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{{Infobox_gene}}
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'''Roundabout homolog 4''' is a [[protein]] that in humans is encoded by the ''ROBO4'' [[gene]].<ref name="pmid11076864">{{cite journal | vauthors = Huminiecki L, Bicknell R | title = In silico cloning of novel endothelial-specific genes | journal = Genome Research | volume = 10 | issue = 11 | pages = 1796–806 | date = November 2000 | pmid = 11076864 | pmc = 310981 | doi = 10.1101/gr.150700 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ROBO4 roundabout homolog 4, magic roundabout (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54538| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = Roundabout homolog 4, magic roundabout (Drosophila)
| HGNCid = 17985
| Symbol = ROBO4
| AltSymbols =; FLJ20798; MGC133352; MGC133353; MRB
| OMIM = 607528
| ECnumber = 
| Homologene = 10397
| MGIid = 1921394
| GeneAtlas_image1 = PBB_GE_ROBO4_220758_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030334 |text = regulation of cell migration}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 54538
    | Hs_Ensembl = ENSG00000154133
    | Hs_RefseqProtein = NP_061928
    | Hs_RefseqmRNA = NM_019055
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 124258797
    | Hs_GenLoc_end = 124272939
    | Hs_Uniprot = Q8WZ75
    | Mm_EntrezGene = 74144
    | Mm_Ensembl = ENSMUSG00000032125
    | Mm_RefseqmRNA = NM_028783
    | Mm_RefseqProtein = NP_083059
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 37151717
    | Mm_GenLoc_end = 37163693
    | Mm_Uniprot = Q6IR38
  }}
}}
'''Roundabout homolog 4, magic roundabout (Drosophila)''', also known as '''ROBO4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ROBO4 roundabout homolog 4, magic roundabout (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54538| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Further reading ==
{{PBB_Summary
| section_title =
| summary_text =
}}
 
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Schmucker D | title = Downstream of guidance receptors: entering the baroque period of axon guidance signaling | journal = Neuron | volume = 40 | issue = 1 | pages = 4–6 | date = September 2003 | pmid = 14527427 | doi = 10.1016/S0896-6273(03)00603-2 }}
| citations =
* {{cite journal | vauthors = Huminiecki L, Gorn M, Suchting S, Poulsom R, Bicknell R | title = Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis | journal = Genomics | volume = 79 | issue = 4 | pages = 547–52 | date = April 2002 | pmid = 11944987 | doi = 10.1006/geno.2002.6745 }}
*{{cite journal | author=Schmucker D |title=Downstream of guidance receptors: entering the baroque period of axon guidance signaling. |journal=Neuron |volume=40 |issue= 1 |pages= 4-6 |year= 2003 |pmid= 14527427 |doi= }}
* {{cite journal | vauthors = Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien CB, Wu JY, Urness LD, Li DY | title = Robo4 is a vascular-specific receptor that inhibits endothelial migration | journal = Developmental Biology | volume = 261 | issue = 1 | pages = 251–67 | date = September 2003 | pmid = 12941633 | doi = 10.1016/S0012-1606(03)00258-6 }}
*{{cite journal  | author=Huminiecki L, Bicknell R |title=In silico cloning of novel endothelial-specific genes. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1796-806 |year= 2001 |pmid= 11076864 |doi=  }}
* {{cite journal | vauthors = Bedell VM, Yeo SY, Park KW, Chung J, Seth P, Shivalingappa V, Zhao J, Obara T, Sukhatme VP, Drummond IA, Li DY, Ramchandran R | title = roundabout4 is essential for angiogenesis in vivo | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 18 | pages = 6373–8 | date = May 2005 | pmid = 15849270 | pmc = 1088354 | doi = 10.1073/pnas.0408318102 }}
*{{cite journal | author=Huminiecki L, Gorn M, Suchting S, ''et al.'' |title=Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis. |journal=Genomics |volume=79 |issue= 4 |pages= 547-52 |year= 2002 |pmid= 11944987 |doi= 10.1006/geno.2002.6745 }}
* {{cite journal | vauthors = Seth P, Lin Y, Hanai J, Shivalingappa V, Duyao MP, Sukhatme VP | title = Magic roundabout, a tumor endothelial marker: expression and signaling | journal = Biochemical and Biophysical Research Communications | volume = 332 | issue = 2 | pages = 533–41 | date = July 2005 | pmid = 15894287 | doi = 10.1016/j.bbrc.2005.03.250 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD | title = Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry | journal = Journal of Proteome Research | volume = 4 | issue = 6 | pages = 2070–80 | year = 2006 | pmid = 16335952 | pmc = 1850943 | doi = 10.1021/pr0502065 }}
*{{cite journal  | author=Park KW, Morrison CM, Sorensen LK, ''et al.'' |title=Robo4 is a vascular-specific receptor that inhibits endothelial migration. |journal=Dev. Biol. |volume=261 |issue= 1 |pages= 251-67 |year= 2003 |pmid= 12941633 |doi=  }}
* {{cite journal | vauthors = Gröne J, Doebler O, Loddenkemper C, Hotz B, Buhr HJ, Bhargava S | title = Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer | journal = Oncology Reports | volume = 15 | issue = 6 | pages = 1437–43 | date = June 2006 | pmid = 16685377 | doi = 10.3892/or.15.6.1437 }}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
* {{cite journal | vauthors = Okada Y, Yano K, Jin E, Funahashi N, Kitayama M, Doi T, Spokes K, Beeler DL, Shih SC, Okada H, Danilov TA, Maynard E, Minami T, Oettgen P, Aird WC | title = A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium | journal = Circulation Research | volume = 100 | issue = 12 | pages = 1712–22 | date = June 2007 | pmid = 17495228 | doi = 10.1161/01.RES.0000269779.10644.dc }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Bedell VM, Yeo SY, Park KW, ''et al.'' |title=roundabout4 is essential for angiogenesis in vivo. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 18 |pages= 6373-8 |year= 2005 |pmid= 15849270 |doi= 10.1073/pnas.0408318102 }}
*{{cite journal | author=Seth P, Lin Y, Hanai J, ''et al.'' |title=Magic roundabout, a tumor endothelial marker: expression and signaling. |journal=Biochem. Biophys. Res. Commun. |volume=332 |issue= 2 |pages= 533-41 |year= 2005 |pmid= 15894287 |doi= 10.1016/j.bbrc.2005.03.250 }}
*{{cite journal | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
*{{cite journal | author=Gröne J, Doebler O, Loddenkemper C, ''et al.'' |title=Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer. |journal=Oncol. Rep. |volume=15 |issue= 6 |pages= 1437-43 |year= 2007 |pmid= 16685377 |doi= }}
*{{cite journal | author=Okada Y, Yano K, Jin E, ''et al.'' |title=A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium. |journal=Circ. Res. |volume=100 |issue= 12 |pages= 1712-22 |year= 2007 |pmid= 17495228 |doi= 10.1161/01.RES.0000269779.10644.dc }}
}}
{{refend}}
{{refend}}


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Latest revision as of 09:23, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Roundabout homolog 4 is a protein that in humans is encoded by the ROBO4 gene.[1][2]

References

  1. ↑ Huminiecki L, Bicknell R (November 2000). "In silico cloning of novel endothelial-specific genes". Genome Research. 10 (11): 1796–806. doi:10.1101/gr.150700. PMC 310981. PMID 11076864.
  2. ↑ "Entrez Gene: ROBO4 roundabout homolog 4, magic roundabout (Drosophila)".

Further reading

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