NEO1: Difference between revisions

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Identifiers
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External IDs	GeneCards: [1]
Orthologs
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Latest revision as of 12:50, 5 September 2017

Neogenin is a protein that in humans is encoded by the NEO1 gene.^[1]^[2]

Interactions

NEO1 has been shown to interact with PTK2.^[3]

References

↑ Meyerhardt JA, Look AT, Bigner SH, Fearon ER (Apr 1997). "Identification and characterization of neogenin, a DCC-related gene". Oncogene. 14 (10): 1129–36. doi:10.1038/sj.onc.1200935. PMID 9121761.
↑ "Entrez Gene: NEO1 neogenin homolog 1 (chicken)".
↑ Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC (Nov 2004). "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204–12. doi:10.1038/nn1330. PMID 15494733.

Vielmetter J, Kayyem JF, Roman JM, Dreyer WJ (1995). "Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer". J. Cell Biol. 127 (6 Pt 2): 2009–20. doi:10.1083/jcb.127.6.2009. PMC 2120299. PMID 7806578.
Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS, Culotti JG, Tessier-Lavigne M (1996). "Deleted in Colorectal Cancer (DCC) encodes a netrin receptor". Cell. 87 (2): 175–85. doi:10.1016/S0092-8674(00)81336-7. PMID 8861902.
Vielmetter J, Chen XN, Miskevich F, Lane RP, Yamakawa K, Korenberg JR, Dreyer WJ (1997). "Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23". Genomics. 41 (3): 414–21. doi:10.1006/geno.1997.4688. PMID 9169140.
Wang H, Copeland NG, Gilbert DJ, Jenkins NA, Tessier-Lavigne M (1999). "Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors". J. Neurosci. 19 (12): 4938–47. PMID 10366627.
Srinivasan K, Strickland P, Valdes A, Shin GC, Hinck L (2003). "Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis". Dev. Cell. 4 (3): 371–82. doi:10.1016/S1534-5807(03)00054-6. PMID 12636918.
Ho SM, Lau KM, Mok SC, Syed V (2003). "Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells". Oncogene. 22 (27): 4243–56. doi:10.1038/sj.onc.1206437. PMID 12833147.
Matsunaga E, Tauszig-Delamasure S, Monnier PP, Mueller BK, Strittmatter SM, Mehlen P, Chédotal A (2004). "RGM and its receptor neogenin regulate neuronal survival". Nat. Cell Biol. 6 (8): 749–55. doi:10.1038/ncb1157. PMID 15258591.
Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC (2005). "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204–12. doi:10.1038/nn1330. PMID 15494733.
Lee JE, Kim HJ, Bae JY, Kim SW, Park JS, Shin HJ, Han W, Kim SW, Kang KS, Noh DY (2006). "Neogenin expression may be inversely correlated to the tumorigenicity of human breast cancer". BMC Cancer. 5: 154. doi:10.1186/1471-2407-5-154. PMC 1322231. PMID 16324219.
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[pmid9121761-1] Meyerhardt JA, Look AT, Bigner SH, Fearon ER (Apr 1997). "Identification and characterization of neogenin, a DCC-related gene". Oncogene. 14 (10): 1129–36. doi:10.1038/sj.onc.1200935. PMID 9121761.

[entrez-2] "Entrez Gene: NEO1 neogenin homolog 1 (chicken)".

