SCG5: Difference between revisions

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{{Infobox_gene}}
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'''Neuroendocrine protein 7B2''' is a [[protein]] that in humans is encoded by the ''SCG5'' [[gene]].<ref name="pmid8162254">{{cite journal | vauthors = Lloyd RV, Jin L | title = Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas | journal = Diagn Mol Pathol | volume = 3 | issue = 1 | pages = 38–45 |date=May 1994 | pmid = 8162254 | pmc =  | doi =10.1097/00019606-199403010-00007  }}</ref><ref name="pmid12646671">{{cite journal | vauthors = Taupenot L, Harper KL, O'Connor DT | title = The chromogranin-secretogranin family | journal = N Engl J Med | volume = 348 | issue = 12 | pages = 1134–49 |date=Mar 2003 | pmid = 12646671 | pmc =  | doi = 10.1056/NEJMra021405 }}</ref><ref name="pmid3134253">{{cite journal | author = Martens GJ | title = Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2 | journal = FEBS Lett. | volume = 234 | issue = 1 | pages = 160–4 |date=July 1988 | pmid = 3134253 | doi = 10.1016/0014-5793(88)81324-3  | url =  }}</ref>  The [[protein]] expressed by this gene is widely distributed in [[neuroendocrine]] tissues. It functions as a [[chaperone (protein)|chaperone protein]] for the [[proprotein convertase 2|proprotein convertase PC2]] by blocking the aggregation of this protein and is required for the production of an active PC2 enzyme.<ref name="entrez">{{cite web | title = Entrez Gene: SCG5 secretogranin V (7B2 protein)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6447| accessdate = }}</ref><ref name="pmid11439082">{{cite journal | vauthors = Mbikay M, Seidah NG, Chrétien M | title = Neuroendocrine secretory protein 7B2: structure, expression and functions | journal = Biochem. J. | volume = 357 | issue = Pt 2 | pages = 329–42 |date=July 2001 | pmid = 11439082 | pmc = 1221959  | url = http://www.biochemj.org/bj/357/0329/bj3570329.htm | doi = 10.1042/0264-6021:3570329 }}</ref> It is an intrinsically disordered protein that may also function as a chaperone for other proteins in addition to proPC2.
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==References==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = Secretogranin V (7B2 protein)
| HGNCid = 10816
| Symbol = SCG5
| AltSymbols =; 7B2; P7B2; SGNE1; SgV
| OMIM = 173120
| ECnumber = 
| Homologene = 37722
| MGIid = 98289
| GeneAtlas_image1 = PBB_GE_SCG5_203889_at_tn.png
| Function = {{GNF_GO|id=GO:0004857 |text = enzyme inhibitor activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}} {{GNF_GO|id=GO:0008047 |text = enzyme activator activity}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0030141 |text = secretory granule}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0016486 |text = peptide hormone processing}} {{GNF_GO|id=GO:0046883 |text = regulation of hormone secretion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6447
    | Hs_Ensembl = ENSG00000166922
    | Hs_RefseqProtein = NP_003011
    | Hs_RefseqmRNA = NM_003020
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 30721223
    | Hs_GenLoc_end = 30776584
    | Hs_Uniprot = P05408
    | Mm_EntrezGene = 20394
    | Mm_Ensembl = ENSMUSG00000023236
    | Mm_RefseqmRNA = NM_009162
    | Mm_RefseqProtein = NP_033188
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 113577206
    | Mm_GenLoc_end = 113629888
    | Mm_Uniprot = Q3TT51
  }}
}}
'''Secretogranin V (7B2 protein)''', also known as '''SCG5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SCG5 secretogranin V (7B2 protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6447| accessdate = }}</ref>


