AKAP5: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''A-kinase anchor protein 5''' is a [[protein]] that in humans is encoded by the ''AKAP5'' [[gene]].<ref name="pmid1512224">{{cite journal | vauthors = Carr DW, Stofko-Hahn RE, Fraser ID, Cone RD, Scott JD | title = Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79 | journal = J Biol Chem | volume = 267 | issue = 24 | pages = 16816–23 |date=Sep 1992 | pmid = 1512224 | pmc =  | doi =  }}</ref><ref name="pmid1618839">{{cite journal | vauthors = Carr DW, Hausken ZE, Fraser ID, Stofko-Hahn RE, Scott JD | title = Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain | journal = J Biol Chem | volume = 267 | issue = 19 | pages = 13376–82 |date=Aug 1992 | pmid = 1618839 | pmc = | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AKAP5 A kinase (PRKA) anchor protein 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9495| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = A kinase (PRKA) anchor protein 5
| HGNCid = 375
| Symbol = AKAP5
| AltSymbols =; AKAP75; AKAP79; H21
| OMIM = 604688
| ECnumber = 
| Homologene = 15854
| MGIid = 2685104
| GeneAtlas_image1 = PBB_GE_AKAP5_207800_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0051018 |text = protein kinase A binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0006605 |text = protein targeting}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9495
    | Hs_Ensembl = ENSG00000179841
    | Hs_RefseqProtein = NP_004848
    | Hs_RefseqmRNA = NM_004857
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 64003568
    | Hs_GenLoc_end = 64006178
    | Hs_Uniprot = P24588
    | Mm_EntrezGene = 238276
    | Mm_Ensembl = ENSMUSG00000021057
    | Mm_RefseqmRNA = XM_138063
    | Mm_RefseqProtein = XP_138063
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 77246657
    | Mm_GenLoc_end = 77248894
    | Mm_Uniprot = 
  }}
}}
'''A kinase (PRKA) anchor protein 5''', also known as '''AKAP5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AKAP5 A kinase (PRKA) anchor protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9495| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of [[protein kinase A]] (PKA) and confining the holoenzyme to discrete locations within the cell. This gene is intronless and encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to [[protein kinase C]] and the phosphatase [[calcineurin]]. It is predominantly expressed in [[cerebral cortex]] and may anchor the PKA protein at [[postsynaptic density|postsynaptic densities]] (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in [[T lymphocyte]]s and may function to inhibit [[interleukin 2]] transcription by disrupting calcineurin-dependent dephosphorylation of [[NFAT]].<ref name="entrez" />
{{PBB_Summary
 
| section_title =
== Interactions ==
| summary_text = The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene is intronless and encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.<ref name="entrez">{{cite web | title = Entrez Gene: AKAP5 A kinase (PRKA) anchor protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9495| accessdate = }}</ref>
 
