ITM2B: Difference between revisions

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Latest revision as of 00:12, 1 September 2017

Integral membrane protein 2B (ITM2B or BRI2) is a protein that in humans is encoded by the ITM2B gene.^[1]^[2]

ITM2B or BRI2 is a gene located on chromosome 13. The gene is connected to familial Danish dementia and familial British dementia causing amyloid and pre-filbrillar effects similar to those seen in Alzheimer's.

References

↑ Pittois K, Deleersnijder W, Merregaert J (Nov 1998). "cDNA sequence analysis, chromosomal assignment and expression pattern of the gene coding for integral membrane protein 2B". Gene. 217 (1–2): 141–9. doi:10.1016/S0378-1119(98)00354-0. PMID 9795190.
↑ "Entrez Gene: ITM2B integral membrane protein 2B".

Rostagno A, Tomidokoro Y, Lashley T, et al. (2005). "Chromosome 13 dementias". Cell. Mol. Life Sci. 62 (16): 1814–25. doi:10.1007/s00018-005-5092-5. PMID 15968464.
Ernst B, Dalby MA, Dalby A (1970). "Luria testing in demented patients". Acta Neurol. Scand. 46: Suppl 43:97–8. doi:10.1111/j.1600-0447.1970.tb01106.x. PMID 5466275.
Vidal R, Frangione B, Rostagno A, et al. (1999). "A stop-codon mutation in the BRI gene associated with familial British dementia". Nature. 399 (6738): 776–81. doi:10.1038/21637. PMID 10391242.
Vidal R, Revesz T, Rostagno A, et al. (2000). "A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4920–5. doi:10.1073/pnas.080076097. PMC 18333. PMID 10781099.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Fleischer A, Ayllón V, Dumoutier L, et al. (2002). "Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2". Oncogene. 21 (20): 3181–9. doi:10.1038/sj.onc.1205464. PMID 12082633.
Austen B, el-Agnaf O, Nagala S, et al. (2003). "Properties of neurotoxic peptides related to the BRI gene". Biochem. Soc. Trans. 30 (4): 557–9. doi:10.1042/BST0300557. PMID 12196136.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Akiyama H, Kondo H, Arai T, et al. (2004). "Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain". Acta Neuropathol. 107 (1): 53–8. doi:10.1007/s00401-003-0783-1. PMID 14586629.
Choi SI, Vidal R, Frangione B, Levy E (2004). "Axonal transport of British and Danish amyloid peptides via secretory vesicles". FASEB J. 18 (2): 373–5. doi:10.1096/fj.03-0730fje. PMID 14656991.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Matsuda S, Giliberto L, Matsuda Y, et al. (2005). "The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production". J. Biol. Chem. 280 (32): 28912–6. doi:10.1074/jbc.C500217200. PMID 15983050.
Fotinopoulou A, Tsachaki M, Vlavaki M, et al. (2005). "BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production". J. Biol. Chem. 280 (35): 30768–72. doi:10.1074/jbc.C500231200. PMID 16027166.
Ghiso J, Rostagno A, Tomidokoro Y, et al. (2006). "Genetic alterations of the BRI2 gene: familial British and Danish dementias". Brain Pathol. 16 (1): 71–9. doi:10.1111/j.1750-3639.2006.tb00563.x. PMID 16612984.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by expanding it.

[pmid9795190-1] Pittois K, Deleersnijder W, Merregaert J (Nov 1998). "cDNA sequence analysis, chromosomal assignment and expression pattern of the gene coding for integral membrane protein 2B". Gene. 217 (1–2): 141–9. doi:10.1016/S0378-1119(98)00354-0. PMID 9795190.

[entrez-2] "Entrez Gene: ITM2B integral membrane protein 2B".

[1]

[2]