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{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Mbikay M, Seidah NG, Chrétien M |title=Neuroendocrine secretory protein 7B2: structure, expression and functions. |journal=Biochem. J. |volume=357 |issue= Pt 2 |pages= 329–42 |year= 2001 |pmid= 11439082 |doi=10.1042/0264-6021:3570329  | pmc=1221959  }}
| citations =
*{{cite journal   |vauthors=Paquet L, Lazure C, Seidah NG, etal |title=The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man. |journal=Biochem. Biophys. Res. Commun. |volume=174 |issue= 1 |pages= 156–62 |year= 1991 |pmid= 1989596 |doi=10.1016/0006-291X(91)90499-W }}
*{{cite journal  | author=Mbikay M, Seidah NG, Chrétien M |title=Neuroendocrine secretory protein 7B2: structure, expression and functions. |journal=Biochem. J. |volume=357 |issue= Pt 2 |pages= 329-42 |year= 2001 |pmid= 11439082 |doi= }}
*{{cite journal   |vauthors=Roebroek AJ, Dehaen MR, van Bokhoven A, etal |title=Regional mapping of the human gene encoding the novel pituitary polypeptide 7B2 to chromosome 15q13----q14 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=50 |issue= 2–3 |pages= 158–60 |year= 1989 |pmid= 2776483 |doi=10.1159/000132749 }}
*{{cite journal  | author=Taupenot L, Harper KL, O'Connor DT |title=The chromogranin-secretogranin family. |journal=N. Engl. J. Med. |volume=348 |issue= 12 |pages= 1134-49 |year= 2003 |pmid= 12646671 |doi= 10.1056/NEJMra021405 }}
*{{cite journal   |vauthors=Benjannet S, Marcinkiewicz M, Falgueyret JP, etal |title=Secretory protein 7B2 is associated with pancreatic hormones within normal islets and some experimentally induced tumors |journal=Endocrinology |volume=123 |issue= 2 |pages= 874–84 |year= 1988 |pmid= 2840270 |doi=10.1210/endo-123-2-874 }}
*{{cite journal | author=Paquet L, Lazure C, Seidah NG, ''et al.'' |title=The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man. |journal=Biochem. Biophys. Res. Commun. |volume=174 |issue= 1 |pages= 156-62 |year= 1991 |pmid= 1989596 |doi=  }}
*{{cite journal  | author=Martens GJ |title=Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2 |journal=FEBS Lett. |volume=234 |issue= 1 |pages= 160–4 |year= 1988 |pmid= 3134253 |doi=10.1016/0014-5793(88)81324-3 }}
*{{cite journal | author=Roebroek AJ, Dehaen MR, van Bokhoven A, ''et al.'' |title=Regional mapping of the human gene encoding the novel pituitary polypeptide 7B2 to chromosome 15q13----q14 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=50 |issue= 2-3 |pages= 158-60 |year= 1989 |pmid= 2776483 |doi=  }}
*{{cite journal   |vauthors=Brayton KA, Aimi J, Qiu H, etal |title=Cloning, characterization, and sequence of a porcine cDNA encoding a secreted neuronal and endocrine protein |journal=DNA |volume=7 |issue= 10 |pages= 713–9 |year= 1989 |pmid= 3234177 |doi=10.1089/dna.1988.7.713 }}
*{{cite journal | author=Benjannet S, Marcinkiewicz M, Falgueyret JP, ''et al.'' |title=Secretory protein 7B2 is associated with pancreatic hormones within normal islets and some experimentally induced tumors. |journal=Endocrinology |volume=123 |issue= 2 |pages= 874-84 |year= 1988 |pmid= 2840270 |doi=  }}
*{{cite journal   |vauthors=Marcinkiewicz M, Benjannet S, Falgueyret JP, etal |title=Identification and localization of 7B2 protein in human, porcine, and rat thyroid gland and in human medullary carcinoma |journal=Endocrinology |volume=123 |issue= 2 |pages= 866–73 |year= 1988 |pmid= 3293987 |doi=10.1210/endo-123-2-866 }}
*{{cite journal  | author=Martens GJ |title=Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2. |journal=FEBS Lett. |volume=234 |issue= 1 |pages= 160-4 |year= 1988 |pmid= 3134253 |doi=  }}
*{{cite journal   |vauthors=Marcinkiewicz M, Benjannet S, Cantin M, etal |title=CNS distribution of a novel pituitary protein '7B2': localization in secretory and synaptic vesicles |journal=Brain Res. |volume=380 |issue= 2 |pages= 349–56 |year= 1986 |pmid= 3530373 |doi=10.1016/0006-8993(86)90233-7 }}
*{{cite journal | author=Brayton KA, Aimi J, Qiu H, ''et al.'' |title=Cloning, characterization, and sequence of a porcine cDNA encoding a secreted neuronal and endocrine protein. |journal=DNA |volume=7 |issue= 10 |pages= 713-9 |year= 1989 |pmid= 3234177 |doi=  }}
*{{cite journal   |vauthors=Seidah NG, Hsi KL, De Serres G, etal |title=Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus |journal=Arch. Biochem. Biophys. |volume=225 |issue= 2 |pages= 525–34 |year= 1983 |pmid= 6625600 |doi=10.1016/0003-9861(83)90063-2 }}
*{{cite journal | author=Marcinkiewicz M, Benjannet S, Falgueyret JP, ''et al.'' |title=Identification and localization of 7B2 protein in human, porcine, and rat thyroid gland and in human medullary carcinoma. |journal=Endocrinology |volume=123 |issue= 2 |pages= 866-73 |year= 1988 |pmid= 3293987 |doi=  }}
*{{cite journal  | vauthors=Benjannet S, Savaria D, Chrétien M, Seidah NG |title=7B2 is a specific intracellular binding protein of the prohormone convertase PC2 |journal=J. Neurochem. |volume=64 |issue= 5 |pages= 2303–11 |year= 1995 |pmid= 7722516 |doi=10.1046/j.1471-4159.1995.64052303.x }}
*{{cite journal | author=Marcinkiewicz M, Benjannet S, Cantin M, ''et al.'' |title=CNS distribution of a novel pituitary protein '7B2': localization in secretory and synaptic vesicles. |journal=Brain Res. |volume=380 |issue= 2 |pages= 349-56 |year= 1986 |pmid= 3530373 |doi=  }}
*{{cite journal  | vauthors=Braks JA, Martens GJ |title=7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway |journal=Cell |volume=78 |issue= 2 |pages= 263–73 |year= 1994 |pmid= 7913882 |doi=10.1016/0092-8674(94)90296-8 }}
*{{cite journal | author=Seidah NG, Hsi KL, De Serres G, ''et al.'' |title=Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus. |journal=Arch. Biochem. Biophys. |volume=225 |issue= 2 |pages= 525-34 |year= 1983 |pmid= 6625600 |doi=  }}
*{{cite journal  | vauthors=Braks JA, Broers CA, Danger JM, Martens GJ |title=Structural organization of the gene encoding the neuroendocrine chaperone 7B2 |journal=Eur. J. Biochem. |volume=236 |issue= 1 |pages= 60–7 |year= 1996 |pmid= 8617287 |doi=10.1111/j.1432-1033.1996.00060.x }}
*{{cite journal  | author=Benjannet S, Savaria D, Chrétien M, Seidah NG |title=7B2 is a specific intracellular binding protein of the prohormone convertase PC2. |journal=J. Neurochem. |volume=64 |issue= 5 |pages= 2303-11 |year= 1995 |pmid= 7722516 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Braks JA, Martens GJ |title=7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway. |journal=Cell |volume=78 |issue= 2 |pages= 263-73 |year= 1994 |pmid= 7913882 |doi= }}
*{{cite journal   |vauthors=Bourdeau I, Antonini SR, Lacroix A, etal |title=Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators |journal=Oncogene |volume=23 |issue= 8 |pages= 1575–85 |year= 2004 |pmid= 14767469 |doi= 10.1038/sj.onc.1207277 }}
*{{cite journal  | author=Lloyd RV, Jin L |title=Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas. |journal=Diagn. Mol. Pathol. |volume=3 |issue= 1 |pages= 38-45 |year= 1994 |pmid= 8162254 |doi= }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Braks JA, Broers CA, Danger JM, Martens GJ |title=Structural organization of the gene encoding the neuroendocrine chaperone 7B2. |journal=Eur. J. Biochem. |volume=236 |issue= 1 |pages= 60-7 |year= 1996 |pmid= 8617287 |doi=  }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Dasgupta I, Sanglas L, Enghild JJ, Lindberg I  |title=The neuroendocrine protein 7B2 is intrinsically disordered. |journal=Biochemistry  |volume=51 |issue= 38 |pages= 7456–64 |year=2012 |pmid=22947085 |doi= 10.1021/bi300871k |pmc=3457758}}
*{{cite journal | author=Bourdeau I, Antonini SR, Lacroix A, ''et al.'' |title=Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators. |journal=Oncogene |volume=23 |issue= 8 |pages= 1575-85 |year= 2004 |pmid= 14767469 |doi= 10.1038/sj.onc.1207277 }}
*{{cite journal  | vauthors=Helwig M, Hoshino A, Berridge C, Lee SN, Lorenzen N, Otzen DE, Eriksen JL, Lindberg I|title=The  neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins.. |journal=J Biol Chem |volume=288 |issue=2 |pages= 1114–247  |year=2013 |pmid=23172224  |doi= 10.1074/jbc.M112.417071 |pmc=3542996}}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Nerve tissue protein}}
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{{gene-15-stub}}