}}
AKAP5 has been shown to [[Protein-protein interaction|interact]] with:
* [[Calcineurin]]<ref name = pmid9765270>{{cite journal | date = Oct 1998 | vauthors = Kashishian A, Howard M, Loh C, Gallatin WM, Hoekstra MF, Lai Y | title = AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region | journal = J. Biol. Chem. | volume = 273 | issue = 42 | pages = 27412–9 | pmid = 9765270 | doi = 10.1074/jbc.273.42.27412}}</ref>  and
* [[GABRB3]].<ref name = pmid12595241>{{cite journal | date = Jan 2003 | vauthors = Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ | title = A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits | journal = Mol. Cell. Neurosci. | volume = 22 | issue = 1 | pages = 87–97 | pmid = 12595241 | doi = 10.1016/s1044-7431(02)00017-9}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|AKAP5}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Lester LB, Scott JD |title=Anchoring and scaffold proteins for kinases and phosphatases |journal=Recent Prog. Horm. Res. |volume=52 |issue=  |pages= 409–29; discussion 429–30 |year= 1997 |pmid= 9238861 |doi=  }}
| citations =
*{{cite journal  | vauthors=Michel JJ, Scott JD |title=AKAP mediated signal transduction |journal=Annu. Rev. Pharmacol. Toxicol. |volume=42 |issue=  |pages= 235–57 |year= 2002 |pmid= 11807172 |doi= 10.1146/annurev.pharmtox.42.083101.135801 }}
*{{cite journal  | author=Lester LB, Scott JD |title=Anchoring and scaffold proteins for kinases and phosphatases. |journal=Recent Prog. Horm. Res. |volume=52 |issue=  |pages= 409-29; discussion 429-30 |year= 1997 |pmid= 9238861 |doi=  }}
*{{cite journal  | vauthors=Hirsch AH, Glantz SB, Li Y |title=Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta |journal=J. Biol. Chem. |volume=267 |issue= 4 |pages= 2131–4 |year= 1992 |pmid= 1733921 |doi=  |display-authors=etal}}
*{{cite journal  | author=Michel JJ, Scott JD |title=AKAP mediated signal transduction. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=42 |issue=  |pages= 235-57 |year= 2002 |pmid= 11807172 |doi= 10.1146/annurev.pharmtox.42.083101.135801 }}
*{{cite journal  | vauthors=Carr DW, Stofko-Hahn RE, Fraser ID |title=Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif |journal=J. Biol. Chem. |volume=266 |issue= 22 |pages= 14188–92 |year= 1991 |pmid= 1860836 |doi=  |display-authors=etal}}
*{{cite journal  | author=Carr DW, Stofko-Hahn RE, Fraser ID, ''et al.'' |title=Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79. |journal=J. Biol. Chem. |volume=267 |issue= 24 |pages= 16816-23 |year= 1992 |pmid= 1512224 |doi=  }}
*{{cite journal  | vauthors=Coghlan VM, Perrino BA, Howard M |title=Association of protein kinase A and protein phosphatase 2B with a common anchoring protein |journal=Science |volume=267 |issue= 5194 |pages= 108–11 |year= 1995 |pmid= 7528941 |doi=10.1126/science.7528941 |display-authors=etal}}
*{{cite journal  | author=Carr DW, Hausken ZE, Fraser ID, ''et al.'' |title=Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. |journal=J. Biol. Chem. |volume=267 |issue= 19 |pages= 13376-82 |year= 1992 |pmid= 1618839 |doi=  }}
*{{cite journal  | vauthors=Glantz SB, Li Y, Rubin CS |title=Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton |journal=J. Biol. Chem. |volume=268 |issue= 17 |pages= 12796–804 |year= 1993 |pmid= 8509414 |doi=  }}
*{{cite journal  | author=Hirsch AH, Glantz SB, Li Y, ''et al.'' |title=Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta. |journal=J. Biol. Chem. |volume=267 |issue= 4 |pages= 2131-4 |year= 1992 |pmid= 1733921 |doi=  }}
*{{cite journal  | vauthors=Faux MC, Scott JD |title=Regulation of the AKAP79-protein kinase C interaction by Ca2+/Calmodulin |journal=J. Biol. Chem. |volume=272 |issue= 27 |pages= 17038–44 |year= 1997 |pmid= 9202019 |doi=10.1074/jbc.272.27.17038 }}
*{{cite journal  | author=Carr DW, Stofko-Hahn RE, Fraser ID, ''et al.'' |title=Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif. |journal=J. Biol. Chem. |volume=266 |issue= 22 |pages= 14188-92 |year= 1991 |pmid= 1860836 |doi=  }}
*{{cite journal  | vauthors=Kashishian A, Howard M, Loh C |title=AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region |journal=J. Biol. Chem. |volume=273 |issue= 42 |pages= 27412–9 |year= 1998 |pmid= 9765270 |doi=10.1074/jbc.273.42.27412 |display-authors=etal}}
*{{cite journal  | author=Coghlan VM, Perrino BA, Howard M, ''et al.'' |title=Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. |journal=Science |volume=267 |issue= 5194 |pages= 108-11 |year= 1995 |pmid= 7528941 |doi=  }}
*{{cite journal  | vauthors=Paolillo M, Feliciello A, Porcellini A |title=The type and the localization of cAMP-dependent protein kinase regulate transmission of cAMP signals to the nucleus in cortical and cerebellar granule cells |journal=J. Biol. Chem. |volume=274 |issue= 10 |pages= 6546–52 |year= 1999 |pmid= 10037748 |doi=10.1074/jbc.274.10.6546 |display-authors=etal}}
