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{{Infobox_gene}}
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'''Pinin''' is a [[protein]] that in humans is encoded by the ''PNN'' [[gene]].<ref name="pmid8922384">{{cite journal |vauthors=Ouyang P, Sugrue SP | title = Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex | journal = J Cell Biol | volume = 135 | issue = 4 | pages = 1027–42 |date=January 1997 | pmid = 8922384 | pmc = 2133386 | doi =10.1083/jcb.135.4.1027 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PNN pinin, desmosome associated protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5411| accessdate = }}</ref>
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| image =
| image_source =
| PDB =
| Name = Pinin, desmosome associated protein
| HGNCid = 9162
| Symbol = PNN
| AltSymbols =; DRS; SDK3; memA; pinin
| OMIM = 603154
| ECnumber =
| Homologene = 37656
| MGIid = 1100514
| GeneAtlas_image1 = PBB_GE_PNN_212037_at_tn.png
| GeneAtlas_image2 = PBB_GE_PNN_212036_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005882 |text = intermediate filament}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005911 |text = intercellular junction}} {{GNF_GO|id=GO:0016607 |text = nuclear speck}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5411
    | Hs_Ensembl = ENSG00000100941
    | Hs_RefseqProtein = NP_002678
    | Hs_RefseqmRNA = NM_002687
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 38714151
    | Hs_GenLoc_end = 38721178
    | Hs_Uniprot = Q9H307
    | Mm_EntrezGene = 18949
    | Mm_Ensembl = ENSMUSG00000020994
    | Mm_RefseqmRNA = NM_008891
    | Mm_RefseqProtein = NP_032917
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 59985004
    | Mm_GenLoc_end = 59991917
    | Mm_Uniprot = Q3TUQ5
  }}
}}
'''Pinin, desmosome associated protein''', also known as '''PNN''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PNN pinin, desmosome associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5411| accessdate = }}</ref>