[pmid15494733-3] Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC (Nov 2004). "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204–12. doi:10.1038/nn1330. PMID 15494733.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Neogenin''' is a [[protein]] that in humans is encoded by the ''NEO1'' [[gene]].<ref name="pmid9121761">{{cite journal | vauthors = Meyerhardt JA, Look AT, Bigner SH, Fearon ER | title = Identification and characterization of neogenin, a DCC-related gene | journal = Oncogene | volume = 14 | issue = 10 | pages = 1129–36 | date = Apr 1997 | pmid = 9121761 | pmc =  | doi = 10.1038/sj.onc.1200935 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NEO1 neogenin homolog 1 (chicken)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4756| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Interactions ==
-{{GNF_Protein_box
- | image = PBB_Protein_NEO1_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1x5f.
- | PDB = {{PDB2|1x5f}}, {{PDB2|1x5g}}, {{PDB2|1x5h}}, {{PDB2|1x5i}}, {{PDB2|1x5j}}, {{PDB2|1x5k}}
- | Name = Neogenin homolog 1 (chicken)
- | HGNCid = 7754
- | Symbol = NEO1
- | AltSymbols =; HsT17534; NGN
- | OMIM = 601907
- | ECnumber =
- | Homologene = 1870
- | MGIid = 1097159
- | GeneAtlas_image1 = PBB_GE_NEO1_204321_at_tn.png
- | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}} {{GNF_GO|id=GO:0045296 |text = cadherin binding}}
- | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007520 |text = myoblast fusion}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 4756
-    | Hs_Ensembl = ENSG00000067141
-    | Hs_RefseqProtein = NP_002490
-    | Hs_RefseqmRNA = NM_002499
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 15
-    | Hs_GenLoc_start = 71131928
-    | Hs_GenLoc_end = 71384592
-    | Hs_Uniprot = Q92859
-    | Mm_EntrezGene = 18007
-    | Mm_Ensembl = ENSMUSG00000032340
-    | Mm_RefseqmRNA = NM_001042752
-    | Mm_RefseqProtein = NP_001036217
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 9
-    | Mm_GenLoc_start = 58674694
-    | Mm_GenLoc_end = 58834562
-    | Mm_Uniprot = Q7TQG5
-  }}
-}}
-'''Neogenin homolog 1 (chicken)''', also known as '''NEO1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NEO1 neogenin homolog 1 (chicken)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4756| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+NEO1 has been shown to [[Protein-protein interaction|interact]] with [[PTK2]].<ref name=pmid15494733>{{cite journal | vauthors = Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC | title = Focal adhesion kinase in netrin-1 signaling | journal = Nat. Neurosci. | volume = 7 | issue = 11 | pages = 1204–12 | date = Nov 2004 | pmid = 15494733 | doi = 10.1038/nn1330 }}</ref>
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Vielmetter J, Kayyem JF, Roman JM, Dreyer WJ | title = Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer. | journal = J. Cell Biol. | volume = 127 | issue = 6 Pt 2 | pages = 2009–20 | year = 1995 | pmid = 7806578 | pmc = 2120299 | doi = 10.1083/jcb.127.6.2009 }}
-| citations =
+* {{cite journal | vauthors = Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS, Culotti JG, Tessier-Lavigne M | title = Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. | journal = Cell | volume = 87 | issue = 2 | pages = 175–85 | year = 1996 | pmid = 8861902 | doi = 10.1016/S0092-8674(00)81336-7 }}
-*{{cite journal  | author=Vielmetter J, Kayyem JF, Roman JM, Dreyer WJ |title=Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer. |journal=J. Cell Biol. |volume=127 |issue= 6 Pt 2 |pages= 2009-20 |year= 1995 |pmid= 7806578 |doi=  }}
+* {{cite journal | vauthors = Vielmetter J, Chen XN, Miskevich F, Lane RP, Yamakawa K, Korenberg JR, Dreyer WJ | title = Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23. | journal = Genomics | volume = 41 | issue = 3 | pages = 414–21 | year = 1997 | pmid = 9169140 | doi = 10.1006/geno.1997.4688 }}
-*{{cite journal  | author=Keino-Masu K, Masu M, Hinck L, ''et al.'' |title=Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. |journal=Cell |volume=87 |issue= 2 |pages= 175-85 |year= 1996 |pmid= 8861902 |doi=  }}
+* {{cite journal | vauthors = Wang H, Copeland NG, Gilbert DJ, Jenkins NA, Tessier-Lavigne M | title = Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors. | journal = J. Neurosci. | volume = 19 | issue = 12 | pages = 4938–47 | year = 1999 | pmid = 10366627 | doi =  }}
