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{{Infobox_gene}}
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'''SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1''' is a [[protein]] that in humans is encoded by the ''SMARCD1'' [[gene]].<ref name="pmid8804307">{{cite journal | vauthors = Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR | title = Diversity and specialization of mammalian SWI/SNF complexes | journal = Genes Dev | volume = 10 | issue = 17 | pages = 2117–30 |date=Nov 1996 | pmid = 8804307 | pmc =  | doi =10.1101/gad.10.17.2117 }}</ref><ref name="pmid9693044">{{cite journal | vauthors = Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U | title = Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome | journal = Genomics | volume = 51 | issue = 1 | pages = 140–3 |date=Sep 1998 | pmid = 9693044 | pmc = | doi = 10.1006/geno.1998.5343 }}</ref><ref name="pmid12917342">{{cite journal | vauthors = Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK | title = BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation | journal = Mol Cell Biol | volume = 23 | issue = 17 | pages = 6210–20 |date=Aug 2003 | pmid = 12917342 | pmc = 180928 | doi =10.1128/MCB.23.17.6210-6220.2003 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6602| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_SMARCD1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1uhr.
| PDB = {{PDB2|1uhr}}
| Name = SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
| HGNCid = 11106
| Symbol = SMARCD1
| AltSymbols =; BAF60A; CRACD1; Rsc6p
| OMIM = 601735
| ECnumber =
| Homologene = 20670
| MGIid = 1933623
| GeneAtlas_image1 = PBB_GE_SMARCD1_203183_s_at_tn.png
  | GeneAtlas_image2 = PBB_GE_SMARCD1_209518_at_tn.png
  | Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}}  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0016585 |text = chromatin remodeling complex}}
| Process = {{GNF_GO|id=GO:0006338 |text = chromatin remodeling}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6602
    | Hs_Ensembl = ENSG00000066117
    | Hs_RefseqProtein = NP_003067
    | Hs_RefseqmRNA = NM_003076
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 48765402
    | Hs_GenLoc_end = 48780690
    | Hs_Uniprot = Q96GM5
    | Mm_EntrezGene = 83797
    | Mm_Ensembl = ENSMUSG00000023018
    | Mm_RefseqmRNA = NM_031842
    | Mm_RefseqProtein = NP_114030
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 99530351
    | Mm_GenLoc_end = 99542024
    | Mm_Uniprot = Q68FH8
  }}
}}
'''SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1''', also known as '''SMARCD1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6602| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6602| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6602| accessdate = }}</ref>
}}
}}
==Interactions==
SMARCD1 has been shown to [[Protein-protein interaction|interact]] with [[Glucocorticoid receptor]].<ref name=pmid12917342 />


