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{{Infobox_gene}}
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'''Lymphocyte-specific protein 1''' is a [[protein]] that in humans is encoded by the ''LSP1'' [[gene]].<ref name="pmid2174784">{{cite journal |vauthors=Kadiyala RK, McIntyre BW, Krensky AM | title = Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen | journal = Eur J Immunol | volume = 20 | issue = 11 | pages = 2417–23 |date=Jan 1991 | pmid = 2174784 | pmc =  | doi =10.1002/eji.1830201109 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LSP1 lymphocyte-specific protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4046| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Lymphocyte-specific protein 1
| HGNCid = 6707
| Symbol = LSP1
| AltSymbols =; WP34; pp52
| OMIM = 153432
| ECnumber = 
| Homologene = 1750
| MGIid = 96832
| GeneAtlas_image1 = PBB_GE_LSP1_203523_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}}
| Component = {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4046
    | Hs_Ensembl = ENSG00000130592
    | Hs_RefseqProtein = XP_001130890
    | Hs_RefseqmRNA = XM_001130890
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 1830776
    | Hs_GenLoc_end = 1870069
    | Hs_Uniprot = P33241
    | Mm_EntrezGene = 16985
    | Mm_Ensembl = ENSMUSG00000018819
    | Mm_RefseqmRNA = NM_019391
    | Mm_RefseqProtein = NP_062264
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 142270247
    | Mm_GenLoc_end = 142303989
    | Mm_Uniprot = P19973
  }}
}}
'''Lymphocyte-specific protein 1''', also known as '''LSP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LSP1 lymphocyte-specific protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4046| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: LSP1 lymphocyte-specific protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4046| accessdate = }}</ref>
| summary_text = This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Kadiyala RK, McIntyre BW, Krensky AM |title=Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen. |journal=Eur. J. Immunol. |volume=20 |issue= 11 |pages= 2417-23 |year= 1991 |pmid= 2174784 |doi=  }}
*{{cite journal  |vauthors=Jongstra-Bilen J, Young AJ, Chong R, Jongstra J |title=Human and mouse LSP1 genes code for highly conserved phosphoproteins |journal=J. Immunol. |volume=144 |issue= 3 |pages= 1104–10 |year= 1990 |pmid= 2295815 |doi=  }}
*{{cite journal  | author=Jongstra-Bilen J, Young AJ, Chong R, Jongstra J |title=Human and mouse LSP1 genes code for highly conserved phosphoproteins. |journal=J. Immunol. |volume=144 |issue= 3 |pages= 1104-10 |year= 1990 |pmid= 2295815 |doi=  }}
*{{cite journal  | author=Klein DP |title=Lymphocyte-specific Ca2+-binding protein LSP1 is associated with the cytoplasmic face of the plasma membrane |journal=Mol. Cell. Biol. |volume=9 |issue= 7 |pages= 3043–8 |year= 1989 |pmid= 2674678 |doi=  | pmc=362773 |name-list-format=vanc| author2=Jongstra-Bilen J | author3=Ogryzlo K | display-authors=3  | last4=Chong  | first4=R  | last5=Jongstra  | first5=J }}
*{{cite journal | author=Klein DP, Jongstra-Bilen J, Ogryzlo K, ''et al.'' |title=Lymphocyte-specific Ca2+-binding protein LSP1 is associated with the cytoplasmic face of the plasma membrane. |journal=Mol. Cell. Biol. |volume=9 |issue= 7 |pages= 3043-8 |year= 1989 |pmid= 2674678 |doi=  }}
*{{cite journal  |vauthors=Li Y, Guerrero A, Howard TH |title=The actin-binding protein, lymphocyte-specific protein 1, is expressed in human leukocytes and human myeloid and lymphoid cell lines |journal=J. Immunol. |volume=155 |issue= 7 |pages= 3563–9 |year= 1995 |pmid= 7561054 |doi=  }}
*{{cite journal  | author=Li Y, Guerrero A, Howard TH |title=The actin-binding protein, lymphocyte-specific protein 1, is expressed in human leukocytes and human myeloid and lymphoid cell lines. |journal=J. Immunol. |volume=155 |issue= 7 |pages= 3563-9 |year= 1995 |pmid= 7561054 |doi=  }}
*{{cite journal  | author=Misener VL |title=Expression of mouse LSP1/S37 isoforms. S37 is expressed in embryonic mesenchymal cells |journal=J. Cell Sci. |volume=107 |issue=  12|pages= 3591–600 |year= 1995 |pmid= 7706408 |doi=  |name-list-format=vanc| author2=Hui C  | author3=Malapitan IA | display-authors=3  | last4=Ittel  | first4=ME  | last5=Joyner  | first5=AL  | last6=Jongstra  | first6=J }}
