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{{Infobox_gene}}
{{PBB_Controls
'''Chondroitin sulfate proteoglycan 4''', also known as '''melanoma-associated chondroitin sulfate proteoglycan''' ('''MCSP''') or '''neuron-glial antigen 2''' ('''NG2'''), is a [[chondroitin sulfate proteoglycan]] that in humans is encoded by the ''CSPG4'' [[gene]].<ref name="pmid8790396">{{cite journal | vauthors = Pluschke G, Vanek M, Evans A, Dittmar T, Schmid P, Itin P, Filardo EJ, Reisfeld RA | title = Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan | journal = Proc Natl Acad Sci U S A | volume = 93 | issue = 18 | pages = 9710–5 |date=Oct 1996 | pmid = 8790396 | pmc = 38494 | doi =10.1073/pnas.93.18.9710  }}</ref><ref name="pmid16407841">{{cite journal | vauthors = Luo W, Wang X, Kageshita T, Wakasugi S, Karpf AR, Ferrone S | title = Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells | journal = Oncogene | volume = 25 | issue = 20 | pages = 2873–84 |date=May 2006 | pmid = 16407841 | pmc = | doi = 10.1038/sj.onc.1209319 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CSPG4 chondroitin sulfate proteoglycan 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1464| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
CSPG4 plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on [[endothelium|endothelial]] [[basement membrane]]s. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human [[melanoma|malignant melanoma]] cells.<ref name="entrez" />
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Chondroitin sulfate proteoglycan 4
| HGNCid = 2466
| Symbol = CSPG4
| AltSymbols =; MSK16; HMW-MAA; MCSP; MCSPG; MEL-CSPG; NG2
| OMIM = 601172
| ECnumber = 
| Homologene = 20445
| MGIid = 2153093
| GeneAtlas_image1 = PBB_GE_CSPG4_204736_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CSPG4_214297_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005082 |text = receptor signaling protein tyrosine phosphatase signaling protein activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008268 |text = receptor signaling protein tyrosine kinase signaling protein activity}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009888 |text = tissue development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1464
    | Hs_Ensembl = ENSG00000173546
    | Hs_RefseqProtein = NP_001888
    | Hs_RefseqmRNA = NM_001897
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 73754019
    | Hs_GenLoc_end = 73792151
    | Hs_Uniprot = Q6UVK1
    | Mm_EntrezGene = 121021
    | Mm_Ensembl = ENSMUSG00000032911
    | Mm_RefseqmRNA = NM_139001
    | Mm_RefseqProtein = NP_620570
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 56663297
    | Mm_GenLoc_end = 56697272
    | Mm_Uniprot = Q09J74
  }}
}}
'''Chondroitin sulfate proteoglycan 4''', also known as '''CSPG4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CSPG4 chondroitin sulfate proteoglycan 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1464| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==See also==
{{PBB_Summary
* [[NG2-glia]]
| section_title =  
| summary_text = A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.<ref name="entrez">{{cite web | title = Entrez Gene: CSPG4 chondroitin sulfate proteoglycan 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1464| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Kirschfink M, Blase L, Engelmann S, Schwartz-Albiez R |title=Secreted chondroitin sulfate proteoglycan of human B cell lines binds to the complement protein C1q and inhibits complex formation of C1. |journal=J. Immunol. |volume=158 |issue= 3 |pages= 1324–31 |year= 1997 |pmid= 9013976 |doi=  }}
| citations =
*{{cite journal  | vauthors=Iida J, Meijne AM, Oegema TR |title=A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5955–62 |year= 1998 |pmid= 9488735 |doi=10.1074/jbc.273.10.5955  |display-authors=etal}}
*{{cite journal  | author=Pluschke G, Vanek M, Evans A, ''et al.'' |title=Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 18 |pages= 9710-5 |year= 1996 |pmid= 8790396 |doi=  }}
*{{cite journal  | vauthors=Eisenmann KM, McCarthy JB, Simpson MA |title=Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. |journal=Nat. Cell Biol. |volume=1 |issue= 8 |pages= 507–13 |year= 2000 |pmid= 10587647 |doi= 10.1038/70302 |display-authors=etal}}
