BRF1 (gene): Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Transcription factor IIIB 90 kDa subunit''' is a [[protein]] that in humans is encoded by the ''BRF1'' [[gene]].<ref name="pmid7624363">{{cite journal | vauthors = Wang Z, Roeder RG | title = Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high-mobility-group protein 2-related domains | journal = Proc Natl Acad Sci U S A | volume = 92 | issue = 15 | pages = 7026–30 |date=August 1995 | pmid = 7624363 | pmc = 41464 | doi =10.1073/pnas.92.15.7026  }}</ref><ref name="pmid8943358">{{cite journal | vauthors = Mital R, Kobayashi R, Hernandez N | title = RNA polymerase III transcription from the human U6 and adenovirus type 2 VAI promoters has different requirements for human BRF, a subunit of human TFIIIB | journal = Mol Cell Biol | volume = 16 | issue = 12 | pages = 7031–42 |date=January 1997 | pmid = 8943358 | pmc = 231706 | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BRF1 BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2972| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
| HGNCid = 11551
| Symbol = BRF1
| AltSymbols =; BRF; FLJ42674; FLJ43034; GTF3B; MGC105048; TAF3B2; TAF3C; TAFIII90; TF3B90; TFIIIB90; hBRF
| OMIM = 604902
| ECnumber = 
| Homologene = 1161
| MGIid = 1919558
| GeneAtlas_image1 = PBB_GE_BRF1_203754_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_BRF1_215677_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_BRF1_215676_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003709 |text = RNA polymerase III transcription factor activity}} {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0000126 |text = transcription factor TFIIIB complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
| Process = {{GNF_GO|id=GO:0006352 |text = transcription initiation}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006384 |text = transcription initiation from RNA polymerase III promoter}} {{GNF_GO|id=GO:0009303 |text = rRNA transcription}} {{GNF_GO|id=GO:0009304 |text = tRNA transcription}} {{GNF_GO|id=GO:0043488 |text = regulation of mRNA stability}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2972
    | Hs_Ensembl = ENSG00000185024
    | Hs_RefseqProtein = NP_001510
    | Hs_RefseqmRNA = NM_001519
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 104746670
    | Hs_GenLoc_end = 104838374
    | Hs_Uniprot = Q92994
    | Mm_EntrezGene = 72308
    | Mm_Ensembl = ENSMUSG00000011158
    | Mm_RefseqmRNA = NM_028193
    | Mm_RefseqProtein = NP_082469
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 113407670
    | Mm_GenLoc_end = 113448429
    | Mm_Uniprot = Q6PED6
  }}
}}
'''BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)''', also known as '''BRF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BRF1 BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2972| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes one of the three subunits of the [[RNA polymerase III]] [[Transcription (genetics)|transcription]] factor complex. This complex plays a central role in transcription initiation by [[RNA]] polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Three alternatively spliced variants encoding three different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. A transcript encoding a fourth isoform has not yet been completely characterized.<ref name="entrez" />
{{PBB_Summary
 