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==Interactions==
Pinin has been shown to [[Protein-protein interaction|interact]] with [[Keratin 8]],<ref name=pmid10809736>{{cite journal |doi=10.1074/jbc.275.20.14910 |last=Shi |first=J |authorlink= |author2=Sugrue S P  |date=May 2000 |title=Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus |journal=J. Biol. Chem. |volume=275 |issue=20 |pages=14910–5 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10809736 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Keratin 18]],<ref name=pmid10809736/> [[Keratin 19]],<ref name=pmid10809736/> [[CTBP1]],<ref name=pmid15542832>{{cite journal |last=Alpatov |first=Roman |authorlink= |author2=Munguba Gustavo Costa |author3=Caton Paul |author4=Joo Jeong Hoon |author5=Shi Yang |author6=Shi Yujiang |author7=Hunt Marguerite E |author8=Sugrue Stephen P  |date=December 2004  |title=Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene |journal=Mol. Cell. Biol. |volume=24 |issue=23 |pages=10223–35 |publisher= |location = United States| issn = 0270-7306| pmid = 15542832 |doi = 10.1128/MCB.24.23.10223-10235.2004 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=529029 }}</ref> [[RNPS1]],<ref name=pmid17353931>{{cite journal |last=Ewing |first=Rob M |author2=Chu Peter |author3=Elisma Fred |author4=Li Hongyan |author5=Taylor Paul |author6=Climie Shane |author7=McBroom-Cerajewski Linda |author8=Robinson Mark D |author9=O'Connor Liam |author10=Li Michael |author11=Taylor Rod |author12=Dharsee Moyez |author13=Ho Yuen |author14=Heilbut Adrian |author15=Moore Lynda |author16=Zhang Shudong |author17=Ornatsky Olga |author18=Bukhman Yury V |author19=Ethier Martin |author20=Sheng Yinglun |author21=Vasilescu Julian |author22=Abu-Farha Mohamed |author23=Lambert Jean-Philippe |author24=Duewel Henry S |author25=Stewart Ian I |author26=Kuehl Bonnie |author27=Hogue Kelly |author28=Colwill Karen |author29=Gladwish Katharine |author30=Muskat Brenda |author31=Kinach Robert |author32=Adams Sally-Lin |author33=Moran Michael F |author34=Morin Gregg B |author35=Topaloglou Thodoros |author36=Figeys Daniel |year=2007|title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages=89 |publisher= |location = England| issn = | pmid = 17353931 |doi = 10.1038/msb4100134 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1847948 }}</ref><ref name=pmid14517304>{{cite journal |doi=10.1128/MCB.23.20.7363-7376.2003 |last=Li |first=Chin |authorlink= |author2=Lin Ru-Inn |author3=Lai Ming-Chih |author4=Ouyang Pin |author5=Tarn Woan-Yuh  |date=October 2003  |title=Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1 |journal=Mol. Cell. Biol. |volume=23 |issue=20 |pages=7363–76 |publisher= |location = United States| issn = 0270-7306| pmid = 14517304 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=230327 }}</ref> [[PRPF4B]],<ref name=pmid12077342>{{cite journal |doi=10.1128/MCB.22.14.5141-5156.2002 |last=Dellaire |first=Graham |authorlink= |author2=Makarov Evgeny M |author3=Cowger Jeff J M |author4=Longman Dasa |author5=Sutherland Heidi G E |author6=Lührmann Reinhard |author7=Torchia Joseph |author8=Bickmore Wendy A  |date=July 2002  |title=Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes |journal=Mol. Cell. Biol. |volume=22 |issue=14 |pages=5141–56 |publisher= |location = United States| issn = 0270-7306| pmid = 12077342 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=139773 }}</ref> [[SFRS4]],<ref name=pmid14578391>{{cite journal |doi=10.1167/iovs.03-0240 |last=Zimowska |first=Grazyna |authorlink= |author2=Shi Jia |author3=Munguba Gustavo |author4=Jackson Moira R |author5=Alpatov Roman |author6=Simmons Matthew N |author7=Shi Yujiang |author8=Sugrue Stephen P  |date=November 2003  |title=Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells |journal=Invest. Ophthalmol. Vis. Sci. |volume=44 |issue=11 |pages=4715–23 |publisher= |location = United States| issn = 0146-0404| pmid = 14578391 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[PPIG (gene)|PPIG]],<ref name=pmid15358154>{{cite journal |last=Lin |first=Chun Lun |authorlink= |author2=Leu Steve |author3=Lu Ming Chu |author4=Ouyang Pin  |date=August 2004  |title=Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue=3 |pages=638–47 |publisher= |location = United States| issn = 0006-291X| pmid = 15358154 |doi = 10.1016/j.bbrc.2004.07.013 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[SRRM2]]<ref name=pmid14578391/> and [[SFRS18]].<ref name=pmid14578391/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Ouyang P, Sugrue SP |title=Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex. |journal=J. Cell Biol. |volume=135 |issue= 4 |pages= 1027-42 |year= 1997 |pmid= 8922384 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Brandner JM, Reidenbach S, Franke WW |title=Evidence that "pinin", reportedly a differentiation-specific desmosomal protein, is actually a widespread nuclear protein. |journal=Differentiation |volume=62 |issue= 3 |pages= 119–27 |year= 1998 |pmid= 9447706 |doi=10.1046/j.1432-0436.1997.6230119.x }}
*{{cite journal | author=Brandner JM, Reidenbach S, Franke WW |title=Evidence that "pinin", reportedly a differentiation-specific desmosomal protein, is actually a widespread nuclear protein. |journal=Differentiation |volume=62 |issue= 3 |pages= 119-27 |year= 1998 |pmid= 9447706 |doi=  }}
*{{cite journal   |vauthors=Degen WG, Agterbos MA, Muyrers JP, etal |title=memA/DRS, a putative mediator of multiprotein complexes, is overexpressed in the metastasizing human melanoma cell lines BLM and MV3. |journal=Biochim. Biophys. Acta |volume=1444 |issue= 3 |pages= 384–94 |year= 1999 |pmid= 10095061 |doi=  10.1016/s0167-4781(99)00012-3}}
*{{cite journal  | author=Degen WG, Agterbos MA, Muyrers JP, ''et al.'' |title=memA/DRS, a putative mediator of multiprotein complexes, is overexpressed in the metastasizing human melanoma cell lines BLM and MV3. |journal=Biochim. Biophys. Acta |volume=1444 |issue= 3 |pages= 384-94 |year= 1999 |pmid= 10095061 |doi= }}
