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'''Oxysterol-binding protein-related protein 5''' is a [[protein]] that in humans is encoded by the ''OSBPL5'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OSBPL5 oxysterol binding protein-like 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114879| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Oxysterol binding protein-like 5
| HGNCid = 16392
| Symbol = OSBPL5
| AltSymbols =; FLJ42929; OBPH1; ORP5
| OMIM = 606733
| ECnumber = 
| Homologene = 68725
| MGIid = 1930265
| Function = {{GNF_GO|id=GO:0008142 |text = oxysterol binding}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006869 |text = lipid transport}} {{GNF_GO|id=GO:0006893 |text = Golgi to plasma membrane transport}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}} {{GNF_GO|id=GO:0008203 |text = cholesterol metabolic process}} {{GNF_GO|id=GO:0030301 |text = cholesterol transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 114879
    | Hs_Ensembl = ENSG00000021762
    | Hs_RefseqProtein = NP_065947
    | Hs_RefseqmRNA = NM_020896
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 3064922
    | Hs_GenLoc_end = 3143116
    | Hs_Uniprot = Q9H0X9
    | Mm_EntrezGene = 79196
    | Mm_Ensembl = ENSMUSG00000037606
    | Mm_RefseqmRNA = NM_024289
    | Mm_RefseqProtein = NP_077251
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 143498152
    | Mm_GenLoc_end = 143551353
    | Mm_Uniprot = Q9ER64
  }}
}}
'''Oxysterol binding protein-like 5''', also known as '''OSBPL5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OSBPL5 oxysterol binding protein-like 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114879| accessdate = }}</ref>


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| section_title =  
| summary_text = This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: OSBPL5 oxysterol binding protein-like 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114879| accessdate = }}</ref>
| summary_text = This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
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| citations =  
| citations =  
*{{cite journal  | author=Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E |title=Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism. |journal=J. Lipid Res. |volume=40 |issue= 12 |pages= 2204-11 |year= 2000 |pmid= 10588946 |doi=  }}
*{{cite journal  | vauthors=Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E |title=Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism |journal=J. Lipid Res. |volume=40 |issue= 12 |pages= 2204–11 |year= 2000 |pmid= 10588946 |doi=  }}
*{{cite journal | author=Nagase T, Kikuno R, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143-50 |year= 2000 |pmid= 10819331 |doi=  }}
*{{cite journal   |vauthors=Nagase T, Kikuno R, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 2 |pages= 143–50 |year= 2000 |pmid= 10819331 |doi=10.1093/dnares/7.2.143 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
*{{cite journal | author=Lehto M, Laitinen S, Chinetti G, ''et al.'' |title=The OSBP-related protein family in humans. |journal=J. Lipid Res. |volume=42 |issue= 8 |pages= 1203-13 |year= 2001 |pmid= 11483621 |doi=  }}
*{{cite journal   |vauthors=Lehto M, Laitinen S, Chinetti G, etal |title=The OSBP-related protein family in humans |journal=J. Lipid Res. |volume=42 |issue= 8 |pages= 1203–13 |year= 2001 |pmid= 11483621 |doi=  }}
*{{cite journal | author=Jaworski CJ, Moreira E, Li A, ''et al.'' |title=A family of 12 human genes containing oxysterol-binding domains. |journal=Genomics |volume=78 |issue= 3 |pages= 185-96 |year= 2002 |pmid= 11735225 |doi= 10.1006/geno.2001.6663 }}
*{{cite journal   |vauthors=Jaworski CJ, Moreira E, Li A, etal |title=A family of 12 human genes containing oxysterol-binding domains |journal=Genomics |volume=78 |issue= 3 |pages= 185–96 |year= 2002 |pmid= 11735225 |doi= 10.1006/geno.2001.6663 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Higashimoto K, Soejima H, Yatsuki H, ''et al.'' |title=Characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouse. |journal=Genomics |volume=80 |issue= 6 |pages= 575-84 |year= 2003 |pmid= 12504849 |doi=  }}
*{{cite journal   |vauthors=Higashimoto K, Soejima H, Yatsuki H, etal |title=Characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouse |journal=Genomics |volume=80 |issue= 6 |pages= 575–84 |year= 2003 |pmid= 12504849 |doi=10.1006/geno.2002.7006 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
*{{cite journal | author=Ma J, Dempsey AA, Stamatiou D, ''et al.'' |title=Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. |journal=Atherosclerosis |volume=191 |issue= 1 |pages= 63-72 |year= 2007 |pmid= 16806233 |doi= 10.1016/j.atherosclerosis.2006.05.032 }}
*{{cite journal   |vauthors=Ma J, Dempsey AA, Stamatiou D, etal |title=Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects |journal=Atherosclerosis |volume=191 |issue= 1 |pages= 63–72 |year= 2007 |pmid= 16806233 |doi= 10.1016/j.atherosclerosis.2006.05.032 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
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Revision as of 00:37, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Oxysterol-binding protein-related protein 5 is a protein that in humans is encoded by the OSBPL5 gene.[1]

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: OSBPL5 oxysterol binding protein-like 5".

Further reading



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