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{{Infobox_gene}}
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'''Neuroblast differentiation-associated protein AHNAK''', also known as desmoyokin, is a [[protein]] that in humans is encoded by the ''AHNAK'' [[gene]].<ref name="pmid7987395">{{cite journal | vauthors = James MR, ((Richard CW III)), Schott JJ, Yousry C, Clark K, Bell J, Terwilliger JD, Hazan J, Dubay C, Vignal A | title = A radiation hybrid map of 506 STS markers spanning human chromosome 11 | journal = Nat Genet | volume = 8 | issue = 1 | pages = 70–6 |date=Jan 1995 | pmid = 7987395 | pmc =  | doi = 10.1038/ng0994-70 |display-authors=etal}}</ref><ref name="pmid12153988">{{cite journal |vauthors=Hohaus A, Person V, Behlke J, Schaper J, Morano I, Haase H | title = The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2+ channels and the actin-based cytoskeleton | journal = FASEB J | volume = 16 | issue = 10 | pages = 1205–16 |date=Aug 2002 | pmid = 12153988 | pmc =  | doi = 10.1096/fj.01-0855com }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AHNAK AHNAK nucleoprotein (desmoyokin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79026| accessdate = }}</ref> AHNAK was originally identified in 1989 (in [[Bovinae|bovine]] muzzle [[Epidermis (skin)|epidermal]] cells) and named desmoyokin due to its localization pattern (that resembled a [[yoke]]) in the [[Desmosome|desmosomal]] plaque.<ref name="pmid2677021">{{cite journal |vauthors=Hieda Y, Tsukita S, Tsukita S | title = A new high molecular mass protein showing unique localization in desmosomal plaque. | journal = J. Cell Biol. | volume = 109 | issue = 4 | pages = 1511–1518 |date=Oct 1989 | pmid = 2677021 | pmc = 2115823 | doi=10.1083/jcb.109.4.1511}}</ref> AHNAK has been shown to be essential for [[Pseudopodia|pseudopod]] protrusion and cell [[Cell migration|migration]].
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<ref name="pmid20388789">{{cite journal |vauthors=Shankar J, Messenberg A, Chan J, Underhill TM, Foster LJ, Nabi IR | title = Pseudopodial actin dynamics control epithelial-mesenchymal transition in metastatic cancer cells. | journal = Cancer Res. | volume = 70 | issue = 9 | pages = 3780–3790 |date=May 2010 | pmid = 20388789 | doi=10.1158/0008-5472.CAN-09-4439}}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = AHNAK nucleoprotein (desmoyokin)
| HGNCid = 347
| Symbol = AHNAK
| AltSymbols =; AHNAKRS; MGC5395
| OMIM = 103390
| ECnumber =
| Homologene = 67425
| MGIid = 1316648
| GeneAtlas_image1 = PBB_GE_AHNAK_211986_at_tn.png
  | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0007399 |text = nervous system development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 79026
    | Hs_Ensembl = ENSG00000124942
    | Hs_RefseqProtein = NP_001611
    | Hs_RefseqmRNA = NM_001620
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 62015775
    | Hs_GenLoc_end = 62070908
    | Hs_Uniprot = Q09666
    | Mm_EntrezGene = 66395
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_001052079
    | Mm_RefseqProtein = XP_001052079
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''AHNAK nucleoprotein (desmoyokin)''', also known as '''AHNAK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AHNAK AHNAK nucleoprotein (desmoyokin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79026| accessdate = }}</ref>