| section_title =
==Interactions==
| summary_text = This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Three alternatively spliced variants encoding three different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. A transcript encoding a fourth isoform has not yet been completely characterized.<ref name="entrez">{{cite web | title = Entrez Gene: BRF1 BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2972| accessdate = }}</ref>
BRF1 (gene) has been shown to [[Protein-protein interaction|interact]] with:
}}
* [[Retinoblastoma protein|RB1]],<ref name = pmid10330166/><ref name = pmid11997511>{{cite journal | date = June 2002 | vauthors = Johnston IM, Allison SJ, Morton JP, Schramm L, Scott PH, White RJ | title = CK2 forms a stable complex with TFIIIB and activates RNA polymerase III transcription in human cells | journal = Mol. Cell. Biol. | volume = 22 | issue = 11 | pages = 3757–68  | pmid = 11997511 | pmc = 133823 | doi = 10.1128/mcb.22.11.3757-3768.2002}}</ref>
* [[Retinoblastoma-like protein 1|RBL1]],<ref name = pmid10330166/>
* [[Retinoblastoma-like protein 2|RBL2]],<ref name = pmid10330166>{{cite journal | date = June 1999 | vauthors = Sutcliffe JE, Cairns CA, McLees A, Allison SJ, Tosh K, White RJ | title = RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130 | journal = Mol. Cell. Biol. | volume = 19 | issue = 6 | pages = 4255–61  | pmid = 10330166 | pmc = 104385 | doi = 10.1128/mcb.19.6.4255}}</ref> and
* [[TATA binding protein|TBP]]<ref name = pmid7624363 /><ref name = pmid10921893>{{cite journal | date = August 2000 | vauthors = McCulloch V, Hardin P, Peng W, Ruppert JM, Lobo-Ruppert SM | title = Alternatively spliced hBRF variants function at different RNA polymerase III promoters | journal = EMBO J. | volume = 19 | issue = 15 | pages = 4134–43  | pmid = 10921893 | pmc = 306597 | doi = 10.1093/emboj/19.15.4134}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Chesnokov I, Chu WM, Botchan MR, Schmid CW |title=p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner |journal=Mol. Cell. Biol. |volume=16 |issue= 12 |pages= 7084–8 |year= 1997 |pmid= 8943363 |doi= | pmc=231711 }}
| citations =
*{{cite journal  | vauthors=Chu WM, Wang Z, Roeder RG, Schmid CW |title=RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2 |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14755–61 |year= 1997 |pmid= 9169441 |doi=10.1074/jbc.272.23.14755 }}
*{{cite journal  | author=Wang Z, Roeder RG |title=Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high-mobility-group protein 2-related domains. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 15 |pages= 7026-30 |year= 1995 |pmid= 7624363 |doi=  }}
*{{cite journal  | vauthors=Wang Z, Roeder RG |title=Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation |journal=Genes Dev. |volume=11 |issue= 10 |pages= 1315–26 |year= 1997 |pmid= 9171375 |doi=10.1101/gad.11.10.1315 }}
*{{cite journal  | author=Mital R, Kobayashi R, Hernandez N |title=RNA polymerase III transcription from the human U6 and adenovirus type 2 VAI promoters has different requirements for human BRF, a subunit of human TFIIIB. |journal=Mol. Cell. Biol. |volume=16 |issue= 12 |pages= 7031-42 |year= 1997 |pmid= 8943358 |doi=  }}
*{{cite journal | vauthors = Sutcliffe JE, Cairns CA, McLees A, Allison SJ, Tosh K, White RJ | title = RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130 | journal = Mol. Cell. Biol. | volume = 19 | issue = 6 | pages = 4255–61 |date=June 1999 | pmid = 10330166 | pmc = 104385 | doi = 10.1128/mcb.19.6.4255}}
*{{cite journal  | author=Chesnokov I, Chu WM, Botchan MR, Schmid CW |title=p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner. |journal=Mol. Cell. Biol. |volume=16 |issue= 12 |pages= 7084-8 |year= 1997 |pmid= 8943363 |doi=  }}
*{{cite journal  | vauthors=Hsieh YJ, Wang Z, Kovelman R, Roeder RG |title=Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4944–52 |year= 1999 |pmid= 10373544 |doi= | pmc=84305 }}
*{{cite journal  | author=Chu WM, Wang Z, Roeder RG, Schmid CW |title=RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14755-61 |year= 1997 |pmid= 9169441 |doi=  }}
*{{cite journal | vauthors = Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG | title = The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity | journal = Mol. Cell. Biol. | volume = 19 | issue = 11 | pages = 7697–704 |date=November 1999 | pmid = 10523658 | pmc = 84812 | doi =  10.1128/mcb.19.11.7697}}
*{{cite journal  | author=Wang Z, Roeder RG |title=Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation. |journal=Genes Dev. |volume=11 |issue= 10 |pages= 1315-26 |year= 1997 |pmid= 9171375 |doi=  }}
*{{cite journal | vauthors = McCulloch V, Hardin P, Peng W, Ruppert JM, Lobo-Ruppert SM | title = Alternatively spliced hBRF variants function at different RNA polymerase III promoters | journal = EMBO J. | volume = 19 | issue = 15 | pages = 4134–43 |date=August 2000 | pmid = 10921893 | pmc = 306597 | doi = 10.1093/emboj/19.15.4134 }}
*{{cite journal | author=Sutcliffe JE, Cairns CA, McLees A, ''et al.'' |title=RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4255-61 |year= 1999 |pmid= 10330166 |doi= }}
*{{cite journal | vauthors = Johnston IM, Allison SJ, Morton JP, Schramm L, Scott PH, White RJ | title = CK2 forms a stable complex with TFIIIB and activates RNA polymerase III transcription in human cells | journal = Mol. Cell. Biol. | volume = 22 | issue = 11 | pages = 3757–68 |date=June 2002 | pmid = 11997511 | pmc = 133823 | doi = 10.1128/MCB.22.11.3757-3768.2002 }}
*{{cite journal  | author=Hsieh YJ, Wang Z, Kovelman R, Roeder RG |title=Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4944-52 |year= 1999 |pmid= 10373544 |doi=  }}
*{{cite journal  | vauthors=Cabart P, Murphy S |title=Assembly of human small nuclear RNA gene-specific transcription factor IIIB complex de novo on and off promoter |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 26831–8 |year= 2002 |pmid= 12016223 |doi= 10.1074/jbc.M203119200 }}
*{{cite journal | author=Hsieh YJ, Kundu TK, Wang Z, ''et al.'' |title=The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7697-704 |year= 1999 |pmid= 10523658 |doi=  }}
*{{cite journal  | author=Willis IM |title=A universal nomenclature for subunits of the RNA polymerase III transcription initiation factor TFIIIB |journal=Genes Dev. |volume=16 |issue= 11 |pages= 1337–8 |year= 2002 |pmid= 12066800 |doi=10.1101/gad.998102 }}
*{{cite journal | author=McCulloch V, Hardin P, Peng W, ''et al.'' |title=Alternatively spliced hBRF variants function at different RNA polymerase III promoters. |journal=EMBO J. |volume=19 |issue= 15 |pages= 4134-43 |year= 2000 |pmid= 10921893 |doi= 10.1093/emboj/19.15.4134 }}
*{{cite journal | vauthors = Stoecklin G, Colombi M, Raineri I, Leuenberger S, Mallaun M, Schmidlin M, Gross B, Lu M, Kitamura T, Moroni C | title = Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover | journal = EMBO J. | volume = 21 | issue = 17 | pages = 4709–18 |date=September 2002 | pmid = 12198173 | pmc = 126184 | doi = 10.1093/emboj/cdf444}}
*{{cite journal | author=Johnston IM, Allison SJ, Morton JP, ''et al.'' |title=CK2 forms a stable complex with TFIIIB and activates RNA polymerase III transcription in human cells. |journal=Mol. Cell. Biol. |volume=22 |issue= 11 |pages= 3757-68 |year= 2002 |pmid= 11997511 |doi= }}
*{{cite journal  | vauthors=Weser S, Riemann J, Seifart KH, Meissner W |title=Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene |journal=Nucleic Acids Res. |volume=31 |issue= 9 |pages= 2408–16 |year= 2003 |pmid= 12711686 |doi=10.1093/nar/gkg345 | pmc=154231  }}
*{{cite journal  | author=Cabart P, Murphy S |title=Assembly of human small nuclear RNA gene-specific transcription factor IIIB complex de novo on and off promoter. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 26831-8 |year= 2002 |pmid= 12016223 |doi= 10.1074/jbc.M203119200 }}
*{{cite journal | vauthors = Schmidlin M, Lu M, Leuenberger SA, Stoecklin G, Mallaun M, Gross B, Gherzi R, Hess D, Hemmings BA, Moroni C | title = The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B | journal = EMBO J. | volume = 23 | issue = 24 | pages = 4760–9 |date=December 2004  | pmid = 15538381 | pmc = 535089 | doi = 10.1038/sj.emboj.7600477 }}
*{{cite journal  | author=Willis IM |title=A universal nomenclature for subunits of the RNA polymerase III transcription initiation factor TFIIIB. |journal=Genes Dev. |volume=16 |issue= 11 |pages= 1337-8 |year= 2002 |pmid= 12066800 |doi=  }}
*{{cite journal | author=Stoecklin G, Colombi M, Raineri I, ''et al.'' |title=Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover. |journal=EMBO J. |volume=21 |issue= 17 |pages= 4709-18 |year= 2002 |pmid= 12198173 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Weser S, Riemann J, Seifart KH, Meissner W |title=Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene. |journal=Nucleic Acids Res. |volume=31 |issue= 9 |pages= 2408-16 |year= 2003 |pmid= 12711686 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Schmidlin M, Lu M, Leuenberger SA, ''et al.'' |title=The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B. |journal=EMBO J. |volume=23 |issue= 24 |pages= 4760-9 |year= 2005 |pmid= 15538381 |doi= 10.1038/sj.emboj.7600477 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{FactorBook|BRF1}}
* {{UCSC gene info|BRF1}}
 