*{{cite journal  | author=Glantz SB, Li Y, Rubin CS |title=Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton. |journal=J. Biol. Chem. |volume=268 |issue= 17 |pages= 12796-804 |year= 1993 |pmid= 8509414 |doi=  }}
*{{cite journal  | vauthors=Dodge KL, Carr DW, Sanborn BM |title=Protein kinase A anchoring to the myometrial plasma membrane is required for cyclic adenosine 3',5'-monophosphate regulation of phosphatidylinositide turnover |journal=Endocrinology |volume=140 |issue= 11 |pages= 5165–70 |year= 1999 |pmid= 10537145 |doi=10.1210/en.140.11.5165 }}
*{{cite journal  | author=Faux MC, Scott JD |title=Regulation of the AKAP79-protein kinase C interaction by Ca2+/Calmodulin. |journal=J. Biol. Chem. |volume=272 |issue= 27 |pages= 17038-44 |year= 1997 |pmid= 9202019 |doi=  }}
*{{cite journal  | vauthors=Fraser ID, Cong M, Kim J |title=Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling |journal=Curr. Biol. |volume=10 |issue= 7 |pages= 409–12 |year= 2000 |pmid= 10753752 |doi=10.1016/S0960-9822(00)00419-X |display-authors=etal}}
*{{cite journal  | author=Kashishian A, Howard M, Loh C, ''et al.'' |title=AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region. |journal=J. Biol. Chem. |volume=273 |issue= 42 |pages= 27412-9 |year= 1998 |pmid= 9765270 |doi=  }}
*{{cite journal  | vauthors=Sík A, Gulácsi A, Lai Y |title=Localization of the A kinase anchoring protein AKAP79 in the human hippocampus |journal=Eur. J. Neurosci. |volume=12 |issue= 4 |pages= 1155–64 |year= 2000 |pmid= 10762347 |doi=10.1046/j.1460-9568.2000.00002.x |display-authors=etal}}
*{{cite journal  | author=Paolillo M, Feliciello A, Porcellini A, ''et al.'' |title=The type and the localization of cAMP-dependent protein kinase regulate transmission of cAMP signals to the nucleus in cortical and cerebellar granule cells. |journal=J. Biol. Chem. |volume=274 |issue= 10 |pages= 6546-52 |year= 1999 |pmid= 10037748 |doi=  }}
*{{cite journal  | vauthors=Colledge M, Dean RA, Scott GK |title=Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex |journal=Neuron |volume=27 |issue= 1 |pages= 107–19 |year= 2000 |pmid= 10939335 |doi=10.1016/S0896-6273(00)00013-1 |display-authors=etal}}
*{{cite journal  | author=Dodge KL, Carr DW, Sanborn BM |title=Protein kinase A anchoring to the myometrial plasma membrane is required for cyclic adenosine 3',5'-monophosphate regulation of phosphatidylinositide turnover. |journal=Endocrinology |volume=140 |issue= 11 |pages= 5165-70 |year= 1999 |pmid= 10537145 |doi=  }}
*{{cite journal  | vauthors=Indolfi C, Stabile E, Coppola C |title=Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals |journal=Circ. Res. |volume=88 |issue= 3 |pages= 319–24 |year= 2001 |pmid= 11179200 |doi=  10.1161/01.res.88.3.319|display-authors=etal}}
*{{cite journal  | author=Fraser ID, Cong M, Kim J, ''et al.'' |title=Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling. |journal=Curr. Biol. |volume=10 |issue= 7 |pages= 409-12 |year= 2000 |pmid= 10753752 |doi=  }}
*{{cite journal  | vauthors=Dart C, Leyland ML |title=Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1 |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20499–505 |year= 2001 |pmid= 11287423 |doi= 10.1074/jbc.M101425200 }}
*{{cite journal  | author=Sík A, Gulácsi A, Lai Y, ''et al.'' |title=Localization of the A kinase anchoring protein AKAP79 in the human hippocampus. |journal=Eur. J. Neurosci. |volume=12 |issue= 4 |pages= 1155-64 |year= 2000 |pmid= 10762347 |doi=  }}
*{{cite journal  | vauthors=Xie G, Raufman JP |title=Association of protein kinase A with AKAP150 facilitates pepsinogen secretion from gastric chief cells |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=281 |issue= 4 |pages= G1051–8 |year= 2001 |pmid= 11557526 |doi=  }}
*{{cite journal  | author=Colledge M, Dean RA, Scott GK, ''et al.'' |title=Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex. |journal=Neuron |volume=27 |issue= 1 |pages= 107-19 |year= 2000 |pmid= 10939335 |doi=  }}
*{{cite journal  | author=Indolfi C, Stabile E, Coppola C, ''et al.'' |title=Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals. |journal=Circ. Res. |volume=88 |issue= 3 |pages= 319-24 |year= 2001 |pmid= 11179200 |doi=  }}
*{{cite journal  | author=Dart C, Leyland ML |title=Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20499-505 |year= 2001 |pmid= 11287423 |doi= 10.1074/jbc.M101425200 }}
*{{cite journal  | author=Xie G, Raufman JP |title=Association of protein kinase A with AKAP150 facilitates pepsinogen secretion from gastric chief cells. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=281 |issue= 4 |pages= G1051-8 |year= 2001 |pmid= 11557526 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
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[[Category:A-kinase-anchoring proteins]]

