CSTF3: Difference between revisions

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Revision as of 10:08, 30 August 2017

Cleavage stimulation factor 77 kDa subunit is a protein that in humans is encoded by the CSTF3 gene.^[1]^[2]

The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms.^[2]

Interactions

CSTF3 has been shown to interact with CSTF2.^[3]

References

↑ Takagaki Y, Manley JL (December 1994). "A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein". Nature. 372 (6505): 471–4. doi:10.1038/372471a0. PMID 7984242.
↑ ^2.0 ^2.1 "Entrez Gene: CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa".
↑ Takagaki, Y; Manley J L (March 2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component". Mol. Cell. Biol. UNITED STATES. 20 (5): 1515–25. doi:10.1128/MCB.20.5.1515-1525.2000. ISSN 0270-7306. PMC 85326. PMID 10669729.

External links

Human CSTF3 genome location and CSTF3 gene details page in the UCSC Genome Browser.

Takagaki Y, Manley JL (1992). "A human polyadenylation factor is a G protein beta-subunit homologue". J. Biol. Chem. 267 (33): 23471–4. PMID 1358884.
Takagaki Y, MacDonald CC, Shenk T, Manley JL (1992). "The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1403–7. doi:10.1073/pnas.89.4.1403. PMC 48459. PMID 1741396.
Murthy KG, Manley JL (1995). "The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation". Genes Dev. 9 (21): 2672–83. doi:10.1101/gad.9.21.2672. PMID 7590244.
Takagaki Y, Manley JL (2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component". Mol. Cell. Biol. 20 (5): 1515–25. doi:10.1128/MCB.20.5.1515-1525.2000. PMC 85326. PMID 10669729.
Emili A, Schieltz DM, Yates JR, Hartwell LH (2001). "Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1". Mol. Cell. 7 (1): 13–20. doi:10.1016/S1097-2765(01)00150-2. PMID 11172707.
Benoit B, Juge F, Iral F, et al. (2002). "Chimeric human CstF-77/Drosophila Suppressor of forked proteins rescue suppressor of forked mutant lethality and mRNA 3' end processing in Drosophila". Proc. Natl. Acad. Sci. U.S.A. 99 (16): 10593–8. doi:10.1073/pnas.162191899. PMC 124984. PMID 12149458.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kaufmann I, Martin G, Friedlein A, et al. (2005). "Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase". EMBO J. 23 (3): 616–26. doi:10.1038/sj.emboj.7600070. PMC 1271804. PMID 14749727.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kim J, Bhinge AA, Morgan XC, Iyer VR (2005). "Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment". Nat. Methods. 2 (1): 47–53. doi:10.1038/nmeth726. PMID 15782160.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. doi:10.1038/nature04632. PMID 16554811.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[pmid7984242-1] Takagaki Y, Manley JL (December 1994). "A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein". Nature. 372 (6505): 471–4. doi:10.1038/372471a0. PMID 7984242.

[entrez-2] 2.0 ^2.1 "Entrez Gene: CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa".

