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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein NDRG2''' is a [[protein]] that in humans is encoded by the ''NDRG2'' [[gene]] (NMYC downstrean-regulated gene 2).<ref name="pmid10831399">{{cite journal | vauthors = Kalaydjieva L, Gresham D, Gooding R, Heather L, Baas F, de Jonge R, Blechschmidt K, Angelicheva D, Chandler D, Worsley P, Rosenthal A, King RH, Thomas PK | title = N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom | journal = Am J Hum Genet | volume = 67 | issue = 1 | pages = 47–58 |date=Aug 2000 | pmid = 10831399 | pmc = 1287101 | doi = 10.1086/302978 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NDRG2 NDRG family member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57447| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = NDRG family member 2
| HGNCid = 14460
| Symbol = NDRG2
| AltSymbols =; DKFZp781G1938; FLJ25522; KIAA1248; SYLD
| OMIM = 605272
| ECnumber = 
| Homologene = 22785
| MGIid = 1352498
| GeneAtlas_image1 = PBB_GE_NDRG2_214279_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NDRG2_206453_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 57447
    | Hs_Ensembl = ENSG00000165795
    | Hs_RefseqProtein = NP_057334
    | Hs_RefseqmRNA = NM_016250
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 20554763
    | Hs_GenLoc_end = 20563775
    | Hs_Uniprot = Q9UN36
    | Mm_EntrezGene = 29811
    | Mm_Ensembl = ENSMUSG00000004558
    | Mm_RefseqmRNA = NM_013864
    | Mm_RefseqProtein = NP_038892
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 50827232
    | Mm_GenLoc_end = 50835302
    | Mm_Uniprot = Q8CGR9
  }}
}}
'''NDRG family member 2''', also known as '''NDRG2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NDRG2 NDRG family member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57447| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the [[N-myc]] downregulated gene family which belongs to the [[alpha/beta hydrolase fold|alpha/beta hydrolase]] superfamily. The protein encoded by this gene is a [[cytoplasm]]ic protein that may play a role in [[neurite]] outgrowth. This gene may be involved in [[glioblastoma multiforme|glioblastoma]] and aggressive [[meningioma]] [[carcinogenesis]] (via cell proliferation<ref name="pmid12845671">{{cite journal | vauthors = Deng Y, Yao L, Chau L, Ng SS, Peng Y, Liu X, Au WS, Wang J, Li F, Ji S, Han H, Nie X, Li Q, Kung HF, Leung SY, Lin MC | title = N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation | journal = Int. J. Cancer | volume = 106 | issue = 3 | pages = 342–7 |date=September 2003 | pmid = 12845671 | doi = 10.1002/ijc.11228 | url = }}</ref>).<ref name="pmid16103061">{{cite journal | vauthors = Lusis EA, Watson MA, Chicoine MR, Lyman M, Roerig P, Reifenberger G, Gutmann DH, Perry A | title = Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma | journal = Cancer Res. | volume = 65 | issue = 16 | pages = 7121–6 |date=August 2005 | pmid = 16103061 | doi = 10.1158/0008-5472.CAN-05-0043 | url = }}</ref> Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: NDRG2 NDRG family member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57447| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
{{Clear}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Nagase T, Ishikawa K, Kikuno R, etal |title=Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 5 |pages= 337–45 |year= 2000 |pmid= 10574462 |doi=10.1093/dnares/6.5.337 }}
| citations =
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal | author=Nagase T, Ishikawa K, Kikuno R, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 5 |pages= 337-45 |year= 2000 |pmid= 10574462 |doi=  }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 }}
*{{cite journal  | author=Kalaydjieva L, Gresham D, Gooding R, ''et al.'' |title=N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom. |journal=Am. J. Hum. Genet. |volume=67 |issue= 1 |pages= 47-58 |year= 2000 |pmid= 10831399 |doi=  }}
*{{cite journal   |vauthors=Zhou RH, Kokame K, Tsukamoto Y, etal |title=Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. |journal=Genomics |volume=73 |issue= 1 |pages= 86–97 |year= 2001 |pmid= 11352569 |doi= 10.1006/geno.2000.6496 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal   |vauthors=Qu X, Zhai Y, Wei H, etal |title=Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family. |journal=Mol. Cell. Biochem. |volume=229 |issue= 1-2 |pages= 35–44 |year= 2002 |pmid= 11936845 |doi=10.1023/A:1017934810825  }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal   |vauthors=Ohki T, Hongo S, Nakada N, etal |title=Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells. |journal=Brain Res. Dev. Brain Res. |volume=135 |issue= 1-2 |pages= 55–63 |year= 2002 |pmid= 11978393 |doi=10.1016/S0165-3806(02)00300-0 }}
*{{cite journal | author=Zhou RH, Kokame K, Tsukamoto Y, ''et al.'' |title=Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. |journal=Genomics |volume=73 |issue= 1 |pages= 86-97 |year= 2001 |pmid= 11352569 |doi= 10.1006/geno.2000.6496 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Qu X, Zhai Y, Wei H, ''et al.'' |title=Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family. |journal=Mol. Cell. Biochem. |volume=229 |issue= 1-2 |pages= 35-44 |year= 2002 |pmid= 11936845 |doi=  }}
