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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Replication factor C subunit 5''' is a [[protein]] that in humans is encoded by the ''RFC5'' [[gene]].<ref name="pmid7774928">{{cite journal | vauthors = Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K | title = Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23 | journal = Genomics | volume = 25 | issue = 1 | pages = 274–8 | date = Jan 1995 | pmid = 7774928 | pmc =  | doi = 10.1016/0888-7543(95)80135-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RFC5 replication factor C (activator 1) 5, 36.5kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5985| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Replication factor C (activator 1) 5, 36.5kDa
| HGNCid = 9973
| Symbol = RFC5
| AltSymbols =; MGC1155; RFC36
| OMIM = 600407
| ECnumber = 
| Homologene = 6730
| MGIid = 
| GeneAtlas_image1 = PBB_GE_RFC5_203209_at_tn.png
| GeneAtlas_image2 = PBB_GE_RFC5_203210_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_RFC5_213734_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0017111 |text = nucleoside-triphosphatase activity}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005663 |text = DNA replication factor C complex}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5985
    | Hs_Ensembl = ENSG00000111445
    | Hs_RefseqProtein = XP_001132724
    | Hs_RefseqmRNA = XM_001132724
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 116938893
    | Hs_GenLoc_end = 116954421
    | Hs_Uniprot = P40937
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Replication factor C (activator 1) 5, 36.5kDa''', also known as '''RFC5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RFC5 replication factor C (activator 1) 5, 36.5kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5985| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: RFC5 replication factor C (activator 1) 5, 36.5kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5985| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
RFC5 has been shown to [[Protein-protein interaction|interact]] with:
* [[BRD4]],<ref name = pmid12192049>{{cite journal | vauthors = Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K | title = A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase | journal = Molecular and Cellular Biology | volume = 22 | issue = 18 | pages = 6509–20 | date = Sep 2002 | pmid = 12192049 | pmc = 135621 | doi =  10.1128/mcb.22.18.6509-6520.2002}}</ref>
* [[CHTF18]],<ref name = pmid12930902>{{cite journal | vauthors = Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J | title = The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 18 | pages = 10237–42 | date = Sep 2003 | pmid = 12930902 | pmc = 193545 | doi = 10.1073/pnas.1434308100 }}</ref>
* [[PCNA]],<ref name = pmid9228079/><ref name = pmid8999859>{{cite journal | vauthors = Mossi R, Jónsson ZO, Allen BL, Hardin SH, Hübscher U | title = Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen | journal = The Journal of Biological Chemistry | volume = 272 | issue = 3 | pages = 1769–76 | date = Jan 1997 | pmid = 8999859 | doi =  10.1074/jbc.272.3.1769}}</ref><ref name = pmid12171929>{{cite journal | vauthors = Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T | title = A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein | journal = The Journal of Biological Chemistry | volume = 277 | issue = 43 | pages = 40362–7 | date = Oct 2002 | pmid = 12171929 | doi = 10.1074/jbc.M206194200 }}</ref>
* [[RFC2]],<ref name = pmid9228079>{{cite journal | vauthors = Cai J, Gibbs E, Uhlmann F, Phillips B, Yao N, O'Donnell M, Hurwitz J | title = A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme | journal = The Journal of Biological Chemistry | volume = 272 | issue = 30 | pages = 18974–81 | date = Jul 1997 | pmid = 9228079 | doi =  10.1074/jbc.272.30.18974}}</ref><ref name = pmid9751713>{{cite journal | vauthors = Cai J, Yao N, Gibbs E, Finkelstein J, Phillips B, O'Donnell M, Hurwitz J | title = ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 20 | pages = 11607–12 | date = Sep 1998 | pmid = 9751713 | pmc = 21688 | doi =  10.1073/pnas.95.20.11607}}</ref>  and
* [[RFC4]].<ref name = pmid9228079/><ref name = pmid9751713/><ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name = pmid9488738>{{cite journal | vauthors = Ellison V, Stillman B | title = Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity | journal = The Journal of Biological Chemistry | volume = 273 | issue = 10 | pages = 5979–87 | date = Mar 1998 | pmid = 9488738 | doi =  10.1074/jbc.273.10.5979}}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = O'Donnell M, Onrust R, Dean FB, Chen M, Hurwitz J | title = Homology in accessory proteins of replicative polymerases--E. coli to humans | journal = Nucleic Acids Research | volume = 21 | issue = 1 | pages = 1–3 | date = Jan 1993 | pmid = 8441605 | pmc = 309057 | doi = 10.1093/nar/21.1.1 }}