@@ Line 1: / Line 1: @@
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+'''Integral membrane protein 2B''' ('''ITM2B''' or '''BRI2''') is a [[protein]] that in humans is encoded by the ''ITM2B'' [[gene]].<ref name="pmid9795190">{{cite journal |vauthors=Pittois K, Deleersnijder W, Merregaert J | title = cDNA sequence analysis, chromosomal assignment and expression pattern of the gene coding for integral membrane protein 2B | journal = Gene | volume = 217 | issue = 1-2 | pages = 141–9 |date=Nov 1998 | pmid = 9795190 | pmc =  | doi =10.1016/S0378-1119(98)00354-0  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ITM2B integral membrane protein 2B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9445| accessdate = }}</ref>
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Integral membrane protein 2B
- | HGNCid = 6174
- | Symbol = ITM2B
- | AltSymbols =; ABRI; BRI; BRI2; BRICD2B; E25B; E3-16; FBD
- | OMIM = 603904
- | ECnumber =
- | Homologene = 7388
- | MGIid = 1309517
- | GeneAtlas_image1 = PBB_GE_ITM2B_217732_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_ITM2B_217731_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
- | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
- | Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}}
-  | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 9445
-    | Hs_Ensembl = ENSG00000136156
-    | Hs_RefseqProtein = NP_068839
-    | Hs_RefseqmRNA = NM_021999
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 13
-    | Hs_GenLoc_start = 47705307
-    | Hs_GenLoc_end = 47734233
-    | Hs_Uniprot = Q9Y287
-    | Mm_EntrezGene = 16432
-    | Mm_Ensembl = ENSMUSG00000022108
-    | Mm_RefseqmRNA = NM_008410
-    | Mm_RefseqProtein = NP_032436
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 14
-    | Mm_GenLoc_start = 72096384
-    | Mm_GenLoc_end = 72119432
-    | Mm_Uniprot = Q3TVJ0
-  }}
-}}
-'''Integral membrane protein 2B''', also known as '''ITM2B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ITM2B integral membrane protein 2B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9445| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+''ITM2B'' or ''BRI2'' is a gene located on chromosome 13. The gene is connected to [[familial Danish dementia]] and [[familial British dementia]] causing amyloid and pre-filbrillar effects similar to those seen in [[Alzheimer's]].
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Rostagno A, Tomidokoro Y, Lashley T, ''et al.'' |title=Chromosome 13 dementias. |journal=Cell. Mol. Life Sci. |volume=62 |issue= 16 |pages= 1814-25 |year= 2005 |pmid= 15968464 |doi= 10.1007/s00018-005-5092-5 }}
+*{{cite journal   |vauthors=Rostagno A, Tomidokoro Y, Lashley T, etal |title=Chromosome 13 dementias. |journal=Cell. Mol. Life Sci. |volume=62 |issue= 16 |pages= 1814–25 |year= 2005 |pmid= 15968464 |doi= 10.1007/s00018-005-5092-5 }}
-*{{cite journal  | author=Ernst B, Dalby MA, Dalby A |title=Luria testing in demented patients. |journal=Acta Neurol. Scand. |volume=46 |issue=  |pages= Suppl 43:97-8 |year= 1970 |pmid= 5466275 |doi=  }}
+*{{cite journal  |vauthors=Ernst B, Dalby MA, Dalby A |title=Luria testing in demented patients. |journal=Acta Neurol. Scand. |volume=46 |issue=  |pages= Suppl 43:97–8 |year= 1970 |pmid= 5466275 |doi=10.1111/j.1600-0447.1970.tb01106.x  }}
-*{{cite journal  | author=Pittois K, Deleersnijder W, Merregaert J |title=cDNA sequence analysis, chromosomal assignment and expression pattern of the gene coding for integral membrane protein 2B. |journal=Gene |volume=217 |issue= 1-2 |pages= 141-9 |year= 1998 |pmid= 9795190 |doi=  }}
+*{{cite journal   |vauthors=Vidal R, Frangione B, Rostagno A, etal |title=A stop-codon mutation in the BRI gene associated with familial British dementia. |journal=Nature |volume=399 |issue= 6738 |pages= 776–81 |year= 1999 |pmid= 10391242 |doi= 10.1038/21637 }}
-*{{cite journal  | author=Vidal R, Frangione B, Rostagno A, ''et al.'' |title=A stop-codon mutation in the BRI gene associated with familial British dementia. |journal=Nature |volume=399 |issue= 6738 |pages= 776-81 |year= 1999 |pmid= 10391242 |doi= 10.1038/21637 }}
+*{{cite journal   |vauthors=Vidal R, Revesz T, Rostagno A, etal |title=A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4920–5 |year= 2000 |pmid= 10781099 |doi= 10.1073/pnas.080076097  | pmc=18333 }}
-*{{cite journal  | author=Vidal R, Revesz T, Rostagno A, ''et al.'' |title=A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4920-5 |year= 2000 |pmid= 10781099 |doi= 10.1073/pnas.080076097 }}
