HIPK3: Difference between revisions

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{{Infobox_gene}}
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'''Homeodomain-interacting protein kinase 3''' is an [[enzyme]] that in humans is encoded by the ''HIPK3'' [[gene]].<ref name="pmid9373137">{{cite journal |vauthors=Begley DA, Berkenpas MB, Sampson KE, Abraham I | title = Identification and sequence of human PKY, a putative kinase with increased expression in multidrug-resistant cells, with homology to yeast protein kinase Yak1 | journal = Gene | volume = 200 | issue = 1–2 | pages = 35–43 |date=Dec 1997 | pmid = 9373137 | pmc =  | doi =10.1016/S0378-1119(97)00350-8  }}</ref><ref name="pmid9748262">{{cite journal |vauthors=Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y | title = Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors | journal = J Biol Chem | volume = 273 | issue = 40 | pages = 25875–9 |date=Nov 1998 | pmid = 9748262 | pmc =  | doi =10.1074/jbc.273.40.25875 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HIPK3 homeodomain interacting protein kinase 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10114| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Homeodomain interacting protein kinase 3
| HGNCid = 4915
| Symbol = HIPK3
| AltSymbols =; DYRK6; FIST3; PKY; YAK1
| OMIM = 604424
| ECnumber = 
| Homologene = 55923
| MGIid = 1314882
| GeneAtlas_image1 = PBB_GE_HIPK3_210148_at_tn.png
| GeneAtlas_image2 = PBB_GE_HIPK3_207764_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016605 |text = PML body}}
  | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0018105 |text = peptidyl-serine phosphorylation}} {{GNF_GO|id=GO:0018107 |text = peptidyl-threonine phosphorylation}} {{GNF_GO|id=GO:0043508 |text = negative regulation of JNK activity}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10114
    | Hs_Ensembl = ENSG00000110422
    | Hs_RefseqProtein = NP_001041665
    | Hs_RefseqmRNA = NM_001048200
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 33235981
    | Hs_GenLoc_end = 33332427
    | Hs_Uniprot = Q9H422
    | Mm_EntrezGene = 15259
    | Mm_Ensembl = ENSMUSG00000027177
    | Mm_RefseqmRNA = XM_001001388
    | Mm_RefseqProtein = XP_001001388
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 104230595
    | Mm_GenLoc_end = 104295083
    | Mm_Uniprot = O35694
  }}
}}
'''Homeodomain interacting protein kinase 3''', also known as '''HIPK3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HIPK3 homeodomain interacting protein kinase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10114| accessdate = }}</ref>
 