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==Interactions==
AHNAK has been shown to [[Protein-protein interaction|interact]] with [[S100B]].<ref name=pmid11312263>{{cite journal |last=Gentil |first=B J |author2=Delphin C|author3=Mbele G O|author4=Deloulme J C|author5=Ferro M|author6=Garin J|author7= Baudier J |date=Jun 2001 |title=The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B |journal=J. Biol. Chem. |volume=276 |issue=26 |pages=23253–61 |publisher= |location = United States| issn = 0021-9258| pmid = 11312263 |doi = 10.1074/jbc.M010655200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==External links==
* {{UCSC gene info|AHNAK}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{Refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=Shtivelman E, Cohen FE, Bishop JM |title=A human gene (AHNAK) encoding an unusually large protein with a 1.2-microns polyionic rod structure. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 12 |pages= 5472-6 |year= 1992 |pmid= 1608957 |doi=  }}
*{{cite journal  | vauthors=Shtivelman E, Cohen FE, Bishop JM |title=A human gene (AHNAK) encoding an unusually large protein with a 1.2-microns polyionic rod structure. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 12 |pages= 5472–6 |year= 1992 |pmid= 1608957 |doi=10.1073/pnas.89.12.5472  | pmc=49314 }}
*{{cite journal  | author=Kudoh J, Wang Y, Minoshima S, ''et al.'' |title=Localization of the human AHNAK/desmoyokin gene (AHNAK) to chromosome band 11q12 by somatic cell hybrid analysis and fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=70 |issue= 3-4 |pages= 218-20 |year= 1995 |pmid= 7789175 |doi=  }}
*{{cite journal  |vauthors=Kudoh J, Wang Y, Minoshima S |title=Localization of the human AHNAK/desmoyokin gene (AHNAK) to chromosome band 11q12 by somatic cell hybrid analysis and fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=70 |issue= 3-4 |pages= 218–20 |year= 1995 |pmid= 7789175 |doi=10.1159/000134037 |display-authors=etal}}
*{{cite journal  | author=James MR, Richard CW, Schott JJ, ''et al.'' |title=A radiation hybrid map of 506 STS markers spanning human chromosome 11. |journal=Nat. Genet. |volume=8 |issue= 1 |pages= 70-6 |year= 1995 |pmid= 7987395 |doi= 10.1038/ng0994-70 }}
*{{cite journal  |vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491  | pmc=16267 |display-authors=etal}}
*{{cite journal  | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi=  }}
*{{cite journal  |vauthors=Gentil BJ, Delphin C, Mbele GO |title=The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23253–61 |year= 2001 |pmid= 11312263 |doi= 10.1074/jbc.M010655200 |display-authors=etal}}
*{{cite journal  | author=Gentil BJ, Delphin C, Mbele GO, ''et al.'' |title=The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23253-61 |year= 2001 |pmid= 11312263 |doi= 10.1074/jbc.M010655200 }}
*{{cite journal  |vauthors=Sussman J, Stokoe D, Ossina N, Shtivelman E |title=Protein kinase B phosphorylates AHNAK and regulates its subcellular localization. |journal=J. Cell Biol. |volume=154 |issue= 5 |pages= 1019–30 |year= 2001 |pmid= 11535620 |doi= 10.1083/jcb.200105121 | pmc=2196192 }}
*{{cite journal  | author=Sussman J, Stokoe D, Ossina N, Shtivelman E |title=Protein kinase B phosphorylates AHNAK and regulates its subcellular localization. |journal=J. Cell Biol. |volume=154 |issue= 5 |pages= 1019-30 |year= 2001 |pmid= 11535620 |doi= 10.1083/jcb.200105121 }}
*{{cite journal  |vauthors=Wernyj RP, Ewing CM, Isaacs WB |title=Multiple antibodies to titin immunoreact with AHNAK and localize to the mitotic spindle machinery. |journal=Cell Motil. Cytoskeleton |volume=50 |issue= 2 |pages= 101–13 |year= 2004 |pmid= 11746675 |doi= 10.1002/cm.1044 }}
*{{cite journal  | author=Wernyj RP, Ewing CM, Isaacs WB |title=Multiple antibodies to titin immunoreact with AHNAK and localize to the mitotic spindle machinery. |journal=Cell Motil. Cytoskeleton |volume=50 |issue= 2 |pages= 101-13 |year= 2004 |pmid= 11746675 |doi= 10.1002/cm.1044 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Hohaus A, Person V, Behlke J, ''et al.'' |title=The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2+ channels and the actin-based cytoskeleton. |journal=FASEB J. |volume=16 |issue= 10 |pages= 1205-16 |year= 2002 |pmid= 12153988 |doi= 10.1096/fj.01-0855com }}