*{{cite journal  | author=Misener VL, Hui C, Malapitan IA, ''et al.'' |title=Expression of mouse LSP1/S37 isoforms. S37 is expressed in embryonic mesenchymal cells. |journal=J. Cell. Sci. |volume=107 ( Pt 12) |issue=  |pages= 3591-600 |year= 1995 |pmid= 7706408 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Howard T |title=The 47-kD protein increased in neutrophil actin dysfunction with 47- and 89-kD protein abnormalities is lymphocyte-specific protein |journal=Blood |volume=83 |issue= 1 |pages= 231–41 |year= 1994 |pmid= 8274738 |doi=  |name-list-format=vanc| author2=Li Y  | author3=Torres M  | display-authors=3  | last4=Guerrero  | first4=A  | last5=Coates  | first5=T }}
*{{cite journal  | author=Howard T, Li Y, Torres M, ''et al.'' |title=The 47-kD protein increased in neutrophil actin dysfunction with 47- and 89-kD protein abnormalities is lymphocyte-specific protein. |journal=Blood |volume=83 |issue= 1 |pages= 231-41 |year= 1994 |pmid= 8274738 |doi=  }}
*{{cite journal  | author=May W |title=Human lymphocyte-specific pp52 gene is a member of a highly conserved dispersed family |journal=Genomics |volume=15 |issue= 3 |pages= 515–20 |year= 1993 |pmid= 8468046 |doi= 10.1006/geno.1993.1102 |name-list-format=vanc| author2=Korenberg JR  | author3=Chen XN  | display-authors=3  | last4=Lunsford  | first4=Lynn  | last5=Wood  | first5=William J.  | last6=Thompson  | first6=Alexic  | last7=Wall  | first7=Randolph  | last8=Denny | first8=Christopher T. }}
*{{cite journal  | author=May W, Korenberg JR, Chen XN, ''et al.'' |title=Human lymphocyte-specific pp52 gene is a member of a highly conserved dispersed family. |journal=Genomics |volume=15 |issue= 3 |pages= 515-20 |year= 1993 |pmid= 8468046 |doi= 10.1006/geno.1993.1102 }}
*{{cite journal  | author=Thompson AA |title=Alternatively spliced exons encode the tissue-specific 5' termini of leukocyte pp52 and stromal cell S37 mRNA isoforms |journal=Genomics |volume=32 |issue= 3 |pages= 352–7 |year= 1997 |pmid= 8838798 |doi=10.1006/geno.1996.0129 |name-list-format=vanc| author2=Omori SA  | author3=Gilly MJ  | display-authors=3  | last4=May  | first4=William  | last5=Gordon  | first5=Melinda S.  | last6=Wood  | first6=Jr.  | last7=Miyoshi  | first7=Erina  | last8=Malone  | first8=Cindy Sue  | last9=Gimble  | first9=Jeff }}
*{{cite journal | author=Thompson AA, Omori SA, Gilly MJ, ''et al.'' |title=Alternatively spliced exons encode the tissue-specific 5' termini of leukocyte pp52 and stromal cell S37 mRNA isoforms. |journal=Genomics |volume=32 |issue= 3 |pages= 352-7 |year= 1997 |pmid= 8838798 |doi=  }}
*{{cite journal  |vauthors=Huang CK, Zhan L, Ai Y, Jongstra J |title=LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils |journal=J. Biol. Chem. |volume=272 |issue= 1 |pages= 17–9 |year= 1997 |pmid= 8995217 |doi=10.1074/jbc.272.1.17 }}
*{{cite journal  | author=Huang CK, Zhan L, Ai Y, Jongstra J |title=LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils. |journal=J. Biol. Chem. |volume=272 |issue= 1 |pages= 17-9 |year= 1997 |pmid= 8995217 |doi=  }}
*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-format=vanc| author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | display-authors=3  | last4=Suyama  | first4=A | last5=Sugano  | first5=S  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Palker TJ |title=Developmental regulation of lymphocyte-specific protein 1 (LSP1) expression in thymus during human T-cell maturation |journal=Hybridoma |volume=17 |issue= 6 |pages= 497–507 |year= 1999 |pmid= 9890705 |doi=10.1089/hyb.1998.17.497  |name-list-format=vanc| author2=Fong AM  | author3=Scearce RM  | display-authors=3  | last4=Patel  | first4=Dhavalkumar D.  | last5=Haynes  | first5=Barton F. }}
*{{cite journal  | author=Palker TJ, Fong AM, Scearce RM, ''et al.'' |title=Developmental regulation of lymphocyte-specific protein 1 (LSP1) expression in thymus during human T-cell maturation. |journal=Hybridoma |volume=17 |issue= 6 |pages= 497-507 |year= 1999 |pmid= 9890705 |doi=  }}
*{{cite journal  | author=Pulford K |title=Lymphocyte-specific protein 1: a specific marker of human leucocytes |journal=Immunology |volume=96 |issue= 2 |pages= 262–71 |year= 1999 |pmid= 10233704 |doi=10.1046/j.1365-2567.1999.00677.x | pmc=2326732  |name-list-format=vanc| author2=Jones M  | author3=Banham AH  | display-authors=3  | last4=Haralambieva  | last5=Mason  | first4=E  | first5=DY  }}
