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{{Underlinked|date=May 2016}}
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{{Infobox_gene}}
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'''Cellular retinoic acid-binding protein 1''' is a [[protein]] that in humans is encoded by the ''CRABP1'' [[gene]].<ref name="pmid9154115">{{cite journal | vauthors = Flagiello D, Apiou F, Gibaud A, Poupon MF, Dutrillaux B, Malfoy B | title = Assignment of the genes for cellular retinoic acid binding protein 1 (CRABP1) and 2 (CRABP2) to human chromosome band 15q24 and 1q21.3, respectively, by in situ hybridization | journal = Cytogenet Cell Genet | volume = 76 | issue = 1–2 | pages = 17–8 |date=Jun 1997 | pmid = 9154115 | pmc = | doi =10.1159/000134502  }}</ref><ref name="entrez"/>
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{{GNF_Protein_box
| image = PBB_Protein_CRABP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cbi.
| PDB = {{PDB2|1cbi}}, {{PDB2|1cbr}}, {{PDB2|2cbr}}
| Name = Cellular retinoic acid binding protein 1
| HGNCid = 2338
| Symbol = CRABP1
| AltSymbols =; CRABP; CRABP-I; CRABPI; RBP5
| OMIM = 180230
| ECnumber = 
| Homologene = 3222
| MGIid = 88490
| GeneAtlas_image1 = PBB_GE_CRABP1_205350_at_tn.png
| Function = {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0016918 |text = retinal binding}}  
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1381
    | Hs_Ensembl = ENSG00000166426
    | Hs_RefseqProtein = NP_004369
    | Hs_RefseqmRNA = NM_004378
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 76419744
    | Hs_GenLoc_end = 76427620
    | Hs_Uniprot = P29762
    | Mm_EntrezGene = 12903
    | Mm_Ensembl = ENSMUSG00000032291
    | Mm_RefseqmRNA = NM_013496
    | Mm_RefseqProtein = NP_038524
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 54562944
    | Mm_GenLoc_end = 54571246
    | Mm_Uniprot = Q6P071
  }}
}}
'''Cellular retinoic acid binding protein 1''', also known as '''CRABP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CRABP1 cellular retinoic acid binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1381| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = A number of specific carrier proteins for members of the vitamin A family have been discovered. Cellular retinoic acid-binding protein is assumed to play an important role in retinoic acid-mediated differentiation and proliferation processes.  CRABP1 is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid. CRABP1 is constitutively expressed and is believed to have different functions in the cell than the related CRABP2.<ref name="entrez">{{cite web | title = Entrez Gene: CRABP1 cellular retinoic acid binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1381| accessdate = }}</ref>
| summary_text = A number of specific carrier proteins for members of the vitamin A family have been discovered. Cellular retinoic acid-binding protein is assumed to play an important role in retinoic acid-mediated differentiation and proliferation processes.  CRABP1 is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid. CRABP1 is constitutively expressed and is believed to have different functions in the cell than the related CRABP2.<ref name="entrez">{{cite web | title = Entrez Gene: CRABP1 cellular retinoic acid binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1381| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CRABP1}}
* {{UCSC gene info|RBP5}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Eller MS, Oleksiak MF, McQuaid TJ, ''et al.'' |title=The molecular cloning and expression of two CRABP cDNAs from human skin. |journal=Exp. Cell Res. |volume=198 |issue= 2 |pages= 328-36 |year= 1992 |pmid= 1309505 |doi=  }}
*{{cite journal  | vauthors=Eller MS, Oleksiak MF, McQuaid TJ |title=The molecular cloning and expression of two CRABP cDNAs from human skin |journal=Exp. Cell Res. |volume=198 |issue= 2 |pages= 328–36 |year= 1992 |pmid= 1309505 |doi=10.1016/0014-4827(92)90387-N |display-authors=etal}}
*{{cite journal  | author=Aström A, Tavakkol A, Pettersson U, ''et al.'' |title=Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. |journal=J. Biol. Chem. |volume=266 |issue= 26 |pages= 17662-6 |year= 1991 |pmid= 1654334 |doi=  }}
*{{cite journal  | vauthors=Aström A, Tavakkol A, Pettersson U |title=Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro |journal=J. Biol. Chem. |volume=266 |issue= 26 |pages= 17662–6 |year= 1991 |pmid= 1654334 |doi=  |display-authors=etal}}
