TRIM29: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Tripartite motif-containing protein 29''' is a [[protein]] that in humans is encoded by the ''TRIM29'' [[gene]].<ref name="pmid11331580">{{cite journal | vauthors = Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A | title = The tripartite motif family identifies cell compartments | journal = EMBO J. | volume = 20 | issue = 9 | pages = 2140–51  | date = May 2001 | pmid = 11331580 | pmc = 125245 | doi = 10.1093/emboj/20.9.2140 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TRIM29 tripartite motif-containing 29| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23650| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_TRIM29_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2csv.
| PDB = {{PDB2|2csv}}
| Name = Tripartite motif-containing 29
| HGNCid = 17274
| Symbol = TRIM29
| AltSymbols =; ATDC; FLJ36085
| OMIM = 610658
| ECnumber = 
| Homologene = 8100
| MGIid = 
| GeneAtlas_image1 = PBB_GE_TRIM29_202504_at_tn.png
| GeneAtlas_image2 = PBB_GE_TRIM29_211002_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_TRIM29_211001_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23650
    | Hs_Ensembl = ENSG00000137699
    | Hs_RefseqProtein = NP_036233
    | Hs_RefseqmRNA = NM_012101
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 119487205
    | Hs_GenLoc_end = 119514073
    | Hs_Uniprot = Q14134
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Tripartite motif-containing 29''', also known as '''TRIM29''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TRIM29 tripartite motif-containing 29| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23650| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene belongs to the [[Tripartite motif family|TRIM protein family]]. It has multiple [[zinc finger]] motifs and a [[leucine zipper]] motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.<ref name="entrez">{{cite web | title = Entrez Gene: TRIM29 tripartite motif-containing 29| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23650| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
TRIM29 has been shown to [[Protein-protein interaction|interact]] with [[TRIM23]]<ref name="pmid11331580"/> and [[GCC1]].<ref name=pmid16189514>{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8  | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kapp LN, Painter RB, Yu LC, van Loon N, Richard CW, James MR, Cox DR, Murnane JP | title = Cloning of a candidate gene for ataxia-telangiectasia group D | journal = Am. J. Hum. Genet. | volume = 51 | issue = 1 | pages = 45–54 | year = 1992 | pmid = 1609804 | pmc = 1682873 | doi =  }}
| citations =
* {{cite journal | vauthors = Hosoi Y, Kapp LN | title = Expression of a candidate ataxia-telangiectasia group D gene in cultured fibroblast cell lines and human tissues | journal = Int. J. Radiat. Biol. | volume = 66 | issue = 6 Suppl | pages = S71-6 | year = 1994 | pmid = 7530755 | doi = 10.1080/09553009414551891 }}
*{{cite journal | author=Kapp LN, Painter RB, Yu LC, ''et al.'' |title=Cloning of a candidate gene for ataxia-telangiectasia group D. |journal=Am. J. Hum. Genet. |volume=51 |issue= 1 |pages= 45-54 |year= 1992 |pmid= 1609804 |doi=  }}
* {{cite journal | vauthors = Brzoska PM, Chen H, Zhu Y, Levin NA, Disatnik MH, Mochly-Rosen D, Murnane JP, Christman MF | title = The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 17 | pages = 7824–8 | year = 1995 | pmid = 7644499 | pmc = 41238 | doi = 10.1073/pnas.92.17.7824 }}
*{{cite journal | author=Hosoi Y, Kapp LN |title=Expression of a candidate ataxia-telangiectasia group D gene in cultured fibroblast cell lines and human tissues. |journal=Int. J. Radiat. Biol. |volume=66 |issue= 6 Suppl |pages= S71-6 |year= 1995 |pmid= 7530755 |doi= }}
* {{cite journal | vauthors = Murnane JP, Zhu Y, Young BR, Christman MF | title = Expression of the candidate A-T gene ATDC is not detectable in a human cell line with a normal response to ionizing radiation | journal = Int. J. Radiat. Biol. | volume = 66 | issue = 6 Suppl | pages = S77-84 | year = 1994 | pmid = 7836856 | doi = 10.1080/09553009414551901 }}
*{{cite journal | author=Brzoska PM, Chen H, Zhu Y, ''et al.'' |title=The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 17 |pages= 7824-8 |year= 1995 |pmid= 7644499 |doi= }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Murnane JP, Zhu Y, Young BR, Christman MF |title=Expression of the candidate A-T gene ATDC is not detectable in a human cell line with a normal response to ionizing radiation. |journal=Int. J. Radiat. Biol. |volume=66 |issue= 6 Suppl |pages= S77-84 |year= 1995 |pmid= 7836856 |doi= }}