*{{cite journal  | author=Pulford K, Jones M, Banham AH, ''et al.'' |title=Lymphocyte-specific protein 1: a specific marker of human leucocytes. |journal=Immunology |volume=96 |issue= 2 |pages= 262-71 |year= 1999 |pmid= 10233704 |doi=  }}
*{{cite journal  |vauthors=Zhang Q, Li Y, Howard TH |title=Human lymphocyte-specific protein 1, the protein overexpressed in neutrophil actin dysfunction with 47-kDa and 89-kDa protein abnormalities (NAD 47/89), has multiple F-actin binding domains |journal=J. Immunol. |volume=165 |issue= 4 |pages= 2052–8 |year= 2000 |pmid= 10925289 |doi=  10.4049/jimmunol.165.4.2052}}
*{{cite journal  | author=Zhang Q, Li Y, Howard TH |title=Human lymphocyte-specific protein 1, the protein overexpressed in neutrophil actin dysfunction with 47-kDa and 89-kDa protein abnormalities (NAD 47/89), has multiple F-actin binding domains. |journal=J. Immunol. |volume=165 |issue= 4 |pages= 2052-8 |year= 2000 |pmid= 10925289 |doi=  }}
*{{cite journal  |vauthors=Zhang Q, Li Y, Howard TH |title=Hair-forming activity of human lymphocyte specific protein 1 requires cooperation between its caldesmon-like domains and the villin headpiece-like domains |journal=Cell Motil. Cytoskeleton |volume=49 |issue= 4 |pages= 179–88 |year= 2002 |pmid= 11746662 |doi= 10.1002/cm.1031 }}
*{{cite journal  | author=Zhang Q, Li Y, Howard TH |title=Hair-forming activity of human lymphocyte specific protein 1 requires cooperation between its caldesmon-like domains and the villin headpiece-like domains. |journal=Cell Motil. Cytoskeleton |volume=49 |issue= 4 |pages= 179-88 |year= 2002 |pmid= 11746662 |doi= 10.1002/cm.1031 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Wong MJ, Malapitan IA, Sikorski BA, Jongstra J |title=A cell-free binding assay maps the LSP1 cytoskeletal binding site to the COOH-terminal 30 amino acids |journal=Biochim. Biophys. Acta |volume=1642 |issue= 1–2 |pages= 17–24 |year= 2003 |pmid= 12972289 |doi=10.1016/S0167-4889(03)00082-X  }}
*{{cite journal  | author=Wong MJ, Malapitan IA, Sikorski BA, Jongstra J |title=A cell-free binding assay maps the LSP1 cytoskeletal binding site to the COOH-terminal 30 amino acids. |journal=Biochim. Biophys. Acta |volume=1642 |issue= 1-2 |pages= 17-24 |year= 2003 |pmid= 12972289 |doi=  }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Harrison RE, Sikorski BA, Jongstra J |title=Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton |journal=J. Cell Sci. |volume=117 |issue= Pt 10 |pages= 2151–7 |year= 2005 |pmid= 15090600 |doi= 10.1242/jcs.00955 }}
*{{cite journal | author=Harrison RE, Sikorski BA, Jongstra J |title=Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton. |journal=J. Cell. Sci. |volume=117 |issue= Pt 10 |pages= 2151-7 |year= 2005 |pmid= 15090600 |doi= 10.1242/jcs.00955 }}
*{{cite journal  | author=Hassel S |title=Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry |journal=Proteomics |volume=4 |issue= 5 |pages= 1346–58 |year= 2004 |pmid= 15188402 |doi= 10.1002/pmic.200300770  |name-list-format=vanc| author2=Eichner A  | author3=Yakymovych M  | display-authors=3  | last4=Hellman  | first4=Ulf  | last5=Knaus  | first5=Petra  | last6=Souchelnytskyi  | first6=Serhiy }}
*{{cite journal  | author=Hassel S, Eichner A, Yakymovych M, ''et al.'' |title=Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. |journal=Proteomics |volume=4 |issue= 5 |pages= 1346-58 |year= 2004 |pmid= 15188402 |doi= 10.1002/pmic.200300770 }}
}}
}}
{{refend}}
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Revision as of 20:14, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Lymphocyte-specific protein 1 is a protein that in humans is encoded by the LSP1 gene.[1][2]

This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms.[2]

References

  1. ↑ Kadiyala RK, McIntyre BW, Krensky AM (Jan 1991). "Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen". Eur J Immunol. 20 (11): 2417–23. doi:10.1002/eji.1830201109. PMID 2174784.
  2. ↑ 2.0 2.1 "Entrez Gene: LSP1 lymphocyte-specific protein 1".

Further reading



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