*{{cite journal  | author=Kirschfink M, Blase L, Engelmann S, Schwartz-Albiez R |title=Secreted chondroitin sulfate proteoglycan of human B cell lines binds to the complement protein C1q and inhibits complex formation of C1. |journal=J. Immunol. |volume=158 |issue= 3 |pages= 1324-31 |year= 1997 |pmid= 9013976 |doi= }}
*{{cite journal  | vauthors=Barritt DS, Pearn MT, Zisch AH |title=The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2. |journal=J. Cell. Biochem. |volume=79 |issue= 2 |pages= 213–24 |year= 2000 |pmid= 10967549 |doi=10.1002/1097-4644(20001101)79:2<213::AID-JCB50>3.0.CO;2-G |pmc=3501957|display-authors=etal}}
*{{cite journal  | author=Iida J, Meijne AM, Oegema TR, ''et al.'' |title=A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5955-62 |year= 1998 |pmid= 9488735 |doi= }}
*{{cite journal  | vauthors=Iida J, Pei D, Kang T |title=Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 18786–94 |year= 2001 |pmid= 11278606 |doi= 10.1074/jbc.M010053200 |display-authors=etal}}
*{{cite journal  | author=Eisenmann KM, McCarthy JB, Simpson MA, ''et al.'' |title=Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. |journal=Nat. Cell Biol. |volume=1 |issue= 8 |pages= 507-13 |year= 2000 |pmid= 10587647 |doi= 10.1038/70302 }}
*{{cite journal  | vauthors=Staub E, Hinzmann B, Rosenthal A |title=A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family. |journal=FEBS Lett. |volume=527 |issue= 1-3 |pages= 114–8 |year= 2002 |pmid= 12220645 |doi=10.1016/S0014-5793(02)03195-2  }}
*{{cite journal  | author=Barritt DS, Pearn MT, Zisch AH, ''et al.'' |title=The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2. |journal=J. Cell. Biochem. |volume=79 |issue= 2 |pages= 213-24 |year= 2000 |pmid= 10967549 |doi= }}
*{{cite journal  | vauthors=Stegmüller J, Werner H, Nave KA, Trotter J |title=The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling. |journal=J. Biol. Chem. |volume=278 |issue= 6 |pages= 3590–8 |year= 2003 |pmid= 12458226 |doi= 10.1074/jbc.M210010200 }}
*{{cite journal  | author=Iida J, Pei D, Kang T, ''et al.'' |title=Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 18786-94 |year= 2001 |pmid= 11278606 |doi= 10.1074/jbc.M010053200 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Staub E, Hinzmann B, Rosenthal A |title=A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family. |journal=FEBS Lett. |volume=527 |issue= 1-3 |pages= 114-8 |year= 2002 |pmid= 12220645 |doi=  }}
*{{cite journal  | vauthors=Legg J, Jensen UB, Broad S |title=Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis. |journal=Development |volume=130 |issue= 24 |pages= 6049–63 |year= 2004 |pmid= 14573520 |doi= 10.1242/dev.00837 |display-authors=etal}}
*{{cite journal  | author=Stegmüller J, Werner H, Nave KA, Trotter J |title=The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling. |journal=J. Biol. Chem. |volume=278 |issue= 6 |pages= 3590-8 |year= 2003 |pmid= 12458226 |doi= 10.1074/jbc.M210010200 }}
*{{cite journal  | vauthors=Ghali L, Wong ST, Tidman N |title=Epidermal and hair follicle progenitor cells express melanoma-associated chondroitin sulfate proteoglycan core protein. |journal=J. Invest. Dermatol. |volume=122 |issue= 2 |pages= 433–42 |year= 2004 |pmid= 15009727 |doi= 10.1046/j.0022-202X.2004.22207.x |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Fukushi J, Makagiansar IT, Stallcup WB |title=NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. |journal=Mol. Biol. Cell |volume=15 |issue= 8 |pages= 3580–90 |year= 2005 |pmid= 15181153 |doi= 10.1091/mbc.E04-03-0236  | pmc=491820 }}
*{{cite journal  | author=Legg J, Jensen UB, Broad S, ''et al.'' |title=Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis. |journal=Development |volume=130 |issue= 24 |pages= 6049-63 |year= 2004 |pmid= 14573520 |doi= 10.1242/dev.00837 }}
*{{cite journal  | vauthors=Yang J, Price MA, Neudauer CL |title=Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms. |journal=J. Cell Biol. |volume=165 |issue= 6 |pages= 881–91 |year= 2004 |pmid= 15210734 |doi= 10.1083/jcb.200403174  | pmc=2172406 |display-authors=etal}}