-*{{cite journal  | author=Meyerhardt JA, Look AT, Bigner SH, Fearon ER |title=Identification and characterization of neogenin, a DCC-related gene. |journal=Oncogene |volume=14 |issue= 10 |pages= 1129-36 |year= 1997 |pmid= 9121761 |doi= 10.1038/sj.onc.1200935 }}
+* {{cite journal | vauthors = Srinivasan K, Strickland P, Valdes A, Shin GC, Hinck L | title = Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis. | journal = Dev. Cell | volume = 4 | issue = 3 | pages = 371–82 | year = 2003 | pmid = 12636918 | doi = 10.1016/S1534-5807(03)00054-6 }}
-*{{cite journal  | author=Vielmetter J, Chen XN, Miskevich F, ''et al.'' |title=Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23. |journal=Genomics |volume=41 |issue= 3 |pages= 414-21 |year= 1997 |pmid= 9169140 |doi= 10.1006/geno.1997.4688 }}
+* {{cite journal | vauthors = Ho SM, Lau KM, Mok SC, Syed V | title = Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells. | journal = Oncogene | volume = 22 | issue = 27 | pages = 4243–56 | year = 2003 | pmid = 12833147 | doi = 10.1038/sj.onc.1206437 }}
-*{{cite journal  | author=Wang H, Copeland NG, Gilbert DJ, ''et al.'' |title=Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors. |journal=J. Neurosci. |volume=19 |issue= 12 |pages= 4938-47 |year= 1999 |pmid= 10366627 |doi=  }}
+* {{cite journal | vauthors = Matsunaga E, Tauszig-Delamasure S, Monnier PP, Mueller BK, Strittmatter SM, Mehlen P, Chédotal A | title = RGM and its receptor neogenin regulate neuronal survival. | journal = Nat. Cell Biol. | volume = 6 | issue = 8 | pages = 749–55 | year = 2004 | pmid = 15258591 | doi = 10.1038/ncb1157 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC | title = Focal adhesion kinase in netrin-1 signaling. | journal = Nat. Neurosci. | volume = 7 | issue = 11 | pages = 1204–12 | year = 2005 | pmid = 15494733 | doi = 10.1038/nn1330 }}
-*{{cite journal  | author=Srinivasan K, Strickland P, Valdes A, ''et al.'' |title=Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis. |journal=Dev. Cell |volume=4 |issue= 3 |pages= 371-82 |year= 2003 |pmid= 12636918 |doi=  }}
+* {{cite journal | vauthors = Lee JE, Kim HJ, Bae JY, Kim SW, Park JS, Shin HJ, Han W, Kim SW, Kang KS, Noh DY | title = Neogenin expression may be inversely correlated to the tumorigenicity of human breast cancer. | journal = BMC Cancer | volume = 5 | pages = 154 | year = 2006 | pmid = 16324219 | pmc = 1322231 | doi = 10.1186/1471-2407-5-154 }}
-*{{cite journal  | author=Ho SM, Lau KM, Mok SC, Syed V |title=Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells. |journal=Oncogene |volume=22 |issue= 27 |pages= 4243-56 |year= 2003 |pmid= 12833147 |doi= 10.1038/sj.onc.1206437 }}
+* {{cite journal | vauthors = Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD | title = Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. | journal = J. Proteome Res. | volume = 4 | issue = 6 | pages = 2070–80 | year = 2006 | pmid = 16335952 | pmc = 1850943 | doi = 10.1021/pr0502065 }}
-*{{cite journal  | author=Matsunaga E, Tauszig-Delamasure S, Monnier PP, ''et al.'' |title=RGM and its receptor neogenin regulate neuronal survival. |journal=Nat. Cell Biol. |volume=6 |issue= 8 |pages= 749-55 |year= 2004 |pmid= 15258591 |doi= 10.1038/ncb1157 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Ren XR, Ming GL, Xie Y, ''et al.'' |title=Focal adhesion kinase in netrin-1 signaling. |journal=Nat. Neurosci. |volume=7 |issue= 11 |pages= 1204-12 |year= 2005 |pmid= 15494733 |doi= 10.1038/nn1330 }}
-*{{cite journal  | author=Lee JE, Kim HJ, Bae JY, ''et al.'' |title=Neogenin expression may be inversely correlated to the tumorigenicity of human breast cancer. |journal=BMC Cancer |volume=5 |issue=  |pages= 154 |year= 2006 |pmid= 16324219 |doi= 10.1186/1471-2407-5-154 }}
-*{{cite journal  | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
-}}
 {{refend}}
-{{protein-stub}}
+{{PDB Gallery|geneid=4756}}
-{{WikiDoc Sources}}
+[[Category:Human proteins]]
+{{gene-15-stub}}

NEO1: Difference between revisions

Latest revision as of 12:50, 5 September 2017

Interactions

References

Further reading

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