*{{cite journal   |vauthors=Deng Y, Yao L, Chau L, etal |title=N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. |journal=Int. J. Cancer |volume=106 |issue= 3 |pages= 342–7 |year= 2003 |pmid= 12845671 |doi= 10.1002/ijc.11228 }}
*{{cite journal | author=Ohki T, Hongo S, Nakada N, ''et al.'' |title=Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells. |journal=Brain Res. Dev. Brain Res. |volume=135 |issue= 1-2 |pages= 55-63 |year= 2002 |pmid= 11978393 |doi=  }}
*{{cite journal   |vauthors=Choi SC, Kim KD, Kim JT, etal |title=Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells. |journal=FEBS Lett. |volume=553 |issue= 3 |pages= 413–8 |year= 2003 |pmid= 14572661 |doi=10.1016/S0014-5793(03)01030-5  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Deng Y, Yao L, Chau L, ''et al.'' |title=N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. |journal=Int. J. Cancer |volume=106 |issue= 3 |pages= 342-7 |year= 2003 |pmid= 12845671 |doi= 10.1002/ijc.11228 }}
*{{cite journal  | vauthors=Devroe E, Erdjument-Bromage H, Tempst P, Silver PA |title=Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24444–51 |year= 2004 |pmid= 15067004 |doi= 10.1074/jbc.M401999200 }}
*{{cite journal | author=Choi SC, Kim KD, Kim JT, ''et al.'' |title=Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells. |journal=FEBS Lett. |volume=553 |issue= 3 |pages= 413-8 |year= 2003 |pmid= 14572661 |doi= }}
*{{cite journal   |vauthors=Mitchelmore C, Büchmann-Møller S, Rask L, etal |title=NDRG2: a novel Alzheimer's disease associated protein. |journal=Neurobiol. Dis. |volume=16 |issue= 1 |pages= 48–58 |year= 2004 |pmid= 15207261 |doi= 10.1016/j.nbd.2004.01.003 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Murray JT, Campbell DG, Morrice N, etal |title=Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3. |journal=Biochem. J. |volume=384 |issue= Pt 3 |pages= 477–88 |year= 2005 |pmid= 15461589 |doi= 10.1042/BJ20041057  | pmc=1134133 }}
*{{cite journal | author=Devroe E, Erdjument-Bromage H, Tempst P, Silver PA |title=Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24444-51 |year= 2004 |pmid= 15067004 |doi= 10.1074/jbc.M401999200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Mitchelmore C, Büchmann-Møller S, Rask L, ''et al.'' |title=NDRG2: a novel Alzheimer's disease associated protein. |journal=Neurobiol. Dis. |volume=16 |issue= 1 |pages= 48-58 |year= 2004 |pmid= 15207261 |doi= 10.1016/j.nbd.2004.01.003 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930 }}
*{{cite journal | author=Murray JT, Campbell DG, Morrice N, ''et al.'' |title=Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3. |journal=Biochem. J. |volume=384 |issue= Pt 3 |pages= 477-88 |year= 2005 |pmid= 15461589 |doi= 10.1042/BJ20041057 }}
*{{cite journal   |vauthors=Hu XL, Liu XP, Lin SX, etal |title=NDRG2 expression and mutation in human liver and pancreatic cancers. |journal=World J. Gastroenterol. |volume=10 |issue= 23 |pages= 3518–21 |year= 2005 |pmid= 15526377 |doi=  }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Devroe E, Silver PA, Engelman A |title=HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases. |journal=Virology |volume=331 |issue= 1 |pages= 181–9 |year= 2005 |pmid= 15582665 |doi= 10.1016/j.virol.2004.10.023 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal   |vauthors=Amente S, Napolitano G, Licciardo P, etal |title=Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation. |journal=FEBS Lett. |volume=579 |issue= 3 |pages= 683–9 |year= 2005 |pmid= 15670829 |doi= 10.1016/j.febslet.2004.12.045 }}
*{{cite journal | author=Hu XL, Liu XP, Lin SX, ''et al.'' |title=NDRG2 expression and mutation in human liver and pancreatic cancers. |journal=World J. Gastroenterol. |volume=10 |issue= 23 |pages= 3518-21 |year= 2005 |pmid= 15526377 |doi=  }}
*{{cite journal   |vauthors=Lusis EA, Watson MA, Chicoine MR, etal |title=Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma. |journal=Cancer Res. |volume=65 |issue= 16 |pages= 7121–6 |year= 2005 |pmid= 16103061 |doi= 10.1158/0008-5472.CAN-05-0043 }}
*{{cite journal  | author=Devroe E, Silver PA, Engelman A |title=HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases. |journal=Virology |volume=331 |issue= 1 |pages= 181-9 |year= 2005 |pmid= 15582665 |doi= 10.1016/j.virol.2004.10.023 }}
*{{cite journal | author=Amente S, Napolitano G, Licciardo P, ''et al.'' |title=Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation. |journal=FEBS Lett. |volume=579 |issue= 3 |pages= 683-9 |year= 2005 |pmid= 15670829 |doi= 10.1016/j.febslet.2004.12.045 }}
*{{cite journal | author=Lusis EA, Watson MA, Chicoine MR, ''et al.'' |title=Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma. |journal=Cancer Res. |volume=65 |issue= 16 |pages= 7121-6 |year= 2005 |pmid= 16103061 |doi= 10.1158/0008-5472.CAN-05-0043 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
[[Category:Human proteins]]
{{WikiDoc Sources}}
 
