SFRS9: Difference between revisions

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{{Infobox_gene}}
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'''Splicing factor, arginine/serine-rich 9''', also known as '''SFRS9''', is a human [[gene]] encoding an [[SR protein]] involved in splice site selection in [[alternative splicing]].<ref name="entrez">{{cite web | title = Entrez Gene: SFRS9 splicing factor, arginine/serine-rich 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8683| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_SFRS9_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wg4.
| PDB = {{PDB2|1wg4}}
| Name = Splicing factor, arginine/serine-rich 9
| HGNCid = 10791
| Symbol = SFRS9
| AltSymbols =; SRp30c
| OMIM = 601943
| ECnumber = 
| Homologene = 20819
| MGIid = 104896
| GeneAtlas_image1 = PBB_GE_SFRS9_201698_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SFRS9_200044_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006376 |text = mRNA splice site selection}} {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8683
    | Hs_Ensembl = ENSG00000111786
    | Hs_RefseqProtein = NP_003760
    | Hs_RefseqmRNA = NM_003769
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 119383855
    | Hs_GenLoc_end = 119391941
    | Hs_Uniprot = Q13242
    | Mm_EntrezGene = 108014
    | Mm_Ensembl = ENSMUSG00000029538
    | Mm_RefseqmRNA = NM_025573
    | Mm_RefseqProtein = NP_079849
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 115588176
    | Mm_GenLoc_end = 115594079
    | Mm_Uniprot = Q3TXM9
  }}
}}
'''Splicing factor, arginine/serine-rich 9''', also known as '''SFRS9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SFRS9 splicing factor, arginine/serine-rich 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8683| accessdate = }}</ref>
 
