NEK9: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS (v470))
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Serine/threonine-protein kinase Nek9''' is an [[enzyme]] that in humans is encoded by the ''NEK9'' [[gene]].<ref name="pmid11864968">{{cite journal | vauthors = Holland PM, Milne A, Garka K, Johnson RS, Willis C, Sims JE, Rauch CT, Bird TA, Virca GD | title = Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 18 | pages = 16229–40 | date = May 2002 | pmid = 11864968 | pmc =  | doi = 10.1074/jbc.M108662200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NEK9 NIMA (never in mitosis gene a)- related kinase 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91754| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = NIMA (never in mitosis gene a)- related kinase 9
| HGNCid = 18591
| Symbol = NEK9
| AltSymbols =; DKFZp434D0935; MGC138306; MGC16714; NERCC; NERCC1; Nek8
| OMIM = 609798
| ECnumber = 
| Homologene = 13222
| MGIid = 2387995
| GeneAtlas_image1 = PBB_GE_NEK9_212299_at_tn.png
| GeneAtlas_image2 = PBB_GE_NEK9_214738_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 91754
    | Hs_Ensembl = ENSG00000119638
    | Hs_RefseqProtein = NP_149107
    | Hs_RefseqmRNA = NM_033116
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 74618575
    | Hs_GenLoc_end = 74663483
    | Hs_Uniprot = Q8TD19
    | Mm_EntrezGene = 217718
    | Mm_Ensembl = ENSMUSG00000034290
    | Mm_RefseqmRNA = XM_994284
    | Mm_RefseqProtein = XP_999378
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 86188618
    | Mm_GenLoc_end = 86228449
    | Mm_Uniprot = Q148U2
  }}
}}
'''NIMA (never in mitosis gene a)- related kinase 9''', also known as '''NEK9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NEK9 NIMA (never in mitosis gene a)- related kinase 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91754| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
NEK9 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
* [[NEK6]],<ref name = pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue =  | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref><ref name = pmid12840024>{{cite journal | vauthors = Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J | title = A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases | journal = The Journal of Biological Chemistry | volume = 278 | issue = 37 | pages = 34897–909 | date = Sep 2003 | pmid = 12840024 | doi = 10.1074/jbc.M303663200 }}</ref><ref name = pmid12101123>{{cite journal | vauthors = Roig J, Mikhailov A, Belham C, Avruch J | title = Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression | journal = Genes & Development | volume = 16 | issue = 13 | pages = 1640–58 | date = Jul 2002 | pmid = 12101123 | pmc = 186374 | doi = 10.1101/gad.972202 }}</ref>
| section_title =  
* [[Ran (biology)|RAN]],<ref name = pmid12101123/> and
| summary_text =  
* [[Structure specific recognition protein 1|SSRP1]].<ref name = pmid14660563>{{cite journal | vauthors = Tan BC, Lee SC | title = Nek9, a novel FACT-associated protein, modulates interphase progression | journal = The Journal of Biological Chemistry | volume = 279 | issue = 10 | pages = 9321–30 | date = Mar 2004 | pmid = 14660563 | doi = 10.1074/jbc.M311477200 }}</ref>
}}


==References==
== Model organisms ==
{{reflist|2}}
 
==Further reading==
[[Model organism]]s have been used in the study of NEK9 function. A conditional [[knockout mouse]] line called ''Nek9<sup>tm1a(EUCOMM)Wtsi</sup>'' was generated at the [[Wellcome Trust Sanger Institute]].<ref name="mgp_reference">{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |journal=Acta Ophthalmologica|volume=88 |pages=925–7|doi=10.1111/j.1755-3768.2010.4142.x }}</ref> Male and female animals underwent a standardized [[phenotypic screen]]<ref name="IMPCsearch_ref">{{cite web |url=http://www.mousephenotype.org/data/search?q=Nek9#fq=*:*&facet=gene |title=International Mouse Phenotyping Consortium}}</ref> to determine the effects of deletion.<ref name="pmid21677750">{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref><ref name="pmid23870131">{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | date = Jul 2013 | pmid = 23870131 | pmc = 3717207 | doi = 10.1016/j.cell.2013.06.022 }}</ref> Additional screens performed:  - In-depth immunological phenotyping<ref name="iii_ref">{{cite web |url= http://www.immunophenotyping.org/data/search?keys=Nek9&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}</ref>
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: left;" |
|+ ''Nek9'' knockout mouse phenotype
|-
! Characteristic!! Phenotype
|-
| colspan=2; style="text-align: center;" | All data available at.<ref name="IMPCsearch_ref"/><ref name="iii_ref" />
| Peripheral blood leukocytes 6 Weeks || bgcolor="#488ED3"|Normal
 
