MADD (gene): Difference between revisions

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{{Infobox_gene}}
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'''MAP kinase-activating death domain protein''' is an [[enzyme]] that in humans is encoded by the ''MADD'' [[gene]].<ref name="pmid9115275">{{cite journal |vauthors=Schievella AR, Chen JH, Graham JR, Lin LL | title = MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase | journal = J Biol Chem | volume = 272 | issue = 18 | pages = 12069–75 |date=Jun 1997 | pmid = 9115275 | pmc =  | doi =10.1074/jbc.272.18.12069 }}</ref><ref name="pmid9796103">{{cite journal |vauthors=Chow VT, Lim KM, Lim D | title = The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22 | journal = Genome | volume = 41 | issue = 4 | pages = 543–52 |date=Nov 1998 | pmid = 9796103 | pmc =  | doi =10.1139/gen-41-4-543 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MADD MAP-kinase activating death domain| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8567| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = MAP-kinase activating death domain
| HGNCid = 6766
| Symbol = MADD
| AltSymbols =; DENN; IG20; KIAA0358; RAB3GEP
| OMIM = 603584
| ECnumber =
| Homologene = 14249
| MGIid = 2444672
  | GeneAtlas_image1 = PBB_GE_MADD_38398_at_tn.png
| GeneAtlas_image2 = PBB_GE_MADD_210252_s_at_tn.png
  | Function =
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8567
    | Hs_Ensembl = ENSG00000110514
    | Hs_RefseqProtein = NP_003673
    | Hs_RefseqmRNA = NM_003682
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 47247535
    | Hs_GenLoc_end = 47308158
    | Hs_Uniprot =   
    | Mm_EntrezGene = 228355
    | Mm_Ensembl = ENSMUSG00000040687
    | Mm_RefseqmRNA = NM_145527
    | Mm_RefseqProtein = NP_663502
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 90938200
    | Mm_GenLoc_end = 90984657
    | Mm_Uniprot =   
  }}
}}
'''MAP-kinase activating death domain''', also known as '''MADD''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MADD MAP-kinase activating death domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8567| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: MADD MAP-kinase activating death domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8567| accessdate = }}</ref>
| summary_text = [[Tumor necrosis factor alpha]] (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for [[apoptosis]]. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Chow VT, Lee SS |title=DENN, a novel human gene differentially expressed in normal and neoplastic cells. |journal=DNA Seq. |volume=6 |issue= 5 |pages= 263-73 |year= 1997 |pmid= 8988362 |doi=  }}
*{{cite journal  |vauthors=Chow VT, Lee SS |title=DENN, a novel human gene differentially expressed in normal and neoplastic cells |journal=DNA Seq. |volume=6 |issue= 5 |pages= 263–73 |year= 1997 |pmid= 8988362 |doi=10.3109/10425179609020873 }}
*{{cite journal | author=Schievella AR, Chen JH, Graham JR, Lin LL |title=MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase. |journal=J. Biol. Chem. |volume=272 |issue= 18 |pages= 12069-75 |year= 1997 |pmid= 9115275 |doi= }}
*{{cite journal   |vauthors=Nagase T, Ishikawa K, Nakajima D, etal |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Res. |volume=4 |issue= 2 |pages= 141–50 |year= 1997 |pmid= 9205841 |doi=10.1093/dnares/4.2.141  }}
*{{cite journal  | author=Nagase T, Ishikawa K, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141-50 |year= 1997 |pmid= 9205841 |doi=  }}
*{{cite journal  |vauthors=Zhang Y, Zhou L, Miller CA |title=A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 5 |pages= 2586–91 |year= 1998 |pmid= 9482930 |doi=10.1073/pnas.95.5.2586  | pmc=19423 }}