[pmid10669729-3] Takagaki, Y; Manley J L (March 2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component". Mol. Cell. Biol. UNITED STATES. 20 (5): 1515–25. doi:10.1128/MCB.20.5.1515-1525.2000. ISSN 0270-7306. PMC 85326. PMID 10669729.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Cleavage stimulation factor 77 kDa subunit''' is a [[protein]] that in humans is encoded by the ''CSTF3'' [[gene]].<ref name="pmid7984242">{{cite journal | vauthors = Takagaki Y, Manley JL | title = A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein | journal = Nature | volume = 372 | issue = 6505 | pages = 471–4 |date=December 1994 | pmid = 7984242 | pmc =  | doi = 10.1038/372471a0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1479| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image = PBB_Protein_CSTF3_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ond.
- | PDB = {{PDB2|2ond}}, {{PDB2|2ooe}}
- | Name = Cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
- | HGNCid = 2485
- | Symbol = CSTF3
- | AltSymbols =; CSTF-77; MGC117398; MGC43001; MGC75122
- | OMIM = 600367
- | ECnumber =
- | Homologene = 1014
- | MGIid = 1351825
-  | GeneAtlas_image1 = PBB_GE_CSTF3_203947_at_tn.png
- | Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}}
- | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006378 |text = mRNA polyadenylation}} {{GNF_GO|id=GO:0006379 |text = mRNA cleavage}} {{GNF_GO|id=GO:0006396 |text = RNA processing}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 1479
-    | Hs_Ensembl = ENSG00000176102
-    | Hs_RefseqProtein = NP_001028677
-    | Hs_RefseqmRNA = NM_001033505
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 11
-    | Hs_GenLoc_start = 33062713
-    | Hs_GenLoc_end = 33139613
-    | Hs_Uniprot = Q12996
-    | Mm_EntrezGene = 228410
-    | Mm_Ensembl = ENSMUSG00000027176
-    | Mm_RefseqmRNA = NM_001037326
-    | Mm_RefseqProtein = NP_001032403
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 2
-    | Mm_GenLoc_start = 104391362
-    | Mm_GenLoc_end = 104466264
-    | Mm_Uniprot = Q3TV86
-  }}
-}}
-'''Cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa''', also known as '''CSTF3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1479| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1479| accessdate = }}</ref>
+| summary_text = The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez" />
 }}
+==Interactions==
+CSTF3 has been shown to [[Protein-protein interaction|interact]] with [[CSTF2]].<ref name=pmid10669729>{{cite journal |doi=10.1128/MCB.20.5.1515-1525.2000 |last=Takagaki |first=Y |author2=Manley J L |date=March 2000  |title=Complex protein interactions within the human polyadenylation machinery identify a novel component |journal=Mol. Cell. Biol. |volume=20 |issue=5 |pages=1515–25 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10669729 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=85326 }}</ref>
 ==References==
-{{reflist|2}}
+{{reflist}}
+==External links==
+* {{UCSC gene info|CSTF3}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Takagaki Y, Manley JL |title=A human polyadenylation factor is a G protein beta-subunit homologue. |journal=J. Biol. Chem. |volume=267 |issue= 33 |pages= 23471-4 |year= 1992 |pmid= 1358884 |doi=  }}
+*{{cite journal  | vauthors=Takagaki Y, Manley JL |title=A human polyadenylation factor is a G protein beta-subunit homologue. |journal=J. Biol. Chem. |volume=267 |issue= 33 |pages= 23471–4 |year= 1992 |pmid= 1358884 |doi=  }}
-*{{cite journal  | author=Takagaki Y, MacDonald CC, Shenk T, Manley JL |title=The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1403-7 |year= 1992 |pmid= 1741396 |doi=  }}
+*{{cite journal  | vauthors=Takagaki Y, MacDonald CC, Shenk T, Manley JL |title=The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1403–7 |year= 1992 |pmid= 1741396 |doi=  10.1073/pnas.89.4.1403| pmc=48459  }}
-*{{cite journal  | author=Murthy KG, Manley JL |title=The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. |journal=Genes Dev. |volume=9 |issue= 21 |pages= 2672-83 |year= 1995 |pmid= 7590244 |doi=  }}
+*{{cite journal  | vauthors=Murthy KG, Manley JL |title=The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. |journal=Genes Dev. |volume=9 |issue= 21 |pages= 2672–83 |year= 1995 |pmid= 7590244 |doi=10.1101/gad.9.21.2672  }}
