ARHGEF7: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Rho guanine nucleotide exchange factor 7''' is a [[protein]] that in humans is encoded by the ''ARHGEF7'' [[gene]].<ref name="pmid9207241">{{cite journal | vauthors = Oh WK, Yoo JC, Jo D, Song YH, Kim MG, Park D | title = Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion | journal = Biochem Biophys Res Commun | volume = 235 | issue = 3 | pages = 794–8 | date = Jul 1997 | pmid = 9207241 | pmc =  | doi = 10.1006/bbrc.1997.6875 }}</ref><ref name="pmid9726964">{{cite journal | vauthors = Bagrodia S, Taylor SJ, Jordon KA, Van Aelst L, Cerione RA | title = A novel regulator of p21-activated kinases | journal = J Biol Chem | volume = 273 | issue = 37 | pages = 23633–6 | date = Oct 1998 | pmid = 9726964 | pmc = | doi = 10.1074/jbc.273.37.23633 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8874| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_ARHGEF7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1by1.
| PDB = {{PDB2|1by1}}, {{PDB2|1zsg}}, {{PDB2|2ak5}}, {{PDB2|2df6}}, {{PDB2|2esw}}, {{PDB2|2g6f}}
| Name = Rho guanine nucleotide exchange factor (GEF) 7
| HGNCid = 15607
| Symbol = ARHGEF7
| AltSymbols =; PAK3; BETA-PIX; COOL1; DKFZp761K1021; KIAA0142; KIAA0412; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PIXB
| OMIM = 605477
| ECnumber = 
| Homologene = 2895
| MGIid = 1860493
| GeneAtlas_image1 = PBB_GE_ARHGEF7_202548_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ARHGEF7_202547_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005089 |text = Rho guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0035023 |text = regulation of Rho protein signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8874
    | Hs_Ensembl = ENSG00000102606
    | Hs_RefseqProtein = NP_003890
    | Hs_RefseqmRNA = NM_003899
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 110565783
    | Hs_GenLoc_end = 110756081
    | Hs_Uniprot = Q14155
    | Mm_EntrezGene = 54126
    | Mm_Ensembl = ENSMUSG00000031511
    | Mm_RefseqmRNA = NM_017402
    | Mm_RefseqProtein = NP_059098
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 11728141
    | Mm_GenLoc_end = 11835191
    | Mm_Uniprot = Q6XPA5
  }}
}}
'''Rho guanine nucleotide exchange factor (GEF) 7''', also known as '''ARHGEF7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8874| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Rho family of GTPases|Rho GTPase]] play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through [[G protein-coupled receptor]]s. The encoded protein belongs to a family of [[cytoplasmic]] proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein can induce [[membrane ruffling]]. Multiple [[alternatively spliced]] transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8874| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
ARHGEF7 has been shown to [[Protein-protein interaction|interact]] with:
==Further reading==
{{div col|colwidth=20em}}
* [[Cbl gene]],<ref name = pmid12935897>{{cite journal | vauthors = Flanders JA, Feng Q, Bagrodia S, Laux MT, Singavarapu A, Cerione RA | title = The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins | journal = FEBS Lett. | volume = 550 | issue = 1-3 | pages = 119–23 | date = Aug 2003 | pmid = 12935897 | doi =  10.1016/s0014-5793(03)00853-6}}</ref>
* [[GIT1]],<ref name = pmid12473661>{{cite journal | vauthors = Kim S, Ko J, Shin H, Lee JR, Lim C, Han JH, Altrock WD, Garner CC, Gundelfinger ED, Premont RT, Kaang BK, Kim E | title = The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo | journal = J. Biol. Chem. | volume = 278 | issue = 8 | pages = 6291–300 | date = Feb 2003 | pmid = 12473661 | doi = 10.1074/jbc.M212287200 }}</ref><ref name = pmid10428811>{{cite journal | vauthors = Bagrodia S, Bailey D, Lenard Z, Hart M, Guan JL, Premont RT, Taylor SJ, Cerione RA | title = A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins | journal = J. Biol. Chem. | volume = 274 | issue = 32 | pages = 22393–400 | date = Aug 1999 | pmid = 10428811 | doi =  10.1074/jbc.274.32.22393}}</ref>
* [[SHANK1]]<ref name = pmid12626503/>
* [[SHANK2]],<ref name = pmid12626503/> and
* [[SHANK3]].<ref name = pmid12626503>{{cite journal | vauthors = Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, Kim E | title = The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42 | journal = J. Biol. Chem. | volume = 278 | issue = 21 | pages = 19220–9 | date = May 2003 | pmid = 12626503 | doi = 10.1074/jbc.M301052200 }}</ref>
{{Div col end}}
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K | title = The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression | journal = Gene | volume = 146 | issue = 2 | pages = 199–207 | year = 1994 | pmid = 8076819 | doi = 10.1016/0378-1119(94)90293-3 }}
| citations =