*{{cite journal | author=Zhang Y, Zhou L, Miller CA |title=A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 5 |pages= 2586-91 |year= 1998 |pmid= 9482930 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Ishihara D, Sasaki M, etal |title=Statistical analysis of the 5' untranslated region of human mRNA using "Oligo-Capped" cDNA libraries |journal=Genomics |volume=64 |issue= 3 |pages= 286–97 |year= 2000 |pmid= 10756096 |doi= 10.1006/geno.2000.6076 }}
*{{cite journal  | author=Chow VT, Lim KM, Lim D |title=The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22. |journal=Genome |volume=41 |issue= 4 |pages= 543-52 |year= 1998 |pmid= 9796103 |doi=  }}
*{{cite journal  |vauthors=Telliez JB, Bean KM, Lin LL |title=LRDD, a novel leucine rich repeat and death domain containing protein |journal=Biochim. Biophys. Acta |volume=1478 |issue= 2 |pages= 280–8 |year= 2000 |pmid= 10825539 |doi=10.1016/S0167-4838(00)00029-7 }}
*{{cite journal  | author=Suzuki Y, Ishihara D, Sasaki M, ''et al.'' |title=Statistical analysis of the 5' untranslated region of human mRNA using "Oligo-Capped" cDNA libraries. |journal=Genomics |volume=64 |issue= 3 |pages= 286-97 |year= 2000 |pmid= 10756096 |doi= 10.1006/geno.2000.6076 }}
*{{cite journal  |vauthors=Iwasaki K, Toyonaga R |title=The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission |journal=EMBO J. |volume=19 |issue= 17 |pages= 4806–16 |year= 2000 |pmid= 10970871 |doi= 10.1093/emboj/19.17.4806  | pmc=302062 }}
*{{cite journal | author=Telliez JB, Bean KM, Lin LL |title=LRDD, a novel leucine rich repeat and death domain containing protein. |journal=Biochim. Biophys. Acta |volume=1478 |issue= 2 |pages= 280-8 |year= 2000 |pmid= 10825539 |doi= }}
*{{cite journal   |vauthors=Al-Zoubi AM, Efimova EV, Kaithamana S, etal |title=Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3 |journal=J. Biol. Chem. |volume=276 |issue= 50 |pages= 47202–11 |year= 2002 |pmid= 11577081 |doi= 10.1074/jbc.M104835200 }}
*{{cite journal  | author=Iwasaki K, Toyonaga R |title=The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission. |journal=EMBO J. |volume=19 |issue= 17 |pages= 4806-16 |year= 2000 |pmid= 10970871 |doi= 10.1093/emboj/19.17.4806 }}
*{{cite journal  |vauthors=Lim KM, Chow VT |title=Induction of marked apoptosis in mammalian cancer cell lines by antisense DNA treatment to abolish expression of DENN (differentially expressed in normal and neoplastic cells) |journal=Mol. Carcinog. |volume=35 |issue= 3 |pages= 110–26 |year= 2002 |pmid= 12410563 |doi= 10.1002/mc.10082 }}
*{{cite journal  | author=Al-Zoubi AM, Efimova EV, Kaithamana S, ''et al.'' |title=Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3. |journal=J. Biol. Chem. |volume=276 |issue= 50 |pages= 47202-11 |year= 2002 |pmid= 11577081 |doi= 10.1074/jbc.M104835200 }}
*{{cite journal  |vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902  | pmc=187542 }}
*{{cite journal | author=Lim KM, Chow VT |title=Induction of marked apoptosis in mammalian cancer cell lines by antisense DNA treatment to abolish expression of DENN (differentially expressed in normal and neoplastic cells). |journal=Mol. Carcinog. |volume=35 |issue= 3 |pages= 110-26 |year= 2002 |pmid= 12410563 |doi= 10.1002/mc.10082 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 }}
*{{cite journal   |vauthors=Efimova E, Martinez O, Lokshin A, etal |title=IG20, a MADD splice variant, increases cell susceptibility to gamma-irradiation and induces soluble mediators that suppress tumor cell growth |journal=Cancer Res. |volume=63 |issue= 24 |pages= 8768–76 |year= 2004 |pmid= 14695193 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Efimova EV, Al-Zoubi AM, Martinez O, etal |title=IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs |journal=Oncogene |volume=23 |issue= 5 |pages= 1076–87 |year= 2004 |pmid= 14716293 |doi= 10.1038/sj.onc.1207210 }}
