API5: Difference between revisions

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{{Infobox_gene}}
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The human [[gene]] '''API5''' encodes the [[protein]] '''Apoptosis inhibitor 5'''.<ref name="pmid9307294">{{cite journal |vauthors=Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R | title = AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal | journal = Cancer Res | volume = 57 | issue = 18 | pages = 4063–9 |date=Oct 1997 | pmid = 9307294 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: API5 apoptosis inhibitor 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8539| accessdate = }}</ref>
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This gene encodes an [[apoptosis]] inhibitory protein whose expression prevents apoptosis after [[growth factor]] deprivation. This protein suppresses the [[transcription factor]] E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a [[Cell nucleus|nuclear]] factor involved in apoptotic [[DNA]] fragmentation. Its depletion enhances the [[Cytotoxicity|cytotoxic]] action of [[Chemotherapy|chemotherapeutic]] drugs.
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Diseases associated with API5 include colon [[adenocarcinoma]], and [[cervical cancer]].
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Apoptosis inhibitor 5
| HGNCid = 594
| Symbol = API5
| AltSymbols =; AAC-11; AAC11; API5L1
| OMIM = 609774
| ECnumber = 
| Homologene = 4809
| MGIid = 1888993
| Function = {{GNF_GO|id=GO:0017134 |text = fibroblast growth factor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8539
    | Hs_Ensembl = ENSG00000166181
    | Hs_RefseqProtein = NP_006586
    | Hs_RefseqmRNA = NM_006595
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 43290109
    | Hs_GenLoc_end = 43322655
    | Hs_Uniprot = Q9BZZ5
    | Mm_EntrezGene = 11800
    | Mm_Ensembl = ENSMUSG00000027193
    | Mm_RefseqmRNA = NM_007466
    | Mm_RefseqProtein = NP_031492
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 94212571
    | Mm_GenLoc_end = 94238912
    | Mm_Uniprot = Q3U517
  }}
}}
'''Apoptosis inhibitor 5''', also known as '''API5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: API5 apoptosis inhibitor 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8539| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|API5}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal | author=Tewari M, Yu M, Ross B, ''et al.'' |title=AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. |journal=Cancer Res. |volume=57 |issue= 18 |pages= 4063-9 |year= 1997 |pmid= 9307294 |doi=  }}
*{{cite journal |vauthors=Gianfrancesco F, Esposito T, Ciccodicola A |title=Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 3-4 |pages= 164–6 |year= 1999 |pmid= 10393420 |doi=10.1159/000015247 |display-authors=etal}}
*{{cite journal  | author=Gianfrancesco F, Esposito T, Ciccodicola A, ''et al.'' |title=Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 3-4 |pages= 164-6 |year= 1999 |pmid= 10393420 |doi= }}
*{{cite journal |vauthors=Kim JW, Cho HS, Kim JH |title=AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis. |journal=Lab. Invest. |volume=80 |issue= 4 |pages= 587–94 |year= 2000 |pmid= 10780674 |doi=10.1038/labinvest.3780008 |display-authors=etal}}
*{{cite journal | author=Kim JW, Cho HS, Kim JH, ''et al.'' |title=AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis. |journal=Lab. Invest. |volume=80 |issue= 4 |pages= 587-94 |year= 2000 |pmid= 10780674 |doi= }}
*{{cite journal |vauthors=Van den Berghe L, Laurell H, Huez I |title=FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2. |journal=Mol. Endocrinol. |volume=14 |issue= 11 |pages= 1709–24 |year= 2001 |pmid= 11075807 |doi=10.1210/me.14.11.1709 |display-authors=etal}}
*{{cite journal | author=Van den Berghe L, Laurell H, Huez I, ''et al.'' |title=FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2. |journal=Mol. Endocrinol. |volume=14 |issue= 11 |pages= 1709-24 |year= 2001 |pmid= 11075807 |doi= }}
*{{cite journal |vauthors=Sutherland HG, Mumford GK, Newton K |title=Large-scale identification of mammalian proteins localized to nuclear sub-compartments. |journal=Hum. Mol. Genet. |volume=10 |issue= 18 |pages= 1995–2011 |year= 2001 |pmid= 11555636 |doi=10.1093/hmg/10.18.1995 |display-authors=etal}}
*{{cite journal | author=Sutherland HG, Mumford GK, Newton K, ''et al.'' |title=Large-scale identification of mammalian proteins localized to nuclear sub-compartments. |journal=Hum. Mol. Genet. |volume=10 |issue= 18 |pages= 1995-2011 |year= 2001 |pmid= 11555636 |doi= }}
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal |vauthors=Li Z, Hu CY, Mo BQ |title=[Effect of beta-carotene on gene expression of breast cancer cells] |journal=Ai Zheng |volume=22 |issue= 4 |pages= 380–4 |year= 2003 |pmid= 12703993 |doi= |display-authors=etal}}
*{{cite journal | author=Li Z, Hu CY, Mo BQ, ''et al.'' |title=[Effect of beta-carotene on gene expression of breast cancer cells] |journal=Ai Zheng |volume=22 |issue= 4 |pages= 380-4 |year= 2003 |pmid= 12703993 |doi= }}
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal |vauthors=Andersen JS, Lam YW, Leung AK |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |display-authors=etal}}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal |vauthors=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells. |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339–46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
*{{cite journal | author=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells. |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339-46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
*{{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal |vauthors=Morris EJ, Michaud WA, Ji JY |title=Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. |journal=PLoS Genet. |volume=2 |issue= 11 |pages= e196 |year= 2006 |pmid= 17112319 |doi= 10.1371/journal.pgen.0020196 | pmc=1636698 |display-authors=etal}} {{open access}}
*{{cite journal | author=Morris EJ, Michaud WA, Ji JY, ''et al.'' |title=Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. |journal=PLoS Genet. |volume=2 |issue= 11 |pages= e196 |year= 2006 |pmid= 17112319 |doi= 10.1371/journal.pgen.0020196 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 18:07, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

The human gene API5 encodes the protein Apoptosis inhibitor 5.[1][2]

This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of chemotherapeutic drugs.

Diseases associated with API5 include colon adenocarcinoma, and cervical cancer.


References

  1. ↑ Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R (Oct 1997). "AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal". Cancer Res. 57 (18): 4063–9. PMID 9307294.
  2. ↑ "Entrez Gene: API5 apoptosis inhibitor 5".

External links

Further reading



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