STS-1 (gene): Difference between revisions

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''For the 1981 spaceflight see: [[STS-1]]''{{Infobox_gene}}
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'''Ubiquitin-associated and SH3 domain-containing protein B''' is a [[protein]] that in humans is encoded by the ''UBASH3B'' [[gene]].<ref name="pmid11853319">{{cite journal | vauthors = Nagase T, Kikuno R, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins | journal = DNA Res | volume = 8 | issue = 6 | pages = 319–27 |date=Feb 2002 | pmid = 11853319 | pmc =  | doi =10.1093/dnares/8.6.319 }}</ref><ref name="pmid12370296">{{cite journal | vauthors = Carpino N, Kobayashi R, Zang H, Takahashi Y, Jou ST, Feng J, Nakajima H, Ihle JN | title = Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein | journal = Mol Cell Biol | volume = 22 | issue = 21 | pages = 7491–500 |date=Oct 2002 | pmid = 12370296 | pmc = 135669 | doi =10.1128/MCB.22.21.7491-7500.2002 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STS-1 Cbl-interacting protein Sts-1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84959| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_STS-1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2cpw.
| PDB = {{PDB2|2cpw}}
| Name = Cbl-interacting protein Sts-1
| HGNCid =
| Symbol = STS-1
| AltSymbols =; KIAA1959; MGC15437; p70
| OMIM = 609201
| ECnumber =
| Homologene = 13152
| MGIid = 1920078
  | GeneAtlas_image1 = PBB_GE_STS-1_gnf1h01005_at_tn.png
| GeneAtlas_image2 = PBB_GE_STS-1_gnf1h06108_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_STS-1_gnf1h09784_s_at_tn.png
  | Function =
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 84959
    | Hs_Ensembl = ENSG00000154127
    | Hs_RefseqProtein = NP_116262
    | Hs_RefseqmRNA = NM_032873
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 122031640
    | Hs_GenLoc_end = 122190390
    | Hs_Uniprot = Q8TF42
    | Mm_EntrezGene = 72828
    | Mm_Ensembl = ENSMUSG00000032020
    | Mm_RefseqmRNA = NM_176860
    | Mm_RefseqProtein = NP_789830
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 40764710
    | Mm_GenLoc_end = 40908563
    | Mm_Uniprot = Q8BGG7
  }}
}}
'''Cbl-interacting protein Sts-1''', also known as '''STS-1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: STS-1 Cbl-interacting protein Sts-1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84959| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.<ref name="entrez">{{cite web | title = Entrez Gene: STS-1 Cbl-interacting protein Sts-1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84959| accessdate = }}</ref>
| summary_text = This gene encodes a protein that contains a [[ubiquitin associated protein domain]] at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Nagase T, Kikuno R, Ohara O |title=Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. |journal=DNA Res. |volume=8 |issue= 6 |pages= 319-27 |year= 2002 |pmid= 11853319 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Carpino N, Kobayashi R, Zang H, ''et al.'' |title=Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein. |journal=Mol. Cell. Biol. |volume=22 |issue= 21 |pages= 7491-500 |year= 2002 |pmid= 12370296 |doi= }}
*{{cite journal   |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal   |vauthors=Kowanetz K, Crosetto N, Haglund K, etal |title=Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. |journal=J. Biol. Chem. |volume=279 |issue= 31 |pages= 32786–95 |year= 2004 |pmid= 15159412 |doi= 10.1074/jbc.M403759200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Guo F, Sigua C, Bali P, etal |title=Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells. |journal=Blood |volume=105 |issue= 3 |pages= 1246–55 |year= 2005 |pmid= 15388581 |doi= 10.1182/blood-2004-05-2041 }}
*{{cite journal | author=Kowanetz K, Crosetto N, Haglund K, ''et al.'' |title=Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. |journal=J. Biol. Chem. |volume=279 |issue= 31 |pages= 32786-95 |year= 2004 |pmid= 15159412 |doi= 10.1074/jbc.M403759200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Guo F, Sigua C, Bali P, ''et al.'' |title=Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells. |journal=Blood |volume=105 |issue= 3 |pages= 1246-55 |year= 2005 |pmid= 15388581 |doi= 10.1182/blood-2004-05-2041 }}
*{{cite journal   |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal   |vauthors=Hoeller D, Crosetto N, Blagoev B, etal |title=Regulation of ubiquitin-binding proteins by monoubiquitination. |journal=Nat. Cell Biol. |volume=8 |issue= 2 |pages= 163–9 |year= 2006 |pmid= 16429130 |doi= 10.1038/ncb1354 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Hoeller D, Crosetto N, Blagoev B, ''et al.'' |title=Regulation of ubiquitin-binding proteins by monoubiquitination. |journal=Nat. Cell Biol. |volume=8 |issue= 2 |pages= 163-9 |year= 2006 |pmid= 16429130 |doi= 10.1038/ncb1354 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=84959}}
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Revision as of 07:14, 11 September 2017

For the 1981 spaceflight see: STS-1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ubiquitin-associated and SH3 domain-containing protein B is a protein that in humans is encoded by the UBASH3B gene.[1][2][3]

This gene encodes a protein that contains a ubiquitin associated protein domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.[3]

References

  1. ↑ Nagase T, Kikuno R, Ohara O (Feb 2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
  2. ↑ Carpino N, Kobayashi R, Zang H, Takahashi Y, Jou ST, Feng J, Nakajima H, Ihle JN (Oct 2002). "Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein". Mol Cell Biol. 22 (21): 7491–500. doi:10.1128/MCB.22.21.7491-7500.2002. PMC 135669. PMID 12370296.
  3. ↑ 3.0 3.1 "Entrez Gene: STS-1 Cbl-interacting protein Sts-1".

Further reading



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