Latest revision as of 01:51, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

A-kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene.[1][2][3]

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene is intronless and encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin 2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.[3]

Interactions

AKAP5 has been shown to interact with:

References

  1. ↑ Carr DW, Stofko-Hahn RE, Fraser ID, Cone RD, Scott JD (Sep 1992). "Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79". J Biol Chem. 267 (24): 16816–23. PMID 1512224.
  2. ↑ Carr DW, Hausken ZE, Fraser ID, Stofko-Hahn RE, Scott JD (Aug 1992). "Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain". J Biol Chem. 267 (19): 13376–82. PMID 1618839.
  3. ↑ 3.0 3.1 "Entrez Gene: AKAP5 A kinase (PRKA) anchor protein 5".
  4. ↑ Kashishian A, Howard M, Loh C, Gallatin WM, Hoekstra MF, Lai Y (Oct 1998). "AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region". J. Biol. Chem. 273 (42): 27412–9. doi:10.1074/jbc.273.42.27412. PMID 9765270.
  5. ↑ Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ (Jan 2003). "A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits". Mol. Cell. Neurosci. 22 (1): 87–97. doi:10.1016/s1044-7431(02)00017-9. PMID 12595241.

External links

Further reading

  • Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29, discussion 429–30. PMID 9238861.
  • Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
  • Hirsch AH, Glantz SB, Li Y, et al. (1992). "Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta". J. Biol. Chem. 267 (4): 2131–4. PMID 1733921.
  • Carr DW, Stofko-Hahn RE, Fraser ID, et al. (1991). "Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif". J. Biol. Chem. 266 (22): 14188–92. PMID 1860836.
  • Coghlan VM, Perrino BA, Howard M, et al. (1995). "Association of protein kinase A and protein phosphatase 2B with a common anchoring protein". Science. 267 (5194): 108–11. doi:10.1126/science.7528941. PMID 7528941.
  • Glantz SB, Li Y, Rubin CS (1993). "Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton". J. Biol. Chem. 268 (17): 12796–804. PMID 8509414.
  • Faux MC, Scott JD (1997). "Regulation of the AKAP79-protein kinase C interaction by Ca2+/Calmodulin". J. Biol. Chem. 272 (27): 17038–44. doi:10.1074/jbc.272.27.17038. PMID 9202019.
  • Kashishian A, Howard M, Loh C, et al. (1998). "AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region". J. Biol. Chem. 273 (42): 27412–9. doi:10.1074/jbc.273.42.27412. PMID 9765270.
  • Paolillo M, Feliciello A, Porcellini A, et al. (1999). "The type and the localization of cAMP-dependent protein kinase regulate transmission of cAMP signals to the nucleus in cortical and cerebellar granule cells". J. Biol. Chem. 274 (10): 6546–52. doi:10.1074/jbc.274.10.6546. PMID 10037748.
  • Dodge KL, Carr DW, Sanborn BM (1999). "Protein kinase A anchoring to the myometrial plasma membrane is required for cyclic adenosine 3',5'-monophosphate regulation of phosphatidylinositide turnover". Endocrinology. 140 (11): 5165–70. doi:10.1210/en.140.11.5165. PMID 10537145.
  • Fraser ID, Cong M, Kim J, et al. (2000). "Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling". Curr. Biol. 10 (7): 409–12. doi:10.1016/S0960-9822(00)00419-X. PMID 10753752.
  • Sík A, Gulácsi A, Lai Y, et al. (2000). "Localization of the A kinase anchoring protein AKAP79 in the human hippocampus". Eur. J. Neurosci. 12 (4): 1155–64. doi:10.1046/j.1460-9568.2000.00002.x. PMID 10762347.
  • Colledge M, Dean RA, Scott GK, et al. (2000). "Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex". Neuron. 27 (1): 107–19. doi:10.1016/S0896-6273(00)00013-1. PMID 10939335.
  • Indolfi C, Stabile E, Coppola C, et al. (2001). "Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals". Circ. Res. 88 (3): 319–24. doi:10.1161/01.res.88.3.319. PMID 11179200.
  • Dart C, Leyland ML (2001). "Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1". J. Biol. Chem. 276 (23): 20499–505. doi:10.1074/jbc.M101425200. PMID 11287423.
  • Xie G, Raufman JP (2001). "Association of protein kinase A with AKAP150 facilitates pepsinogen secretion from gastric chief cells". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (4): G1051–8. PMID 11557526.


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