NPAT (gene): Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Protein NPAT''' also known as '''nuclear protein of the ATM locus''' is a [[protein]] that in humans is encoded by the ''NPAT'' [[gene]].<ref name="pmid9205109">{{cite journal | vauthors = Imai T, Sugawara T, Nishiyama A, Shimada R, Ohki R, Seki N, Sagara M, Ito H, Yamauchi M, Hori T | title = The structure and organization of the human NPAT gene | journal = Genomics | volume = 42 | issue = 3 | pages = 388–92 | date = Jun 1997 | pmid = 9205109 | pmc = | doi = 10.1006/geno.1997.4769 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NPAT nuclear protein, ataxia-telangiectasia locus| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4863| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Nuclear protein, ataxia-telangiectasia locus
| HGNCid = 7896
| Symbol = NPAT
| AltSymbols =; E14
| OMIM = 601448
| ECnumber = 
| Homologene = 1888
| MGIid = 107605
| GeneAtlas_image1 = PBB_GE_NPAT_209798_at_tn.png
| GeneAtlas_image2 = PBB_GE_NPAT_211584_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4863
    | Hs_Ensembl = ENSG00000149308
    | Hs_RefseqProtein = NP_002510
    | Hs_RefseqmRNA = NM_002519
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 107534879
    | Hs_GenLoc_end = 107598539
    | Hs_Uniprot = 
    | Mm_EntrezGene = 244879
    | Mm_Ensembl = ENSMUSG00000033054
    | Mm_RefseqmRNA = XM_146900
    | Mm_RefseqProtein = XP_146900
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 53299442
    | Mm_GenLoc_end = 53335351
    | Mm_Uniprot = 
  }}
}}
'''Nuclear protein, ataxia-telangiectasia locus''', also known as '''NPAT''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NPAT nuclear protein, ataxia-telangiectasia locus| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4863| accessdate = }}</ref>


