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'''Exosome complex exonuclease RRP44''' or '''Dis3''' is an [[enzyme]] that in humans is encoded by the ''DIS3'' [[gene]].<ref name="pmid11935316">{{cite journal | vauthors = Rozenblum E, Vahteristo P, Sandberg T, Bergthorsson JT, Syrjakoski K, Weaver D, Haraldsson K, Johannsdottir HK, Vehmanen P, Nigam S, Golberger N, Robbins C, Pak E, Dutra A, Gillander E, Stephan DA, Bailey-Wilson J, Juo SH, Kainu T, Arason A, Barkardottir RB, Nevanlinna H, Borg A, Kallioniemi OP | title = A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes | journal = Hum Genet | volume = 110 | issue = 2 | pages = 111–21 |date=Apr 2002 | pmid = 11935316 | pmc =  | doi = 10.1007/s00439-001-0646-6 }}</ref><ref name="pmid9562621">{{cite journal | vauthors = Shiomi T, Fukushima K, Suzuki N, Nakashima N, Noguchi E, Nishimoto T | title = Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3 | journal = J Biochem | volume = 123 | issue = 5 | pages = 883–90 |date=Jul 1998 | pmid = 9562621 | pmc = | doi = 10.1093/oxfordjournals.jbchem.a022020}}</ref> Its protein product is an [[RNase]] enzyme homologous to the yeast protein Rrp44, and can be part of the [[exosome complex]] in the nucleus of eukaryotic cells.<ref name="entrez">{{cite web | title = Entrez Gene: DIS3 DIS3 mitotic control homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22894| accessdate = }}</ref><ref name="Tomecki">{{cite journal
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|last6=Szczesny
| image =
|first6=RJ
| image_source =
|last7=Drazkowska
| PDB =  
|first7=K
| Name = DIS3 mitotic control homolog (S. cerevisiae)
|last8=Pastula
| HGNCid = 20604
|first8=A
| Symbol = DIS3
|last9=Andersen
| AltSymbols =; KIAA1008; DKFZp667L1817; FLJ10484; MGC33035; RP11-342J4.3; RRP44; bA555G22.1; dis3p
|first9=JS
| OMIM = 607533
|last10=Stepien
| ECnumber =
|first10=Piotr P
  | Homologene = 6910
|last11=Dziembowski
| MGIid = 1919912
|first11=Andrzej
| GeneAtlas_image1 = PBB_GE_DIS3_214194_at_tn.png
|last12=Jensen
| GeneAtlas_image2 = PBB_GE_DIS3_218362_s_at_tn.png
|first12=Torben Heick
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0004527 |text = exonuclease activity}} {{GNF_GO|id=GO:0004540 |text = ribonuclease activity}} {{GNF_GO|id=GO:0016219 |text = GDP-dissociation stimulator activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
|title=The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L
| Component = {{GNF_GO|id=GO:0000178 |text = exosome (RNase complex)}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
|journal=The EMBO Journal
| Process = {{GNF_GO|id=GO:0006364 |text = rRNA processing}}
|volume=29
| Orthologs = {{GNF_Ortholog_box
|issue=14  
    | Hs_EntrezGene = 22894
|pages=2342–57
    | Hs_Ensembl = ENSG00000083520
|year=2010
    | Hs_RefseqProtein = NP_055768
|pmid=20531386
    | Hs_RefseqmRNA = NM_014953
|pmc=2910271
    | Hs_GenLoc_db =
|doi=10.1038/emboj.2010.121
    | Hs_GenLoc_chr = 13
|display-authors=8
    | Hs_GenLoc_start = 72227541
|last1 = Tomecki|first1 = R.}}</ref>
    | Hs_GenLoc_end = 72254268
    | Hs_Uniprot = Q9Y2L1
    | Mm_EntrezGene = 72662
    | Mm_Ensembl = ENSMUSG00000033166
    | Mm_RefseqmRNA = NM_028315
    | Mm_RefseqProtein = NP_082591
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 97960402
    | Mm_GenLoc_end = 97982874
    | Mm_Uniprot =
  }}
}}
'''DIS3 mitotic control homolog (S. cerevisiae)''', also known as '''DIS3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DIS3 DIS3 mitotic control homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22894| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal  | vauthors=Nakajima D, Okazaki N, Yamakawa H |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |display-authors=etal}}
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal  | vauthors=Yu W, Andersson B, Worley KC |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  |display-authors=etal}}
*{{cite journal  | author=Shiomi T, Fukushima K, Suzuki N, ''et al.'' |title=Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3. |journal=J. Biochem. |volume=123 |issue= 5 |pages= 883-90 |year= 1998 |pmid= 9562621 |doi= }}
*{{cite journal  | vauthors=Nagase T, Ishikawa K, Suyama M |title=Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 1 |pages= 63–70 |year= 1999 |pmid= 10231032 |doi=10.1093/dnares/6.1.63 |display-authors=etal}}
*{{cite journal  | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 1 |pages= 63-70 |year= 1999 |pmid= 10231032 |doi=  }}
*{{cite journal  | vauthors=Brouwer R, Allmang C, Raijmakers R |title=Three novel components of the human exosome. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6177–84 |year= 2001 |pmid= 11110791 |doi= 10.1074/jbc.M007603200 |display-authors=etal}}
*{{cite journal  | author=Brouwer R, Allmang C, Raijmakers R, ''et al.'' |title=Three novel components of the human exosome. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6177-84 |year= 2001 |pmid= 11110791 |doi= 10.1074/jbc.M007603200 }}
*{{cite journal  | vauthors=Chen CY, Gherzi R, Ong SE |title=AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. |journal=Cell |volume=107 |issue= 4 |pages= 451–64 |year= 2002 |pmid= 11719186 |doi=10.1016/S0092-8674(01)00578-5 |display-authors=etal}}
*{{cite journal  | author=Chen CY, Gherzi R, Ong SE, ''et al.'' |title=AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. |journal=Cell |volume=107 |issue= 4 |pages= 451-64 |year= 2002 |pmid= 11719186 |doi=  }}
*{{cite journal  | vauthors=Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ |title=Protein-protein interactions of hCsl4p with other human exosome subunits. |journal=J. Mol. Biol. |volume=315 |issue= 4 |pages= 809–18 |year= 2002 |pmid= 11812149 |doi= 10.1006/jmbi.2001.5265 }}
*{{cite journal  | author=Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ |title=Protein-protein interactions of hCsl4p with other human exosome subunits. |journal=J. Mol. Biol. |volume=315 |issue= 4 |pages= 809-18 |year= 2002 |pmid= 11812149 |doi= 10.1006/jmbi.2001.5265 }}
*{{cite journal  | vauthors=Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ |title=Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. |journal=J. Mol. Biol. |volume=323 |issue= 4 |pages= 653–63 |year= 2002 |pmid= 12419256 |doi=10.1016/S0022-2836(02)00947-6 }}
*{{cite journal  | author=Rozenblum E, Vahteristo P, Sandberg T, ''et al.'' |title=A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes. |journal=Hum. Genet. |volume=110 |issue= 2 |pages= 111-21 |year= 2002 |pmid= 11935316 |doi= 10.1007/s00439-001-0646-6 }}
*{{cite journal  | vauthors=Scherl A, Couté Y, Déon C |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100–9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 | pmc=133617 |display-authors=etal}}
*{{cite journal  | author=Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ |title=Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. |journal=J. Mol. Biol. |volume=323 |issue= 4 |pages= 653-63 |year= 2002 |pmid= 12419256 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Scherl A, Couté Y, Déon C, ''et al.'' |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100-9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Dunham A, Matthews LH, Burton J |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }}
*{{cite journal  | author=Dunham A, Matthews LH, Burton J, ''et al.'' |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522-8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal  | vauthors=Andersen JS, Lam YW, Leung AK |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 18:28, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene.[1][2] Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the nucleus of eukaryotic cells.[3][4]