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==References==
{{reflist}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Begley DA, Berkenpas MB, Sampson KE, Abraham I |title=Identification and sequence of human PKY, a putative kinase with increased expression in multidrug-resistant cells, with homology to yeast protein kinase Yak1. |journal=Gene |volume=200 |issue= 1-2 |pages= 35-43 |year= 1997 |pmid= 9373137 |doi=  }}
*{{cite journal  | author=Moilanen AM |title=Activation of Androgen Receptor Function by a Novel Nuclear Protein Kinase |journal=Mol. Biol. Cell |volume=9 |issue= 9 |pages= 2527–43 |year= 1999 |pmid= 9725910 |doi=  10.1091/mbc.9.9.2527| pmc=25523  |name-list-format=vanc| author2=Karvonen U  | author3=Poukka H  | display-authors=3  | last4=Jänne  | first4=OA  | last5=Palvimo  | first5=JJ }}
*{{cite journal  | author=Moilanen AM, Karvonen U, Poukka H, ''et al.'' |title=Activation of androgen receptor function by a novel nuclear protein kinase. |journal=Mol. Biol. Cell |volume=9 |issue= 9 |pages= 2527-43 |year= 1999 |pmid= 9725910 |doi=  }}
*{{cite journal  | author=Scaffidi C |title=Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase |journal=J. Immunol. |volume=164 |issue= 3 |pages= 1236–42 |year= 2000 |pmid= 10640736 |doi= 10.4049/jimmunol.164.3.1236|name-list-format=vanc| author2=Volkland J  | author3=Blomberg I  | display-authors=3  | last4=Hoffmann  | first4=I  | last5=Krammer  | first5=PH  | last6=Peter  | first6=ME }}
*{{cite journal  | author=Kim YH, Choi CY, Lee SJ, ''et al.'' |title=Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25875-9 |year= 1998 |pmid= 9748262 |doi=  }}
*{{cite journal  |vauthors=Nupponen NN, Visakorpi T |title=Assignment of the protein kinase homolog of YAK1 (HIPK3) to human chromosome band 11p13 by in situ hybridization |journal=Cytogenet. Cell Genet. |volume=87 |issue= 1–2 |pages= 102–3 |year= 2000 |pmid= 10640824 |doi=10.1159/000015404 }}
*{{cite journal  | author=Scaffidi C, Volkland J, Blomberg I, ''et al.'' |title=Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase. |journal=J. Immunol. |volume=164 |issue= 3 |pages= 1236-42 |year= 2000 |pmid= 10640736 |doi=  }}
*{{cite journal  | author=Dias Neto E |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491  | pmc=16267  |name-list-format=vanc| author2=Correa RG  | author3=Verjovski-Almeida S  | display-authors=3  | last4=Briones  | first4=MR  | last5=Nagai  | first5=MA  | last6=Da Silva Jr  | first6=W  | last7=Zago  | first7=MA  | last8=Bordin  | first8=S  | last9=Costa  | first9=FF }}
*{{cite journal  | author=Nupponen NN, Visakorpi T |title=Assignment of the protein kinase homolog of YAK1 (HIPK3) to human chromosome band 11p13 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 1-2 |pages= 102-3 |year= 2000 |pmid= 10640824 |doi=  }}
*{{cite journal  |vauthors=Minty A, Dumont X, Kaghad M, Caput D |title=Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif |journal=J. Biol. Chem. |volume=275 |issue= 46 |pages= 36316–23 |year= 2000 |pmid= 10961991 |doi= 10.1074/jbc.M004293200 }}
*{{cite journal  | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi=  }}
*{{cite journal  | author=Rochat-Steiner V |title=Fist/Hipk3: A FAS/Fadd-Interacting Serine/Threonine Kinase That Induces Fadd Phosphorylation and Inhibits FAS-Mediated Jun Nh2-Terminal Kinase Activation |journal=J. Exp. Med. |volume=192 |issue= 8 |pages= 1165–74 |year= 2000 |pmid= 11034606 |doi=10.1084/jem.192.8.1165  | pmc=2311455  |name-list-format=vanc| author2=Becker K  | author3=Micheau O  | display-authors=3  | last4=Schneider  | first4=P.  | last5=Burns  | first5=K.  | last6=Tschopp  | first6=J. }}
*{{cite journal  | author=Minty A, Dumont X, Kaghad M, Caput D |title=Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif. |journal=J. Biol. Chem. |volume=275 |issue= 46 |pages= 36316-23 |year= 2000 |pmid= 10961991 |doi= 10.1074/jbc.M004293200 }}
*{{cite journal  |vauthors=Curtin JF, Cotter TG |title=JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 17090–100 |year= 2004 |pmid= 14766760 |doi= 10.1074/jbc.M307629200 }}
*{{cite journal  | author=Rochat-Steiner V, Becker K, Micheau O, ''et al.'' |title=FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation. |journal=J. Exp. Med. |volume=192 |issue= 8 |pages= 1165-74 |year= 2000 |pmid= 11034606 |doi=  }}