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==Interactions==
SFRS9 has been shown to [[Protein-protein interaction|interact]] with [[Y box binding protein 1]]<ref name=pmid12604611>{{cite journal |last=Raffetseder |first=Ute |authorlink= |author2=Frye Björn |author3=Rauen Thomas |author4=Jürchott Karsten |author5=Royer Hans-Dieter |author6=Jansen Petra Lynen |author7=Mertens Peter R  |date=May 2003 |title=Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection |journal=J. Biol. Chem. |volume=278 |issue=20 |pages=18241–8 |publisher= |location = United States| issn = 0021-9258| pmid = 12604611 |doi = 10.1074/jbc.M212518200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[NOL3]].<ref name=pmid10196175>{{cite journal |doi=10.1074/jbc.274.16.10951 |last=Stoss |first=O |authorlink= |author2=Schwaiger F W |author3=Cooper T A |author4=Stamm S  |date=Apr 1999 |title=Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c |journal=J. Biol. Chem. |volume=274 |issue=16 |pages=10951–62 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10196175 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Screaton GR, Cáceres JF, Mayeda A, ''et al.'' |title=Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. |journal=EMBO J. |volume=14 |issue= 17 |pages= 4336-49 |year= 1995 |pmid= 7556075 |doi=  }}
*{{cite journal   |vauthors=Screaton GR, Cáceres JF, Mayeda A, etal |title=Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. |journal=EMBO J. |volume=14 |issue= 17 |pages= 4336–49 |year= 1995 |pmid= 7556075 |doi= | pmc=394518 }}
*{{cite journal | author=Nayler O, Strätling W, Bourquin JP, ''et al.'' |title=SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements. |journal=Nucleic Acids Res. |volume=26 |issue= 15 |pages= 3542-9 |year= 1998 |pmid= 9671816 |doi= }}
*{{cite journal   |vauthors=Nayler O, Strätling W, Bourquin JP, etal |title=SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements. |journal=Nucleic Acids Res. |volume=26 |issue= 15 |pages= 3542–9 |year= 1998 |pmid= 9671816 |doi=10.1093/nar/26.15.3542  | pmc=147731  }}
*{{cite journal  | author=Yuan Y, Li DM, Sun H |title=PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. |journal=J. Biol. Chem. |volume=273 |issue= 32 |pages= 20347-53 |year= 1998 |pmid= 9685386 |doi= }}
*{{cite journal  |author1=Yuan Y |author2=Li DM |author3=Sun H |title=PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. |journal=J. Biol. Chem. |volume=273 |issue= 32 |pages= 20347–53 |year= 1998 |pmid= 9685386 |doi=10.1074/jbc.273.32.20347  }}
*{{cite journal | author=Petersen-Mahrt SK, Estmer C, Ohrmalm C, ''et al.'' |title=The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation. |journal=EMBO J. |volume=18 |issue= 4 |pages= 1014-24 |year= 1999 |pmid= 10022843 |doi= 10.1093/emboj/18.4.1014 }}
*{{cite journal   |vauthors=Petersen-Mahrt SK, Estmer C, Ohrmalm C, etal |title=The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation. |journal=EMBO J. |volume=18 |issue= 4 |pages= 1014–24 |year= 1999 |pmid= 10022843 |doi= 10.1093/emboj/18.4.1014 | pmc=1171193 }}
*{{cite journal  | author=Stoss O, Schwaiger FW, Cooper TA, Stamm S |title=Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 10951-62 |year= 1999 |pmid= 10196175 |doi=  }}
*{{cite journal  |author1=Stoss O |author2=Schwaiger FW |author3=Cooper TA |author4=Stamm S |title=Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 10951–62 |year= 1999 |pmid= 10196175 |doi=10.1074/jbc.274.16.10951 }}
*{{cite journal | author=Elliott DJ, Bourgeois CF, Klink A, ''et al.'' |title=A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 11 |pages= 5717-22 |year= 2000 |pmid= 10823932 |doi=  }}
*{{cite journal   |vauthors=Elliott DJ, Bourgeois CF, Klink A, etal |title=A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 11 |pages= 5717–22 |year= 2000 |pmid= 10823932 |doi=10.1073/pnas.97.11.5717  | pmc=18499 }}
*{{cite journal | author=Stoss O, Olbrich M, Hartmann AM, ''et al.'' |title=The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites. |journal=J. Biol. Chem. |volume=276 |issue= 12 |pages= 8665-73 |year= 2001 |pmid= 11118435 |doi= 10.1074/jbc.M006851200 }}
*{{cite journal   |vauthors=Stoss O, Olbrich M, Hartmann AM, etal |title=The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites. |journal=J. Biol. Chem. |volume=276 |issue= 12 |pages= 8665–73 |year= 2001 |pmid= 11118435 |doi= 10.1074/jbc.M006851200 }}
*{{cite journal | author=Denegri M, Chiodi I, Corioni M, ''et al.'' |title=Stress-induced nuclear bodies are sites of accumulation of pre-mRNA processing factors. |journal=Mol. Biol. Cell |volume=12 |issue= 11 |pages= 3502-14 |year= 2002 |pmid= 11694584 |doi=  }}
*{{cite journal   |vauthors=Denegri M, Chiodi I, Corioni M, etal |title=Stress-induced nuclear bodies are sites of accumulation of pre-mRNA processing factors. |journal=Mol. Biol. Cell |volume=12 |issue= 11 |pages= 3502–14 |year= 2002 |pmid= 11694584 |doi= 10.1091/mbc.12.11.3502| pmc=60271 }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi= }}