*{{cite journal  |vauthors=Straub BK, Boda J, Kuhn C |title=A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells. |journal=J. Cell Sci. |volume=116 |issue= Pt 24 |pages= 4985–95 |year= 2004 |pmid= 14625392 |doi= 10.1242/jcs.00815 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Straub BK, Boda J, Kuhn C, ''et al.'' |title=A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells. |journal=J. Cell. Sci. |volume=116 |issue= Pt 24 |pages= 4985-95 |year= 2004 |pmid= 14625392 |doi= 10.1242/jcs.00815 }}
*{{cite journal  |vauthors=Haase H, Pagel I, Khalina Y |title=The carboxyl-terminal ahnak domain induces actin bundling and stabilizes muscle contraction. |journal=FASEB J. |volume=18 |issue= 7 |pages= 839–41 |year= 2004 |pmid= 15001564 |doi= 10.1096/fj.03-0446fje |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Lee IH, You JO, Ha KS |title=AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase C. |journal=J. Biol. Chem. |volume=279 |issue= 25 |pages= 26645–53 |year= 2004 |pmid= 15033986 |doi= 10.1074/jbc.M311525200 |display-authors=etal}}
*{{cite journal  | author=Haase H, Pagel I, Khalina Y, ''et al.'' |title=The carboxyl-terminal ahnak domain induces actin bundling and stabilizes muscle contraction. |journal=FASEB J. |volume=18 |issue= 7 |pages= 839-41 |year= 2004 |pmid= 15001564 |doi= 10.1096/fj.03-0446fje }}
*{{cite journal  |vauthors=Stiff T, Shtivelman E, Jeggo P, Kysela B |title=AHNAK interacts with the DNA ligase IV-XRCC4 complex and stimulates DNA ligase IV-mediated double-stranded ligation. |journal=DNA Repair (Amst.) |volume=3 |issue= 3 |pages= 245–56 |year= 2004 |pmid= 15177040 |doi= 10.1016/j.dnarep.2003.11.001 }}
*{{cite journal  | author=Lee IH, You JO, Ha KS, ''et al.'' |title=AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase C. |journal=J. Biol. Chem. |volume=279 |issue= 25 |pages= 26645-53 |year= 2004 |pmid= 15033986 |doi= 10.1074/jbc.M311525200 }}
*{{cite journal  |vauthors=Ahn J, Chung KS, Kim DU |title=Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus. |journal=J. Biochem. Mol. Biol. |volume=37 |issue= 6 |pages= 741–8 |year= 2005 |pmid= 15607035 |doi=  |display-authors=etal}}
*{{cite journal  | author=Stiff T, Shtivelman E, Jeggo P, Kysela B |title=AHNAK interacts with the DNA ligase IV-XRCC4 complex and stimulates DNA ligase IV-mediated double-stranded ligation. |journal=DNA Repair (Amst.) |volume=3 |issue= 3 |pages= 245-56 |year= 2004 |pmid= 15177040 |doi= 10.1016/j.dnarep.2003.11.001 }}
*{{cite journal  |vauthors=Haase H, Alvarez J, Petzhold D |title=Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation. |journal=FASEB J. |volume=19 |issue= 14 |pages= 1969–77 |year= 2006 |pmid= 16319140 |doi= 10.1096/fj.05-3997com |display-authors=etal}}
*{{cite journal  | author=Ahn J, Chung KS, Kim DU, ''et al.'' |title=Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus. |journal=J. Biochem. Mol. Biol. |volume=37 |issue= 6 |pages= 741-8 |year= 2005 |pmid= 15607035 |doi=  }}
*{{cite journal  |vauthors=Tompkins V, Hagen J, Zediak VP, Quelle DE |title=Identification of novel ARF binding proteins by two-hybrid screening. |journal=Cell Cycle |volume=5 |issue= 6 |pages= 641–6 |year= 2006 |pmid= 16582619 |doi=  10.4161/cc.5.6.2560}}
*{{cite journal  | author=Haase H, Alvarez J, Petzhold D, ''et al.'' |title=Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation. |journal=FASEB J. |volume=19 |issue= 14 |pages= 1969-77 |year= 2006 |pmid= 16319140 |doi= 10.1096/fj.05-3997com }}
*{{cite journal  |vauthors=De Seranno S, Benaud C, Assard N |title=Identification of an AHNAK binding motif specific for the Annexin2/S100A10 tetramer. |journal=J. Biol. Chem. |volume=281 |issue= 46 |pages= 35030–8 |year= 2007 |pmid= 16984913 |doi= 10.1074/jbc.M606545200 |display-authors=etal}}
*{{cite journal  | author=Tompkins V, Hagen J, Zediak VP, Quelle DE |title=Identification of novel ARF binding proteins by two-hybrid screening. |journal=Cell Cycle |volume=5 |issue= 6 |pages= 641-6 |year= 2006 |pmid= 16582619 |doi=  }}
*{{cite journal  | author=De Seranno S, Benaud C, Assard N, ''et al.'' |title=Identification of an AHNAK binding motif specific for the Annexin2/S100A10 tetramer. |journal=J. Biol. Chem. |volume=281 |issue= 46 |pages= 35030-8 |year= 2007 |pmid= 16984913 |doi= 10.1074/jbc.M606545200 }}
}}
}}
{{refend}}
{{Refend}}
 