+*{{cite journal   |vauthors=Hu RM, Han ZG, Song HD, etal |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997  | pmc=16901 }}
-*{{cite journal  | author=Hu RM, Han ZG, Song HD, ''et al.'' |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543-8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 }}
+*{{cite journal   |vauthors=Fleischer A, Ayllón V, Dumoutier L, etal |title=Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2. |journal=Oncogene |volume=21 |issue= 20 |pages= 3181–9 |year= 2002 |pmid= 12082633 |doi= 10.1038/sj.onc.1205464 }}
-*{{cite journal  | author=Fleischer A, Ayllón V, Dumoutier L, ''et al.'' |title=Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2. |journal=Oncogene |volume=21 |issue= 20 |pages= 3181-9 |year= 2002 |pmid= 12082633 |doi= 10.1038/sj.onc.1205464 }}
+*{{cite journal   |vauthors=Austen B, el-Agnaf O, Nagala S, etal |title=Properties of neurotoxic peptides related to the BRI gene. |journal=Biochem. Soc. Trans. |volume=30 |issue= 4 |pages= 557–9 |year= 2003 |pmid= 12196136 |doi=10.1042/BST0300557  }}
-*{{cite journal  | author=Austen B, el-Agnaf O, Nagala S, ''et al.'' |title=Properties of neurotoxic peptides related to the BRI gene. |journal=Biochem. Soc. Trans. |volume=30 |issue= 4 |pages= 557-9 |year= 2003 |pmid= 12196136 |doi= 10.1042/ }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Akiyama H, Kondo H, Arai T, etal |title=Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain. |journal=Acta Neuropathol. |volume=107 |issue= 1 |pages= 53–8 |year= 2004 |pmid= 14586629 |doi= 10.1007/s00401-003-0783-1 }}
-*{{cite journal  | author=Akiyama H, Kondo H, Arai T, ''et al.'' |title=Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain. |journal=Acta Neuropathol. |volume=107 |issue= 1 |pages= 53-8 |year= 2004 |pmid= 14586629 |doi= 10.1007/s00401-003-0783-1 }}
+*{{cite journal  |vauthors=Choi SI, Vidal R, Frangione B, Levy E |title=Axonal transport of British and Danish amyloid peptides via secretory vesicles. |journal=FASEB J. |volume=18 |issue= 2 |pages= 373–5 |year= 2004 |pmid= 14656991 |doi= 10.1096/fj.03-0730fje }}
-*{{cite journal  | author=Choi SI, Vidal R, Frangione B, Levy E |title=Axonal transport of British and Danish amyloid peptides via secretory vesicles. |journal=FASEB J. |volume=18 |issue= 2 |pages= 373-5 |year= 2004 |pmid= 14656991 |doi= 10.1096/fj.03-0730fje }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Matsuda S, Giliberto L, Matsuda Y, etal |title=The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production. |journal=J. Biol. Chem. |volume=280 |issue= 32 |pages= 28912–6 |year= 2005 |pmid= 15983050 |doi= 10.1074/jbc.C500217200 }}
-*{{cite journal  | author=Matsuda S, Giliberto L, Matsuda Y, ''et al.'' |title=The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production. |journal=J. Biol. Chem. |volume=280 |issue= 32 |pages= 28912-6 |year= 2005 |pmid= 15983050 |doi= 10.1074/jbc.C500217200 }}
+*{{cite journal   |vauthors=Fotinopoulou A, Tsachaki M, Vlavaki M, etal |title=BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production. |journal=J. Biol. Chem. |volume=280 |issue= 35 |pages= 30768–72 |year= 2005 |pmid= 16027166 |doi= 10.1074/jbc.C500231200 }}
-*{{cite journal  | author=Fotinopoulou A, Tsachaki M, Vlavaki M, ''et al.'' |title=BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production. |journal=J. Biol. Chem. |volume=280 |issue= 35 |pages= 30768-72 |year= 2005 |pmid= 16027166 |doi= 10.1074/jbc.C500231200 }}
+*{{cite journal   |vauthors=Ghiso J, Rostagno A, Tomidokoro Y, etal |title=Genetic alterations of the BRI2 gene: familial British and Danish dementias. |journal=Brain Pathol. |volume=16 |issue= 1 |pages= 71–9 |year= 2006 |pmid= 16612984 |doi=10.1111/j.1750-3639.2006.tb00563.x  }}
-*{{cite journal  | author=Ghiso J, Rostagno A, Tomidokoro Y, ''et al.'' |title=Genetic alterations of the BRI2 gene: familial British and Danish dementias. |journal=Brain Pathol. |volume=16 |issue= 1 |pages= 71-9 |year= 2006 |pmid= 16612984 |doi=  }}
 }}
 {{refend}}
-{{protein-stub}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
-{{WikiDoc Sources}}
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
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+| update_citations = yes
+}}
+{{Amyloidosis}}
+{{gene-13-stub}}

ITM2B: Difference between revisions

Latest revision as of 00:12, 1 September 2017

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