*{{cite journal  | author=Ong DE |title=Cellular retinoid-binding proteins. |journal=Archives of dermatology |volume=123 |issue= 12 |pages= 1693-1695a |year= 1987 |pmid= 2825608 |doi=  }}
*{{cite journal  | author=Ong DE |title=Cellular retinoid-binding proteins |journal=Archives of dermatology |volume=123 |issue= 12 |pages= 1693–1695a |year= 1987 |pmid= 2825608 |doi=10.1001/archderm.123.12.1693 }}
*{{cite journal  | author=Wang L, Li Y, Yan H |title=Structure-function relationships of cellular retinoic acid-binding proteins. Quantitative analysis of the ligand binding properties of the wild-type proteins and site-directed mutants. |journal=J. Biol. Chem. |volume=272 |issue= 3 |pages= 1541-7 |year= 1997 |pmid= 8999826 |doi=  }}
*{{cite journal  | vauthors=Wang L, Li Y, Yan H |title=Structure-function relationships of cellular retinoic acid-binding proteins. Quantitative analysis of the ligand binding properties of the wild-type proteins and site-directed mutants |journal=J. Biol. Chem. |volume=272 |issue= 3 |pages= 1541–7 |year= 1997 |pmid= 8999826 |doi=10.1074/jbc.272.3.1541 }}
*{{cite journal  | author=Liu W, Hellman P, Li Q, ''et al.'' |title=Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells. |journal=Biochem. Biophys. Res. Commun. |volume=229 |issue= 3 |pages= 922-9 |year= 1997 |pmid= 9005841 |doi= 10.1006/bbrc.1996.1903 }}
*{{cite journal  | vauthors=Liu W, Hellman P, Li Q |title=Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells |journal=Biochem. Biophys. Res. Commun. |volume=229 |issue= 3 |pages= 922–9 |year= 1997 |pmid= 9005841 |doi= 10.1006/bbrc.1996.1903 |display-authors=etal}}
*{{cite journal  | author=Flagiello D, Apiou F, Gibaud A, ''et al.'' |title=Assignment of the genes for cellular retinoic acid binding protein 1 (CRABP1) and 2 (CRABP2) to human chromosome band 15q24 and 1q21.3, respectively, by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=76 |issue= 1-2 |pages= 17-8 |year= 1997 |pmid= 9154115 |doi= }}
*{{cite journal  | vauthors=Kreutz M, Fritsche J, Andreesen R, Krause SW |title=Regulation of cellular retinoic acid binding protein (CRABP II) during human monocyte differentiation in vitro |journal=Biochem. Biophys. Res. Commun. |volume=248 |issue= 3 |pages= 830–4 |year= 1998 |pmid= 9704013 |doi= 10.1006/bbrc.1998.9058 }}
*{{cite journal  | author=Kreutz M, Fritsche J, Andreesen R, Krause SW |title=Regulation of cellular retinoic acid binding protein (CRABP II) during human monocyte differentiation in vitro. |journal=Biochem. Biophys. Res. Commun. |volume=248 |issue= 3 |pages= 830-4 |year= 1998 |pmid= 9704013 |doi= 10.1006/bbrc.1998.9058 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Huang Y, de la Chapelle A, Pellegata NS |title=Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma |journal=Int. J. Cancer |volume=104 |issue= 6 |pages= 735–44 |year= 2003 |pmid= 12640681 |doi= 10.1002/ijc.11006 }}
*{{cite journal  | author=Huang Y, de la Chapelle A, Pellegata NS |title=Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma. |journal=Int. J. Cancer |volume=104 |issue= 6 |pages= 735-44 |year= 2003 |pmid= 12640681 |doi= 10.1002/ijc.11006 }}
*{{cite journal  | vauthors=Kim SK, Yoo JI, Cho BK |title=Elevation of CRABP-I in the cerebrospinal fluid of patients with Moyamoya disease |journal=Stroke |volume=34 |issue= 12 |pages= 2835–41 |year= 2004 |pmid= 14605320 |doi= 10.1161/01.STR.0000100159.43123.D7 |display-authors=etal}}
*{{cite journal  | author=Kim SK, Yoo JI, Cho BK, ''et al.'' |title=Elevation of CRABP-I in the cerebrospinal fluid of patients with Moyamoya disease. |journal=Stroke |volume=34 |issue= 12 |pages= 2835-41 |year= 2004 |pmid= 14605320 |doi= 10.1161/01.STR.0000100159.43123.D7 }}
*{{cite journal  | vauthors=Blaese MA, Santo-Hoeltje L, Rodemann HP |title=CRABP I expression and the mediation of the sensitivity of human tumour cells to retinoic acid and irradiation |journal=Int. J. Radiat. Biol. |volume=79 |issue= 12 |pages= 981–91 |year= 2004 |pmid= 14713576 |doi= 10.1080/09553000310001632949 }}
*{{cite journal  | author=Blaese MA, Santo-Hoeltje L, Rodemann HP |title=CRABP I expression and the mediation of the sensitivity of human tumour cells to retinoic acid and irradiation. |journal=Int. J. Radiat. Biol. |volume=79 |issue= 12 |pages= 981-91 |year= 2004 |pmid= 14713576 |doi= 10.1080/09553000310001632949 }}