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NPAT (gene) has been shown to [[Protein-protein_interaction|interact]] with [[Glyceraldehyde 3-phosphate dehydrogenase]]<ref name=pmid12887926>{{cite journal | vauthors = Zheng L, Roeder RG, Luo Y | title = S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component | journal = Cell | volume = 114 | issue = 2 | pages = 255–66 | date = Jul 2003 | pmid = 12887926 | doi = 10.1016/S0092-8674(03)00552-X }}</ref> and [[POU2F1]].<ref name=pmid12887926/>
{{PBB_Summary
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| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Imai T, Yamauchi M, Seki N, Sugawara T, Saito T, Matsuda Y, Ito H, Nagase T, Nomura N, Hori T | title = Identification and characterization of a new gene physically linked to the ATM gene | journal = Genome Research | volume = 6 | issue = 5 | pages = 439–47 | date = May 1996 | pmid = 8743993 | doi = 10.1101/gr.6.5.439 }}
| citations =
* {{cite journal | vauthors = Byrd PJ, McConville CM, Cooper P, Parkhill J, Stankovic T, McGuire GM, Thick JA, Taylor AM | title = Mutations revealed by sequencing the 5' half of the gene for ataxia telangiectasia | journal = Human Molecular Genetics | volume = 5 | issue = 1 | pages = 145–9 | date = Jan 1996 | pmid = 8789452 | doi = 10.1093/hmg/5.1.145 }}
*{{cite journal | author=Imai T, Yamauchi M, Seki N, ''et al.'' |title=Identification and characterization of a new gene physically linked to the ATM gene. |journal=Genome Res. |volume=6 |issue= 5 |pages= 439-47 |year= 1996 |pmid= 8743993 |doi= }}
* {{cite journal | vauthors = Byrd PJ, Cooper PR, Stankovic T, Kullar HS, Watts GD, Robinson PJ, Taylor MR | title = A gene transcribed from the bidirectional ATM promoter coding for a serine rich protein: amino acid sequence, structure and expression studies | journal = Human Molecular Genetics | volume = 5 | issue = 11 | pages = 1785–91 | date = Nov 1996 | pmid = 8923007 | doi = 10.1093/hmg/5.11.1785 }}
*{{cite journal | author=Byrd PJ, McConville CM, Cooper P, ''et al.'' |title=Mutations revealed by sequencing the 5' half of the gene for ataxia telangiectasia. |journal=Hum. Mol. Genet. |volume=5 |issue= 1 |pages= 145-9 |year= 1996 |pmid= 8789452 |doi= }}
* {{cite journal | vauthors = Zhao J, Dynlacht B, Imai T, Hori T, Harlow E | title = Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry | journal = Genes & Development | volume = 12 | issue = 4 | pages = 456–61 | date = Feb 1998 | pmid = 9472014 | pmc = 316526 | doi = 10.1101/gad.12.4.456 }}
*{{cite journal | author=Byrd PJ, Cooper PR, Stankovic T, ''et al.'' |title=A gene transcribed from the bidirectional ATM promoter coding for a serine rich protein: amino acid sequence, structure and expression studies. |journal=Hum. Mol. Genet. |volume=5 |issue= 11 |pages= 1785-91 |year= 1997 |pmid= 8923007 |doi= }}
* {{cite journal | vauthors = Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow E | title = NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription | journal = Genes & Development | volume = 14 | issue = 18 | pages = 2283–97 | date = Sep 2000 | pmid = 10995386 | pmc = 316937 | doi = 10.1101/gad.827700 }}
*{{cite journal  | author=Imai T, Sugawara T, Nishiyama A, ''et al.'' |title=The structure and organization of the human NPAT gene. |journal=Genomics |volume=42 |issue= 3 |pages= 388-92 |year= 1997 |pmid= 9205109 |doi=  }}
* {{cite journal | vauthors = Sagara M, Takeda E, Nishiyama A, Utsumi S, Toyama Y, Yuasa S, Ninomiya Y, Imai T | title = Characterization of functional regions for nuclear localization of NPAT | journal = Journal of Biochemistry | volume = 132 | issue = 6 | pages = 875–9 | date = Dec 2002 | pmid = 12473189 | doi =  10.1093/oxfordjournals.jbchem.a003300}}
*{{cite journal | author=Zhao J, Dynlacht B, Imai T, ''et al.'' |title=Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry. |journal=Genes Dev. |volume=12 |issue= 4 |pages= 456-61 |year= 1998 |pmid= 9472014 |doi= }}
* {{cite journal | vauthors = Gao G, Bracken AP, Burkard K, Pasini D, Classon M, Attwooll C, Sagara M, Imai T, Helin K, Zhao J | title = NPAT expression is regulated by E2F and is essential for cell cycle progression | journal = Molecular and Cellular Biology | volume = 23 | issue = 8 | pages = 2821–33 | date = Apr 2003 | pmid = 12665581 | pmc = 152552 | doi = 10.1128/MCB.23.8.2821-2833.2003 }}
*{{cite journal | author=Zhao J, Kennedy BK, Lawrence BD, ''et al.'' |title=NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. |journal=Genes Dev. |volume=14 |issue= 18 |pages= 2283-97 |year= 2000 |pmid= 10995386 |doi= }}
