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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''ADP-ribosylation factor-like protein 1''' is a [[protein]] that in humans is encoded by the ''ARL1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARL1 ADP-ribosylation factor-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=400| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_ARL1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1r4a.
| PDB = {{PDB2|1r4a}}, {{PDB2|1upt}}
| Name = ADP-ribosylation factor-like 1
| HGNCid = 692
| Symbol = ARL1
| AltSymbols =; ARFL1
| OMIM = 603425
| ECnumber = 
| Homologene = 20319
| MGIid = 99436
| GeneAtlas_image1 = PBB_GE_ARL1_201659_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ARL1_201657_at_tn.png
| GeneAtlas_image3 = PBB_GE_ARL1_201658_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}} {{GNF_GO|id=GO:0008047 |text = enzyme activator activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}}
| Process = {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 400
    | Hs_Ensembl = ENSG00000120805
    | Hs_RefseqProtein = NP_001168
    | Hs_RefseqmRNA = NM_001177
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 100312565
    | Hs_GenLoc_end = 100325645
    | Hs_Uniprot = P40616
    | Mm_EntrezGene = 104303
    | Mm_Ensembl = ENSMUSG00000060904
    | Mm_RefseqmRNA = NM_025859
    | Mm_RefseqProtein = NP_080135
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 88161165
    | Mm_GenLoc_end = 88173856
    | Mm_Uniprot = Q14AC7
  }}
}}
'''ADP-ribosylation factor-like 1''', also known as '''ARL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARL1 ADP-ribosylation factor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=400| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.<ref name="entrez">{{cite web | title = Entrez Gene: ARL1 ADP-ribosylation factor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=400| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Zhang GF, Patton WA, Lee FJ, ''et al.'' |title=Different ARF domains are required for the activation of cholera toxin and phospholipase D. |journal=J. Biol. Chem. |volume=270 |issue= 1 |pages= 21-4 |year= 1995 |pmid= 7814376 |doi=  }}
*{{cite journal  | author=Hong JX, Lee FJ, Patton WA, ''et al.'' |title=Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1). |journal=J. Biol. Chem. |volume=273 |issue= 25 |pages= 15872-6 |year= 1998 |pmid= 9624189 |doi=  }}
*{{cite journal  | author=Zhao L, Helms JB, Brunner J, Wieland FT |title=GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14198-203 |year= 1999 |pmid= 10318838 |doi=  }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal  | author=Van Valkenburgh H, Shern JF, Sharer JD, ''et al.'' |title=ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22826-37 |year= 2001 |pmid= 11303027 |doi= 10.1074/jbc.M102359200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Lu L, Hong W |title=Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi. |journal=Mol. Biol. Cell |volume=14 |issue= 9 |pages= 3767-81 |year= 2004 |pmid= 12972563 |doi= 10.1091/mbc.E03-01-0864 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Lu L, Tai G, Hong W |title=Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network. |journal=Mol. Biol. Cell |volume=15 |issue= 10 |pages= 4426-43 |year= 2005 |pmid= 15269279 |doi= 10.1091/mbc.E03-12-0872 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal  | author=Zahn C, Hommel A, Lu L, ''et al.'' |title=Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells. |journal=Mol. Membr. Biol. |volume=23 |issue= 6 |pages= 475-85 |year= 2007 |pmid= 17127620 |doi= 10.1080/09687860600840100 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}


{{protein-stub}}
ARL1 has been shown to [[Protein-protein interaction|interact]] with [[GOLGA4]]<ref name=pmid12972563>{{cite journal | vauthors = Lu L, Hong W | title = Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi | journal = Mol. Biol. Cell | volume = 14 | issue = 9 | pages = 3767–81  | date = September 2003 | pmid = 12972563 | pmc = 196566 | doi = 10.1091/mbc.E03-01-0864 }}</ref><ref name=pmid11303027>{{cite journal | vauthors = Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA | title = ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins | journal = J. Biol. Chem. | volume = 276 | issue = 25 | pages = 22826–37  | date = June 2001 | pmid = 11303027 | doi = 10.1074/jbc.M102359200 }}</ref> and [[GOLGA1]].<ref name=pmid12972563/>
{{WikiDoc Sources}}
 
== References ==
{{Reflist}}
 
==External links==
* {{UCSC gene info|ARL1}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Zhang GF, Patton WA, Lee FJ, Liyanage M, Han JS, Rhee SG, Moss J, Vaughan M | title = Different ARF domains are required for the activation of cholera toxin and phospholipase D | journal = J. Biol. Chem. | volume = 270 | issue = 1 | pages = 21–4 | year = 1995 | pmid = 7814376 | doi = 10.1074/jbc.270.1.21 }}
* {{cite journal | vauthors = Hong JX, Lee FJ, Patton WA, Lin CY, Moss J, Vaughan M | title = Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1) | journal = J. Biol. Chem. | volume = 273 | issue = 25 | pages = 15872–6 | year = 1998 | pmid = 9624189 | doi = 10.1074/jbc.273.25.15872 }}
* {{cite journal | vauthors = Zhao L, Helms JB, Brunner J, Wieland FT | title = GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23 | journal = J. Biol. Chem. | volume = 274 | issue = 20 | pages = 14198–203 | year = 1999 | pmid = 10318838 | doi = 10.1074/jbc.274.20.14198 }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Rep. | volume = 1 | issue = 3 | pages = 287–92 | year = 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
* {{cite journal | vauthors = Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA | title = ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins | journal = J. Biol. Chem. | volume = 276 | issue = 25 | pages = 22826–37 | year = 2001 | pmid = 11303027 | doi = 10.1074/jbc.M102359200 }}
* {{cite journal | vauthors = Lu L, Hong W | title = Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi | journal = Mol. Biol. Cell | volume = 14 | issue = 9 | pages = 3767–81 | year = 2003 | pmid = 12972563 | pmc = 196566 | doi = 10.1091/mbc.E03-01-0864 }}
* {{cite journal | vauthors = Lu L, Tai G, Hong W | title = Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network | journal = Mol. Biol. Cell | volume = 15 | issue = 10 | pages = 4426–43 | year = 2004 | pmid = 15269279 | pmc = 519138 | doi = 10.1091/mbc.E03-12-0872 }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Res. | volume = 14 | issue = 10B | pages = 2136–44 | year = 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Res. | volume = 34 | issue = Database issue | pages = D415-8 | year = 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
* {{cite journal | vauthors = Zahn C, Hommel A, Lu L, Hong W, Walther DJ, Florian S, Joost HG, Schürmann A | title = Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells | journal = Mol. Membr. Biol. | volume = 23 | issue = 6 | pages = 475–85 | year = 2007 | pmid = 17127620 | doi = 10.1080/09687860600840100 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
{{Refend}}
 
{{PDB Gallery|geneid=400}}
 
 
{{Gene-12-stub}}

Latest revision as of 18:14, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene.[1]

Function

The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.[1]

Interactions

ARL1 has been shown to interact with GOLGA4[2][3] and GOLGA1.[2]

References

  1. ↑ 1.0 1.1 "Entrez Gene: ARL1 ADP-ribosylation factor-like 1".
  2. ↑ 2.0 2.1 Lu L, Hong W (September 2003). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Mol. Biol. Cell. 14 (9): 3767–81. doi:10.1091/mbc.E03-01-0864. PMC 196566. PMID 12972563.
  3. ↑ Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA (June 2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins". J. Biol. Chem. 276 (25): 22826–37. doi:10.1074/jbc.M102359200. PMID 11303027.

External links

Further reading


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