*{{cite journal  | vauthors=Won JY, Nam EC, Yoo SJ |title=The effect of cellular retinoic acid binding protein-I expression on the CYP26-mediated catabolism of all-trans retinoic acid and cell proliferation in head and neck squamous cell carcinoma |journal=Metab. Clin. Exp. |volume=53 |issue= 8 |pages= 1007–12 |year= 2004 |pmid= 15281009 |doi=10.1016/j.metabol.2003.12.015  |display-authors=etal}}
*{{cite journal  | author=Won JY, Nam EC, Yoo SJ, ''et al.'' |title=The effect of cellular retinoic acid binding protein-I expression on the CYP26-mediated catabolism of all-trans retinoic acid and cell proliferation in head and neck squamous cell carcinoma. |journal=Metab. Clin. Exp. |volume=53 |issue= 8 |pages= 1007-12 |year= 2004 |pmid= 15281009 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Ahn J, Chung KS, Kim DU |title=Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus |journal=J. Biochem. Mol. Biol. |volume=37 |issue= 6 |pages= 741–8 |year= 2005 |pmid= 15607035 |doi= |display-authors=etal}}
*{{cite journal  | author=Ahn J, Chung KS, Kim DU, ''et al.'' |title=Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus. |journal=J. Biochem. Mol. Biol. |volume=37 |issue= 6 |pages= 741-8 |year= 2005 |pmid= 15607035 |doi= }}
*{{cite journal  | vauthors=Pfoertner S, Goelden U, Hansen W |title=Cellular retinoic acid binding protein I: expression and functional influence in renal cell carcinoma |journal=Tumour Biol. |volume=26 |issue= 6 |pages= 313–23 |year= 2005 |pmid= 16254461 |doi= 10.1159/000089262 |display-authors=etal}}
*{{cite journal  | author=Pfoertner S, Goelden U, Hansen W, ''et al.'' |title=Cellular retinoic acid binding protein I: expression and functional influence in renal cell carcinoma. |journal=Tumour Biol. |volume=26 |issue= 6 |pages= 313-23 |year= 2005 |pmid= 16254461 |doi= 10.1159/000089262 }}
*{{cite journal  | vauthors=Lind GE, Kleivi K, Meling GI |title=ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis |journal=Cell. Oncol. |volume=28 |issue= 5–6 |pages= 259–72 |year= 2007 |pmid= 17167179 |doi= |display-authors=etal}}
*{{cite journal  | author=Lind GE, Kleivi K, Meling GI, ''et al.'' |title=ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis. |journal=Cell. Oncol. |volume=28 |issue= 5-6 |pages= 259-72 |year= 2007 |pmid= 17167179 |doi= }}
*{{cite journal  | vauthors=Tanaka K, Imoto I, Inoue J |title=Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma |journal=Oncogene |volume=26 |issue= 44 |pages= 6456–68 |year= 2007 |pmid= 17438526 |doi= 10.1038/sj.onc.1210459 |display-authors=etal}}
*{{cite journal  | author=Tanaka K, Imoto I, Inoue J, ''et al.'' |title=Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma. |journal=Oncogene |volume=26 |issue= 44 |pages= 6456-68 |year= 2007 |pmid= 17438526 |doi= 10.1038/sj.onc.1210459 }}
*{{cite journal  | vauthors=Wu Q, Lothe RA, Ahlquist T |title=DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets |journal=Mol. Cancer |volume=6 |issue= |pages= 45 |year= 2007 |pmid= 17623056 |doi= 10.1186/1476-4598-6-45 | pmc=1964763 |display-authors=etal}}
*{{cite journal  | author=Wu Q, Lothe RA, Ahlquist T, ''et al.'' |title=DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets. |journal=Mol. Cancer |volume=6 |issue=  |pages= 45 |year= 2007 |pmid= 17623056 |doi= 10.1186/1476-4598-6-45 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=1381}}
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{{protein-stub}}
[[Category:Lipocalins]]
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Revision as of 10:01, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cellular retinoic acid-binding protein 1 is a protein that in humans is encoded by the CRABP1 gene.[1][2]

A number of specific carrier proteins for members of the vitamin A family have been discovered. Cellular retinoic acid-binding protein is assumed to play an important role in retinoic acid-mediated differentiation and proliferation processes. CRABP1 is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid. CRABP1 is constitutively expressed and is believed to have different functions in the cell than the related CRABP2.[2]

References

  1. Flagiello D, Apiou F, Gibaud A, Poupon MF, Dutrillaux B, Malfoy B (Jun 1997). "Assignment of the genes for cellular retinoic acid binding protein 1 (CRABP1) and 2 (CRABP2) to human chromosome band 15q24 and 1q21.3, respectively, by in situ hybridization". Cytogenet Cell Genet. 76 (1–2): 17–8. doi:10.1159/000134502. PMID 9154115.
  2. 2.0 2.1 "Entrez Gene: CRABP1 cellular retinoic acid binding protein 1".

External links

Further reading