* {{cite journal | vauthors = Wei Y, Jin J, Harper JW | title = The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain | journal = Molecular and Cellular Biology | volume = 23 | issue = 10 | pages = 3669–80 | date = May 2003 | pmid = 12724424 | pmc = 164767 | doi = 10.1128/MCB.23.10.3669-3680.2003 }}
*{{cite journal | author=Sagara M, Takeda E, Nishiyama A, ''et al.'' |title=Characterization of functional regions for nuclear localization of NPAT. |journal=J. Biochem. |volume=132 |issue= 6 |pages= 875-9 |year= 2004 |pmid= 12473189 |doi=  }}
* {{cite journal | vauthors = Zheng L, Roeder RG, Luo Y | title = S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component | journal = Cell | volume = 114 | issue = 2 | pages = 255–66 | date = Jul 2003 | pmid = 12887926 | doi = 10.1016/S0092-8674(03)00552-X }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Ye X, Wei Y, Nalepa G, Harper JW | title = The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells | journal = Molecular and Cellular Biology | volume = 23 | issue = 23 | pages = 8586–600 | date = Dec 2003 | pmid = 14612403 | pmc = 262656 | doi = 10.1128/MCB.23.23.8586-8600.2003 }}
*{{cite journal | author=Gao G, Bracken AP, Burkard K, ''et al.'' |title=NPAT expression is regulated by E2F and is essential for cell cycle progression. |journal=Mol. Cell. Biol. |volume=23 |issue= 8 |pages= 2821-33 |year= 2003 |pmid= 12665581 |doi= }}
* {{cite journal | vauthors = Wang A, Ikura T, Eto K, Ota MS | title = Dynamic interaction of p220(NPAT) and CBP/p300 promotes S-phase entry | journal = Biochemical and Biophysical Research Communications | volume = 325 | issue = 4 | pages = 1509–16 | date = Dec 2004 | pmid = 15555599 | doi = 10.1016/j.bbrc.2004.10.198 }}
*{{cite journal | author=Wei Y, Jin J, Harper JW |title=The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain. |journal=Mol. Cell. Biol. |volume=23 |issue= 10 |pages= 3669-80 |year= 2003 |pmid= 12724424 |doi= }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Zheng L, Roeder RG, Luo Y |title=S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. |journal=Cell |volume=114 |issue= 2 |pages= 255-66 |year= 2003 |pmid= 12887926 |doi= }}
* {{cite journal | vauthors = Kalla C, Scheuermann MO, Kube I, Schlotter M, Mertens D, Döhner H, Stilgenbauer S, Lichter P | title = Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B | journal = European Journal of Cancer | volume = 43 | issue = 8 | pages = 1328–35 | date = May 2007 | pmid = 17449237 | doi = 10.1016/j.ejca.2007.02.005 }}
*{{cite journal | author=Ye X, Wei Y, Nalepa G, Harper JW |title=The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells. |journal=Mol. Cell. Biol. |volume=23 |issue= 23 |pages= 8586-600 |year= 2003 |pmid= 14612403 |doi= }}
* {{cite journal | vauthors = Medina R, van der Deen M, Miele-Chamberland A, Xie RL, van Wijnen AJ, Stein JL, Stein GS | title = The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes | journal = Cancer Research | volume = 67 | issue = 21 | pages = 10334–42 | date = Nov 2007 | pmid = 17974976 | doi = 10.1158/0008-5472.CAN-07-1560 }}
*{{cite journal | author=Wang A, Ikura T, Eto K, Ota MS |title=Dynamic interaction of p220(NPAT) and CBP/p300 promotes S-phase entry. |journal=Biochem. Biophys. Res. Commun. |volume=325 |issue= 4 |pages= 1509-16 |year= 2005 |pmid= 15555599 |doi= 10.1016/j.bbrc.2004.10.198 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Kalla C, Scheuermann MO, Kube I, ''et al.'' |title=Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B. |journal=Eur. J. Cancer |volume=43 |issue= 8 |pages= 1328-35 |year= 2007 |pmid= 17449237 |doi= 10.1016/j.ejca.2007.02.005 }}
*{{cite journal | author=Medina R, van der Deen M, Miele-Chamberland A, ''et al.'' |title=The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes. |journal=Cancer Res. |volume=67 |issue= 21 |pages= 10334-42 |year= 2007 |pmid= 17974976 |doi= 10.1158/0008-5472.CAN-07-1560 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 13:12, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein NPAT also known as nuclear protein of the ATM locus is a protein that in humans is encoded by the NPAT gene.[1][2]

Interactions

NPAT (gene) has been shown to interact with Glyceraldehyde 3-phosphate dehydrogenase[3] and POU2F1.[3]

References

  1. ↑ Imai T, Sugawara T, Nishiyama A, Shimada R, Ohki R, Seki N, Sagara M, Ito H, Yamauchi M, Hori T (Jun 1997). "The structure and organization of the human NPAT gene". Genomics. 42 (3): 388–92. doi:10.1006/geno.1997.4769. PMID 9205109.
  2. ↑ "Entrez Gene: NPAT nuclear protein, ataxia-telangiectasia locus".
  3. ↑ 3.0 3.1 Zheng L, Roeder RG, Luo Y (Jul 2003). "S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component". Cell. 114 (2): 255–66. doi:10.1016/S0092-8674(03)00552-X. PMID 12887926.

Further reading

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