EXOC5: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Exocyst complex component 5''' is a [[protein]] that in humans is encoded by the ''EXOC5'' [[gene]].<ref name="pmid9119050">{{cite journal | vauthors = Guo W, Roth D, Gatti E, De Camilli P, Novick P | title = Identification and characterization of homologues of the Exocyst component Sec10p | journal = FEBS Lett | volume = 404 | issue = 2-3 | pages = 135–9 | date = Apr 1997 | pmid = 9119050 | pmc =  | doi = 10.1016/S0014-5793(97)00109-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EXOC5 exocyst complex component 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10640| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Exocyst complex component 5
| HGNCid = 10696
| Symbol = EXOC5
| AltSymbols =; DKFZp666H126; HSEC10; PRO1912; SEC10; SEC10L1; SEC10P
| OMIM = 604469
| ECnumber = 
| Homologene = 38195
| MGIid = 2145645
| GeneAtlas_image1 = PBB_GE_EXOC5_218748_s_at_tn.png
| Function =  
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006887 |text = exocytosis}} {{GNF_GO|id=GO:0006892 |text = post-Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0048278 |text = vesicle docking}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10640
    | Hs_Ensembl = ENSG00000070367
    | Hs_RefseqProtein = NP_006535
    | Hs_RefseqmRNA = NM_006544
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 56738954
    | Hs_GenLoc_end = 56805370
    | Hs_Uniprot = O00471
    | Mm_EntrezGene = 105504
    | Mm_Ensembl = ENSMUSG00000061244
    | Mm_RefseqmRNA = XM_993269
    | Mm_RefseqProtein = XP_998363
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 47934094
    | Mm_GenLoc_end = 47988618
    | Mm_Uniprot = Q3U8A5
  }}
}}
'''Exocyst complex component 5''', also known as '''EXOC5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EXOC5 exocyst complex component 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10640| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.<ref name="entrez">{{cite web | title = Entrez Gene: EXOC5 exocyst complex component 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10640| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
EXOC5 has been shown to [[Protein-protein interaction|interact]] with [[Arf6]].<ref name=pmid14662749>{{cite journal | vauthors = Prigent M, Dubois T, Raposo G, Derrien V, Tenza D, Rossé C, Camonis J, Chavrier P | title = ARF6 controls post-endocytic recycling through its downstream exocyst complex effector | journal = J. Cell Biol. | volume = 163 | issue = 5 | pages = 1111–21 | date = Dec 2003 | pmid = 14662749 | pmc = 2173613 | doi = 10.1083/jcb.200305029 }}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hsu SC, TerBush D, Abraham M, Guo W | title = The exocyst complex in polarized exocytosis. | journal = Int. Rev. Cytol. | volume = 233 | issue =  | pages = 243–65 | year = 2004 | pmid = 15037366 | doi = 10.1016/S0074-7696(04)33006-8 }}
| citations =
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery. | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Hsu SC, TerBush D, Abraham M, Guo W |title=The exocyst complex in polarized exocytosis. |journal=Int. Rev. Cytol. |volume=233 |issue=  |pages= 243-65 |year= 2004 |pmid= 15037366 |doi= 10.1016/S0074-7696(04)33006-8 }}
* {{cite journal | vauthors = Kee Y, Yoo JS, Hazuka CD, Peterson KE, Hsu SC, Scheller RH | title = Subunit structure of the mammalian exocyst complex. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 26 | pages = 14438–43 | year = 1998 | pmid = 9405631 | pmc = 25013 | doi = 10.1073/pnas.94.26.14438 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Hsu SC, Hazuka CD, Roth R, Foletti DL, Heuser J, Scheller RH | title = Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. | journal = Neuron | volume = 20 | issue = 6 | pages = 1111–22 | year = 1998 | pmid = 9655500 | doi = 10.1016/S0896-6273(00)80493-6 }}
*{{cite journal  | author=Guo W, Roth D, Gatti E, ''et al.'' |title=Identification and characterization of homologues of the Exocyst component Sec10p. |journal=FEBS Lett. |volume=404 |issue= 2-3 |pages= 135-9 |year= 1997 |pmid= 9119050 |doi=  }}
* {{cite journal | vauthors = Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ | title = The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. | journal = J. Biol. Chem. | volume = 276 | issue = 32 | pages = 29792–7 | year = 2001 | pmid = 11406615 | doi = 10.1074/jbc.C100320200 }}