| citations =
* {{cite journal | vauthors = Uhlmann F, Cai J, Flores-Rozas H, Dean FB, Finkelstein J, O'Donnell M, Hurwitz J | title = In vitro reconstitution of human replication factor C from its five subunits | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 13 | pages = 6521–6 | date = Jun 1996 | pmid = 8692848 | pmc = 39056 | doi = 10.1073/pnas.93.13.6521 }}
*{{cite journal | author=Okumura K, Nogami M, Taguchi H, ''et al.'' |title=Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23. |journal=Genomics |volume=25 |issue= 1 |pages= 274-8 |year= 1995 |pmid= 7774928 |doi= }}
* {{cite journal | vauthors = Mossi R, Jónsson ZO, Allen BL, Hardin SH, Hübscher U | title = Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen | journal = The Journal of Biological Chemistry | volume = 272 | issue = 3 | pages = 1769–76 | date = Jan 1997 | pmid = 8999859 | doi = 10.1074/jbc.272.3.1769 }}
*{{cite journal | author=O'Donnell M, Onrust R, Dean FB, ''et al.'' |title=Homology in accessory proteins of replicative polymerases--E. coli to humans. |journal=Nucleic Acids Res. |volume=21 |issue= 1 |pages= 1-3 |year= 1993 |pmid= 8441605 |doi= }}
* {{cite journal | vauthors = Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM | title = The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme | journal = Molecular and Cellular Biology | volume = 17 | issue = 4 | pages = 1817–23 | date = Apr 1997 | pmid = 9121429 | pmc = 232028 | doi =  }}
*{{cite journal  | author=Uhlmann F, Cai J, Flores-Rozas H, ''et al.'' |title=In vitro reconstitution of human replication factor C from its five subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 13 |pages= 6521-6 |year= 1996 |pmid= 8692848 |doi= }}
* {{cite journal | vauthors = Cai J, Gibbs E, Uhlmann F, Phillips B, Yao N, O'Donnell M, Hurwitz J | title = A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme | journal = The Journal of Biological Chemistry | volume = 272 | issue = 30 | pages = 18974–81 | date = Jul 1997 | pmid = 9228079 | doi = 10.1074/jbc.272.30.18974 }}
*{{cite journal | author=Mossi R, Jónsson ZO, Allen BL, ''et al.'' |title=Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen. |journal=J. Biol. Chem. |volume=272 |issue= 3 |pages= 1769-76 |year= 1997 |pmid= 8999859 |doi=  }}
* {{cite journal | vauthors = Loor G, Zhang SJ, Zhang P, Toomey NL, Lee MY | title = Identification of DNA replication and cell cycle proteins that interact with PCNA | journal = Nucleic Acids Research | volume = 25 | issue = 24 | pages = 5041–6 | date = Dec 1997 | pmid = 9396813 | pmc = 147130 | doi = 10.1093/nar/25.24.5041 }}
*{{cite journal | author=Cujec TP, Cho H, Maldonado E, ''et al.'' |title=The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 1817-23 |year= 1997 |pmid= 9121429 |doi= }}
* {{cite journal | vauthors = Ellison V, Stillman B | title = Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity | journal = The Journal of Biological Chemistry | volume = 273 | issue = 10 | pages = 5979–87 | date = Mar 1998 | pmid = 9488738 | doi = 10.1074/jbc.273.10.5979 }}
*{{cite journal | author=Cai J, Gibbs E, Uhlmann F, ''et al.'' |title=A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme. |journal=J. Biol. Chem. |volume=272 |issue= 30 |pages= 18974-81 |year= 1997 |pmid= 9228079 |doi= }}
* {{cite journal | vauthors = Cai J, Yao N, Gibbs E, Finkelstein J, Phillips B, O'Donnell M, Hurwitz J | title = ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 20 | pages = 11607–12 | date = Sep 1998 | pmid = 9751713 | pmc = 21688 | doi = 10.1073/pnas.95.20.11607 }}
*{{cite journal | author=Loor G, Zhang SJ, Zhang P, ''et al.'' |title=Identification of DNA replication and cell cycle proteins that interact with PCNA. |journal=Nucleic Acids Res. |volume=25 |issue= 24 |pages= 5041-6 |year= 1998 |pmid= 9396813 |doi= }}
* {{cite journal | vauthors = Zhang G, Gibbs E, Kelman Z, O'Donnell M, Hurwitz J | title = Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 5 | pages = 1869–74 | date = Mar 1999 | pmid = 10051561 | pmc = 26703 | doi = 10.1073/pnas.96.5.1869 }}
*{{cite journal | author=Ellison V, Stillman B |title=Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5979-87 |year= 1998 |pmid= 9488738 |doi= }}
* {{cite journal | vauthors = Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A | title = Purification and characterization of human DNA damage checkpoint Rad complexes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 20 | pages = 11236–41 | date = Sep 2001 | pmid = 11572977 | pmc = 58713 | doi = 10.1073/pnas.201373498 }}
