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{{Underlinked|date=June 2016}}
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{{Infobox_gene}}
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'''Pleckstrin homology domain-containing family A member 5''' is a [[protein]] that in humans is encoded by the ''PLEKHA5'' [[gene]].<ref name="pmid11214970">{{cite journal | vauthors = Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 7 | issue = 6 | pages = 347–55 |date=Feb 2001 | pmid = 11214970 | pmc = | doi =10.1093/dnares/7.6.347  }}</ref><ref name="pmid11001876">{{cite journal | vauthors = Dowler S, Currie  RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR | title = Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities | journal = Biochem J | volume = 351 | issue = Pt 1 | pages = 19–31 |date=Jan 2001 | pmid = 11001876 | pmc = 1221362 | doi =10.1042/0264-6021:3510019 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PLEKHA5 pleckstrin homology domain containing, family A member 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54477| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_PLEKHA5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dkp.
| PDB = {{PDB2|2dkp}}
| Name = Pleckstrin homology domain containing, family A member 5
| HGNCid = 30036
| Symbol = PLEKHA5
| AltSymbols =; FLJ10667; FLJ31492; KIAA1686; PEPP2
| OMIM = 607770
| ECnumber = 
| Homologene = 10377
| MGIid = 1923802
| GeneAtlas_image1 = PBB_GE_PLEKHA5_220952_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005545 |text = phosphatidylinositol binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 54477
    | Hs_Ensembl = ENSG00000052126
    | Hs_RefseqProtein = NP_061885
    | Hs_RefseqmRNA = NM_019012
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 19173995
    | Hs_GenLoc_end = 19420598
    | Hs_Uniprot = Q9HAU0
    | Mm_EntrezGene = 109135
    | Mm_Ensembl = ENSMUSG00000030231
    | Mm_RefseqmRNA = NM_144920
    | Mm_RefseqProtein = NP_659169
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 140388924
    | Mm_GenLoc_end = 140559516
    | Mm_Uniprot =   
  }}
}}
'''Pleckstrin homology domain containing, family A member 5''', also known as '''PLEKHA5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLEKHA5 pleckstrin homology domain containing, family A member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54477| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
*{{cite journal   |vauthors=Nakajima D, Okazaki N, Yamakawa H, etal |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 }}
*{{cite journal  | author=Dowler S, Currie  RA, Campbell  DG, ''et al.'' |title=Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. |journal=Biochem. J. |volume=351 |issue= Pt 1 |pages= 19-31 |year= 2001 |pmid= 11001876 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Nagase T, Kikuno R, Hattori A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 6 |pages= 347-55 |year= 2001 |pmid= 11214970 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal   |vauthors=Zhang Y, Wolf-Yadlin A, Ross PL, etal |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell. Proteomics |volume=4 |issue= 9 |pages= 1240–50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Zhang Y, Wolf-Yadlin A, Ross PL, ''et al.'' |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell Proteomics |volume=4 |issue= 9 |pages= 1240-50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 }}
*{{cite journal   |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=54477}}
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Latest revision as of 18:17, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Pleckstrin homology domain-containing family A member 5 is a protein that in humans is encoded by the PLEKHA5 gene.[1][2][3]


References

  1. ↑ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
  2. ↑ Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (Jan 2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
  3. ↑ "Entrez Gene: PLEKHA5 pleckstrin homology domain containing, family A member 5".

Further reading



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