GSPT1: Difference between revisions

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{{Infobox_gene}}
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'''Eukaryotic peptide chain release factor GTP-binding subunit ERF3A''' is an [[enzyme]] that in humans is encoded by the ''GSPT1'' [[gene]].<ref name="pmid2511002">{{cite journal | vauthors = Hoshino S, Miyazawa H, Enomoto T, Hanaoka F, Kikuchi Y, Kikuchi A, Ui M | title = A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells | journal = The EMBO Journal | volume = 8 | issue = 12 | pages = 3807–14 | date = Dec 1989 | pmid = 2511002 | pmc = 402068 | doi =  }}</ref><ref name="pmid17700517">{{cite journal | vauthors = Lee JA, Park JE, Lee DH, Park SG, Myung PK, Park BC, Cho S | title = G1 to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1 | journal = Oncogene | volume = 27 | issue = 9 | pages = 1297–305 | date = Feb 2008 | pmid = 17700517 | pmc =  | doi = 10.1038/sj.onc.1210740 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GSPT1 G1 to S phase transition 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2935| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = G1 to S phase transition 1
| HGNCid = 4621
| Symbol = GSPT1
| AltSymbols =; 551G9.2; ETF3A; GST1; eRF3a
| OMIM = 139259
| ECnumber = 
| Homologene = 68226
| MGIid = 1316728
| GeneAtlas_image1 = PBB_GE_GSPT1_201912_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GSPT1_215438_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_GSPT1_217595_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003747 |text = translation release factor activity}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0000082 |text = G1/S transition of mitotic cell cycle}} {{GNF_GO|id=GO:0000184 |text = mRNA catabolic process, nonsense-mediated decay}} {{GNF_GO|id=GO:0006412 |text = translation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2935
    | Hs_Ensembl = ENSG00000103342
    | Hs_RefseqProtein = NP_002085
    | Hs_RefseqmRNA = NM_002094
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 11874040
    | Hs_GenLoc_end = 11917309
    | Hs_Uniprot = P15170
    | Mm_EntrezGene = 14852
    | Mm_Ensembl = ENSMUSG00000062203
    | Mm_RefseqmRNA = NM_146066
    | Mm_RefseqProtein = NP_666178
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 11133733
    | Mm_GenLoc_end = 11167787
    | Mm_Uniprot = Q3UL02
  }}
}}
'''G1 to S phase transition 1''', also known as '''GSPT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GSPT1 G1 to S phase transition 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2935| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
GSPT1 has been shown to [[Protein-protein interaction|interact]] with [[BIRC2]].<ref name=pmid12865429>{{cite journal | vauthors = Hegde R, Srinivasula SM, Datta P, Madesh M, Wassell R, Zhang Z, Cheong N, Nejmeh J, Fernandes-Alnemri T, Hoshino S, Alnemri ES | title = The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein | journal = The Journal of Biological Chemistry | volume = 278 | issue = 40 | pages = 38699–706 | date = Oct 2003 | pmid = 12865429 | doi = 10.1074/jbc.M303179200 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Ozawa K, Murakami Y, Eki T, Yokoyama K, Soeda E, Hoshino S, Ui M, Hanaoka F | title = Mapping of the human GSPT1 gene, a human homolog of the yeast GST1 gene, to chromosomal band 16p13.1 | journal = Somatic Cell and Molecular Genetics | volume = 18 | issue = 2 | pages = 189–94 | date = Mar 1992 | pmid = 1574740 | doi = 10.1007/BF01233164 }}
| citations =
* {{cite journal | vauthors = Kikuchi Y, Shimatake H, Kikuchi A | title = A yeast gene required for the G1-to-S transition encodes a protein containing an A-kinase target site and GTPase domain | journal = The EMBO Journal | volume = 7 | issue = 4 | pages = 1175–82 | date = Apr 1988 | pmid = 2841115 | pmc = 454453 | doi =  }}
