal | vauthors = Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M | title = Interaction of Shc with adaptor protein adaptins | journal = The Journal of Biological Chemistry | volume = 271 | issue = 9 | pages = 5265–9 | date = Mar 1996 | pmid = 8617812 | doi = 10.1074/jbc.271.9.5265 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Benmerah A, Bégue B, Dautry-Varsat A, Cerf-Bensussan N | title = The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein | journal = The Journal of Biological Chemistry | volume = 271 | issue = 20 | pages = 12111–6 | date = May 1996 | pmid = 8662627 | doi = 10.1074/jbc.271.20.12111 }}
*{{cite journal | author=David C, McPherson PS, Mundigl O, de Camilli P |title=A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 331-5 |year= 1996 |pmid= 8552632 |doi= }}
* {{cite journal | vauthors = van Delft S, Schumacher C, Hage W, Verkleij AJ, van Bergen en Henegouwen PM | title = Association and colocalization of Eps15 with adaptor protein-2 and clathrin | journal = The Journal of Cell Biology | volume = 136 | issue = 4 | pages = 811–21 | date = Feb 1997 | pmid = 9049247 | pmc = 2132490 | doi = 10.1083/jcb.136.4.811 }}
*{{cite journal | author=Okabayashi Y, Sugimoto Y, Totty NF, ''et al.'' |title=Interaction of Shc with adaptor protein adaptins. |journal=J. Biol. Chem. |volume=271 |issue= 9 |pages= 5265-9 |year= 1996 |pmid= 8617812 |doi= }}
* {{cite journal | vauthors = Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS | title = Identification and characterization of a nerve terminal-enriched amphiphysin isoform | journal = The Journal of Biological Chemistry | volume = 272 | issue = 26 | pages = 16700–6 | date = Jun 1997 | pmid = 9195986 | doi = 10.1074/jbc.272.26.16700 }}
*{{cite journal | author=Benmerah A, Bégue B, Dautry-Varsat A, Cerf-Bensussan N |title=The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein. |journal=J. Biol. Chem. |volume=271 |issue= 20 |pages= 12111-6 |year= 1996 |pmid= 8662627 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=van Delft S, Schumacher C, Hage W, ''et al.'' |title=Association and colocalization of Eps15 with adaptor protein-2 and clathrin. |journal=J. Cell Biol. |volume=136 |issue= 4 |pages= 811-21 |year= 1997 |pmid= 9049247 |doi= }}
* {{cite journal | vauthors = Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P | title = Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis | journal = Nature | volume = 394 | issue = 6695 | pages = 793–7 | date = Aug 1998 | pmid = 9723620 | doi = 10.1038/29555 }}
*{{cite journal | author=Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS |title=Identification and characterization of a nerve terminal-enriched amphiphysin isoform. |journal=J. Biol. Chem. |volume=272 |issue= 26 |pages= 16700-6 |year= 1997 |pmid= 9195986 |doi= }}
* {{cite journal | vauthors = Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R | title = Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins | journal = Journal of Virology | volume = 73 | issue = 2 | pages = 1350–61 | date = Feb 1999 | pmid = 9882340 | pmc = 103959 | doi =  }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 6 | pages = 355–64 | date = Dec 1998 | pmid = 10048485 | doi = 10.1093/dnares/5.6.355 }}
*{{cite journal  | author=Faber PW, Barnes GT, Srinidhi J, ''et al.'' |title=Huntingtin interacts with a family of WW domain proteins. |journal=Hum. Mol. Genet. |volume=7 |issue= 9 |pages= 1463-74 |year= 1998 |pmid= 9700202 |doi=  }}
* {{cite journal | vauthors = Traub LM, Downs MA, Westrich JL, Fremont DH | title = Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 16 | pages = 8907–12 | date = Aug 1999 | pmid = 10430869 | pmc = 17706 | doi = 10.1073/pnas.96.16.8907 }}
*{{cite journal | author=Chen H, Fre S, Slepnev VI, ''et al.'' |title=Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. |journal=Nature |volume=394 |issue= 6695 |pages= 793-7 |year= 1998 |pmid= 9723620 |doi= 10.1038/29555 }}
