UCHL3: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Ubiquitin carboxyl-terminal hydrolase isozyme L3''' is an [[enzyme]] that in humans is encoded by the ''UCHL3'' [[gene]].<ref name="pmid2530630">{{cite journal | vauthors = Wilkinson KD, Lee KM, Deshpande S, Duerksen-Hughes P, Boss JM, Pohl J | title = The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase | journal = Science | volume = 246 | issue = 4930 | pages = 670–3 |date=Dec 1989 | pmid = 2530630 | pmc =  | doi =10.1126/science.2530630  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7347| accessdate = }}</ref>
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| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Interactions==
{{GNF_Protein_box
UCHL3 has been shown to [[Protein-protein interaction|interact]] with [[NEDD8]] and the [[tauopathy]] and [[Synucleinopathies|synucleinopathy]] associated mutated ubiquitin molecule [[UBB+1]].<ref name="pmid21762696">{{cite journal | vauthors = Dennissen FJ, Kholod N, Hermes DJ, Kemmerling N, Steinbusch HW, Dantuma NP, van Leeuwen FW | title = Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3) | journal = FEBS Lett | volume = 585| issue = 16| pages = 2568–74|date=July 2011 | pmid = 21762696 | doi = 10.1016/j.febslet.2011.06.037 }}</ref><ref name="pmid9790970">{{cite journal | vauthors = Wada H, Kito K, Caskey LS, Yeh ET, Kamitani T | title = Cleavage of the C-terminus of NEDD8 by UCH-L3 | journal = Biochem. Biophys. Res. Commun. | volume = 251 | issue = 3 | pages = 688–92 |date=October 1998 | pmid = 9790970 | doi = 10.1006/bbrc.1998.9532 }}</ref>
| image = PBB_Protein_UCHL3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1uch.
| PDB = {{PDB2|1uch}}, {{PDB2|1xd3}}
| Name = Ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
| HGNCid = 12515
| Symbol = UCHL3
| AltSymbols =;
| OMIM = 603090
| ECnumber =
| Homologene = 4377
| MGIid = 1355274
| GeneAtlas_image1 = PBB_GE_UCHL3_204616_at_tn.png
| Function = {{GNF_GO|id=GO:0004221 |text = ubiquitin thiolesterase activity}} {{GNF_GO|id=GO:0008234 |text = cysteine-type peptidase activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7347
    | Hs_Ensembl = ENSG00000118939
    | Hs_RefseqProtein = NP_005993
    | Hs_RefseqmRNA = NM_006002
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 75021620
    | Hs_GenLoc_end = 75078070
    | Hs_Uniprot = P15374
    | Mm_EntrezGene = 50933
    | Mm_Ensembl = ENSMUSG00000022111
    | Mm_RefseqmRNA = NM_016723
    | Mm_RefseqProtein = NP_057932
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 100540156
    | Mm_GenLoc_end = 100582075
    | Mm_Uniprot = Q9JKB1
  }}
}}
'''Ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)''', also known as '''UCHL3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7347| accessdate = }}</ref>
 
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{{PBB_Summary
| section_title =
| summary_text =
}}


==See also==
==See also==


* [[Ubiquitin carboxy-terminal hydrolase L1]] -- an enzyme  
* [[Ubiquitin carboxy-terminal hydrolase L1]]—an enzyme


