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{{Infobox_gene}}
{{PBB_Controls
'''Jagged-2''' is a [[protein]] that in humans is encoded by the ''JAG2'' [[gene]].<ref name="pmid9315665">{{cite journal |vauthors=Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J | title = Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor | journal = Mol Cell Biol | volume = 17 | issue = 10 | pages = 6057–67 | date = October 1997 | pmid = 9315665 | pmc = 232455 | doi =  }}</ref><ref name="pmid10662552">{{cite journal |vauthors=Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L | title = Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene | journal = Genomics | volume = 63 | issue = 1 | pages = 133–8 | date = April 2000 | pmid = 10662552 | pmc = | doi = 10.1006/geno.1999.6045 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: JAG2 jagged 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3714| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Jagged 2
| HGNCid = 6189
| Symbol = JAG2
| AltSymbols =; HJ2
| OMIM = 602570
| ECnumber = 
| Homologene = 1677
| MGIid = 1098270
| GeneAtlas_image1 = PBB_GE_JAG2_32137_at_tn.png
| GeneAtlas_image2 = PBB_GE_JAG2_209784_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005112 |text = Notch binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0001709 |text = cell fate determination}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007219 |text = Notch signaling pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0009912 |text = auditory receptor cell fate commitment}} {{GNF_GO|id=GO:0016331 |text = morphogenesis of embryonic epithelium}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030155 |text = regulation of cell adhesion}} {{GNF_GO|id=GO:0030326 |text = embryonic limb morphogenesis}} {{GNF_GO|id=GO:0030334 |text = regulation of cell migration}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}} {{GNF_GO|id=GO:0042475 |text = odontogenesis (sensu Vertebrata)}} {{GNF_GO|id=GO:0042492 |text = gamma-delta T cell differentiation}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0045061 |text = thymic T cell selection}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3714
    | Hs_Ensembl = ENSG00000184916
    | Hs_RefseqProtein = NP_002217
    | Hs_RefseqmRNA = NM_002226
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 104679121
    | Hs_GenLoc_end = 104706206
    | Hs_Uniprot = Q9Y219
    | Mm_EntrezGene = 16450
    | Mm_Ensembl = ENSMUSG00000002799
    | Mm_RefseqmRNA = NM_010588
    | Mm_RefseqProtein = NP_034718
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 113356398
    | Mm_GenLoc_end = 113377303
    | Mm_Uniprot = O55138
  }}
}}
'''Jagged 2''', also known as '''JAG2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: JAG2 jagged 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3714| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The [[Notch signaling pathway]] is an [[Cell signaling|intercellular signaling]] mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez"/>
{{PBB_Summary
 
| section_title =
== Interactions ==
| summary_text = The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: JAG2 jagged 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3714| accessdate = }}</ref>
 
}}
JAG2 has been shown to [[Protein-protein interaction|interact]] with [[NOTCH2]].<ref name="pmid10958687">{{cite journal |vauthors=Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H | title = Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2 | journal = Mol. Cell. Biol. | volume = 20 | issue = 18 | pages = 6913–22 | year = 2000 | pmid = 10958687 | pmc = 88767 | doi = 10.1128/MCB.20.18.6913-6922.2000 }}</ref>
 
