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{{ | '''Killer cell lectin-like receptor subfamily G member 1''' is a [[protein]] that in humans is encoded by the ''KLRG1'' [[gene]].<ref name="pmid9862378">{{cite journal |vauthors=Hanke T, Corral L, Vance RE, Raulet DH | title = 2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells | journal = Eur J Immunol | volume = 28 | issue = 12 | pages = 4409–17 |date=Jan 1999 | pmid = 9862378 | pmc = | doi =10.1002/(SICI)1521-4141(199812)28:12<4409::AID-IMMU4409>3.0.CO;2-3 }}</ref><ref name="pmid9842918">{{cite journal |vauthors=Butcher S, Arney KL, Cook GP | title = MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells | journal = Eur J Immunol | volume = 28 | issue = 11 | pages = 3755–62 |date=Dec 1998 | pmid = 9842918 | pmc = | doi =10.1002/(SICI)1521-4141(199811)28:11<3755::AID-IMMU3755>3.0.CO;2-3 }}</ref><ref name="pmid16461340">{{cite journal |vauthors=Ito M, Maruyama T, Saito N, Koganei S, Yamamoto K, Matsumoto N | title = Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity | journal = J Exp Med | volume = 203 | issue = 2 | pages = 289–95 |date=Feb 2006 | pmid = 16461340 | pmc = 2118217 | doi = 10.1084/jem.20051986 }}</ref><ref name="pmid16140789">{{cite journal |vauthors=Thimme R, Appay V, Koschella M, Panther E, Roth E, Hislop AD, Rickinson AB, Rowland-Jones SL, Blum HE, Pircher H | title = Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation | journal = J Virol | volume = 79 | issue = 18 | pages = 12112–6 |date=Sep 2005 | pmid = 16140789 | pmc = 1212638 | doi = 10.1128/JVI.79.18.12112-12116.2005 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KLRG1 killer cell lectin-like receptor subfamily G, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10219| accessdate = }}</ref> | ||
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| summary_text = Natural killer (NK) cells are | | summary_text = Natural killer (NK) cells are [[lymphocyte]]s that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined.<ref name="entrez" /> | ||
}} | }} | ||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |vauthors=Ortega E, Schneider H, Pecht I |title=Possible interactions between the Fc epsilon receptor and a novel mast cell function-associated antigen |journal=Int. Immunol. |volume=3 |issue= 4 |pages= 333–42 |year= 1991 |pmid= 1831652 |doi=10.1093/intimm/3.4.333 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Lamers MB, Lamont AG, Williams DH |title=Human MAFA has alternatively spliced variants |journal=Biochim. Biophys. Acta |volume=1399 |issue= 2–3 |pages= 209–12 |year= 1998 |pmid= 9765598 |doi= 10.1016/s0167-4781(98)00107-9}} | ||
*{{cite journal |vauthors=Voehringer D, Koschella M, Pircher H |title=Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1) |journal=Blood |volume=100 |issue= 10 |pages= 3698–702 |year= 2003 |pmid= 12393723 |doi= 10.1182/blood-2002-02-0657 }} | |||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | |||
*{{cite journal | | *{{cite journal |vauthors=Matsuoka TA, Artner I, Henderson E, etal |title=The MafA transcription factor appears to be responsible for tissue-specific expression of insulin |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 9 |pages= 2930–3 |year= 2004 |pmid= 14973194 |doi= 10.1073/pnas.0306233101 | pmc=365722 }} | ||
*{{cite journal | *{{cite journal |vauthors=Marcolino I, Przybylski GK, Koschella M, etal |title=Frequent expression of the natural killer cell receptor KLRG1 in human cord blood T cells: correlation with replicative history |journal=Eur. J. Immunol. |volume=34 |issue= 10 |pages= 2672–80 |year= 2004 |pmid= 15368283 |doi= 10.1002/eji.200425282 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ibegbu CC, Xu YX, Harris W, etal |title=Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57 |journal=J. Immunol. |volume=174 |issue= 10 |pages= 6088–94 |year= 2005 |pmid= 15879103 |doi= 10.4049/jimmunol.174.10.6088}} | ||
*{{cite journal | *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }} | ||
*{{cite journal | *{{cite journal |vauthors=Bengsch B, Spangenberg HC, Kersting N, etal |title=Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver |journal=J. Virol. |volume=81 |issue= 2 |pages= 945–53 |year= 2007 |pmid= 17079288 |doi= 10.1128/JVI.01354-06 | pmc=1797464 }} | ||
*{{cite journal |vauthors=Schwartzkopff S, Gründemann C, Schweier O, etal |title=Tumor-associated E-cadherin mutations affect binding to the killer cell lectin-like receptor G1 in humans |journal=J. Immunol. |volume=179 |issue= 2 |pages= 1022–9 |year= 2007 |pmid= 17617594 |doi= 10.4049/jimmunol.179.2.1022}} | |||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{ | ==External links== | ||
{{ | * {{UCSC genome browser|KLRG1}} | ||
* {{UCSC gene details|KLRG1}} | |||
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Revision as of 06:33, 2 September 2017
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Killer cell lectin-like receptor subfamily G member 1 is a protein that in humans is encoded by the KLRG1 gene.[1][2][3][4][5]
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined.[5]
References
- ↑ Hanke T, Corral L, Vance RE, Raulet DH (Jan 1999). "2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells". Eur J Immunol. 28 (12): 4409–17. doi:10.1002/(SICI)1521-4141(199812)28:12<4409::AID-IMMU4409>3.0.CO;2-3. PMID 9862378.