-*{{cite journal  | author=Takagaki Y, Manley JL |title=A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein. |journal=Nature |volume=372 |issue= 6505 |pages= 471-4 |year= 1994 |pmid= 7984242 |doi= 10.1038/372471a0 }}
+*{{cite journal  | vauthors=Takagaki Y, Manley JL |title=Complex protein interactions within the human polyadenylation machinery identify a novel component. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1515–25 |year= 2000 |pmid= 10669729 |doi=  10.1128/MCB.20.5.1515-1525.2000| pmc=85326  }}
-*{{cite journal  | author=Takagaki Y, Manley JL |title=Complex protein interactions within the human polyadenylation machinery identify a novel component. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1515-25 |year= 2000 |pmid= 10669729 |doi=  }}
+*{{cite journal  | vauthors=Emili A, Schieltz DM, Yates JR, Hartwell LH |title=Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1. |journal=Mol. Cell |volume=7 |issue= 1 |pages= 13–20 |year= 2001 |pmid= 11172707 |doi=10.1016/S1097-2765(01)00150-2  }}
-*{{cite journal  | author=Emili A, Schieltz DM, Yates JR, Hartwell LH |title=Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1. |journal=Mol. Cell |volume=7 |issue= 1 |pages= 13-20 |year= 2001 |pmid= 11172707 |doi=  }}
+*{{cite journal  | vauthors=Benoit B, Juge F, Iral F |title=Chimeric human CstF-77/Drosophila Suppressor of forked proteins rescue suppressor of forked mutant lethality and mRNA 3' end processing in Drosophila. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 16 |pages= 10593–8 |year= 2002 |pmid= 12149458 |doi= 10.1073/pnas.162191899  | pmc=124984 |display-authors=etal}}
-*{{cite journal  | author=Benoit B, Juge F, Iral F, ''et al.'' |title=Chimeric human CstF-77/Drosophila Suppressor of forked proteins rescue suppressor of forked mutant lethality and mRNA 3' end processing in Drosophila. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 16 |pages= 10593-8 |year= 2002 |pmid= 12149458 |doi= 10.1073/pnas.162191899 }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Kaufmann I, Martin G, Friedlein A |title=Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. |journal=EMBO J. |volume=23 |issue= 3 |pages= 616–26 |year= 2005 |pmid= 14749727 |doi= 10.1038/sj.emboj.7600070  | pmc=1271804 |display-authors=etal}}
-*{{cite journal  | author=Kaufmann I, Martin G, Friedlein A, ''et al.'' |title=Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. |journal=EMBO J. |volume=23 |issue= 3 |pages= 616-26 |year= 2005 |pmid= 14749727 |doi= 10.1038/sj.emboj.7600070 }}
+*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  | vauthors=Kim J, Bhinge AA, Morgan XC, Iyer VR |title=Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment. |journal=Nat. Methods |volume=2 |issue= 1 |pages= 47–53 |year= 2005 |pmid= 15782160 |doi= 10.1038/nmeth726 }}
-*{{cite journal  | author=Kim J, Bhinge AA, Morgan XC, Iyer VR |title=Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment. |journal=Nat. Methods |volume=2 |issue= 1 |pages= 47-53 |year= 2005 |pmid= 15782160 |doi= 10.1038/nmeth726 }}
+*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
+*{{cite journal  | vauthors=Taylor TD, Noguchi H, Totoki Y |title=Human chromosome 11 DNA sequence and analysis including novel gene identification. |journal=Nature |volume=440 |issue= 7083 |pages= 497–500 |year= 2006 |pmid= 16554811 |doi= 10.1038/nature04632 |display-authors=etal}}
-*{{cite journal  | author=Taylor TD, Noguchi H, Totoki Y, ''et al.'' |title=Human chromosome 11 DNA sequence and analysis including novel gene identification. |journal=Nature |volume=440 |issue= 7083 |pages= 497-500 |year= 2006 |pmid= 16554811 |doi= 10.1038/nature04632 }}
+*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
-*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
+*{{cite journal  | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948 |display-authors=etal}}
-*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=1479}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
-{{protein-stub}}
+{{gene-11-stub}}
-{{WikiDoc Sources}}

CSTF3: Difference between revisions

Revision as of 10:08, 30 August 2017

Contents

Interactions

References

External links

Further reading

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