CILP: Difference between revisions

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'''Cartilage intermediate layer protein 1''' is a [[protein]] that in humans is encoded by the ''CILP'' [[gene]].<ref name="pmid9722584">{{cite journal | vauthors = Lorenzo P, Neame P, Sommarin Y, Heinegard D | title = Cloning and deduced amino acid sequence of a novel cartilage protein (CILP) identifies a proform including a nucleotide pyrophosphohydrolase | journal = J Biol Chem | volume = 273 | issue = 36 | pages = 23469–75 |date=Oct 1998 | pmid = 9722584 | pmc =  | doi =10.1074/jbc.273.36.23469 }}</ref><ref name="pmid9722583">{{cite journal | vauthors = Lorenzo P, Bayliss MT, Heinegard D | title = A novel cartilage protein (CILP) present in the mid-zone of human articular cartilage increases with age | journal = J Biol Chem | volume = 273 | issue = 36 | pages = 23463–8 |date=Oct 1998 | pmid = 9722583 | pmc = | doi =10.1074/jbc.273.36.23463 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8483| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
| HGNCid = 1980
| Symbol = CILP
| AltSymbols =; HsT18872
| OMIM = 603489
| ECnumber =
| Homologene = 2679
| MGIid = 2444507
  | GeneAtlas_image1 = PBB_GE_CILP_206227_at_tn.png
  | Function = {{GNF_GO|id=GO:0004721 |text = phosphoprotein phosphatase activity}}  
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}}
| Process = {{GNF_GO|id=GO:0006139 |text = nucleobase, nucleoside, nucleotide and nucleic acid metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8483
    | Hs_Ensembl = ENSG00000138615
    | Hs_RefseqProtein = NP_003604
    | Hs_RefseqmRNA = NM_003613
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 63275398
    | Hs_GenLoc_end = 63290864
    | Hs_Uniprot = O75339
    | Mm_EntrezGene = 214425
    | Mm_Ensembl = ENSMUSG00000042254
    | Mm_RefseqmRNA = NM_173385
    | Mm_RefseqProtein = NP_775561
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 65063186
    | Mm_GenLoc_end = 65078611
    | Mm_Uniprot = Q66K08
  }}
}}
'''Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase''', also known as '''CILP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8483| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. The synthesis of cartilage intermediate layer protein (CILP), which was identified and purified from human articular cartilage, increases in early osteoarthrosis cartilage.  The C-terminal 460 amino acids of the protein show 90% similarity to the pig ectonucleotide pyrophosphohydrolase NTPPHase; this region is preceded by a furin protease consensus cleavage site. Thus, the CILP gene is thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase.<ref name="entrez">{{cite web | title = Entrez Gene: CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8483| accessdate = }}</ref>
| summary_text = Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. The synthesis of cartilage intermediate layer protein (CILP), which was identified and purified from human articular cartilage, increases in early osteoarthrosis cartilage.  The C-terminal 460 amino acids of the protein show 90% similarity to the pig ectonucleotide pyrophosphohydrolase NTPPHase; this region is preceded by a furin protease consensus cleavage site. Thus, the CILP gene is thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CILP}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Lorenzo P, Bayliss MT, Heinegård D |title=A novel cartilage protein (CILP) present in the mid-zone of human articular cartilage increases with age. |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23463-8 |year= 1998 |pmid= 9722583 |doi= }}
*{{cite journal  | vauthors=Nakamura I, Okawa A, Ikegawa S |title=Genomic organization, mapping, and polymorphisms of the gene encoding human cartilage intermediate layer protein (CILP) |journal=J. Hum. Genet. |volume=44 |issue= 3 |pages= 203–5 |year= 1999 |pmid= 10319588 |doi=10.1007/s100380050143 |display-authors=etal}}