*{{cite journal  | author=Ouyang P |title=Antibodies differentiate desmosome-form and nucleus-form pinin: evidence that pinin is a moonlighting protein with dual location at the desmosome and within the nucleus. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 1 |pages= 192–200 |year= 1999 |pmid= 10486276 |doi= 10.1006/bbrc.1999.1353 }}
*{{cite journal  | author=Ouyang P |title=Antibodies differentiate desmosome-form and nucleus-form pinin: evidence that pinin is a moonlighting protein with dual location at the desmosome and within the nucleus. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 1 |pages= 192-200 |year= 1999 |pmid= 10486276 |doi= 10.1006/bbrc.1999.1353 }}
*{{cite journal  |vauthors=Shi Y, Ouyang P, Sugrue SP |title=Characterization of the gene encoding pinin/DRS/memA and evidence for its potential tumor suppressor function. |journal=Oncogene |volume=19 |issue= 2 |pages= 289–97 |year= 2000 |pmid= 10645008 |doi= 10.1038/sj.onc.1203328 }}
*{{cite journal  | author=Shi Y, Ouyang P, Sugrue SP |title=Characterization of the gene encoding pinin/DRS/memA and evidence for its potential tumor suppressor function. |journal=Oncogene |volume=19 |issue= 2 |pages= 289-97 |year= 2000 |pmid= 10645008 |doi= 10.1038/sj.onc.1203328 }}
*{{cite journal  |vauthors=Shi J, Sugrue SP |title=Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 14910–5 |year= 2000 |pmid= 10809736 |doi=10.1074/jbc.275.20.14910  }}
*{{cite journal | author=Shi J, Sugrue SP |title=Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 14910-5 |year= 2000 |pmid= 10809736 |doi=  }}
*{{cite journal   |vauthors=Hu RM, Han ZG, Song HD, etal |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 | pmc=16901 }}
*{{cite journal | author=Hu RM, Han ZG, Song HD, ''et al.'' |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543-8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 }}
*{{cite journal   |vauthors=Jurica MS, Licklider LJ, Gygi SR, etal |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088  | pmc=1370266  }}
*{{cite journal  | author=Jurica MS, Licklider LJ, Gygi SR, ''et al.'' |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426-39 |year= 2002 |pmid= 11991638 |doi= }}
*{{cite journal  |vauthors=Wang P, Lou PJ, Leu S, Ouyang P |title=Modulation of alternative pre-mRNA splicing in vivo by pinin. |journal=Biochem. Biophys. Res. Commun. |volume=294 |issue= 2 |pages= 448–55 |year= 2002 |pmid= 12051732 |doi= 10.1016/S0006-291X(02)00495-3 }}
*{{cite journal | author=Wang P, Lou PJ, Leu S, Ouyang P |title=Modulation of alternative pre-mRNA splicing in vivo by pinin. |journal=Biochem. Biophys. Res. Commun. |volume=294 |issue= 2 |pages= 448-55 |year= 2002 |pmid= 12051732 |doi= 10.1016/S0006-291X(02)00495-3 }}
*{{cite journal   |vauthors=Dellaire G, Makarov EM, Cowger JJ, etal |title=Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes. |journal=Mol. Cell. Biol. |volume=22 |issue= 14 |pages= 5141–56 |year= 2002 |pmid= 12077342 |doi=10.1128/MCB.22.14.5141-5156.2002  | pmc=139773  }}
*{{cite journal | author=Dellaire G, Makarov EM, Cowger JJ, ''et al.'' |title=Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes. |journal=Mol. Cell. Biol. |volume=22 |issue= 14 |pages= 5141-56 |year= 2002 |pmid= 12077342 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Chang WL, Lee DC, Leu S, etal |title=Molecular characterization of a novel nucleolar protein, pNO40. |journal=Biochem. Biophys. Res. Commun. |volume=307 |issue= 3 |pages= 569–77 |year= 2003 |pmid= 12893261 |doi=10.1016/S0006-291X(03)01208-7  }}
*{{cite journal | author=Chang WL, Lee DC, Leu S, ''et al.'' |title=Molecular characterization of a novel nucleolar protein, pNO40. |journal=Biochem. Biophys. Res. Commun. |volume=307 |issue= 3 |pages= 569-77 |year= 2003 |pmid= 12893261 |doi=  }}
*{{cite journal   |vauthors=Li C, Lin RI, Lai MC, etal |title=Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1. |journal=Mol. Cell. Biol. |volume=23 |issue= 20 |pages= 7363–76 |year= 2003 |pmid= 14517304 |doi=10.1128/MCB.23.20.7363-7376.2003  | pmc=230327 }}
*{{cite journal | author=Li C, Lin RI, Lai MC, ''et al.'' |title=Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1. |journal=Mol. Cell. Biol. |volume=23 |issue= 20 |pages= 7363-76 |year= 2003 |pmid= 14517304 |doi=  }}
*{{cite journal   |vauthors=Zimowska G, Shi J, Munguba G, etal |title=Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. |journal=Invest. Ophthalmol. Vis. Sci. |volume=44 |issue= 11 |pages= 4715–23 |year= 2003 |pmid= 14578391 |doi=10.1167/iovs.03-0240 }}
*{{cite journal | author=Zimowska G, Shi J, Munguba G, ''et al.'' |title=Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. |journal=Invest. Ophthalmol. Vis. Sci. |volume=44 |issue= 11 |pages= 4715-23 |year= 2003 |pmid= 14578391 |doi=  }}
*{{cite journal   |vauthors=Sakashita E, Tatsumi S, Werner D, etal |title=Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo. |journal=Mol. Cell. Biol. |volume=24 |issue= 3 |pages= 1174–87 |year= 2004 |pmid= 14729963 |doi=10.1128/MCB.24.3.1174-1187.2004  | pmc=321435 }}
*{{cite journal | author=Sakashita E, Tatsumi S, Werner D, ''et al.'' |title=Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo. |journal=Mol. Cell. Biol. |volume=24 |issue= 3 |pages= 1174-87 |year= 2004 |pmid= 14729963 |doi= }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal  |vauthors=Lin CL, Leu S, Lu MC, Ouyang P |title=Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles. |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue= 3 |pages= 638–47 |year= 2004 |pmid= 15358154 |doi= 10.1016/j.bbrc.2004.07.013 }}
*{{cite journal  | author=Lin CL, Leu S, Lu MC, Ouyang P |title=Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles. |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue= 3 |pages= 638-47 |year= 2004 |pmid= 15358154 |doi= 10.1016/j.bbrc.2004.07.013 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
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Revision as of 07:54, 8 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Pinin is a protein that in humans is encoded by the PNN gene.[1][2]


