LTBP3: Difference between revisions

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{{Underlinked|date=November 2017}}
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{{Infobox_gene}}
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'''Latent-transforming growth factor beta-binding protein 3''' is a [[protein]] that in humans is encoded by the ''LTBP3'' [[gene]].<ref name="pmid7719025">{{cite journal |vauthors=Li X, Yin W, Perez-Jurado L, Bonadio J, Francke U | title = Mapping of human and murine genes for latent TGF-beta binding protein-2 (LTBP2) | journal = Mamm Genome | volume = 6 | issue = 1 | pages = 42–5 |date=May 1995 | pmid = 7719025 | pmc =  | doi =10.1007/BF00350892 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LTBP3 latent transforming growth factor beta binding protein 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4054| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Latent transforming growth factor beta binding protein 3
| HGNCid = 6716
| Symbol = LTBP3
| AltSymbols =; LTBP2; DKFZP586M2123; FLJ33431; FLJ39893; FLJ42533; FLJ44138; LTBP-3; pp6425
| OMIM = 602090
| ECnumber = 
| Homologene = 7405
| MGIid = 1101355
| GeneAtlas_image1 = PBB_GE_LTBP3_219922_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0019838 |text = growth factor binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0007179 |text = transforming growth factor beta receptor signaling pathway}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4054
    | Hs_Ensembl = ENSG00000168056
    | Hs_RefseqProtein = NP_066548
    | Hs_RefseqmRNA = NM_021070
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 65062866
    | Hs_GenLoc_end = 65082275
    | Hs_Uniprot = Q9NS15
    | Mm_EntrezGene = 16998
    | Mm_Ensembl = ENSMUSG00000024940
    | Mm_RefseqmRNA = NM_008520
    | Mm_RefseqProtein = NP_032546
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 5742127
    | Mm_GenLoc_end = 5758525
    | Mm_Uniprot = Q6KAT1
  }}
}}
'''Latent transforming growth factor beta binding protein 3''', also known as '''LTBP3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LTBP3 latent transforming growth factor beta binding protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4054| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J |title=Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action. |journal=Cytokine Growth Factor Rev. |volume=10 |issue= 2 |pages= 99-117 |year= 2000 |pmid= 10743502 |doi=  }}
*{{cite journal  |vauthors=Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J |title=Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action. |journal=Cytokine Growth Factor Rev. |volume=10 |issue= 2 |pages= 99–117 |year= 2000 |pmid= 10743502 |doi=10.1016/S1359-6101(99)00010-6 }}
*{{cite journal  | author=Oklü R, Hesketh R |title=The latent transforming growth factor beta binding protein (LTBP) family. |journal=Biochem. J. |volume=352 Pt 3 |issue=  |pages= 601-10 |year= 2001 |pmid= 11104663 |doi=  }}
*{{cite journal  |vauthors=Oklü R, Hesketh R |title=The latent transforming growth factor beta binding protein (LTBP) family |journal=Biochem. J. |volume=352 Pt 3 |issue=  Pt 3|pages= 601–10 |year= 2001 |pmid= 11104663 |doi=  10.1042/0264-6021:3520601| pmc=1221494 }}
*{{cite journal  | author=Li X, Yin W, Pérez-Jurado L, ''et al.'' |title=Mapping of human and murine genes for latent TGF-beta binding protein-2 (LTBP2). |journal=Mamm. Genome |volume=6 |issue= 1 |pages= 42-5 |year= 1995 |pmid= 7719025 |doi=  }}
*{{cite journal   |vauthors=Morén A, Olofsson A, Stenman G, etal |title=Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein |journal=J. Biol. Chem. |volume=269 |issue= 51 |pages= 32469–78 |year= 1995 |pmid= 7798248 |doi=  }}
*{{cite journal | author=Morén A, Olofsson A, Stenman G, ''et al.'' |title=Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein. |journal=J. Biol. Chem. |volume=269 |issue= 51 |pages= 32469-78 |year= 1995 |pmid= 7798248 |doi=  }}
*{{cite journal   |vauthors=Michel K, Roth S, Trautwein C, etal |title=Analysis of the expression pattern of the latent transforming growth factor beta binding protein isoforms in normal and diseased human liver reveals a new splice variant missing the proteinase-sensitive hinge region |journal=Hepatology |volume=27 |issue= 6 |pages= 1592–9 |year= 1998 |pmid= 9620332 |doi= 10.1002/hep.510270619 }}