|-
| Insulin || bgcolor="#488ED3"|Normal
 
|-
| ''[[Haematology]]'' 6 Weeks || bgcolor="#488ED3"|Normal
 
|-
| Homozygous viability at P14 || bgcolor="#C40000"|Abnormal
 
|-
| [[Recessive]] lethal study || bgcolor="#C40000"|Abnormal
 
|-
| Body weight || bgcolor="#488ED3"|Normal
 
|-
| Neurological assessment || bgcolor="#488ED3"|Normal
 
|-
| Grip strength || bgcolor="#488ED3"|Normal
 
|-
| [[Dysmorphology]] || bgcolor="#488ED3"|Normal
 
|-
| [[Indirect calorimetry]] || bgcolor="#488ED3"|Normal
 
|-
| [[Glucose tolerance test]] || bgcolor="#488ED3"|Normal
 
|-
| [[Auditory brainstem response]] || bgcolor="#488ED3"|Normal
 
|-
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor="#488ED3"|Normal
 
|-
| [[Radiography]] || bgcolor="#488ED3"|Normal
 
|-
| Eye morphology || bgcolor="#488ED3"|Normal
 
|-
| [[Clinical chemistry]] || bgcolor="#488ED3"|Normal
 
|-
| ''[[Haematology]]'' 16 Weeks || bgcolor="#488ED3"|Normal
 
|-
| Peripheral blood leukocytes 16 Weeks || bgcolor="#488ED3"|Normal
 
|-
| Heart weight || bgcolor="#488ED3"|Normal
 
|-
| ''[[Salmonella]]'' infection || bgcolor="#488ED3"|Normal
 
|-
| Cytotoxic T Cell Function || bgcolor="#488ED3"|Normal
 
|-
| Spleen Immunophenotyping || bgcolor="#488ED3"|Normal
 
|-
| Mesenteric Lymph Node Immunophenotyping || bgcolor="#488ED3"|Normal
 
|-
| Bone Marrow Immunophenotyping || bgcolor="#488ED3"|Normal
 
|-
| Epidermal Immune Composition || bgcolor="#488ED3"|Normal
 
|-
|}
{{clear|left}}
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Pelka P, Scimè A, Mandalfino C, Joch M, Abdulla P, Whyte P | title = Adenovirus E1A proteins direct subcellular redistribution of Nek9, a NimA-related kinase | journal = Journal of Cellular Physiology | volume = 212 | issue = 1 | pages = 13–25 | date = Jul 2007 | pmid = 17443675 | doi = 10.1002/jcp.20983 }}
| citations =
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal | author=Pelka P, Scimè A, Mandalfino C, ''et al.'' |title=Adenovirus E1A proteins direct subcellular redistribution of Nek9, a NimA-related kinase. |journal=J. Cell. Physiol. |volume=212 |issue= 1 |pages= 13-25 |year= 2007 |pmid= 17443675 |doi= 10.1002/jcp.20983 }}
* {{cite journal | vauthors = Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H | title = Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry | journal = Molecular & Cellular Proteomics | volume = 6 | issue = 3 | pages = 537–47 | date = Mar 2007 | pmid = 17192257 | doi = 10.1074/mcp.T600062-MCP200 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Wissing J, Jänsch L, Nimtz M, ''et al.'' |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. |journal=Mol. Cell Proteomics |volume=6 |issue= 3 |pages= 537-47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200 }}
* {{cite journal | vauthors = Bowers AJ, Boylan JF | title = Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors | journal = Gene | volume = 328 | issue =  | pages = 135–42 | date = Mar 2004 | pmid = 15019993 | doi = 10.1016/j.gene.2003.12.002 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
* {{cite journal | vauthors = Tan BC, Lee SC | title = Nek9, a novel FACT-associated protein, modulates interphase progression | journal = The Journal of Biological Chemistry | volume = 279 | issue = 10 | pages = 9321–30 | date = Mar 2004 | pmid = 14660563 | doi = 10.1074/jbc.M311477200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J | title = A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases | journal = The Journal of Biological Chemistry | volume = 278 | issue = 37 | pages = 34897–909 | date = Sep 2003 | pmid = 12840024 | doi = 10.1074/jbc.M303663200 }}
*{{cite journal  | author=Bowers AJ, Boylan JF |title=Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors. |journal=Gene |volume=328 |issue=  |pages= 135-42 |year= 2004 |pmid= 15019993 |doi= 10.1016/j.gene.2003.12.002 }}