*{{cite journal   |vauthors=Andersen JS, Lyon CE, Fox AH, etal |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9  }}
*{{cite journal | author=Young PJ, DiDonato CJ, Hu D, ''et al.'' |title=SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1. |journal=Hum. Mol. Genet. |volume=11 |issue= 5 |pages= 577-87 |year= 2002 |pmid= 11875052 |doi=  }}
*{{cite journal   |vauthors=Young PJ, DiDonato CJ, Hu D, etal |title=SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1. |journal=Hum. Mol. Genet. |volume=11 |issue= 5 |pages= 577–87 |year= 2002 |pmid= 11875052 |doi=10.1093/hmg/11.5.577 }}
*{{cite journal  | author=Simard MJ, Chabot B |title=SRp30c is a repressor of 3' splice site utilization. |journal=Mol. Cell. Biol. |volume=22 |issue= 12 |pages= 4001-10 |year= 2002 |pmid= 12024014 |doi=  }}
*{{cite journal  |author1=Simard MJ |author2=Chabot B |title=SRp30c is a repressor of 3' splice site utilization. |journal=Mol. Cell. Biol. |volume=22 |issue= 12 |pages= 4001–10 |year= 2002 |pmid= 12024014 |doi=10.1128/MCB.22.12.4001-4010.2002  | pmc=133842 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Raffetseder U, Frye B, Rauen T, ''et al.'' |title=Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 18241-8 |year= 2003 |pmid= 12604611 |doi= 10.1074/jbc.M212518200 }}
*{{cite journal   |vauthors=Raffetseder U, Frye B, Rauen T, etal |title=Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 18241–8 |year= 2003 |pmid= 12604611 |doi= 10.1074/jbc.M212518200 }}
*{{cite journal  | author=Xu Q, Leung DY, Kisich KO |title=Serine-arginine-rich protein p30 directs alternative splicing of glucocorticoid receptor pre-mRNA to glucocorticoid receptor beta in neutrophils. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 27112-8 |year= 2003 |pmid= 12738786 |doi= 10.1074/jbc.M300824200 }}
*{{cite journal  |author1=Xu Q |author2=Leung DY |author3=Kisich KO |title=Serine-arginine-rich protein p30 directs alternative splicing of glucocorticoid receptor pre-mRNA to glucocorticoid receptor beta in neutrophils. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 27112–8 |year= 2003 |pmid= 12738786 |doi= 10.1074/jbc.M300824200 }}
*{{cite journal | author=Li J, Hawkins IC, Harvey CD, ''et al.'' |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437-47 |year= 2003 |pmid= 14559993 |doi= }}
*{{cite journal   |vauthors=Li J, Hawkins IC, Harvey CD, etal |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437–47 |year= 2003 |pmid= 14559993 |doi=10.1128/MCB.23.21.7437-7447.2003  | pmc=207616  }}
*{{cite journal | author=Kondo S, Yamamoto N, Murakami T, ''et al.'' |title=Tra2 beta, SF2/ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA. |journal=Genes Cells |volume=9 |issue= 2 |pages= 121-30 |year= 2004 |pmid= 15009090 |doi= }}
*{{cite journal   |vauthors=Kondo S, Yamamoto N, Murakami T, etal |title=Tra2 beta, SF2/ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA. |journal=Genes Cells |volume=9 |issue= 2 |pages= 121–30 |year= 2004 |pmid= 15009090 |doi=10.1111/j.1356-9597.2004.00709.x  }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Wang Y, Wang J, Gao L, ''et al.'' |title=Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1. |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 14230-9 |year= 2005 |pmid= 15695522 |doi= 10.1074/jbc.M413846200 }}
*{{cite journal   |vauthors=Wang Y, Wang J, Gao L, etal |title=Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1. |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 14230–9 |year= 2005 |pmid= 15695522 |doi= 10.1074/jbc.M413846200 }}
*{{cite journal | author=Scherer SE, Muzny DM, Buhay CJ, ''et al.'' |title=The finished DNA sequence of human chromosome 12. |journal=Nature |volume=440 |issue= 7082 |pages= 346-51 |year= 2006 |pmid= 16541075 |doi= 10.1038/nature04569 }}
*{{cite journal   |vauthors=Scherer SE, Muzny DM, Buhay CJ, etal |title=The finished DNA sequence of human chromosome 12. |journal=Nature |volume=440 |issue= 7082 |pages= 346–51 |year= 2006 |pmid= 16541075 |doi= 10.1038/nature04569 }}
}}
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{{PDB Gallery|geneid=8683}}
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Revision as of 06:14, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human gene encoding an SR protein involved in splice site selection in alternative splicing.[1]


Interactions

SFRS9 has been shown to interact with Y box binding protein 1[2] and NOL3.[3]

References

  1. "Entrez Gene: SFRS9 splicing factor, arginine/serine-rich 9".
  2. Raffetseder, Ute; Frye Björn; Rauen Thomas; Jürchott Karsten; Royer Hans-Dieter; Jansen Petra Lynen; Mertens Peter R (May 2003). "Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection". J. Biol. Chem. United States. 278 (20): 18241–8. doi:10.1074/jbc.M212518200. ISSN 0021-9258. PMID 12604611.
  3. Stoss, O; Schwaiger F W; Cooper T A; Stamm S (Apr 1999). "Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c". J. Biol. Chem. UNITED STATES. 274 (16): 10951–62. doi:10.1074/jbc.274.16.10951. ISSN 0021-9258. PMID 10196175.

Further reading