*{{cite journal | author=Michel K, Roth S, Trautwein C, ''et al.'' |title=Analysis of the expression pattern of the latent transforming growth factor beta binding protein isoforms in normal and diseased human liver reveals a new splice variant missing the proteinase-sensitive hinge region. |journal=Hepatology |volume=27 |issue= 6 |pages= 1592-9 |year= 1998 |pmid= 9620332 |doi= 10.1002/hep.510270619 }}
*{{cite journal  |vauthors=Saharinen J, Keski-Oja J |title=Specific Sequence Motif of 8-Cys Repeats of TGF-β Binding Proteins, LTBPs, Creates a Hydrophobic Interaction Surface for Binding of Small Latent TGF-β |journal=Mol. Biol. Cell |volume=11 |issue= 8 |pages= 2691–704 |year= 2000 |pmid= 10930463 |doi= 10.1091/mbc.11.8.2691| pmc=14949 }}
*{{cite journal  | author=Saharinen J, Keski-Oja J |title=Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta. |journal=Mol. Biol. Cell |volume=11 |issue= 8 |pages= 2691-704 |year= 2000 |pmid= 10930463 |doi=  }}
*{{cite journal  |vauthors=Brooke JS, Cha JH, Eidels L |title=Latent transforming growth factor β-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursor |journal=BMC Cell Biol. |volume=3|pages= 2 |year= 2002 |pmid= 11846885 |doi=10.1186/1471-2121-3-2  | pmc=65547 }}
*{{cite journal  | author=Brooke JS, Cha JH, Eidels L |title=Latent transforming growth factor beta-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursor. |journal=BMC Cell Biol. |volume=3 |issue=  |pages= 2 |year= 2002 |pmid= 11846885 |doi=  }}
*{{cite journal  |vauthors=Chen Y, Dabovic B, Annes JP, Rifkin DB |title=Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion |journal=FEBS Lett. |volume=517 |issue= 1–3 |pages= 277–80 |year= 2002 |pmid= 12062452 |doi=10.1016/S0014-5793(02)02648-0 }}
*{{cite journal  | author=Chen Y, Dabovic B, Annes JP, Rifkin DB |title=Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion. |journal=FEBS Lett. |volume=517 |issue= 1-3 |pages= 277-80 |year= 2002 |pmid= 12062452 |doi=  }}
*{{cite journal   |vauthors=Penttinen C, Saharinen J, Weikkolainen K, etal |title=Secretion of human latent TGF-beta-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-beta |journal=J. Cell Sci. |volume=115 |issue= Pt 17 |pages= 3457–68 |year= 2003 |pmid= 12154076 |doi=  }}
*{{cite journal | author=Penttinen C, Saharinen J, Weikkolainen K, ''et al.'' |title=Secretion of human latent TGF-beta-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-beta. |journal=J. Cell. Sci. |volume=115 |issue= Pt 17 |pages= 3457-68 |year= 2003 |pmid= 12154076 |doi=  }}
*{{cite journal  |vauthors=Ludbrook SB, Barry ST, Delves CJ, Horgan CM |title=The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3 |journal=Biochem. J. |volume=369 |issue= Pt 2 |pages= 311–8 |year= 2003 |pmid= 12358597 |doi= 10.1042/BJ20020809 | pmc=1223078 }}
*{{cite journal  | author=Ludbrook SB, Barry ST, Delves CJ, Horgan CM |title=The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3. |journal=Biochem. J. |volume=369 |issue= Pt 2 |pages= 311-8 |year= 2003 |pmid= 12358597 |doi= 10.1042/BJ20020809 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Koli K, Hyytiäinen M, Ryynänen MJ, Keski-Oja J |title=Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts |journal=Exp. Cell Res. |volume=310 |issue= 2 |pages= 370–82 |year= 2005 |pmid= 16157329 |doi= 10.1016/j.yexcr.2005.08.008 }}
*{{cite journal  | author=Koli K, Hyytiäinen M, Ryynänen MJ, Keski-Oja J |title=Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts. |journal=Exp. Cell Res. |volume=310 |issue= 2 |pages= 370-82 |year= 2005 |pmid= 16157329 |doi= 10.1016/j.yexcr.2005.08.008 }}
*{{cite journal  |vauthors=Kantola AK, Keski-Oja J, Koli K |title=Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements |journal=Gene |volume=363 |issue=  |pages= 142–50 |year= 2006 |pmid= 16223572 |doi= 10.1016/j.gene.2005.07.042 }}
*{{cite journal  | author=Kantola AK, Keski-Oja J, Koli K |title=Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements. |journal=Gene |volume=363 |issue=  |pages= 142-50 |year= 2006 |pmid= 16223572 |doi= 10.1016/j.gene.2005.07.042 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 20:14, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Latent-transforming growth factor beta-binding protein 3 is a protein that in humans is encoded by the LTBP3 gene.[1][2]


References

  1. ↑ Li X, Yin W, Perez-Jurado L, Bonadio J, Francke U (May 1995). "Mapping of human and murine genes for latent TGF-beta binding protein-2 (LTBP2)". Mamm Genome. 6 (1): 42–5. doi:10.1007/BF00350892. PMID 7719025.
  2. ↑ "Entrez Gene: LTBP3 latent transforming growth factor beta binding protein 3".

Further reading



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