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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Adenylyl cyclase type 6''' is an [[enzyme]] that in humans is encoded by the ''ADCY6'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ADCY6 adenylate cyclase 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=112| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_ADCY6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1azs.
| PDB = {{PDB2|1azs}}, {{PDB2|1cjk}}, {{PDB2|1cjt}}, {{PDB2|1cju}}, {{PDB2|1cjv}}, {{PDB2|1cs4}}, {{PDB2|1cul}}, {{PDB2|1tl7}}, {{PDB2|1u0h}}, {{PDB2|2gvd}}, {{PDB2|2gvz}}
| Name = Adenylate cyclase 6
| HGNCid = 237
| Symbol = ADCY6
| AltSymbols =; DKFZp779F075; KIAA0422
| OMIM = 600294
| ECnumber = 
| Homologene = 22400
| MGIid = 87917
| GeneAtlas_image1 = PBB_GE_ADCY6_209195_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ADCY6_216743_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004016 |text = adenylate cyclase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006171 |text = cAMP biosynthetic process}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 112
    | Hs_Ensembl = ENSG00000174233
    | Hs_RefseqProtein = NP_056085
    | Hs_RefseqmRNA = NM_015270
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 47446248
    | Hs_GenLoc_end = 47464157
    | Hs_Uniprot = O43306
    | Mm_EntrezGene = 11512
    | Mm_Ensembl = ENSMUSG00000022994
    | Mm_RefseqmRNA = NM_007405
    | Mm_RefseqProtein = NP_031431
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 98418007
    | Mm_GenLoc_end = 98435667
    | Mm_Uniprot = Q80U07
  }}
}}
'''Adenylate cyclase 6''', also known as '''ADCY6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ADCY6 adenylate cyclase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=112| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes adenylyl cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger [[cyclic adenosine monophosphate]] (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: ADCY6 adenylate cyclase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=112| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ADCY6}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Nakajima D, Okazaki N, Yamakawa H |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |display-authors=etal}}
| citations =
*{{cite journal  | vauthors=Gaudin C, Homcy CJ, Ishikawa Y |title=Mammalian adenylyl cyclase family members are randomly located on different chromosomes. |journal=Hum. Genet. |volume=94 |issue= 5 |pages= 527–9 |year= 1994 |pmid= 7959689 |doi=10.1007/BF00211020 }}
*{{cite journal  | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal  | vauthors=Haber N, Stengel D, Defer N |title=Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI. |journal=Hum. Genet. |volume=94 |issue= 1 |pages= 69–73 |year= 1994 |pmid= 8034296 |doi=10.1007/BF02272844 |display-authors=etal}}
*{{cite journal  | author=Gaudin C, Homcy CJ, Ishikawa Y |title=Mammalian adenylyl cyclase family members are randomly located on different chromosomes. |journal=Hum. Genet. |volume=94 |issue= 5 |pages= 527-9 |year= 1994 |pmid= 7959689 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | author=Haber N, Stengel D, Defer N, ''et al.'' |title=Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI. |journal=Hum. Genet. |volume=94 |issue= 1 |pages= 69-73 |year= 1994 |pmid= 8034296 |doi=  }}
*{{cite journal  | vauthors=Harry A, Chen Y, Magnusson R |title=Differential regulation of adenylyl cyclases by Galphas. |journal=J. Biol. Chem. |volume=272 |issue= 30 |pages= 19017–21 |year= 1997 |pmid= 9228084 |doi=10.1074/jbc.272.30.19017 |display-authors=etal}}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Harry A, Chen Y, Magnusson R, ''et al.'' |title=Differential regulation of adenylyl cyclases by Galphas. |journal=J. Biol. Chem. |volume=272 |issue= 30 |pages= 19017-21 |year= 1997 |pmid= 9228084 |doi=  }}
*{{cite journal  | vauthors=Mhaouty-Kodja S, Bouet-Alard R, Limon-Boulez I |title=Molecular diversity of adenylyl cyclases in human and rat myometrium. Correlation with global adenylyl cyclase activity during mid- and term pregnancy. |journal=J. Biol. Chem. |volume=272 |issue= 49 |pages= 31100–6 |year= 1998 |pmid= 9388262 |doi=10.1074/jbc.272.49.31100 |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=Ishikawa K, Nagase T, Nakajima D |title=Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 5 |pages= 307–13 |year= 1998 |pmid= 9455477 |doi=10.1093/dnares/4.5.307  |display-authors=etal}}
*{{cite journal  | author=Mhaouty-Kodja S, Bouet-Alard R, Limon-Boulez I, ''et al.'' |title=Molecular diversity of adenylyl cyclases in human and rat myometrium. Correlation with global adenylyl cyclase activity during mid- and term pregnancy. |journal=J. Biol. Chem. |volume=272 |issue= 49 |pages= 31100-6 |year= 1998 |pmid= 9388262 |doi=  }}
*{{cite journal  | vauthors=Leech CA, Castonguay MA, Habener JF |title=Expression of adenylyl cyclase subtypes in pancreatic beta-cells. |journal=Biochem. Biophys. Res. Commun. |volume=254 |issue= 3 |pages= 703–6 |year= 1999 |pmid= 9920805 |doi= 10.1006/bbrc.1998.9906 }}
*{{cite journal  | author=Ishikawa K, Nagase T, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 5 |pages= 307-13 |year= 1998 |pmid= 9455477 |doi= }}