* {{cite journal | vauthors = Page LJ, Sowerby PJ, Lui WW, Robinson MS | title = Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin | journal = The Journal of Cell Biology | volume = 146 | issue = 5 | pages = 993–1004 | date = Sep 1999 | pmid = 10477754 | pmc = 2169493 | doi = 10.1083/jcb.146.5.993 }}
*{{cite journal | author=Berlioz-Torrent C, Shacklett BL, Erdtmann L, ''et al.'' |title=Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins. |journal=J. Virol. |volume=73 |issue= 2 |pages= 1350-61 |year= 1999 |pmid= 9882340 |doi=  }}
* {{cite journal | vauthors = Kim ST, Lim DS, Canman CE, Kastan MB | title = Substrate specificities and identification of putative substrates of ATM kinase family members | journal = The Journal of Biological Chemistry | volume = 274 | issue = 53 | pages = 37538–43 | date = Dec 1999 | pmid = 10608806 | doi = 10.1074/jbc.274.53.37538 }}
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355-64 |year= 1999 |pmid= 10048485 |doi= }}
* {{cite journal | vauthors = Slepnev VI, Ochoa GC, Butler MH, De Camilli P | title = Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites | journal = The Journal of Biological Chemistry | volume = 275 | issue = 23 | pages = 17583–9 | date = Jun 2000 | pmid = 10748223 | doi = 10.1074/jbc.M910430199 }}
*{{cite journal | author=Traub LM, Downs MA, Westrich JL, Fremont DH |title=Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 16 |pages= 8907-12 |year= 1999 |pmid= 10430869 |doi= }}
* {{cite journal | vauthors = Jullien-Flores V, Mahé Y, Mirey G, Leprince C, Meunier-Bisceuil B, Sorkin A, Camonis JH | title = RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis | journal = Journal of Cell Science | volume = 113 | issue = 16 | pages = 2837–44 | date = Aug 2000 | pmid = 10910768 | doi =  }}
*{{cite journal | author=Page LJ, Sowerby PJ, Lui WW, Robinson MS |title=Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. |journal=J. Cell Biol. |volume=146 |issue= 5 |pages= 993-1004 |year= 1999 |pmid= 10477754 |doi= }}
*{{cite journal | author=Kim ST, Lim DS, Canman CE, Kastan MB |title=Substrate specificities and identification of putative substrates of ATM kinase family members. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 37538-43 |year= 2000 |pmid= 10608806 |doi= }}
*{{cite journal | author=Slepnev VI, Ochoa GC, Butler MH, De Camilli P |title=Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites. |journal=J. Biol. Chem. |volume=275 |issue= 23 |pages= 17583-9 |year= 2000 |pmid= 10748223 |doi= 10.1074/jbc.M910430199 }}
*{{cite journal | author=Jullien-Flores V, Mahé Y, Mirey G, ''et al.'' |title=RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis. |journal=J. Cell. Sci. |volume=113 ( Pt 16) |issue= |pages= 2837-44 |year= 2000 |pmid= 10910768 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC gene info|AP2A2}}
{{PDB Gallery|geneid=161}}
 
 
{{gene-11-stub}}

Latest revision as of 18:05, 29 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene.[1][2][3]

Interactions

AP2A2 has been shown to interact with EPN1[4] and SHC1.[5]

References

  1. ↑ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
  2. ↑ Robinson MS (Mar 1989). "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)". The Journal of Cell Biology. 108 (3): 833–42. doi:10.1083/jcb.108.3.833. PMC 2115374. PMID 2564002.
  3. ↑ "Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit".
  4. ↑ Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Aug 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature. 394 (6695): 793–7. doi:10.1038/29555. PMID 9723620.
  5. ↑ Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M (Mar 1996). "Interaction of Shc with adaptor protein adaptins". The Journal of Biological Chemistry. 271 (9): 5265–9. doi:10.1074/jbc.271.9.5265. PMID 8617812.

Further reading

External links


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