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{{ | '''RNA-binding protein Nova-1''' is a [[protein]] that in humans is encoded by the ''NOVA1'' [[gene]].<ref name="pmid8558240">{{cite journal | vauthors = Buckanovich RJ, Yang YY, Darnell RB | title = The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies | journal = J Neurosci | volume = 16 | issue = 3 | pages = 1114–22 |date=Feb 1996 | pmid = 8558240 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NOVA1 neuro-oncological ventral antigen 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4857| accessdate = }}</ref> | ||
}} | |||
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| summary_text = This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct | | summary_text = This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of [[paraneoplastic disease]] antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. [[Alternative splicing|Alternatively spliced]] transcripts encoding distinct [[isoform]]s have been described.<ref name="entrez" /> | ||
}} | }} | ||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Buckanovich RJ, Posner JB, Darnell RB |title=Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system |journal=Neuron |volume=11 |issue= 4 |pages= 657–72 |year= 1993 |pmid= 8398153 |doi=10.1016/0896-6273(93)90077-5 }} | ||
*{{cite journal | vauthors=Buckanovich RJ, Darnell RB |title=The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo |journal=Mol. Cell. Biol. |volume=17 |issue= 6 |pages= 3194–201 |year= 1997 |pmid= 9154818 |doi= | pmc=232172 }} | |||
*{{cite journal | | *{{cite journal |vauthors=Lewis HA, Chen H, Edo C, etal |title=Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains |journal=Structure |volume=7 |issue= 2 |pages= 191–203 |year= 1999 |pmid= 10368286 |doi=10.1016/S0969-2126(99)80025-2 }} | ||
*{{cite journal | *{{cite journal |vauthors=Jensen KB, Dredge BK, Stefani G, etal |title=Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability |journal=Neuron |volume=25 |issue= 2 |pages= 359–71 |year= 2000 |pmid= 10719891 |doi=10.1016/S0896-6273(00)80900-9 }} | ||
*{{cite journal | *{{cite journal |vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S, etal |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491 | pmc=16267 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal | vauthors=Dredge BK, Darnell RB |title=Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer |journal=Mol. Cell. Biol. |volume=23 |issue= 13 |pages= 4687–700 |year= 2003 |pmid= 12808107 |doi=10.1128/MCB.23.13.4687-4700.2003 | pmc=164843 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ule J, Ule A, Spencer J, etal |title=Nova regulates brain-specific splicing to shape the synapse |journal=Nat. Genet. |volume=37 |issue= 8 |pages= 844–52 |year= 2005 |pmid= 16041372 |doi= 10.1038/ng1610 }} | ||
*{{cite journal | *{{cite journal |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }} | ||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=4857}} | |||
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{{ | {{gene-14-stub}} | ||
Latest revision as of 13:11, 5 September 2017
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| Location (UCSC) | n/a | n/a | |||||
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RNA-binding protein Nova-1 is a protein that in humans is encoded by the NOVA1 gene.[1][2]
This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.[2]
References
Further reading
- Buckanovich RJ, Posner JB, Darnell RB (1993). "Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system". Neuron. 11 (4): 657–72. doi:10.1016/0896-6273(93)90077-5. PMID 8398153.
- Buckanovich RJ, Darnell RB (1997). "The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo". Mol. Cell. Biol. 17 (6): 3194–201. PMC 232172. PMID 9154818.
- Lewis HA, Chen H, Edo C, et al. (1999). "Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains". Structure. 7 (2): 191–203. doi:10.1016/S0969-2126(99)80025-2. PMID 10368286.
- Jensen KB, Dredge BK, Stefani G, et al. (2000). "Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability". Neuron. 25 (2): 359–71. doi:10.1016/S0896-6273(00)80900-9. PMID 10719891.
- Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Dredge BK, Darnell RB (2003). "Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer". Mol. Cell. Biol. 23 (13): 4687–700. doi:10.1128/MCB.23.13.4687-4700.2003. PMC 164843. PMID 12808107.
- Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ule J, Ule A, Spencer J, et al. (2005). "Nova regulates brain-specific splicing to shape the synapse". Nat. Genet. 37 (8): 844–52. doi:10.1038/ng1610. PMID 16041372.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
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