 
{{gene-14-stub}}

Latest revision as of 12:43, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein NDRG2 is a protein that in humans is encoded by the NDRG2 gene (NMYC downstrean-regulated gene 2).[1][2]

Function

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma and aggressive meningioma carcinogenesis (via cell proliferation[3]).[4] Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[2]

References

  1. ↑ Kalaydjieva L, Gresham D, Gooding R, Heather L, Baas F, de Jonge R, Blechschmidt K, Angelicheva D, Chandler D, Worsley P, Rosenthal A, King RH, Thomas PK (Aug 2000). "N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom". Am J Hum Genet. 67 (1): 47–58. doi:10.1086/302978. PMC 1287101. PMID 10831399.
  2. ↑ 2.0 2.1 "Entrez Gene: NDRG2 NDRG family member 2".
  3. ↑ Deng Y, Yao L, Chau L, Ng SS, Peng Y, Liu X, Au WS, Wang J, Li F, Ji S, Han H, Nie X, Li Q, Kung HF, Leung SY, Lin MC (September 2003). "N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation". Int. J. Cancer. 106 (3): 342–7. doi:10.1002/ijc.11228. PMID 12845671.
  4. ↑ Lusis EA, Watson MA, Chicoine MR, Lyman M, Roerig P, Reifenberger G, Gutmann DH, Perry A (August 2005). "Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma". Cancer Res. 65 (16): 7121–6. doi:10.1158/0008-5472.CAN-05-0043. PMID 16103061.

Further reading


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