*{{cite journal  | author=Efimova E, Martinez O, Lokshin A, ''et al.'' |title=IG20, a MADD splice variant, increases cell susceptibility to gamma-irradiation and induces soluble mediators that suppress tumor cell growth. |journal=Cancer Res. |volume=63 |issue= 24 |pages= 8768-76 |year= 2004 |pmid= 14695193 |doi= }}
*{{cite journal  |vauthors=Lim KM, Yeo WS, Chow VT |title=Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle |journal=Int. J. Cancer |volume=109 |issue= 1 |pages= 24–37 |year= 2004 |pmid= 14735464 |doi= 10.1002/ijc.11660 }}
*{{cite journal  | author=Efimova EV, Al-Zoubi AM, Martinez O, ''et al.'' |title=IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs. |journal=Oncogene |volume=23 |issue= 5 |pages= 1076-87 |year= 2004 |pmid= 14716293 |doi= 10.1038/sj.onc.1207210 }}
*{{cite journal  |vauthors=Del Villar K, Miller CA |title=Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 12 |pages= 4210–5 |year= 2004 |pmid= 15007167 |doi= 10.1073/pnas.0307349101  | pmc=384720 }}
*{{cite journal | author=Lim KM, Yeo WS, Chow VT |title=Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle. |journal=Int. J. Cancer |volume=109 |issue= 1 |pages= 24-37 |year= 2004 |pmid= 14735464 |doi= 10.1002/ijc.11660 }}
*{{cite journal   |vauthors=Xu Y, Kulkosky J, Acheampong E, etal |title=HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 18 |pages= 7070–5 |year= 2004 |pmid= 15103018 |doi= 10.1073/pnas.0304859101  | pmc=406467 }}
*{{cite journal | author=Del Villar K, Miller CA |title=Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 12 |pages= 4210-5 |year= 2004 |pmid= 15007167 |doi= 10.1073/pnas.0307349101 }}
*{{cite journal   |vauthors=Ramaswamy M, Efimova EV, Martinez O, etal |title=IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC |journal=Oncogene |volume=23 |issue= 36 |pages= 6083–94 |year= 2005 |pmid= 15208670 |doi= 10.1038/sj.onc.1207804 }}
*{{cite journal | author=Xu Y, Kulkosky J, Acheampong E, ''et al.'' |title=HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 18 |pages= 7070-5 |year= 2004 |pmid= 15103018 |doi= 10.1073/pnas.0304859101 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Ramaswamy M, Efimova EV, Martinez O, ''et al.'' |title=IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC. |journal=Oncogene |volume=23 |issue= 36 |pages= 6083-94 |year= 2005 |pmid= 15208670 |doi= 10.1038/sj.onc.1207804 }}
*{{cite journal   |vauthors=Hu YF, Zhang HL, Cai T, etal |title=The IA-2 interactome |journal=Diabetologia |volume=48 |issue= 12 |pages= 2576–81 |year= 2006 |pmid= 16273344 |doi= 10.1007/s00125-005-0037-y }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Hu YF, Zhang HL, Cai T, ''et al.'' |title=The IA-2 interactome. |journal=Diabetologia |volume=48 |issue= 12 |pages= 2576-81 |year= 2006 |pmid= 16273344 |doi= 10.1007/s00125-005-0037-y }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 05:59, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

MAP kinase-activating death domain protein is an enzyme that in humans is encoded by the MADD gene.[1][2][3]

Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.[3]

References

  1. ↑ Schievella AR, Chen JH, Graham JR, Lin LL (Jun 1997). "MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase". J Biol Chem. 272 (18): 12069–75. doi:10.1074/jbc.272.18.12069. PMID 9115275.
  2. ↑ Chow VT, Lim KM, Lim D (Nov 1998). "The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22". Genome. 41 (4): 543–52. doi:10.1139/gen-41-4-543. PMID 9796103.
  3. ↑ 3.0 3.1 "Entrez Gene: MADD MAP-kinase activating death domain".

Further reading



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