*{{cite journal  | author=Lorenzo P, Neame P, Sommarin Y, Heinegård D |title=Cloning and deduced amino acid sequence of a novel cartilage protein (CILP) identifies a proform including a nucleotide pyrophosphohydrolase. |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23469-75 |year= 1998 |pmid= 9722584 |doi=  }}
*{{cite journal  | vauthors=Lorenzo P, Aman P, Sommarin Y, Heinegård D |title=The human CILP gene: exon/intron organization and chromosomal mapping |journal=Matrix Biol. |volume=18 |issue= 5 |pages= 445–54 |year= 2000 |pmid= 10601732 |doi=10.1016/S0945-053X(99)00035-9 }}
*{{cite journal  | author=Nakamura I, Okawa A, Ikegawa S, ''et al.'' |title=Genomic organization, mapping, and polymorphisms of the gene encoding human cartilage intermediate layer protein (CILP). |journal=J. Hum. Genet. |volume=44 |issue= 3 |pages= 203-5 |year= 1999 |pmid= 10319588 |doi=  }}
*{{cite journal  | vauthors=Tsuruha J, Masuko-Hongo K, Kato T |title=Implication of cartilage intermediate layer protein in cartilage destruction in subsets of patients with osteoarthritis and rheumatoid arthritis |journal=Arthritis Rheum. |volume=44 |issue= 4 |pages= 838–45 |year= 2001 |pmid= 11315923 |doi= 10.1002/1529-0131(200104)44:4<838::AID-ANR140>3.0.CO;2-C |display-authors=etal}}
*{{cite journal  | author=Lorenzo P, Aman P, Sommarin Y, Heinegård D |title=The human CILP gene: exon/intron organization and chromosomal mapping. |journal=Matrix Biol. |volume=18 |issue= 5 |pages= 445-54 |year= 2000 |pmid= 10601732 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Tsuruha J, Masuko-Hongo K, Kato T, ''et al.'' |title=Implication of cartilage intermediate layer protein in cartilage destruction in subsets of patients with osteoarthritis and rheumatoid arthritis. |journal=Arthritis Rheum. |volume=44 |issue= 4 |pages= 838-45 |year= 2001 |pmid= 11315923 |doi= 10.1002/1529-0131(200104)44:4<838::AID-ANR140>3.0.CO;2-C }}
*{{cite journal  | vauthors=Hirose J, Ryan LM, Masuda I |title=Up-regulated expression of cartilage intermediate-layer protein and ANK in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease |journal=Arthritis Rheum. |volume=46 |issue= 12 |pages= 3218–29 |year= 2003 |pmid= 12483726 |doi= 10.1002/art.10632 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Johnson K, Farley D, Hu SI, Terkeltaub R |title=One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist |journal=Arthritis Rheum. |volume=48 |issue= 5 |pages= 1302–14 |year= 2003 |pmid= 12746903 |doi= 10.1002/art.10927 }}
*{{cite journal  | author=Hirose J, Ryan LM, Masuda I |title=Up-regulated expression of cartilage intermediate-layer protein and ANK in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease. |journal=Arthritis Rheum. |volume=46 |issue= 12 |pages= 3218-29 |year= 2003 |pmid= 12483726 |doi= 10.1002/art.10632 }}
*{{cite journal  | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}}
*{{cite journal  | author=Johnson K, Farley D, Hu SI, Terkeltaub R |title=One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist. |journal=Arthritis Rheum. |volume=48 |issue= 5 |pages= 1302-14 |year= 2003 |pmid= 12746903 |doi= 10.1002/art.10927 }}
*{{cite journal  | vauthors=Yao Z, Nakamura H, Masuko-Hongo K |title=Characterisation of cartilage intermediate layer protein (CILP)-induced arthropathy in mice |journal=Ann. Rheum. Dis. |volume=63 |issue= 3 |pages= 252–8 |year= 2004 |pmid= 14962958 |doi=10.1136/ard.2003.008045  | pmc=1754905 |display-authors=etal}}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  | vauthors=Du H, Masuko-Hongo K, Nakamura H |title=The prevalence of autoantibodies against cartilage intermediate layer protein, YKL-39, osteopontin, and cyclic citrullinated peptide in patients with early-stage knee osteoarthritis: evidence of a variety of autoimmune processes |journal=Rheumatol. Int. |volume=26 |issue= 1 |pages= 35–41 |year= 2006 |pmid= 15378262 |doi= 10.1007/s00296-004-0497-2 |display-authors=etal}}