*{{cite journal  | author=Colland F |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148  |name-list-format=vanc| author2=Jacq X  | author3=Trouplin V  | display-authors=3  | last4=Mougin  | first4=C  | last5=Groizeleau  | first5=C  | last6=Hamburger  | first6=A  | last7=Meil  | first7=A  | last8=Wojcik  | first8=J  | last9=Legrain  | first9=P }}
*{{cite journal  | author=Curtin JF, Cotter TG |title=JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells. |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 17090-100 |year= 2004 |pmid= 14766760 |doi= 10.1074/jbc.M307629200 }}
*{{cite journal  | author=Rush J |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |name-list-format=vanc| author2=Moritz A  | author3=Lee KA  | display-authors=3  | last4=Guo  | first4=Ailan  | last5=Goss  | first5=Valerie L  | last6=Spek  | first6=Erik J  | last7=Zhang  | first7=Hui  | last8=Zha  | first8=Xiang-Ming  | last9=Polakiewicz  | first9=Roberto D }}
*{{cite journal  | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | author=Venables JP |title=Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon |journal=Hum. Mol. Genet. |volume=14 |issue= 16 |pages= 2289–303 |year= 2005 |pmid= 16000324 |doi= 10.1093/hmg/ddi233 |name-list-format=vanc| author2=Bourgeois CF  | author3=Dalgliesh C  | display-authors=3  | last4=Kister  | first4=L  | last5=Stevenin  | first5=J  | last6=Elliott  | first6=DJ }}
*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal  | author=Taylor TD |title=Human chromosome 11 DNA sequence and analysis including novel gene identification |journal=Nature |volume=440 |issue= 7083 |pages= 497–500 |year= 2006 |pmid= 16554811 |doi= 10.1038/nature04632 |name-list-format=vanc| author2=Noguchi H  | author3=Totoki Y  | display-authors=3  | last4=Toyoda  | first4=Atsushi  | last5=Kuroki  | first5=Yoko  | last6=Dewar  | first6=Ken  | last7=Lloyd  | first7=Christine  | last8=Itoh  | first8=Takehiko  | last9=Takeda  | first9=Tadayuki }}
*{{cite journal  | author=Venables JP, Bourgeois CF, Dalgliesh C, ''et al.'' |title=Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon. |journal=Hum. Mol. Genet. |volume=14 |issue= 16 |pages= 2289-303 |year= 2005 |pmid= 16000324 |doi= 10.1093/hmg/ddi233 }}
*{{cite journal  | author=Lan HC |title=Cyclic AMP Stimulates SF-1-Dependent CYP11A1 Expression through Homeodomain-Interacting Protein Kinase 3-Mediated Jun N-Terminal Kinase and c-Jun Phosphorylation |journal=Mol. Cell. Biol. |volume=27 |issue= 6 |pages= 2027–36 |year= 2007 |pmid= 17210646 |doi= 10.1128/MCB.02253-06 | pmc=1820514  |name-list-format=vanc| author2=Li HJ  | author3=Lin G  | display-authors=3  | last4=Lai  | first4=P.-Y.  | last5=Chung  | first5=B.-c. }}
*{{cite journal  | author=Taylor TD, Noguchi H, Totoki Y, ''et al.'' |title=Human chromosome 11 DNA sequence and analysis including novel gene identification. |journal=Nature |volume=440 |issue= 7083 |pages= 497-500 |year= 2006 |pmid= 16554811 |doi= 10.1038/nature04632 }}
*{{cite journal  | author=Lan HC, Li HJ, Lin G, ''et al.'' |title=Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation. |journal=Mol. Cell. Biol. |volume=27 |issue= 6 |pages= 2027-36 |year= 2007 |pmid= 17210646 |doi= 10.1128/MCB.02253-06 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|HIPK3}}
* {{UCSC gene details|HIPK3}}
 
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Latest revision as of 02:27, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeodomain-interacting protein kinase 3 is an enzyme that in humans is encoded by the HIPK3 gene.[1][2][3]

References

  1. ↑ Begley DA, Berkenpas MB, Sampson KE, Abraham I (Dec 1997). "Identification and sequence of human PKY, a putative kinase with increased expression in multidrug-resistant cells, with homology to yeast protein kinase Yak1". Gene. 200 (1–2): 35–43. doi:10.1016/S0378-1119(97)00350-8. PMID 9373137.
  2. ↑ Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y (Nov 1998). "Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors". J Biol Chem. 273 (40): 25875–9. doi:10.1074/jbc.273.40.25875. PMID 9748262.
  3. ↑ "Entrez Gene: HIPK3 homeodomain interacting protein kinase 3".

Further reading

External links



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