References

  1. ↑ Rozenblum E, Vahteristo P, Sandberg T, Bergthorsson JT, Syrjakoski K, Weaver D, Haraldsson K, Johannsdottir HK, Vehmanen P, Nigam S, Golberger N, Robbins C, Pak E, Dutra A, Gillander E, Stephan DA, Bailey-Wilson J, Juo SH, Kainu T, Arason A, Barkardottir RB, Nevanlinna H, Borg A, Kallioniemi OP (Apr 2002). "A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes". Hum Genet. 110 (2): 111–21. doi:10.1007/s00439-001-0646-6. PMID 11935316.
  2. ↑ Shiomi T, Fukushima K, Suzuki N, Nakashima N, Noguchi E, Nishimoto T (Jul 1998). "Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3". J Biochem. 123 (5): 883–90. doi:10.1093/oxfordjournals.jbchem.a022020. PMID 9562621.
  3. ↑ "Entrez Gene: DIS3 DIS3 mitotic control homolog (S. cerevisiae)".
  4. ↑ Tomecki, R.; Kristiansen, MS; Lykke-Andersen, S; Chlebowski, A; Larsen, KM; Szczesny, RJ; Drazkowska, K; Pastula, A; et al. (2010). "The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L". The EMBO Journal. 29 (14): 2342–57. doi:10.1038/emboj.2010.121. PMC 2910271. PMID 20531386.

Further reading



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