*{{cite journal  | author=Ghali L, Wong ST, Tidman N, ''et al.'' |title=Epidermal and hair follicle progenitor cells express melanoma-associated chondroitin sulfate proteoglycan core protein. |journal=J. Invest. Dermatol. |volume=122 |issue= 2 |pages= 433-42 |year= 2004 |pmid= 15009727 |doi= 10.1046/j.0022-202X.2004.22207.x }}
*{{cite journal  | vauthors=Colland F, Jacq X, Trouplin V |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104  | pmc=442148 |display-authors=etal}}
*{{cite journal  | author=Fukushi J, Makagiansar IT, Stallcup WB |title=NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. |journal=Mol. Biol. Cell |volume=15 |issue= 8 |pages= 3580-90 |year= 2005 |pmid= 15181153 |doi= 10.1091/mbc.E04-03-0236 }}
*{{cite journal  | vauthors=Suzuki Y, Yamashita R, Shirota M |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604  | pmc=515316 |display-authors=etal}}
*{{cite journal  | author=Yang J, Price MA, Neudauer CL, ''et al.'' |title=Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms. |journal=J. Cell Biol. |volume=165 |issue= 6 |pages= 881-91 |year= 2004 |pmid= 15210734 |doi= 10.1083/jcb.200403174 }}
*{{cite journal  | vauthors=Makagiansar IT, Williams S, Dahlin-Huppe K |title=Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility. |journal=J. Biol. Chem. |volume=279 |issue= 53 |pages= 55262–70 |year= 2005 |pmid= 15504744 |doi= 10.1074/jbc.M411045200 |display-authors=etal}}
*{{cite journal  | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | vauthors=Petrini S, Tessa A, Stallcup WB |title=Altered expression of the MCSP/NG2 chondroitin sulfate proteoglycan in collagen VI deficiency. |journal=Mol. Cell. Neurosci. |volume=30 |issue= 3 |pages= 408–17 |year= 2006 |pmid= 16169245 |doi= 10.1016/j.mcn.2005.08.005 |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal  | vauthors=Brekke C, Lundervold A, Enger PØ |title=NG2 expression regulates vascular morphology and function in human brain tumours. |journal=NeuroImage |volume=29 |issue= 3 |pages= 965–76 |year= 2006 |pmid= 16253523 |doi= 10.1016/j.neuroimage.2005.08.026 |display-authors=etal}}
*{{cite journal  | author=Makagiansar IT, Williams S, Dahlin-Huppe K, ''et al.'' |title=Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility. |journal=J. Biol. Chem. |volume=279 |issue= 53 |pages= 55262-70 |year= 2005 |pmid= 15504744 |doi= 10.1074/jbc.M411045200 }}
*{{cite journal  | vauthors=Liu T, Qian WJ, Gritsenko MA |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065  | pmc=1850943 |display-authors=etal}}
*{{cite journal  | author=Petrini S, Tessa A, Stallcup WB, ''et al.'' |title=Altered expression of the MCSP/NG2 chondroitin sulfate proteoglycan in collagen VI deficiency. |journal=Mol. Cell. Neurosci. |volume=30 |issue= 3 |pages= 408-17 |year= 2006 |pmid= 16169245 |doi= 10.1016/j.mcn.2005.08.005 }}
*{{cite journal  | author=Brekke C, Lundervold A, Enger PØ, ''et al.'' |title=NG2 expression regulates vascular morphology and function in human brain tumours. |journal=Neuroimage |volume=29 |issue= 3 |pages= 965-76 |year= 2006 |pmid= 16253523 |doi= 10.1016/j.neuroimage.2005.08.026 }}
*{{cite journal  | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
*{{cite journal | author=Luo W, Wang X, Kageshita T, ''et al.'' |title=Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells. |journal=Oncogene |volume=25 |issue= 20 |pages= 2873-84 |year= 2006 |pmid= 16407841 |doi= 10.1038/sj.onc.1209319 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC gene info|CSPG4}}
{{proteoglycans}}
 
 
{{gene-15-stub}}

Revision as of 10:06, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene.[1][2][3]

CSPG4 plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.[3]

See also

References

  1. ↑ Pluschke G, Vanek M, Evans A, Dittmar T, Schmid P, Itin P, Filardo EJ, Reisfeld RA (Oct 1996). "Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan". Proc Natl Acad Sci U S A. 93 (18): 9710–5. doi:10.1073/pnas.93.18.9710. PMC 38494. PMID 8790396.
  2. ↑ Luo W, Wang X, Kageshita T, Wakasugi S, Karpf AR, Ferrone S (May 2006). "Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells". Oncogene. 25 (20): 2873–84. doi:10.1038/sj.onc.1209319. PMID 16407841.
  3. ↑ 3.0 3.1 "Entrez Gene: CSPG4 chondroitin sulfate proteoglycan 4".

Further reading

External links


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