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{{Infobox_gene}}
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'''Probable E3 ubiquitin-protein ligase HERC1''' is an [[enzyme]] that in humans is encoded by the ''HERC1'' [[gene]].<ref name="pmid8861955">{{cite journal |vauthors=Rosa JL, Casaroli-Marano RP, Buckler AJ, Vilaro S, Barbacid M | title = p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins | journal = EMBO J | volume = 15 | issue = 16 | pages = 4262–73 |date=Dec 1996 | pmid = 8861955 | pmc = 452152 | doi =  }}</ref><ref name="pmid9233772">{{cite journal |vauthors=Rosa JL, Barbacid M | title = A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70 | journal = Oncogene | volume = 15 | issue = 1 | pages = 1–6 |date=Aug 1997 | pmid = 9233772 | pmc =  | doi = 10.1038/sj.onc.1201170 }}</ref><ref name="entrez"/>
| image =
| image_source =
| PDB =
| Name = Hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
| HGNCid = 4867
| Symbol = HERC1
| AltSymbols =; p532; p619
| OMIM = 605109
| ECnumber =
| Homologene = 31207
| MGIid = 2384589
| GeneAtlas_image1 = PBB_GE_HERC1_218306_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0005086 |text = ARF guanyl-nucleotide exchange factor activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}}
| Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8925
    | Hs_Ensembl = ENSG00000103657
    | Hs_RefseqProtein = NP_003913
    | Hs_RefseqmRNA = NM_003922
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 61687871
    | Hs_GenLoc_end = 61913143
    | Hs_Uniprot =
    | Mm_EntrezGene = 235439
    | Mm_Ensembl = ENSMUSG00000038664
    | Mm_RefseqmRNA = XM_899481
    | Mm_RefseqProtein = XP_904574
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 66148530
    | Mm_GenLoc_end = 66306327
    | Mm_Uniprot = 
  }}
}}
'''Hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1''', also known as '''HERC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HERC1 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8925| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein is thought to be involved in membrane transport processes<ref name="entrez">{{cite web | title = Entrez Gene: HERC1 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8925| accessdate = }}</ref>
| summary_text = The protein encoded by this gene stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein is thought to be involved in membrane transport processes<ref name="entrez">{{cite web | title = Entrez Gene: HERC1 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8925| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal  | author=Garcia-Gonzalo FR, Bartrons R, Ventura F, Rosa JL |title=Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins. |journal=FEBS Lett. |volume=579 |issue= 2 |pages= 343-8 |year= 2005 |pmid= 15642342 |doi= 10.1016/j.febslet.2004.11.095 }}
*{{cite journal  |vauthors=Garcia-Gonzalo FR, Bartrons R, Ventura F, Rosa JL |title=Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins |journal=FEBS Lett. |volume=579 |issue= 2 |pages= 343–8 |year= 2005 |pmid= 15642342 |doi= 10.1016/j.febslet.2004.11.095 }}
*{{cite journal | author=Garcia-Gonzalo FR, Muñoz P, González E, ''et al.'' |title=The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells. |journal=FEBS Lett. |volume=559 |issue= 1-3 |pages= 77-83 |year= 2004 |pmid= 14960311 |doi= 10.1016/S0014-5793(04)00030-4 }}
*{{cite journal   |vauthors=Garcia-Gonzalo FR, Muñoz P, González E, etal |title=The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells |journal=FEBS Lett. |volume=559 |issue= 1–3 |pages= 77–83 |year= 2004 |pmid= 14960311 |doi= 10.1016/S0014-5793(04)00030-4 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Garcia-Gonzalo FR, Cruz C, Muñoz P, ''et al.'' |title=Interaction between HERC1 and M2-type pyruvate kinase. |journal=FEBS Lett. |volume=539 |issue= 1-3 |pages= 78-84 |year= 2003 |pmid= 12650930 |doi=  }}
*{{cite journal   |vauthors=Garcia-Gonzalo FR, Cruz C, Muñoz P, etal |title=Interaction between HERC1 and M2-type pyruvate kinase |journal=FEBS Lett. |volume=539 |issue= 1–3 |pages= 78–84 |year= 2003 |pmid= 12650930 |doi=10.1016/S0014-5793(03)00205-9 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Cruz C, Paladugu A, Ventura F, ''et al.'' |title=Assignment of the human P532 gene (HERC1) to chromosome 15q22 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=86 |issue= 1 |pages= 68-9 |year= 1999 |pmid= 10516438 |doi=  }}
*{{cite journal   |vauthors=Cruz C, Paladugu A, Ventura F, etal |title=Assignment of the human P532 gene (HERC1) to chromosome 15q22 by fluorescence in situ hybridization |journal=Cytogenet. Cell Genet. |volume=86 |issue= 1 |pages= 68–9 |year= 1999 |pmid= 10516438 |doi=10.1159/000015414 }}
*{{cite journal | author=Ji Y, Walkowicz MJ, Buiting K, ''et al.'' |title=The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities. |journal=Hum. Mol. Genet. |volume=8 |issue= 3 |pages= 533-42 |year= 1999 |pmid= 9949213 |doi=  }}
*{{cite journal   |vauthors=Ji Y, Walkowicz MJ, Buiting K, etal |title=The ancestral gene for transcribed, low-copy repeats in the [[Prader–Willi syndrome|Prader-Willi]]/[[Angelman syndrome|Angelman]] region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities |journal=Hum. Mol. Genet. |volume=8 |issue= 3 |pages= 533–42 |year= 1999 |pmid= 9949213 |doi=10.1093/hmg/8.3.533  }}
*{{cite journal  | author=Rosa JL, Barbacid M |title=A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70. |journal=Oncogene |volume=15 |issue= 1 |pages= 1-6 |year= 1997 |pmid= 9233772 |doi= 10.1038/sj.onc.1201170 }}
*{{cite journal   |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal   |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | author=Rosa JL, Casaroli-Marano RP, Buckler AJ, ''et al.'' |title=p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins. |journal=EMBO J. |volume=15 |issue= 16 |pages= 4262-73 |year= 1996 |pmid= 8861955 |doi= }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 13:33, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Probable E3 ubiquitin-protein ligase HERC1 is an enzyme that in humans is encoded by the HERC1 gene.[1][2][3]

The protein encoded by this gene stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein is thought to be involved in membrane transport processes[3]

References

  1. ↑ Rosa JL, Casaroli-Marano RP, Buckler AJ, Vilaro S, Barbacid M (Dec 1996). "p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins". EMBO J. 15 (16): 4262–73. PMC 452152. PMID 8861955.
  2. ↑ Rosa JL, Barbacid M (Aug 1997). "A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70". Oncogene. 15 (1): 1–6. doi:10.1038/sj.onc.1201170. PMID 9233772.
  3. ↑ 3.0 3.1 "Entrez Gene: HERC1 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1".

Further reading



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