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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Probable E3 ubiquitin-protein ligase MYCBP2''' also known as '''myc-binding protein 2''' or '''protein associates with myc''' (PAM) is an [[enzyme]] that in humans is encoded by the ''MYCBP2'' [[gene]].<ref name="pmid9689053">{{cite journal | vauthors = Guo Q, Xie J, Dang CV, Liu ET, Bishop JM | title = Identification of a large Myc-binding protein that contains RCC1-like repeats | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 16 | pages = 9172–7  | date = Sep 1998 | pmid = 9689053 | pmc = 21311 | doi = 10.1073/pnas.95.16.9172 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MYCBP2 MYC binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23077| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Structure ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = MYC binding protein 2
| HGNCid = 23386
| Symbol = MYCBP2
| AltSymbols =; PAM; DKFZp686M08244; FLJ10106; FLJ13826; FLJ21597; FLJ21646; KIAA0916
| OMIM = 610392
| ECnumber = 
| Homologene = 9005
| MGIid = 2179432
| GeneAtlas_image1 = PBB_GE_MYCBP2_201959_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MYCBP2_201960_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23077
    | Hs_Ensembl = ENSG00000005810
    | Hs_RefseqProtein = NP_055872
    | Hs_RefseqmRNA = NM_015057
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 76516793
    | Hs_GenLoc_end = 76799180
    | Hs_Uniprot = O75592
    | Mm_EntrezGene = 105689
    | Mm_Ensembl = ENSMUSG00000033004
    | Mm_RefseqmRNA = NM_207215
    | Mm_RefseqProtein = NP_997098
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 101999559
    | Mm_GenLoc_end = 102232127
    | Mm_Uniprot = Q7TPH6
  }}
}}
'''MYC binding protein 2''', also known as '''MYCBP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MYCBP2 MYC binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23077| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
PAM contains a [[N-terminus|N-terminal]] [[leucine zipper]], central [[Myc|MYC]]-binding, and [[C-terminus|C-terminal]] [[histone]]-binding protein homology domains.<ref name="pmid9689053"/>
{{PBB_Summary
| section_title =  
| summary_text =
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MYCBP2 has been shown to [[Protein-protein interaction|interact]] with [[Myc]].<ref name="pmid9689053"/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Res. | volume = 9 | issue = 3 | pages = 99–106 | year = 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 }}
| citations =
* {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 5 | issue = 6 | pages = 355–64 | year = 1998 | pmid = 10048485 | doi = 10.1093/dnares/5.6.355 }}
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
* {{cite journal | vauthors = Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | title = Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells | journal = Genome Res. | volume = 10 | issue = 10 | pages = 1546–60 | year = 2000 | pmid = 11042152 | pmc = 310934 | doi = 10.1101/gr.140200 }}
*{{cite journal  | author=Guo Q, Xie J, Dang CV, ''et al.'' |title=Identification of a large Myc-binding protein that contains RCC1-like repeats. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 16 |pages= 9172-7 |year= 1998 |pmid= 9689053 |doi=  }}
* {{cite journal | vauthors = Murthy V, Han S, Beauchamp RL, Smith N, Haddad LA, Ito N, Ramesh V | title = Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex | journal = J. Biol. Chem. | volume = 279 | issue = 2 | pages = 1351–8 | year = 2004 | pmid = 14559897 | doi = 10.1074/jbc.M310208200 }}
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355-64 |year= 1999 |pmid= 10048485 |doi= }}
* {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nat. Biotechnol. | volume = 22 | issue = 6 | pages = 707–16 | year = 2004 | pmid = 15146197 | doi = 10.1038/nbt971 }}
*{{cite journal | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi=  }}
* {{cite journal | vauthors = Pierre SC, Häusler J, Birod K, Geisslinger G, Scholich K | title = PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate | journal = EMBO J. | volume = 23 | issue = 15 | pages = 3031–40 | year = 2004 | pmid = 15257286 | pmc = 514936 | doi = 10.1038/sj.emboj.7600321 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Murthy V, Han S, Beauchamp RL, ''et al.'' |title=Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex. |journal=J. Biol. Chem. |volume=279 |issue= 2 |pages= 1351-8 |year= 2004 |pmid= 14559897 |doi= 10.1074/jbc.M310208200 }}
* {{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization | journal = Curr. Biol. | volume = 14 | issue = 16 | pages = 1436–50 | year = 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Gao X, Patel TB | title = Histidine residues 912 and 913 in protein associated with Myc are necessary for the inhibition of adenylyl cyclase activity | journal = Mol. Pharmacol. | volume = 67 | issue = 1 | pages = 42–9 | year = 2005 | pmid = 15470080 | doi = 10.1124/mol.104.005355 }}
*{{cite journal  | author=Dunham A, Matthews LH, Burton J, ''et al.'' |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522-8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 }}
* {{cite journal | vauthors = Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H | title = Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer | journal = Mol. Cell. Proteomics | volume = 4 | issue = 6 | pages = 785–95 | year = 2005 | pmid = 15778465 | doi = 10.1074/mcp.M500021-MCP200 }}
*{{cite journal  | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Pierre SC, Häusler J, Birod K, ''et al.'' |title=PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate. |journal=EMBO J. |volume=23 |issue= 15 |pages= 3031-40 |year= 2005 |pmid= 15257286 |doi= 10.1038/sj.emboj.7600321 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal | author=Gao X, Patel TB |title=Histidine residues 912 and 913 in protein associated with Myc are necessary for the inhibition of adenylyl cyclase activity. |journal=Mol. Pharmacol. |volume=67 |issue= 1 |pages= 42-9 |year= 2005 |pmid= 15470080 |doi= 10.1124/mol.104.005355 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Benzinger A, Muster N, Koch HB, ''et al.'' |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. |journal=Mol. Cell Proteomics |volume=4 |issue= 6 |pages= 785-95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 02:18, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Probable E3 ubiquitin-protein ligase MYCBP2 also known as myc-binding protein 2 or protein associates with myc (PAM) is an enzyme that in humans is encoded by the MYCBP2 gene.[1][2]

Structure

PAM contains a N-terminal leucine zipper, central MYC-binding, and C-terminal histone-binding protein homology domains.[1]

Interactions

MYCBP2 has been shown to interact with Myc.[1]

References

  1. ↑ 1.0 1.1 1.2 Guo Q, Xie J, Dang CV, Liu ET, Bishop JM (Sep 1998). "Identification of a large Myc-binding protein that contains RCC1-like repeats". Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9172–7. doi:10.1073/pnas.95.16.9172. PMC 21311. PMID 9689053.
  2. ↑ "Entrez Gene: MYCBP2 MYC binding protein 2".

Further reading


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