*{{cite journal | author=Cai J, Yao N, Gibbs E, ''et al.'' |title=ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 20 |pages= 11607-12 |year= 1998 |pmid= 9751713 |doi= }}
* {{cite journal | vauthors = Griffith JD, Lindsey-Boltz LA, Sancar A | title = Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy | journal = The Journal of Biological Chemistry | volume = 277 | issue = 18 | pages = 15233–6 | date = May 2002 | pmid = 11907025 | doi = 10.1074/jbc.C200129200 }}
*{{cite journal  | author=Zhang G, Gibbs E, Kelman Z, ''et al.'' |title=Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 5 |pages= 1869-74 |year= 1999 |pmid= 10051561 |doi= }}
* {{cite journal | vauthors = Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T | title = A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein | journal = The Journal of Biological Chemistry | volume = 277 | issue = 43 | pages = 40362–7 | date = Oct 2002 | pmid = 12171929 | doi = 10.1074/jbc.M206194200 }}
*{{cite journal | author=Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A |title=Purification and characterization of human DNA damage checkpoint Rad complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 20 |pages= 11236-41 |year= 2001 |pmid= 11572977 |doi= 10.1073/pnas.201373498 }}
* {{cite journal | vauthors = Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K | title = A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase | journal = Molecular and Cellular Biology | volume = 22 | issue = 18 | pages = 6509–20 | date = Sep 2002 | pmid = 12192049 | pmc = 135621 | doi = 10.1128/MCB.22.18.6509-6520.2002 }}
*{{cite journal | author=Griffith JD, Lindsey-Boltz LA, Sancar A |title=Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15233-6 |year= 2002 |pmid= 11907025 |doi= 10.1074/jbc.C200129200 }}
* {{cite journal | vauthors = Venclovas C, Colvin ME, Thelen MP | title = Molecular modeling-based analysis of interactions in the RFC-dependent clamp-loading process | journal = Protein Science | volume = 11 | issue = 10 | pages = 2403–16 | date = Oct 2002 | pmid = 12237462 | pmc = 2373712 | doi = 10.1110/ps.0214302 }}
*{{cite journal | author=Ohta S, Shiomi Y, Sugimoto K, ''et al.'' |title=A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40362-7 |year= 2002 |pmid= 12171929 |doi= 10.1074/jbc.M206194200 }}
* {{cite journal | vauthors = Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J | title = Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment | journal = The Journal of Biological Chemistry | volume = 278 | issue = 32 | pages = 30051–6 | date = Aug 2003 | pmid = 12766176 | doi = 10.1074/jbc.M211591200 }}
*{{cite journal | author=Maruyama T, Farina A, Dey A, ''et al.'' |title=A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase. |journal=Mol. Cell. Biol. |volume=22 |issue= 18 |pages= 6509-20 |year= 2002 |pmid= 12192049 |doi= }}
* {{cite journal | vauthors = Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J | title = The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 18 | pages = 10237–42 | date = Sep 2003 | pmid = 12930902 | pmc = 193545 | doi = 10.1073/pnas.1434308100 }}
*{{cite journal | author=Venclovas C, Colvin ME, Thelen MP |title=Molecular modeling-based analysis of interactions in the RFC-dependent clamp-loading process. |journal=Protein Sci. |volume=11 |issue= 10 |pages= 2403-16 |year= 2003 |pmid= 12237462 |doi= }}
* {{cite journal | vauthors = Zou L, Liu D, Elledge SJ | title = Replication protein A-mediated recruitment and activation of Rad17 complexes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 24 | pages = 13827–32 | date = Nov 2003 | pmid = 14605214 | pmc = 283506 | doi = 10.1073/pnas.2336100100 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J |title=Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 30051-6 |year= 2003 |pmid= 12766176 |doi= 10.1074/jbc.M211591200 }}
*{{cite journal  | author=Bermudez VP, Maniwa Y, Tappin I, ''et al.'' |title=The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 18 |pages= 10237-42 |year= 2003 |pmid= 12930902 |doi= 10.1073/pnas.1434308100 }}
*{{cite journal  | author=Zou L, Liu D, Elledge SJ |title=Replication protein A-mediated recruitment and activation of Rad17 complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 24 |pages= 13827-32 |year= 2004 |pmid= 14605214 |doi= 10.1073/pnas.2336100100 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
{{refend}}
{{refend}}
{{protein-stub}}
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Latest revision as of 09:08, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Replication factor C subunit 5 is a protein that in humans is encoded by the RFC5 gene.[1][2]