{{gene-14-stub}}

Latest revision as of 02:40, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription factor IIIB 90 kDa subunit is a protein that in humans is encoded by the BRF1 gene.[1][2][3]

Function

This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Three alternatively spliced variants encoding three different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. A transcript encoding a fourth isoform has not yet been completely characterized.[3]

Interactions

BRF1 (gene) has been shown to interact with:

References

  1. 1.0 1.1 Wang Z, Roeder RG (August 1995). "Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high-mobility-group protein 2-related domains". Proc Natl Acad Sci U S A. 92 (15): 7026–30. doi:10.1073/pnas.92.15.7026. PMC 41464. PMID 7624363.
  2. Mital R, Kobayashi R, Hernandez N (January 1997). "RNA polymerase III transcription from the human U6 and adenovirus type 2 VAI promoters has different requirements for human BRF, a subunit of human TFIIIB". Mol Cell Biol. 16 (12): 7031–42. PMC 231706. PMID 8943358.
  3. 3.0 3.1 "Entrez Gene: BRF1 BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)".
  4. 4.0 4.1 4.2 Sutcliffe JE, Cairns CA, McLees A, Allison SJ, Tosh K, White RJ (June 1999). "RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130". Mol. Cell. Biol. 19 (6): 4255–61. doi:10.1128/mcb.19.6.4255. PMC 104385. PMID 10330166.
  5. Johnston IM, Allison SJ, Morton JP, Schramm L, Scott PH, White RJ (June 2002). "CK2 forms a stable complex with TFIIIB and activates RNA polymerase III transcription in human cells". Mol. Cell. Biol. 22 (11): 3757–68. doi:10.1128/mcb.22.11.3757-3768.2002. PMC 133823. PMID 11997511.
  6. McCulloch V, Hardin P, Peng W, Ruppert JM, Lobo-Ruppert SM (August 2000). "Alternatively spliced hBRF variants function at different RNA polymerase III promoters". EMBO J. 19 (15): 4134–43. doi:10.1093/emboj/19.15.4134. PMC 306597. PMID 10921893.

Further reading

External links