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Johnston SC, Larsen CN, Cook WJ, etal |title=Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution. |journal=EMBO J. |volume=16 |issue= 13 |pages= 3787–96 |year= 1997 |pmid= 9233788 |doi= 10.1093/emboj/16.13.3787  | pmc=1170002 }}
| citations =
*{{cite journal   |vauthors=Wilkinson KD, Laleli-Sahin E, Urbauer J, etal |title=The binding site for UCH-L3 on ubiquitin: mutagenesis and NMR studies on the complex between ubiquitin and UCH-L3. |journal=J. Mol. Biol. |volume=291 |issue= 5 |pages= 1067–77 |year= 1999 |pmid= 10518943 |doi=10.1006/jmbi.1999.3038 }}
*{{cite journal | author=Wilkinson KD, Lee KM, Deshpande S, ''et al.'' |title=The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. |journal=Science |volume=246 |issue= 4930 |pages= 670-3 |year= 1989 |pmid= 2530630 |doi=  }}
*{{cite journal  | vauthors=Baek SH, Yoo YJ, Tanaka K, Chung CH |title=Molecular cloning of chick UCH-6 which shares high similarity with human UCH-L3: its unusual substrate specificity and tissue distribution. |journal=Biochem. Biophys. Res. Commun. |volume=264 |issue= 1 |pages= 235–40 |year= 1999 |pmid= 10527871 |doi= 10.1006/bbrc.1999.1492 }}
*{{cite journal  | author=Johnston SC, Larsen CN, Cook WJ, ''et al.'' |title=Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution. |journal=EMBO J. |volume=16 |issue= 13 |pages= 3787-96 |year= 1997 |pmid= 9233788 |doi= 10.1093/emboj/16.13.3787 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Wada H, Kito K, Caskey LS, ''et al.'' |title=Cleavage of the C-terminus of NEDD8 by UCH-L3. |journal=Biochem. Biophys. Res. Commun. |volume=251 |issue= 3 |pages= 688-92 |year= 1998 |pmid= 9790970 |doi= 10.1006/bbrc.1998.9532 }}
*{{cite journal   |vauthors=Saito S, Iida A, Sekine A, etal |title=Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population. |journal=J. Hum. Genet. |volume=48 |issue= 5 |pages= 249–70 |year= 2003 |pmid= 12721789 |doi= 10.1007/s10038-003-0021-7 }}
*{{cite journal | author=Wilkinson KD, Laleli-Sahin E, Urbauer J, ''et al.'' |title=The binding site for UCH-L3 on ubiquitin: mutagenesis and NMR studies on the complex between ubiquitin and UCH-L3. |journal=J. Mol. Biol. |volume=291 |issue= 5 |pages= 1067-77 |year= 1999 |pmid= 10518943 |doi=  }}
*{{cite journal   |vauthors=Nam MJ, Madoz-Gurpide J, Wang H, etal |title=Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3. |journal=Proteomics |volume=3 |issue= 11 |pages= 2108–15 |year= 2004 |pmid= 14595809 |doi= 10.1002/pmic.200300594 }}
*{{cite journal  | author=Baek SH, Yoo YJ, Tanaka K, Chung CH |title=Molecular cloning of chick UCH-6 which shares high similarity with human UCH-L3: its unusual substrate specificity and tissue distribution. |journal=Biochem. Biophys. Res. Commun. |volume=264 |issue= 1 |pages= 235-40 |year= 1999 |pmid= 10527871 |doi= 10.1006/bbrc.1999.1492 }}
*{{cite journal   |vauthors=Dunham A, Matthews LH, Burton J, etal |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Saito S, Iida A, Sekine A, ''et al.'' |title=Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population. |journal=J. Hum. Genet. |volume=48 |issue= 5 |pages= 249-70 |year= 2003 |pmid= 12721789 |doi= 10.1007/s10038-003-0021-7 }}
*{{cite journal   |vauthors=Misaghi S, Galardy PJ, Meester WJ, etal |title=Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. |journal=J. Biol. Chem. |volume=280 |issue= 2 |pages= 1512–20 |year= 2005 |pmid= 15531586 |doi= 10.1074/jbc.M410770200 }}
*{{cite journal | author=Nam MJ, Madoz-Gurpide J, Wang H, ''et al.'' |title=Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3. |journal=Proteomics |volume=3 |issue= 11 |pages= 2108-15 |year= 2004 |pmid= 14595809 |doi= 10.1002/pmic.200300594 }}
*{{cite journal   |vauthors=Rolén U, Kobzeva V, Gasparjan N, etal |title=Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines. |journal=Mol. Carcinog. |volume=45 |issue= 4 |pages= 260–9 |year= 2006 |pmid= 16402389 |doi= 10.1002/mc.20177 }}
*{{cite journal | author=Dunham A, Matthews LH, Burton J, ''et al.'' |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522-8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Misaghi S, Galardy PJ, Meester WJ, ''et al.'' |title=Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. |journal=J. Biol. Chem. |volume=280 |issue= 2 |pages= 1512-20 |year= 2005 |pmid= 15531586 |doi= 10.1074/jbc.M410770200 }}
*{{cite journal | author=Rolén U, Kobzeva V, Gasparjan N, ''et al.'' |title=Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines. |journal=Mol. Carcinog. |volume=45 |issue= 4 |pages= 260-9 |year= 2006 |pmid= 16402389 |doi= 10.1002/mc.20177 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=7347}}
{{WikiDoc Sources}}
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{{gene-13-stub}}

Latest revision as of 09:35, 17 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ubiquitin carboxyl-terminal hydrolase isozyme L3 is an enzyme that in humans is encoded by the UCHL3 gene.[1][2]

Interactions

UCHL3 has been shown to interact with NEDD8 and the tauopathy and synucleinopathy associated mutated ubiquitin molecule UBB+1.[3][4]

See also

References

  1. ↑ Wilkinson KD, Lee KM, Deshpande S, Duerksen-Hughes P, Boss JM, Pohl J (Dec 1989). "The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase". Science. 246 (4930): 670–3. doi:10.1126/science.2530630. PMID 2530630.
  2. ↑ "Entrez Gene: UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)".
  3. ↑ Dennissen FJ, Kholod N, Hermes DJ, Kemmerling N, Steinbusch HW, Dantuma NP, van Leeuwen FW (July 2011). "Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)". FEBS Lett. 585 (16): 2568–74. doi:10.1016/j.febslet.2011.06.037. PMID 21762696.
  4. ↑ Wada H, Kito K, Caskey LS, Yeh ET, Kamitani T (October 1998). "Cleavage of the C-terminus of NEDD8 by UCH-L3". Biochem. Biophys. Res. Commun. 251 (3): 688–92. doi:10.1006/bbrc.1998.9532. PMID 9790970.

Further reading


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