* {{cite journal | vauthors = Roig J, Mikhailov A, Belham C, Avruch J | title = Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression | journal = Genes & Development | volume = 16 | issue = 13 | pages = 1640–58 | date = Jul 2002 | pmid = 12101123 | pmc = 186374 | doi = 10.1101/gad.972202 }}
*{{cite journal | author=Tan BC, Lee SC |title=Nek9, a novel FACT-associated protein, modulates interphase progression. |journal=J. Biol. Chem. |volume=279 |issue= 10 |pages= 9321-30 |year= 2004 |pmid= 14660563 |doi= 10.1074/jbc.M311477200 }}
* {{cite journal | vauthors = Ohara O, Nagase T, Mitsui G, Kohga H, Kikuno R, Hiraoka S, Takahashi Y, Kitajima S, Saga Y, Koseki H | title = Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method | journal = DNA Research | volume = 9 | issue = 2 | pages = 47–57 | date = Apr 2002 | pmid = 12056414 | doi = 10.1093/dnares/9.2.47 }}
*{{cite journal | author=Belham C, Roig J, Caldwell JA, ''et al.'' |title=A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 34897-909 |year= 2003 |pmid= 12840024 |doi= 10.1074/jbc.M303663200 }}
*{{cite journal | author=Heilig R, Eckenberg R, Petit JL, ''et al.'' |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601-7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Roig J, Mikhailov A, Belham C, Avruch J |title=Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. |journal=Genes Dev. |volume=16 |issue= 13 |pages= 1640-58 |year= 2002 |pmid= 12101123 |doi= 10.1101/gad.972202 }}
*{{cite journal | author=Ohara O, Nagase T, Mitsui G, ''et al.'' |title=Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. |journal=DNA Res. |volume=9 |issue= 2 |pages= 47-57 |year= 2003 |pmid= 12056414 |doi=  }}
*{{cite journal  | author=Holland PM, Milne A, Garka K, ''et al.'' |title=Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 16229-40 |year= 2002 |pmid= 11864968 |doi= 10.1074/jbc.M108662200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
[[Category:Human proteins]]
{{WikiDoc Sources}}
 
 
{{gene-14-stub}}

Latest revision as of 03:09, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein kinase Nek9 is an enzyme that in humans is encoded by the NEK9 gene.[1][2]

Interactions

NEK9 has been shown to interact with:

Model organisms

Model organisms have been used in the study of NEK9 function. A conditional knockout mouse line called Nek9tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[7] Male and female animals underwent a standardized phenotypic screen[8] to determine the effects of deletion.[9][10][11][12] Additional screens performed: - In-depth immunological phenotyping[13]

References

  1. ↑ Holland PM, Milne A, Garka K, Johnson RS, Willis C, Sims JE, Rauch CT, Bird TA, Virca GD (May 2002). "Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2". The Journal of Biological Chemistry. 277 (18): 16229–40. doi:10.1074/jbc.M108662200. PMID 11864968.
  2. ↑ "Entrez Gene: NEK9 NIMA (never in mitosis gene a)- related kinase 9".
  3. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  4. ↑ Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J (Sep 2003). "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases". The Journal of Biological Chemistry. 278 (37): 34897–909. doi:10.1074/jbc.M303663200. PMID 12840024.
  5. ↑ 5.0 5.1 Roig J, Mikhailov A, Belham C, Avruch J (Jul 2002). "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression". Genes & Development. 16 (13): 1640–58. doi:10.1101/gad.972202. PMC 186374. PMID 12101123.
  6. ↑ Tan BC, Lee SC (Mar 2004). "Nek9, a novel FACT-associated protein, modulates interphase progression". The Journal of Biological Chemistry. 279 (10): 9321–30. doi:10.1074/jbc.M311477200. PMID 14660563.
  7. ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  8. ↑ 8.0 8.1 "International Mouse Phenotyping Consortium".
  9. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  10. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  11. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  12. ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  13. ↑ 13.0 13.1 "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=NEK9&oldid=1416563"