* {{cite journal | vauthors = Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N | title = Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Res. | volume = 2 | issue = 4 | pages = 167–74, 199–210 | year = 1996 | pmid = 8590280 | doi = 10.1093/dnares/2.4.167 }}
*{{cite journal | author=Matoba R, Okubo K, Hori N, ''et al.'' |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. |journal=Gene |volume=146 |issue= 2 |pages= 199-207 |year= 1994 |pmid= 8076819 |doi= }}
* {{cite journal | vauthors = Manser E, Loo TH, Koh CG, Zhao ZS, Chen XQ, Tan L, Tan I, Leung T, Lim L | title = PAK kinases are directly coupled to the PIX family of nucleotide exchange factors | journal = Mol. Cell | volume = 1 | issue = 2 | pages = 183–92 | year = 1998 | pmid = 9659915 | doi = 10.1016/S1097-2765(00)80019-2 }}
*{{cite journal | author=Nagase T, Seki N, Tanaka A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167-74, 199-210 |year= 1996 |pmid= 8590280 |doi= }}
* {{cite journal | vauthors = Turner CE, Brown MC, Perrotta JA, Riedy MC, Nikolopoulos SN, McDonald AR, Bagrodia S, Thomas S, Leventhal PS | title = Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling | journal = J. Cell Biol. | volume = 145 | issue = 4 | pages = 851–63 | year = 1999 | pmid = 10330411 | pmc = 2133183 | doi = 10.1083/jcb.145.4.851 }}
*{{cite journal | author=Oh WK, Yoo JC, Jo D, ''et al.'' |title=Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 3 |pages= 794-8 |year= 1997 |pmid= 9207241 |doi= 10.1006/bbrc.1997.6875 }}
* {{cite journal | vauthors = Bagrodia S, Bailey D, Lenard Z, Hart M, Guan JL, Premont RT, Taylor SJ, Cerione RA | title = A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins | journal = J. Biol. Chem. | volume = 274 | issue = 32 | pages = 22393–400 | year = 1999 | pmid = 10428811 | doi = 10.1074/jbc.274.32.22393 }}
*{{cite journal | author=Manser E, Loo TH, Koh CG, ''et al.'' |title=PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. |journal=Mol. Cell |volume=1 |issue= 2 |pages= 183-92 |year= 1998 |pmid= 9659915 |doi= }}
* {{cite journal | vauthors = Premont RT, Claing A, Vitale N, Perry SJ, Lefkowitz RJ | title = The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing | journal = J. Biol. Chem. | volume = 275 | issue = 29 | pages = 22373–80 | year = 2000 | pmid = 10896954 | doi = 10.1074/jbc.275.29.22373 }}
*{{cite journal | author=Bagrodia S, Taylor SJ, Jordon KA, ''et al.'' |title=A novel regulator of p21-activated kinases. |journal=J. Biol. Chem. |volume=273 |issue= 37 |pages= 23633-6 |year= 1998 |pmid= 9726964 |doi= }}
* {{cite journal | vauthors = Ku GM, Yablonski D, Manser E, Lim L, Weiss A | title = A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT | journal = EMBO J. | volume = 20 | issue = 3 | pages = 457–65 | year = 2001 | pmid = 11157752 | pmc = 133476 | doi = 10.1093/emboj/20.3.457 }}
*{{cite journal | author=Turner CE, Brown MC, Perrotta JA, ''et al.'' |title=Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling. |journal=J. Cell Biol. |volume=145 |issue= 4 |pages= 851-63 |year= 1999 |pmid= 10330411 |doi= }}
* {{cite journal | vauthors = Koh CG, Tan EJ, Manser E, Lim L | title = The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family | journal = Curr. Biol. | volume = 12 | issue = 4 | pages = 317–21 | year = 2002 | pmid = 11864573 | doi = 10.1016/S0960-9822(02)00652-8 }}
*{{cite journal | author=Bagrodia S, Bailey D, Lenard Z, ''et al.'' |title=A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. |journal=J. Biol. Chem. |volume=274 |issue= 32 |pages= 22393-400 |year= 1999 |pmid= 10428811 |doi= }}
* {{cite journal | vauthors = Brown MC, West KA, Turner CE | title = Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway | journal = Mol. Biol. Cell | volume = 13 | issue = 5 | pages = 1550–65 | year = 2002 | pmid = 12006652 | pmc = 111126 | doi = 10.1091/mbc.02-02-0015 }}
*{{cite journal | author=Premont RT, Claing A, Vitale N, ''et al.'' |title=The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22373-80 |year= 2000 |pmid= 10896954 |doi= }}
* {{cite journal | vauthors = Shin EY, Shin KS, Lee CS, Woo KN, Quan SH, Soung NK, Kim YG, Cha CI, Kim SR, Park D, Bokoch GM, Kim EG | title = Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth | journal = J. Biol. Chem. | volume = 277 | issue = 46 | pages = 44417–30 | year = 2003 | pmid = 12226077 | doi = 10.1074/jbc.M203754200 }}
*{{cite journal | author=Ku GM, Yablonski D, Manser E, ''et al.'' |title=A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. |journal=EMBO J. |volume=20 |issue= 3 |pages= 457-65 |year= 2001 |pmid= 11157752 |doi= 10.1093/emboj/20.3.457 }}
* {{cite journal | vauthors = Rosenberger G, Jantke I, Gal A, Kutsche K | title = Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling | journal = Hum. Mol. Genet. | volume = 12 | issue = 2 | pages = 155–67 | year = 2003 | pmid = 12499396 | doi = 10.1093/hmg/ddg019 }}