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Wang W, Xue Y, Zhou S, ''et al.'' |title=Diversity and specialization of mammalian SWI/SNF complexes. |journal=Genes Dev. |volume=10 |issue= 17 |pages= 2117-30 |year= 1996 |pmid= 8804307 |doi=  }}
*{{cite journal   |vauthors=Hillier LD, Lennon G, Becker M, etal |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 }}
*{{cite journal | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
*{{cite journal   |vauthors=Wang W, Côté J, Xue Y, etal |title=Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. |journal=EMBO J. |volume=15 |issue= 19 |pages= 5370–82 |year= 1996 |pmid= 8895581 |doi= | pmc=452280 }}
*{{cite journal | author=Wang W, Côté J, Xue Y, ''et al.'' |title=Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. |journal=EMBO J. |volume=15 |issue= 19 |pages= 5370-82 |year= 1996 |pmid= 8895581 |doi=  }}
*{{cite journal   |vauthors=Cho H, Orphanides G, Sun X, etal |title=A human RNA polymerase II complex containing factors that modify chromatin structure. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5355–63 |year= 1998 |pmid= 9710619 |doi= | pmc=109120 }}
*{{cite journal | author=Ring HZ, Vameghi-Meyers V, Wang W, ''et al.'' |title=Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome. |journal=Genomics |volume=51 |issue= 1 |pages= 140-3 |year= 1998 |pmid= 9693044 |doi= 10.1006/geno.1998.5343 }}
*{{cite journal   |vauthors=O'Neill D, Yang J, Erdjument-Bromage H, etal |title=Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 2 |pages= 349–54 |year= 1999 |pmid= 9892636 |doi=10.1073/pnas.96.2.349  | pmc=15139  }}
*{{cite journal  | author=Cho H, Orphanides G, Sun X, ''et al.'' |title=A human RNA polymerase II complex containing factors that modify chromatin structure. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5355-63 |year= 1998 |pmid= 9710619 |doi=  }}
*{{cite journal  | vauthors=Phelan ML, Sif S, Narlikar GJ, Kingston RE |title=Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. |journal=Mol. Cell |volume=3 |issue= 2 |pages= 247–53 |year= 1999 |pmid= 10078207 |doi=10.1016/S1097-2765(00)80315-9 }}
*{{cite journal | author=O'Neill D, Yang J, Erdjument-Bromage H, ''et al.'' |title=Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 2 |pages= 349-54 |year= 1999 |pmid= 9892636 |doi= }}
*{{cite journal   |vauthors=Ito T, Yamauchi M, Nishina M, etal |title=Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers. |journal=J. Biol. Chem. |volume=276 |issue= 4 |pages= 2852–7 |year= 2001 |pmid= 11053448 |doi= 10.1074/jbc.M009633200 }}
*{{cite journal | author=Phelan ML, Sif S, Narlikar GJ, Kingston RE |title=Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. |journal=Mol. Cell |volume=3 |issue= 2 |pages= 247-53 |year= 1999 |pmid= 10078207 |doi=  }}
*{{cite journal   |vauthors=Xue Y, Canman JC, Lee CS, etal |title=The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 24 |pages= 13015–20 |year= 2001 |pmid= 11078522 |doi= 10.1073/pnas.240208597 | pmc=27170 }}
*{{cite journal | author=Ito T, Yamauchi M, Nishina M, ''et al.'' |title=Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers. |journal=J. Biol. Chem. |volume=276 |issue= 4 |pages= 2852-7 |year= 2001 |pmid= 11053448 |doi= 10.1074/jbc.M009633200 }}
*{{cite journal   |vauthors=Kato H, Tjernberg A, Zhang W, etal |title=SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5498–505 |year= 2002 |pmid= 11734557 |doi= 10.1074/jbc.M108702200 }}
*{{cite journal | author=Xue Y, Canman JC, Lee CS, ''et al.'' |title=The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 24 |pages= 13015-20 |year= 2001 |pmid= 11078522 |doi= 10.1073/pnas.240208597 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Kato H, Tjernberg A, Zhang W, ''et al.'' |title=SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5498-505 |year= 2002 |pmid= 11734557 |doi= 10.1074/jbc.M108702200 }}
*{{cite journal   |vauthors=Nie Z, Yan Z, Chen EH, etal |title=Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner. |journal=Mol. Cell. Biol. |volume=23 |issue= 8 |pages= 2942–52 |year= 2003 |pmid= 12665591 |doi=10.1128/MCB.23.8.2942-2952.2003  | pmc=152562  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Chien CY, Liu WK, Chou CK, Su JY |title=The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation. |journal=FEBS Lett. |volume=543 |issue= 1-3 |pages= 55–60 |year= 2003 |pmid= 12753905 |doi=10.1016/S0014-5793(03)00401-0  }}
*{{cite journal | author=Nie Z, Yan Z, Chen EH, ''et al.'' |title=Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner. |journal=Mol. Cell. Biol. |volume=23 |issue= 8 |pages= 2942-52 |year= 2003 |pmid= 12665591 |doi= }}
*{{cite journal   |vauthors=Kitagawa H, Fujiki R, Yoshimura K, etal |title=The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. |journal=Cell |volume=113 |issue= 7 |pages= 905–17 |year= 2003 |pmid= 12837248 |doi=10.1016/S0092-8674(03)00436-7  }}
*{{cite journal | author=Chien CY, Liu WK, Chou CK, Su JY |title=The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation. |journal=FEBS Lett. |volume=543 |issue= 1-3 |pages= 55-60 |year= 2003 |pmid= 12753905 |doi= }}
*{{cite journal   |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Kitagawa H, Fujiki R, Yoshimura K, ''et al.'' |title=The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. |journal=Cell |volume=113 |issue= 7 |pages= 905-17 |year= 2003 |pmid= 12837248 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Hsiao PW, Fryer CJ, Trotter KW, ''et al.'' |title=BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. |journal=Mol. Cell. Biol. |volume=23 |issue= 17 |pages= 6210-20 |year= 2003 |pmid= 12917342 |doi= }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Assmann EM, Alborghetti MR, Camargo ME, Kobarg J |title=FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. |journal=J. Biol. Chem. |volume=281 |issue= 15 |pages= 9869–81 |year= 2006 |pmid= 16484223 |doi= 10.1074/jbc.M513280200 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Assmann EM, Alborghetti MR, Camargo ME, Kobarg J |title=FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. |journal=J. Biol. Chem. |volume=281 |issue= 15 |pages= 9869-81 |year= 2006 |pmid= 16484223 |doi= 10.1074/jbc.M513280200 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=6602}}
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Latest revision as of 06:39, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 is a protein that in humans is encoded by the SMARCD1 gene.[1][2][3][4]

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Two transcript variants encoding different isoforms have been found for this gene.[4]

Interactions

SMARCD1 has been shown to interact with Glucocorticoid receptor.[3]

References

  1. ↑ Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (Nov 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes Dev. 10 (17): 2117–30. doi:10.1101/gad.10.17.2117. PMID 8804307.
  2. ↑ Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (Sep 1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome". Genomics. 51 (1): 140–3. doi:10.1006/geno.1998.5343. PMID 9693044.
  3. ↑ 3.0 3.1 Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK (Aug 2003). "BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation". Mol Cell Biol. 23 (17): 6210–20. doi:10.1128/MCB.23.17.6210-6220.2003. PMC 180928. PMID 12917342.
  4. ↑ 4.0 4.1 "Entrez Gene: SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1".

Further reading



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