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Revision as of 19:16, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neuroblast differentiation-associated protein AHNAK, also known as desmoyokin, is a protein that in humans is encoded by the AHNAK gene.[1][2][3] AHNAK was originally identified in 1989 (in bovine muzzle epidermal cells) and named desmoyokin due to its localization pattern (that resembled a yoke) in the desmosomal plaque.[4] AHNAK has been shown to be essential for pseudopod protrusion and cell migration. [5]


Interactions

AHNAK has been shown to interact with S100B.[6]

References

  1. ↑ James MR, Richard CW III, Schott JJ, Yousry C, Clark K, Bell J, Terwilliger JD, Hazan J, Dubay C, Vignal A, et al. (Jan 1995). "A radiation hybrid map of 506 STS markers spanning human chromosome 11". Nat Genet. 8 (1): 70–6. doi:10.1038/ng0994-70. PMID 7987395.
  2. ↑ Hohaus A, Person V, Behlke J, Schaper J, Morano I, Haase H (Aug 2002). "The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2+ channels and the actin-based cytoskeleton". FASEB J. 16 (10): 1205–16. doi:10.1096/fj.01-0855com. PMID 12153988.
  3. ↑ "Entrez Gene: AHNAK AHNAK nucleoprotein (desmoyokin)".
  4. ↑ Hieda Y, Tsukita S, Tsukita S (Oct 1989). "A new high molecular mass protein showing unique localization in desmosomal plaque". J. Cell Biol. 109 (4): 1511–1518. doi:10.1083/jcb.109.4.1511. PMC 2115823. PMID 2677021.
  5. ↑ Shankar J, Messenberg A, Chan J, Underhill TM, Foster LJ, Nabi IR (May 2010). "Pseudopodial actin dynamics control epithelial-mesenchymal transition in metastatic cancer cells". Cancer Res. 70 (9): 3780–3790. doi:10.1158/0008-5472.CAN-09-4439. PMID 20388789.
  6. ↑ Gentil, B J; Delphin C; Mbele G O; Deloulme J C; Ferro M; Garin J; Baudier J (Jun 2001). "The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B". J. Biol. Chem. United States. 276 (26): 23253–61. doi:10.1074/jbc.M010655200. ISSN 0021-9258. PMID 11312263.

External links

Further reading



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