*{{cite journal | author=Koh CG, Tan EJ, Manser E, Lim L |title=The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. |journal=Curr. Biol. |volume=12 |issue= 4 |pages= 317-21 |year= 2002 |pmid= 11864573 |doi= }}
* {{cite journal | vauthors = Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, Kim E | title = The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42 | journal = J. Biol. Chem. | volume = 278 | issue = 21 | pages = 19220–9 | year = 2003 | pmid = 12626503 | doi = 10.1074/jbc.M301052200 }}
*{{cite journal | author=Brown MC, West KA, Turner CE |title=Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway. |journal=Mol. Biol. Cell |volume=13 |issue= 5 |pages= 1550-65 |year= 2002 |pmid= 12006652 |doi= 10.1091/mbc.02-02-0015 }}
* {{cite journal | vauthors = Mignone F, Grillo G, Liuni S, Pesole G | title = Computational identification of protein coding potential of conserved sequence tags through cross-species evolutionary analysis | journal = Nucleic Acids Res. | volume = 31 | issue = 15 | pages = 4639–45 | year = 2003 | pmid = 12888525 | pmc = 169873 | doi = 10.1093/nar/gkg483 }}
*{{cite journal | author=Shin EY, Shin KS, Lee CS, ''et al.'' |title=Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 44417-30 |year= 2003 |pmid= 12226077 |doi= 10.1074/jbc.M203754200 }}
* {{cite journal | vauthors = Yamamoto Y, Fujimoto Y, Arai R, Fujie M, Usami S, Yamada T | title = Retrotransposon-mediated restoration of Chlorella telomeres: accumulation of Zepp retrotransposons at termini of newly formed minichromosomes | journal = Nucleic Acids Res. | volume = 31 | issue = 15 | pages = 4646–53 | year = 2003 | pmid = 12888526 | pmc = 169880 | doi = 10.1093/nar/gkg490 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Flanders JA, Feng Q, Bagrodia S, Laux MT, Singavarapu A, Cerione RA | title = The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins | journal = FEBS Lett. | volume = 550 | issue = 1–3 | pages = 119–23 | year = 2003 | pmid = 12935897 | doi = 10.1016/S0014-5793(03)00853-6 }}
*{{cite journal | author=Rosenberger G, Jantke I, Gal A, Kutsche K |title=Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling. |journal=Hum. Mol. Genet. |volume=12 |issue= 2 |pages= 155-67 |year= 2003 |pmid= 12499396 |doi= }}
* {{cite journal | vauthors = Shin EY, Woo KN, Lee CS, Koo SH, Kim YG, Kim WJ, Bae CD, Chang SI, Kim EG | title = Basic fibroblast growth factor stimulates activation of Rac1 through a p85 betaPIX phosphorylation-dependent pathway | journal = J. Biol. Chem. | volume = 279 | issue = 3 | pages = 1994–2004 | year = 2004 | pmid = 14557270 | doi = 10.1074/jbc.M307330200 }}
*{{cite journal | author=Park E, Na M, Choi J, ''et al.'' |title=The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42. |journal=J. Biol. Chem. |volume=278 |issue= 21 |pages= 19220-9 |year= 2003 |pmid= 12626503 |doi= 10.1074/jbc.M301052200 }}
* {{cite journal | vauthors = Lim CS, Kim SH, Jung JG, Kim JK, Song WK | title = Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion | journal = J. Biol. Chem. | volume = 278 | issue = 52 | pages = 52116–23 | year = 2004 | pmid = 14559906 | doi = 10.1074/jbc.M310974200 }}
*{{cite journal | author=Mignone F, Grillo G, Liuni S, Pesole G |title=Computational identification of protein coding potential of conserved sequence tags through cross-species evolutionary analysis. |journal=Nucleic Acids Res. |volume=31 |issue= 15 |pages= 4639-45 |year= 2003 |pmid= 12888525 |doi= }}
*{{cite journal | author=Yamamoto Y, Fujimoto Y, Arai R, ''et al.'' |title=Retrotransposon-mediated restoration of Chlorella telomeres: accumulation of Zepp retrotransposons at termini of newly formed minichromosomes. |journal=Nucleic Acids Res. |volume=31 |issue= 15 |pages= 4646-53 |year= 2003 |pmid= 12888526 |doi=  }}
*{{cite journal  | author=Flanders JA, Feng Q, Bagrodia S, ''et al.'' |title=The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins. |journal=FEBS Lett. |volume=550 |issue= 1-3 |pages= 119-23 |year= 2003 |pmid= 12935897 |doi=  }}
*{{cite journal  | author=Shin EY, Woo KN, Lee CS, ''et al.'' |title=Basic fibroblast growth factor stimulates activation of Rac1 through a p85 betaPIX phosphorylation-dependent pathway. |journal=J. Biol. Chem. |volume=279 |issue= 3 |pages= 1994-2004 |year= 2004 |pmid= 14557270 |doi= 10.1074/jbc.M307330200 }}
*{{cite journal  | author=Lim CS, Kim SH, Jung JG, ''et al.'' |title=Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52116-23 |year= 2004 |pmid= 14559906 |doi= 10.1074/jbc.M310974200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
*[https://web.archive.org/web/20110722013716/http://cmkb.cellmigration.org/report.cgi?report=orth_overview&gene_id=8874 ARHGEF7] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway]
* {{UCSC gene info|ARHGEF7}}
* {{UCSC gene info|PAK3}}
 