* {{cite journal | vauthors = Leonhardt EA, Kapp LN, Young BR, Murnane JP | title = Nucleotide sequence analysis of a candidate gene for ataxia-telangiectasia group D (ATDC) | journal = Genomics | volume = 19 | issue = 1 | pages = 130–6 | year = 1994 | pmid = 8188213 | doi = 10.1006/geno.1994.1022 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Richard CW, Cox DR, Kapp L, Murnane J, Cornelis F, Julier C, Lathrop GM, James MR | title = A radiation hybrid map of human chromosome 11q22-q23 containing the ataxia-telangiectasia disease locus | journal = Genomics | volume = 17 | issue = 1 | pages = 1–5 | year = 1993 | pmid = 8406440 | doi = 10.1006/geno.1993.1275 }}
*{{cite journal | author=Leonhardt EA, Kapp LN, Young BR, Murnane JP |title=Nucleotide sequence analysis of a candidate gene for ataxia-telangiectasia group D (ATDC). |journal=Genomics |volume=19 |issue= 1 |pages= 130-6 |year= 1994 |pmid= 8188213 |doi= 10.1006/geno.1994.1022 }}
* {{cite journal | vauthors = Laderoute KR, Knapp AM, Green CJ, Sutherland RM, Kapp LN | title = Expression of the ATDC (ataxia telangiectasia group D-complementing) gene in A431 human squamous carcinoma cells | journal = Int. J. Cancer | volume = 66 | issue = 6 | pages = 772–8 | year = 1996 | pmid = 8647648 | doi = 10.1002/(SICI)1097-0215(19960611)66:6<772::AID-IJC11>3.0.CO;2-5 }}
*{{cite journal | author=Richard CW, Cox DR, Kapp L, ''et al.'' |title=A radiation hybrid map of human chromosome 11q22-q23 containing the ataxia-telangiectasia disease locus. |journal=Genomics |volume=17 |issue= 1 |pages= 1-5 |year= 1993 |pmid= 8406440 |doi= 10.1006/geno.1993.1275 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Laderoute KR, Knapp AM, Green CJ, ''et al.'' |title=Expression of the ATDC (ataxia telangiectasia group D-complementing) gene in A431 human squamous carcinoma cells. |journal=Int. J. Cancer |volume=66 |issue= 6 |pages= 772-8 |year= 1996 |pmid= 8647648 |doi= 10.1002/(SICI)1097-0215(19960611)66:6<772::AID-IJC11>3.0.CO;2-5 }}
* {{cite journal | vauthors = Tauchi H, Green C, Knapp M, Laderoute K, Kapp L | title = Altered splicing of the ATDC message in ataxia telangiectasia group D cells results in the absence of a functional protein | journal = Mutagenesis | volume = 15 | issue = 2 | pages = 105–8 | year = 2000 | pmid = 10719033 | doi = 10.1093/mutage/15.2.105 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal | author=Tauchi H, Green C, Knapp M, ''et al.'' |title=Altered splicing of the ATDC message in ataxia telangiectasia group D cells results in the absence of a functional protein. |journal=Mutagenesis |volume=15 |issue= 2 |pages= 105-8 |year= 2000 |pmid= 10719033 |doi=  }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Reymond A, Meroni G, Fantozzi A, ''et al.'' |title=The tripartite motif family identifies cell compartments. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2140-51 |year= 2001 |pmid= 11331580 |doi= 10.1093/emboj/20.9.2140 }}
* {{cite journal | vauthors = Hosoi Y, Kapp LN, Murnane JP, Matsumoto Y, Enomoto A, Ono T, Miyagawa K | title = Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC | journal = Biochem. Biophys. Res. Commun. | volume = 348 | issue = 2 | pages = 728–34 | year = 2006 | pmid = 16890201 | doi = 10.1016/j.bbrc.2006.07.115 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–92 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Hosoi Y, Kapp LN, Murnane JP, ''et al.'' |title=Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC. |journal=Biochem. Biophys. Res. Commun. |volume=348 |issue= 2 |pages= 728-34 |year= 2006 |pmid= 16890201 |doi= 10.1016/j.bbrc.2006.07.115 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=23650}}
{{WikiDoc Sources}}
 
 
{{gene-11-stub}}

Latest revision as of 16:32, 8 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tripartite motif-containing protein 29 is a protein that in humans is encoded by the TRIM29 gene.[1][2]

Function

The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.[2]

Interactions

TRIM29 has been shown to interact with TRIM23[1] and GCC1.[3]

References

  1. ↑ 1.0 1.1 Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
  2. ↑ 2.0 2.1 "Entrez Gene: TRIM29 tripartite motif-containing 29".
  3. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading


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