Latest revision as of 05:58, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neuroendocrine protein 7B2 is a protein that in humans is encoded by the SCG5 gene.[1][2][3] The protein expressed by this gene is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 by blocking the aggregation of this protein and is required for the production of an active PC2 enzyme.[4][5] It is an intrinsically disordered protein that may also function as a chaperone for other proteins in addition to proPC2.

References

  1. ↑ Lloyd RV, Jin L (May 1994). "Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas". Diagn Mol Pathol. 3 (1): 38–45. doi:10.1097/00019606-199403010-00007. PMID 8162254.
  2. ↑ Taupenot L, Harper KL, O'Connor DT (Mar 2003). "The chromogranin-secretogranin family". N Engl J Med. 348 (12): 1134–49. doi:10.1056/NEJMra021405. PMID 12646671.
  3. ↑ Martens GJ (July 1988). "Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2". FEBS Lett. 234 (1): 160–4. doi:10.1016/0014-5793(88)81324-3. PMID 3134253.
  4. ↑ "Entrez Gene: SCG5 secretogranin V (7B2 protein)".
  5. ↑ Mbikay M, Seidah NG, Chrétien M (July 2001). "Neuroendocrine secretory protein 7B2: structure, expression and functions". Biochem. J. 357 (Pt 2): 329–42. doi:10.1042/0264-6021:3570329. PMC 1221959. PMID 11439082.

Further reading


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