 
{{PDB Gallery|geneid=8874}}
 
 
{{gene-13-stub}}

Latest revision as of 18:14, 29 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene.[1][2][3]

Function

Rho GTPase play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined.[3]

Interactions

ARHGEF7 has been shown to interact with:

References

  1. ↑ Oh WK, Yoo JC, Jo D, Song YH, Kim MG, Park D (Jul 1997). "Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion". Biochem Biophys Res Commun. 235 (3): 794–8. doi:10.1006/bbrc.1997.6875. PMID 9207241.
  2. ↑ Bagrodia S, Taylor SJ, Jordon KA, Van Aelst L, Cerione RA (Oct 1998). "A novel regulator of p21-activated kinases". J Biol Chem. 273 (37): 23633–6. doi:10.1074/jbc.273.37.23633. PMID 9726964.
  3. ↑ 3.0 3.1 "Entrez Gene: ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7".
  4. ↑ Flanders JA, Feng Q, Bagrodia S, Laux MT, Singavarapu A, Cerione RA (Aug 2003). "The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins". FEBS Lett. 550 (1–3): 119–23. doi:10.1016/s0014-5793(03)00853-6. PMID 12935897.
  5. ↑ Kim S, Ko J, Shin H, Lee JR, Lim C, Han JH, Altrock WD, Garner CC, Gundelfinger ED, Premont RT, Kaang BK, Kim E (Feb 2003). "The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo". J. Biol. Chem. 278 (8): 6291–300. doi:10.1074/jbc.M212287200. PMID 12473661.
  6. ↑ Bagrodia S, Bailey D, Lenard Z, Hart M, Guan JL, Premont RT, Taylor SJ, Cerione RA (Aug 1999). "A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins". J. Biol. Chem. 274 (32): 22393–400. doi:10.1074/jbc.274.32.22393. PMID 10428811.
  7. ↑ 7.0 7.1 7.2 Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, Kim E (May 2003). "The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42". J. Biol. Chem. 278 (21): 19220–9. doi:10.1074/jbc.M301052200. PMID 12626503.

Further reading

External links



Retrieved from "https://www.wikidoc.org/index.php?title=ARHGEF7&oldid=1416205"