LRRK1: Difference between revisions

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Latest revision as of 18:09, 2 September 2017

Leucine-rich repeat serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the LRRK1 gene.^[1]^[2]^[3]

References

↑ Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (May 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
↑ Bosgraaf L, Van Haastert PJ (Dec 2003). "Roc, a Ras/GTPase domain in complex proteins". Biochim Biophys Acta. 1643 (1–3): 5–10. doi:10.1016/j.bbamcr.2003.08.008. PMID 14654223.
↑ "Entrez Gene: LRRK1 leucine-rich repeat kinase 1".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Korr D, Toschi L, Donner P, et al. (2006). "LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain". Cell. Signal. 18 (6): 910–20. doi:10.1016/j.cellsig.2005.08.015. PMID 16243488.
Zody MC, Garber M, Sharpe T, et al. (2006). "Analysis of the DNA sequence and duplication history of human chromosome 15". Nature. 440 (7084): 671–5. doi:10.1038/nature04601. PMID 16572171.
Haugarvoll K, Toft M, Ross OA, et al. (2007). "Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway". Neurosci. Lett. 416 (3): 299–301. doi:10.1016/j.neulet.2007.02.020. PMID 17324517.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Greggio E, Lewis PA, van der Brug MP, et al. (2007). "Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1". J. Neurochem. 102 (1): 93–102. doi:10.1111/j.1471-4159.2007.04523.x. PMID 17394548.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[pmid11347906-1] Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (May 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.

[pmid14654223-2] Bosgraaf L, Van Haastert PJ (Dec 2003). "Roc, a Ras/GTPase domain in complex proteins". Biochim Biophys Acta. 1643 (1–3): 5–10. doi:10.1016/j.bbamcr.2003.08.008. PMID 14654223.

[entrez-3] "Entrez Gene: LRRK1 leucine-rich repeat kinase 1".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
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+'''Leucine-rich repeat serine/threonine-protein kinase 1''' is an [[enzyme]] that in humans is encoded by the ''LRRK1'' [[gene]].<ref name="pmid11347906">{{cite journal |vauthors=Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 8 | issue = 2 | pages = 85–95 |date=May 2001 | pmid = 11347906 | pmc =  | doi =10.1093/dnares/8.2.85  }}</ref><ref name="pmid14654223">{{cite journal |vauthors=Bosgraaf L, Van Haastert PJ | title = Roc, a Ras/GTPase domain in complex proteins | journal = Biochim Biophys Acta | volume = 1643 | issue = 1-3 | pages = 5–10 |date=Dec 2003 | pmid = 14654223 | pmc =  | doi =10.1016/j.bbamcr.2003.08.008  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LRRK1 leucine-rich repeat kinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79705| accessdate = }}</ref>
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- | image =
- | image_source =
- | PDB =
- | Name = Leucine-rich repeat kinase 1
- | HGNCid = 18608
- | Symbol = LRRK1
- | AltSymbols =; FLJ23119; FLJ27465; KIAA1790; RIPK6; Roco1
- | OMIM =
- | ECnumber =
-  | Homologene = 23464
- | MGIid = 2142227
- | GeneAtlas_image1 = PBB_GE_LRRK1_219441_s_at_tn.png
-  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}}
- | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
- | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 79705
-    | Hs_Ensembl = ENSG00000154237
-    | Hs_RefseqProtein = NP_078928
-    | Hs_RefseqmRNA = NM_024652
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 15
-    | Hs_GenLoc_start = 99277073
-    | Hs_GenLoc_end = 99427834
-    | Hs_Uniprot = Q38SD2
-    | Mm_EntrezGene = 233328
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA = XM_920478
-    | Mm_RefseqProtein = XP_925571
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''Leucine-rich repeat kinase 1''', also known as '''LRRK1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LRRK1 leucine-rich repeat kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79705| accessdate = }}</ref>
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@@ Line 55: / Line 9: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Bosgraaf L, Van Haastert PJ |title=Roc, a Ras/GTPase domain in complex proteins. |journal=Biochim. Biophys. Acta |volume=1643 |issue= 1-3 |pages= 5-10 |year= 2004 |pmid= 14654223 |doi=  }}
+*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  }}
-*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
+*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Nagase T, Nakayama M, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=8 |issue= 2 |pages= 85-95 |year= 2001 |pmid= 11347906 |doi=  }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Korr D, Toschi L, Donner P, etal |title=LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain. |journal=Cell. Signal. |volume=18 |issue= 6 |pages= 910–20 |year= 2006 |pmid= 16243488 |doi= 10.1016/j.cellsig.2005.08.015 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Zody MC, Garber M, Sharpe T, etal |title=Analysis of the DNA sequence and duplication history of human chromosome 15. |journal=Nature |volume=440 |issue= 7084 |pages= 671–5 |year= 2006 |pmid= 16572171 |doi= 10.1038/nature04601 }}
-*{{cite journal  | author=Korr D, Toschi L, Donner P, ''et al.'' |title=LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain. |journal=Cell. Signal. |volume=18 |issue= 6 |pages= 910-20 |year= 2006 |pmid= 16243488 |doi= 10.1016/j.cellsig.2005.08.015 }}
+*{{cite journal   |vauthors=Haugarvoll K, Toft M, Ross OA, etal |title=Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway. |journal=Neurosci. Lett. |volume=416 |issue= 3 |pages= 299–301 |year= 2007 |pmid= 17324517 |doi= 10.1016/j.neulet.2007.02.020 }}
-*{{cite journal  | author=Zody MC, Garber M, Sharpe T, ''et al.'' |title=Analysis of the DNA sequence and duplication history of human chromosome 15. |journal=Nature |volume=440 |issue= 7084 |pages= 671-5 |year= 2006 |pmid= 16572171 |doi= 10.1038/nature04601 }}
+*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948 }}
-*{{cite journal  | author=Haugarvoll K, Toft M, Ross OA, ''et al.'' |title=Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway. |journal=Neurosci. Lett. |volume=416 |issue= 3 |pages= 299-301 |year= 2007 |pmid= 17324517 |doi= 10.1016/j.neulet.2007.02.020 }}
+*{{cite journal   |vauthors=Greggio E, Lewis PA, van der Brug MP, etal |title=Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1. |journal=J. Neurochem. |volume=102 |issue= 1 |pages= 93–102 |year= 2007 |pmid= 17394548 |doi= 10.1111/j.1471-4159.2007.04523.x }}
-*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
-*{{cite journal  | author=Greggio E, Lewis PA, van der Brug MP, ''et al.'' |title=Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1. |journal=J. Neurochem. |volume=102 |issue= 1 |pages= 93-102 |year= 2007 |pmid= 17394548 |doi= 10.1111/j.1471-4159.2007.04523.x }}
 }}
 {{refend}}
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LRRK1: Difference between revisions

Latest revision as of 18:09, 2 September 2017

References

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