*{{cite journal  | author=Yao Z, Nakamura H, Masuko-Hongo K, ''et al.'' |title=Characterisation of cartilage intermediate layer protein (CILP)-induced arthropathy in mice. |journal=Ann. Rheum. Dis. |volume=63 |issue= 3 |pages= 252-8 |year= 2004 |pmid= 14962958 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Du H, Masuko-Hongo K, Nakamura H, ''et al.'' |title=The prevalence of autoantibodies against cartilage intermediate layer protein, YKL-39, osteopontin, and cyclic citrullinated peptide in patients with early-stage knee osteoarthritis: evidence of a variety of autoimmune processes. |journal=Rheumatol. Int. |volume=26 |issue= 1 |pages= 35-41 |year= 2006 |pmid= 15378262 |doi= 10.1007/s00296-004-0497-2 }}
*{{cite journal  | vauthors=Seki S, Kawaguchi Y, Chiba K |title=A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease |journal=Nat. Genet. |volume=37 |issue= 6 |pages= 607–12 |year= 2005 |pmid= 15864306 |doi= 10.1038/ng1557 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Mori M, Nakajima M, Mikami Y |title=Transcriptional regulation of the cartilage intermediate layer protein (CILP) gene |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 1 |pages= 121–7 |year= 2006 |pmid= 16413503 |doi= 10.1016/j.bbrc.2005.12.159 |display-authors=etal}}
*{{cite journal  | author=Seki S, Kawaguchi Y, Chiba K, ''et al.'' |title=A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. |journal=Nat. Genet. |volume=37 |issue= 6 |pages= 607-12 |year= 2005 |pmid= 15864306 |doi= 10.1038/ng1557 }}
*{{cite journal  | vauthors=Virtanen IM, Song YQ, Cheung KM |title=Phenotypic and population differences in the association between CILP and lumbar disc disease |journal=J. Med. Genet. |volume=44 |issue= 4 |pages= 285–8 |year= 2007 |pmid= 17220213 |doi= 10.1136/jmg.2006.047076 | pmc=2598035 |display-authors=etal}}
*{{cite journal  | author=Mori M, Nakajima M, Mikami Y, ''et al.'' |title=Transcriptional regulation of the cartilage intermediate layer protein (CILP) gene. |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 1 |pages= 121-7 |year= 2006 |pmid= 16413503 |doi= 10.1016/j.bbrc.2005.12.159 }}
*{{cite journal  | author=Virtanen IM, Song YQ, Cheung KM, ''et al.'' |title=Phenotypic and population differences in the association between CILP and lumbar disc disease. |journal=J. Med. Genet. |volume=44 |issue= 4 |pages= 285-8 |year= 2007 |pmid= 17220213 |doi= 10.1136/jmg.2006.047076 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 09:43, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cartilage intermediate layer protein 1 is a protein that in humans is encoded by the CILP gene.[1][2][3]

Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. The synthesis of cartilage intermediate layer protein (CILP), which was identified and purified from human articular cartilage, increases in early osteoarthrosis cartilage. The C-terminal 460 amino acids of the protein show 90% similarity to the pig ectonucleotide pyrophosphohydrolase NTPPHase; this region is preceded by a furin protease consensus cleavage site. Thus, the CILP gene is thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase.[3]

References

  1. ↑ Lorenzo P, Neame P, Sommarin Y, Heinegard D (Oct 1998). "Cloning and deduced amino acid sequence of a novel cartilage protein (CILP) identifies a proform including a nucleotide pyrophosphohydrolase". J Biol Chem. 273 (36): 23469–75. doi:10.1074/jbc.273.36.23469. PMID 9722584.
  2. ↑ Lorenzo P, Bayliss MT, Heinegard D (Oct 1998). "A novel cartilage protein (CILP) present in the mid-zone of human articular cartilage increases with age". J Biol Chem. 273 (36): 23463–8. doi:10.1074/jbc.273.36.23463. PMID 9722583.
  3. ↑ 3.0 3.1 "Entrez Gene: CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase".

External links

Further reading



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