*{{cite journal | author=Kee Y, Yoo JS, Hazuka CD, ''et al.'' |title=Subunit structure of the mammalian exocyst complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14438-43 |year= 1998 |pmid= 9405631 |doi= }}
* {{cite journal | vauthors = Polzin A, Shipitsin M, Goi T, Feig LA, Turner TJ | title = Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles. | journal = Mol. Cell. Biol. | volume = 22 | issue = 6 | pages = 1714–22 | year = 2002 | pmid = 11865051 | pmc = 135608 | doi = 10.1128/MCB.22.6.1714-1722.2002 }}
*{{cite journal | author=Hsu SC, Hazuka CD, Roth R, ''et al.'' |title=Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. |journal=Neuron |volume=20 |issue= 6 |pages= 1111-22 |year= 1998 |pmid= 9655500 |doi= }}
* {{cite journal | vauthors = Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR | title = The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. | journal = Nature | volume = 422 | issue = 6932 | pages = 629–33 | year = 2003 | pmid = 12687004 | doi = 10.1038/nature01533 }}
*{{cite journal | author=Brymora A, Valova VA, Larsen MR, ''et al.'' |title=The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29792-7 |year= 2001 |pmid= 11406615 |doi= 10.1074/jbc.C100320200 }}
* {{cite journal | vauthors = Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA | title = Ral GTPases regulate exocyst assembly through dual subunit interactions. | journal = J. Biol. Chem. | volume = 278 | issue = 51 | pages = 51743–8 | year = 2004 | pmid = 14525976 | doi = 10.1074/jbc.M308702200 }}
*{{cite journal | author=Polzin A, Shipitsin M, Goi T, ''et al.'' |title=Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles. |journal=Mol. Cell. Biol. |volume=22 |issue= 6 |pages= 1714-22 |year= 2002 |pmid= 11865051 |doi=  }}
* {{cite journal | vauthors = Prigent M, Dubois T, Raposo G, Derrien V, Tenza D, Rossé C, Camonis J, Chavrier P | title = ARF6 controls post-endocytic recycling through its downstream exocyst complex effector. | journal = J. Cell Biol. | volume = 163 | issue = 5 | pages = 1111–21 | year = 2004 | pmid = 14662749 | pmc = 2173613 | doi = 10.1083/jcb.200305029 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. | journal = Nat. Biotechnol. | volume = 22 | issue = 6 | pages = 707–16 | year = 2005 | pmid = 15146197 | doi = 10.1038/nbt971 }}
*{{cite journal | author=Inoue M, Chang L, Hwang J, ''et al.'' |title=The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. |journal=Nature |volume=422 |issue= 6932 |pages= 629-33 |year= 2003 |pmid= 12687004 |doi= 10.1038/nature01533 }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Moskalenko S, Tong C, Rosse C, ''et al.'' |title=Ral GTPases regulate exocyst assembly through dual subunit interactions. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51743-8 |year= 2004 |pmid= 14525976 |doi= 10.1074/jbc.M308702200 }}
*{{cite journal | author=Prigent M, Dubois T, Raposo G, ''et al.'' |title=ARF6 controls post-endocytic recycling through its downstream exocyst complex effector. |journal=J. Cell Biol. |volume=163 |issue= 5 |pages= 1111-21 |year= 2004 |pmid= 14662749 |doi= 10.1083/jcb.200305029 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-14-stub}}

Revision as of 00:40, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Exocyst complex component 5 is a protein that in humans is encoded by the EXOC5 gene.[1][2]

Function

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.[2]

Interactions

EXOC5 has been shown to interact with Arf6.[3]

References

  1. ↑ Guo W, Roth D, Gatti E, De Camilli P, Novick P (Apr 1997). "Identification and characterization of homologues of the Exocyst component Sec10p". FEBS Lett. 404 (2–3): 135–9. doi:10.1016/S0014-5793(97)00109-9. PMID 9119050.
  2. ↑ 2.0 2.1 "Entrez Gene: EXOC5 exocyst complex component 5".
  3. ↑ Prigent M, Dubois T, Raposo G, Derrien V, Tenza D, Rossé C, Camonis J, Chavrier P (Dec 2003). "ARF6 controls post-endocytic recycling through its downstream exocyst complex effector". J. Cell Biol. 163 (5): 1111–21. doi:10.1083/jcb.200305029. PMC 2173613. PMID 14662749.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=EXOC5&oldid=1416544"