Function

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[2]

Interactions

RFC5 has been shown to interact with:

References

  1. ↑ Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K (Jan 1995). "Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23". Genomics. 25 (1): 274–8. doi:10.1016/0888-7543(95)80135-9. PMID 7774928.
  2. ↑ 2.0 2.1 "Entrez Gene: RFC5 replication factor C (activator 1) 5, 36.5kDa".
  3. ↑ Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K (Sep 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase". Molecular and Cellular Biology. 22 (18): 6509–20. doi:10.1128/mcb.22.18.6509-6520.2002. PMC 135621. PMID 12192049.
  4. ↑ Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10237–42. doi:10.1073/pnas.1434308100. PMC 193545. PMID 12930902.
  5. ↑ 5.0 5.1 5.2 Cai J, Gibbs E, Uhlmann F, Phillips B, Yao N, O'Donnell M, Hurwitz J (Jul 1997). "A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme". The Journal of Biological Chemistry. 272 (30): 18974–81. doi:10.1074/jbc.272.30.18974. PMID 9228079.
  6. ↑ Mossi R, Jónsson ZO, Allen BL, Hardin SH, Hübscher U (Jan 1997). "Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen". The Journal of Biological Chemistry. 272 (3): 1769–76. doi:10.1074/jbc.272.3.1769. PMID 8999859.
  7. ↑ Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The Journal of Biological Chemistry. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
  8. ↑ 8.0 8.1 Cai J, Yao N, Gibbs E, Finkelstein J, Phillips B, O'Donnell M, Hurwitz J (Sep 1998). "ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits". Proceedings of the National Academy of Sciences of the United States of America. 95 (20): 11607–12. doi:10.1073/pnas.95.20.11607. PMC 21688. PMID 9751713.
  9. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  10. ↑ Ellison V, Stillman B (Mar 1998). "Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity". The Journal of Biological Chemistry. 273 (10): 5979–87. doi:10.1074/jbc.273.10.5979. PMID 9488738.

Further reading

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