Interactions

Pinin has been shown to interact with Keratin 8,[3] Keratin 18,[3] Keratin 19,[3] CTBP1,[4] RNPS1,[5][6] PRPF4B,[7] SFRS4,[8] PPIG,[9] SRRM2[8] and SFRS18.[8]

References

  1. ↑ Ouyang P, Sugrue SP (January 1997). "Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex". J Cell Biol. 135 (4): 1027–42. doi:10.1083/jcb.135.4.1027. PMC 2133386. PMID 8922384.
  2. ↑ "Entrez Gene: PNN pinin, desmosome associated protein".
  3. ↑ 3.0 3.1 3.2 Shi, J; Sugrue S P (May 2000). "Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus". J. Biol. Chem. UNITED STATES. 275 (20): 14910–5. doi:10.1074/jbc.275.20.14910. ISSN 0021-9258. PMID 10809736.
  4. ↑ Alpatov, Roman; Munguba Gustavo Costa; Caton Paul; Joo Jeong Hoon; Shi Yang; Shi Yujiang; Hunt Marguerite E; Sugrue Stephen P (December 2004). "Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene". Mol. Cell. Biol. United States. 24 (23): 10223–35. doi:10.1128/MCB.24.23.10223-10235.2004. ISSN 0270-7306. PMC 529029. PMID 15542832.
  5. ↑ Ewing, Rob M; Chu Peter; Elisma Fred; Li Hongyan; Taylor Paul; Climie Shane; McBroom-Cerajewski Linda; Robinson Mark D; O'Connor Liam; Li Michael; Taylor Rod; Dharsee Moyez; Ho Yuen; Heilbut Adrian; Moore Lynda; Zhang Shudong; Ornatsky Olga; Bukhman Yury V; Ethier Martin; Sheng Yinglun; Vasilescu Julian; Abu-Farha Mohamed; Lambert Jean-Philippe; Duewel Henry S; Stewart Ian I; Kuehl Bonnie; Hogue Kelly; Colwill Karen; Gladwish Katharine; Muskat Brenda; Kinach Robert; Adams Sally-Lin; Moran Michael F; Morin Gregg B; Topaloglou Thodoros; Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. England. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  6. ↑ Li, Chin; Lin Ru-Inn; Lai Ming-Chih; Ouyang Pin; Tarn Woan-Yuh (October 2003). "Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1". Mol. Cell. Biol. United States. 23 (20): 7363–76. doi:10.1128/MCB.23.20.7363-7376.2003. ISSN 0270-7306. PMC 230327. PMID 14517304.
  7. ↑ Dellaire, Graham; Makarov Evgeny M; Cowger Jeff J M; Longman Dasa; Sutherland Heidi G E; Lührmann Reinhard; Torchia Joseph; Bickmore Wendy A (July 2002). "Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes". Mol. Cell. Biol. United States. 22 (14): 5141–56. doi:10.1128/MCB.22.14.5141-5156.2002. ISSN 0270-7306. PMC 139773. PMID 12077342.
  8. ↑ 8.0 8.1 8.2 Zimowska, Grazyna; Shi Jia; Munguba Gustavo; Jackson Moira R; Alpatov Roman; Simmons Matthew N; Shi Yujiang; Sugrue Stephen P (November 2003). "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells". Invest. Ophthalmol. Vis. Sci. United States. 44 (11): 4715–23. doi:10.1167/iovs.03-0240. ISSN 0146-0404. PMID 14578391.
  9. ↑ Lin, Chun Lun; Leu Steve; Lu Ming Chu; Ouyang Pin (August 2004). "Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles". Biochem. Biophys. Res. Commun. United States. 321 (3): 638–47. doi:10.1016/j.bbrc.2004.07.013. ISSN 0006-291X. PMID 15358154.

Further reading


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