*{{cite journal  | vauthors=Barcova M, Speth C, Kacani L |title=Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1. |journal=Pflugers Arch. |volume=437 |issue= 4 |pages= 538–46 |year= 1999 |pmid= 10089566 |doi=10.1007/s004240050815 |display-authors=etal}}
*{{cite journal  | author=Leech CA, Castonguay MA, Habener JF |title=Expression of adenylyl cyclase subtypes in pancreatic beta-cells. |journal=Biochem. Biophys. Res. Commun. |volume=254 |issue= 3 |pages= 703-6 |year= 1999 |pmid= 9920805 |doi= 10.1006/bbrc.1998.9906 }}
*{{cite journal  | vauthors=Raimundo S, Giray J, Volff JN |title=Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues. |journal=Clin. Chim. Acta |volume=285 |issue= 1-2 |pages= 155–61 |year= 1999 |pmid= 10481931 |doi=10.1016/S0009-8981(99)00067-4 |display-authors=etal}}
*{{cite journal  | author=Barcova M, Speth C, Kacani L, ''et al.'' |title=Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1. |journal=Pflugers Arch. |volume=437 |issue= 4 |pages= 538-46 |year= 1999 |pmid= 10089566 |doi=  }}
*{{cite journal  | vauthors=Speth C, Joebstl B, Barcova M, Dierich MP |title=HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. |journal=AIDS |volume=14 |issue= 6 |pages= 629–36 |year= 2000 |pmid= 10807185 |doi=10.1097/00002030-200004140-00001 }}
*{{cite journal  | author=Raimundo S, Giray J, Volff JN, ''et al.'' |title=Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues. |journal=Clin. Chim. Acta |volume=285 |issue= 1-2 |pages= 155-61 |year= 1999 |pmid= 10481931 |doi=  }}
*{{cite journal  | vauthors=Patke CL, Shearer WT |title=gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression. |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 5 |pages= 975–82 |year= 2000 |pmid= 10808179 |doi= 10.1067/mai.2000.105315 }}
*{{cite journal  | author=Speth C, Joebstl B, Barcova M, Dierich MP |title=HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. |journal=AIDS |volume=14 |issue= 6 |pages= 629-36 |year= 2000 |pmid= 10807185 |doi=  }}
*{{cite journal  | vauthors=Wicker R, Catalan AG, Cailleux A |title=Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues. |journal=Biochim. Biophys. Acta |volume=1493 |issue= 1-2 |pages= 279–83 |year= 2000 |pmid= 10978539 |doi=  10.1016/s0167-4781(00)00187-1|display-authors=etal}}
*{{cite journal  | author=Patke CL, Shearer WT |title=gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression. |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 5 |pages= 975-82 |year= 2000 |pmid= 10808179 |doi= 10.1067/mai.2000.105315 }}
*{{cite journal  | vauthors=Vanvooren V, Allgeier A, Cosson E |title=Expression of multiple adenylyl cyclase isoforms in human and dog thyroid. |journal=Mol. Cell. Endocrinol. |volume=170 |issue= 1-2 |pages= 185–96 |year= 2001 |pmid= 11162902 |doi=10.1016/S0303-7207(00)00322-1 |display-authors=etal}}
*{{cite journal  | author=Wicker R, Catalan AG, Cailleux A, ''et al.'' |title=Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues. |journal=Biochim. Biophys. Acta |volume=1493 |issue= 1-2 |pages= 279-83 |year= 2000 |pmid= 10978539 |doi=  }}
*{{cite journal  | vauthors=Patrizio M, Colucci M, Levi G |title=Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. |journal=J. Neurochem. |volume=77 |issue= 2 |pages= 399–407 |year= 2001 |pmid= 11299302 |doi=10.1046/j.1471-4159.2001.00249.x }}
*{{cite journal  | author=Vanvooren V, Allgeier A, Cosson E, ''et al.'' |title=Expression of multiple adenylyl cyclase isoforms in human and dog thyroid. |journal=Mol. Cell. Endocrinol. |volume=170 |issue= 1-2 |pages= 185-96 |year= 2001 |pmid= 11162902 |doi=  }}
*{{cite journal  | vauthors=Côté M, Guillon G, Payet MD, Gallo-Payet N |title=Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 9 |pages= 4495–503 |year= 2001 |pmid= 11549699 |doi=10.1210/jc.86.9.4495  }}
*{{cite journal  | author=Patrizio M, Colucci M, Levi G |title=Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. |journal=J. Neurochem. |volume=77 |issue= 2 |pages= 399-407 |year= 2001 |pmid= 11299302 |doi=  }}
*{{cite journal  | vauthors=Speth C, Schabetsberger T, Mohsenipour I |title=Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons. |journal=J. Virol. |volume=76 |issue= 7 |pages= 3179–88 |year= 2002 |pmid= 11884542 |doi=10.1128/JVI.76.7.3179-3188.2002  | pmc=136041 |display-authors=etal}}
*{{cite journal  | author=Côté M, Guillon G, Payet MD, Gallo-Payet N |title=Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 9 |pages= 4495-503 |year= 2001 |pmid= 11549699 |doi= }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Speth C, Schabetsberger T, Mohsenipour I, ''et al.'' |title=Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons. |journal=J. Virol. |volume=76 |issue= 7 |pages= 3179-88 |year= 2002 |pmid= 11884542 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{refend}}


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Revision as of 17:50, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Adenylyl cyclase type 6 is an enzyme that in humans is encoded by the ADCY6 gene.[1]

Function

This gene encodes adenylyl cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: ADCY6 adenylate cyclase 6".

External links

Further reading


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