- ↑ Butcher S, Arney KL, Cook GP (Dec 1998). "MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells". Eur J Immunol. 28 (11): 3755–62. doi:10.1002/(SICI)1521-4141(199811)28:11<3755::AID-IMMU3755>3.0.CO;2-3. PMID 9842918.
- ↑ Ito M, Maruyama T, Saito N, Koganei S, Yamamoto K, Matsumoto N (Feb 2006). "Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity". J Exp Med. 203 (2): 289–95. doi:10.1084/jem.20051986. PMC 2118217. PMID 16461340.
- ↑ Thimme R, Appay V, Koschella M, Panther E, Roth E, Hislop AD, Rickinson AB, Rowland-Jones SL, Blum HE, Pircher H (Sep 2005). "Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation". J Virol. 79 (18): 12112–6. doi:10.1128/JVI.79.18.12112-12116.2005. PMC 1212638. PMID 16140789.
- ↑ 5.0 5.1 "Entrez Gene: KLRG1 killer cell lectin-like receptor subfamily G, member 1".
Further reading
- Ortega E, Schneider H, Pecht I (1991). "Possible interactions between the Fc epsilon receptor and a novel mast cell function-associated antigen". Int. Immunol. 3 (4): 333–42. doi:10.1093/intimm/3.4.333. PMID 1831652.
- Lamers MB, Lamont AG, Williams DH (1998). "Human MAFA has alternatively spliced variants". Biochim. Biophys. Acta. 1399 (2–3): 209–12. doi:10.1016/s0167-4781(98)00107-9. PMID 9765598.
- Voehringer D, Koschella M, Pircher H (2003). "Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1)". Blood. 100 (10): 3698–702. doi:10.1182/blood-2002-02-0657. PMID 12393723.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Matsuoka TA, Artner I, Henderson E, et al. (2004). "The MafA transcription factor appears to be responsible for tissue-specific expression of insulin". Proc. Natl. Acad. Sci. U.S.A. 101 (9): 2930–3. doi:10.1073/pnas.0306233101. PMC 365722. PMID 14973194.
- Marcolino I, Przybylski GK, Koschella M, et al. (2004). "Frequent expression of the natural killer cell receptor KLRG1 in human cord blood T cells: correlation with replicative history". Eur. J. Immunol. 34 (10): 2672–80. doi:10.1002/eji.200425282. PMID 15368283.
- Ibegbu CC, Xu YX, Harris W, et al. (2005). "Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57". J. Immunol. 174 (10): 6088–94. doi:10.4049/jimmunol.174.10.6088. PMID 15879103.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Bengsch B, Spangenberg HC, Kersting N, et al. (2007). "Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver". J. Virol. 81 (2): 945–53. doi:10.1128/JVI.01354-06. PMC 1797464. PMID 17079288.
- Schwartzkopff S, Gründemann C, Schweier O, et al. (2007). "Tumor-associated E-cadherin mutations affect binding to the killer cell lectin-like receptor G1 in humans". J. Immunol. 179 (2): 1022–9. doi:10.4049/jimmunol.179.2.1022. PMID 17617594.
External links
- KLRG1 human gene location in the UCSC Genome Browser.
- KLRG1 human gene details in the UCSC Genome Browser.
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