[[MicroRNA]] miR-1280 has been shown to inhibit JAG2 expression.<ref>{{Cite journal|title = A MicroRNA-1280/JAG2 network comprises a novel bilogical target in high-risk medulloblastoma|author = Wang|author2 = Remke|author3 = Bhat|author4 = Wong|author5 = Zhou|author6 = Ramaswamy|author7 = Dubuc|author8 = Fonkem|author9 = Salem|author10 = Zhang|author11 = Hsieh|author12 = O'Rourke|author13 = Wu|author14 = Li|author15 = Hawkins|author16 = Kohane|author17 = Wu|author18 = Wu|author19 = Taylor|date = February 2015|journal = Oncotarget|doi = 10.18632/oncotarget.2779|pmid = 25576913|volume=6|pages=2709–24|pmc=4413612}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal |vauthors=Shawber C, Boulter J, Lindsell CE, Weinmaster G | title = Jagged2: a serrate-like gene expressed during rat embryogenesis | journal = Dev. Biol. | volume = 180 | issue = 1 | pages = 370–6 | year = 1997 | pmid = 8948600 | doi = 10.1006/dbio.1996.0310 }}
| citations =
*{{cite journal |vauthors=Valsecchi C, Ghezzi C, Ballabio A, Rugarli EI | title = JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions | journal = Mech. Dev. | volume = 69 | issue = 1–2 | pages = 203–7 | year = 1998 | pmid = 9486542 | doi = 10.1016/S0925-4773(97)00146-9 }}
*{{cite journal | author=Shawber C, Boulter J, Lindsell CE, Weinmaster G |title=Jagged2: a serrate-like gene expressed during rat embryogenesis. |journal=Dev. Biol. |volume=180 |issue= 1 |pages= 370-6 |year= 1997 |pmid= 8948600 |doi= 10.1006/dbio.1996.0310 }}
*{{cite journal |vauthors=Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S | title = Human Ligands of the Notch Receptor | journal = Am. J. Pathol. | volume = 154 | issue = 3 | pages = 785–94 | year = 1999 | pmid = 10079256 | pmc = 1866435 | doi = 10.1016/S0002-9440(10)65325-4 }}
*{{cite journal | author=Luo B, Aster JC, Hasserjian RP, ''et al.'' |title=Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. |journal=Mol. Cell. Biol. |volume=17 |issue= 10 |pages= 6057-67 |year= 1997 |pmid= 9315665 |doi=  }}
*{{cite journal |vauthors=Lanford PJ, Lan Y, Jiang R, Lindsell C, Weinmaster G, Gridley T, Kelley MW | title = Notch signalling pathway mediates hair cell development in mammalian cochlea | journal = Nat. Genet. | volume = 21 | issue = 3 | pages = 289–92 | year = 1999 | pmid = 10080181 | doi = 10.1038/6804 }}
*{{cite journal  | author=Valsecchi C, Ghezzi C, Ballabio A, Rugarli EI |title=JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions. |journal=Mech. Dev. |volume=69 |issue= 1-2 |pages= 203-7 |year= 1998 |pmid= 9486542 |doi= }}
*{{cite journal |vauthors=Felli MP, Maroder M, Mitsiadis TA, Campese AF, Bellavia D, Vacca A, Mann RS, Frati L, Lendahl U, Gulino A, Screpanti I | title = Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development | journal = Int. Immunol. | volume = 11 | issue = 7 | pages = 1017–25 | year = 1999 | pmid = 10383933 | doi = 10.1093/intimm/11.7.1017 }}
*{{cite journal | author=Gray GE, Mann RS, Mitsiadis E, ''et al.'' |title=Human ligands of the Notch receptor. |journal=Am. J. Pathol. |volume=154 |issue= 3 |pages= 785-94 |year= 1999 |pmid= 10079256 |doi= }}
*{{cite journal |vauthors=Tsai S, Fero J, Bartelmez S | title = Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact | journal = Blood | volume = 96 | issue = 3 | pages = 950–7 | year = 2000 | pmid = 10910909 | doi =  }}
*{{cite journal | author=Lanford PJ, Lan Y, Jiang R, ''et al.'' |title=Notch signalling pathway mediates hair cell development in mammalian cochlea. |journal=Nat. Genet. |volume=21 |issue= 3 |pages= 289-92 |year= 1999 |pmid= 10080181 |doi= 10.1038/6804 }}
*{{cite journal |vauthors=Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H | title = Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2 | journal = Mol. Cell. Biol. | volume = 20 | issue = 18 | pages = 6913–22 | year = 2000 | pmid = 10958687 | pmc = 88767 | doi = 10.1128/MCB.20.18.6913-6922.2000 }}
*{{cite journal | author=Felli MP, Maroder M, Mitsiadis TA, ''et al.'' |title=Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development. |journal=Int. Immunol. |volume=11 |issue= 7 |pages= 1017-25 |year= 1999 |pmid= 10383933 |doi=  }}
*{{cite journal |vauthors=Shimizu K, Chiba S, Saito T, Kumano K, Hirai H | title = Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors | journal = Biochem. Biophys. Res. Commun. | volume = 276 | issue = 1 | pages = 385–9 | year = 2000 | pmid = 11006133 | doi = 10.1006/bbrc.2000.3469 }}
*{{cite journal  | author=Deng Y, Madan A, Banta AB, ''et al.'' |title=Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene. |journal=Genomics |volume=63 |issue= 1 |pages= 133-8 |year= 2000 |pmid= 10662552 |doi= 10.1006/geno.1999.6045 }}
*{{cite journal |vauthors=Cereseto A, Tsai S | title = Jagged2 induces cell cycling in confluent fibroblasts susceptible to density-dependent inhibition of cell division | journal = J. Cell. Physiol. | volume = 185 | issue = 3 | pages = 425–31 | year = 2000 | pmid = 11056013 | doi = 10.1002/1097-4652(200012)185:3<425::AID-JCP13>3.0.CO;2-U }}
*{{cite journal | author=Tsai S, Fero J, Bartelmez S |title=Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact. |journal=Blood |volume=96 |issue= 3 |pages= 950-7 |year= 2000 |pmid= 10910909 |doi=  }}
*{{cite journal |vauthors=Lindner V, Booth C, Prudovsky I, Small D, Maciag T, Liaw L | title = Members of the Jagged/Notch Gene Families Are Expressed in Injured Arteries and Regulate Cell Phenotype via Alterations in Cell Matrix and Cell-Cell Interaction | journal = Am. J. Pathol. | volume = 159 | issue = 3 | pages = 875–83 | year = 2001 | pmid = 11549580 | pmc = 1850458 | doi = 10.1016/S0002-9440(10)61763-4 }}
*{{cite journal | author=Shimizu K, Chiba S, Hosoya N, ''et al.'' |title=Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. |journal=Mol. Cell. Biol. |volume=20 |issue= 18 |pages= 6913-22 |year= 2000 |pmid= 10958687 |doi= }}
*{{cite journal |vauthors=Hayashi T, Kageyama Y, Ishizaka K, Xia G, Kihara K, Oshima H | title = Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes | journal = J. Androl. | volume = 22 | issue = 6 | pages = 999–1011 | year = 2002 | pmid = 11700865 | doi =  }}
*{{cite journal | author=Shimizu K, Chiba S, Saito T, ''et al.'' |title=Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors. |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 1 |pages= 385-9 |year= 2000 |pmid= 11006133 |doi= 10.1006/bbrc.2000.3469 }}
*{{cite journal |vauthors=Ikeuchi T, Sisodia SS | title = The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage | journal = J. Biol. Chem. | volume = 278 | issue = 10 | pages = 7751–4 | year = 2003 | pmid = 12551931 | doi = 10.1074/jbc.C200711200 }}
*{{cite journal | author=Cereseto A, Tsai S |title=Jagged2 induces cell cycling in confluent fibroblasts susceptible to density-dependent inhibition of cell division. |journal=J. Cell. Physiol. |volume=185 |issue= 3 |pages= 425-31 |year= 2000 |pmid= 11056013 |doi= 10.1002/1097-4652(200012)185:3<425::AID-JCP13>3.0.CO;2-U }}
*{{cite journal |vauthors=Houde C, Li Y, Song L, Barton K, Zhang Q, Godwin J, Nand S, Toor A, Alkan S, Smadja NV, Avet-Loiseau H, Lima CS, Miele L, Coignet LJ | title = Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines | journal = Blood | volume = 104 | issue = 12 | pages = 3697–704 | year = 2004 | pmid = 15292061 | doi = 10.1182/blood-2003-12-4114 }}
*{{cite journal | author=Lindner V, Booth C, Prudovsky I, ''et al.'' |title=Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction. |journal=Am. J. Pathol. |volume=159 |issue= 3 |pages= 875-83 |year= 2001 |pmid= 11549580 |doi= }}
*{{cite journal |vauthors=Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Hayashi T, Kageyama Y, Ishizaka K, ''et al.'' |title=Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes. |journal=J. Androl. |volume=22 |issue= 6 |pages= 999-1011 |year= 2002 |pmid= 11700865 |doi=  }}
*{{cite journal |vauthors=Yao Y, Yao J, Radparvar M, Blazquez-Medela AM, Guihard PJ, Jumabay M, Boström KI | title = Reducing Jagged 1 and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein deficiency. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 110 | issue = 47 | pages = 19071–6 | year = 2013 | pmid = 24191040 | doi = 10.1073/pnas.1310905110 | pmc=3839731}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ikeuchi T, Sisodia SS |title=The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 7751-4 |year= 2003 |pmid= 12551931 |doi= 10.1074/jbc.C200711200 }}
*{{cite journal | author=Houde C, Li Y, Song L, ''et al.'' |title=Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines. |journal=Blood |volume=104 |issue= 12 |pages= 3697-704 |year= 2004 |pmid= 15292061 |doi= 10.1182/blood-2003-12-4114 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Notch signaling pathway}}
{{WikiDoc Sources}}
 
 
{{gene-14-stub}}

Revision as of 02:16, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Jagged-2 is a protein that in humans is encoded by the JAG2 gene.[1][2][3]

Function

The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.[3]

Interactions

JAG2 has been shown to interact with NOTCH2.[4]

MicroRNA miR-1280 has been shown to inhibit JAG2 expression.[5]

References

  1. ↑ Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J (October 1997). "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor". Mol Cell Biol. 17 (10): 6057–67. PMC 232455. PMID 9315665.
  2. ↑ Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L (April 2000). "Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene". Genomics. 63 (1): 133–8. doi:10.1006/geno.1999.6045. PMID 10662552.
  3. ↑ 3.0 3.1 "Entrez Gene: JAG2 jagged 2".
  4. ↑ Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC 88767. PMID 10958687.
  5. ↑ Wang; Remke; Bhat; Wong; Zhou; Ramaswamy; Dubuc; Fonkem; Salem; Zhang; Hsieh; O'Rourke; Wu; Li; Hawkins; Kohane; Wu; Wu; Taylor (February 2015). "A MicroRNA-1280/JAG2 network comprises a novel bilogical target in high-risk medulloblastoma". Oncotarget. 6: 2709–24. doi:10.18632/oncotarget.2779. PMC 4413612. PMID 25576913.

Further reading


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