*{{cite journal | author=Ozawa K, Murakami Y, Eki T, ''et al.'' |title=Mapping of the human GSPT1 gene, a human homolog of the yeast GST1 gene, to chromosomal band 16p13.1. |journal=Somat. Cell Mol. Genet. |volume=18 |issue= 2 |pages= 189-94 |year= 1992 |pmid= 1574740 |doi= }}
* {{cite journal | vauthors = Czaplinski K, Ruiz-Echevarria MJ, Paushkin SV, Han X, Weng Y, Perlick HA, Dietz HC, Ter-Avanesyan MD, Peltz SW | title = The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs | journal = Genes & Development | volume = 12 | issue = 11 | pages = 1665–77 | date = Jun 1998 | pmid = 9620853 | pmc = 316864 | doi = 10.1101/gad.12.11.1665 }}
*{{cite journal | author=Hoshino S, Miyazawa H, Enomoto T, ''et al.'' |title=A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells. |journal=EMBO J. |volume=8 |issue= 12 |pages= 3807-14 |year= 1990 |pmid= 2511002 |doi=  }}
* {{cite journal | vauthors = Hoshino S, Imai M, Mizutani M, Kikuchi Y, Hanaoka F, Ui M, Katada T | title = Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 35 | pages = 22254–9 | date = Aug 1998 | pmid = 9712840 | doi = 10.1074/jbc.273.35.22254 }}
*{{cite journal | author=Kikuchi Y, Shimatake H, Kikuchi A |title=A yeast gene required for the G1-to-S transition encodes a protein containing an A-kinase target site and GTPase domain. |journal=EMBO J. |volume=7 |issue= 4 |pages= 1175-82 |year= 1988 |pmid= 2841115 |doi= }}
* {{cite journal | vauthors = Merkulova TI, Frolova LY, Lazar M, Camonis J, Kisselev LL | title = C-terminal domains of human translation termination factors eRF1 and eRF3 mediate their in vivo interaction | journal = FEBS Letters | volume = 443 | issue = 1 | pages = 41–7 | date = Jan 1999 | pmid = 9928949 | doi = 10.1016/S0014-5793(98)01669-X }}
*{{cite journal | author=Czaplinski K, Ruiz-Echevarria MJ, Paushkin SV, ''et al.'' |title=The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs. |journal=Genes Dev. |volume=12 |issue= 11 |pages= 1665-77 |year= 1998 |pmid= 9620853 |doi= }}
* {{cite journal | vauthors = Hoshino S, Imai M, Kobayashi T, Uchida N, Katada T | title = The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein | journal = The Journal of Biological Chemistry | volume = 274 | issue = 24 | pages = 16677–80 | date = Jun 1999 | pmid = 10358005 | doi = 10.1074/jbc.274.24.16677 }}
*{{cite journal | author=Hoshino S, Imai M, Mizutani M, ''et al.'' |title=Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1. |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22254-9 |year= 1998 |pmid= 9712840 |doi= }}
* {{cite journal | vauthors = Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD | title = Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q | journal = Genomics | volume = 60 | issue = 3 | pages = 295–308 | date = Sep 1999 | pmid = 10493829 | doi = 10.1006/geno.1999.5927 }}
*{{cite journal | author=Merkulova TI, Frolova LY, Lazar M, ''et al.'' |title=C-terminal domains of human translation termination factors eRF1 and eRF3 mediate their in vivo interaction. |journal=FEBS Lett. |volume=443 |issue= 1 |pages= 41-7 |year= 1999 |pmid= 9928949 |doi= }}
* {{cite journal | vauthors = Cosson B, Berkova N, Couturier A, Chabelskaya S, Philippe M, Zhouravleva G | title = Poly(A)-binding protein and eRF3 are associated in vivo in human and Xenopus cells | journal = Biology of the Cell / Under the Auspices of the European Cell Biology Organization | volume = 94 | issue = 4-5 | pages = 205–16 | date = Sep 2002 | pmid = 12489690 | doi = 10.1016/S0248-4900(02)01194-2 }}
*{{cite journal | author=Hoshino S, Imai M, Kobayashi T, ''et al.'' |title=The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 16677-80 |year= 1999 |pmid= 10358005 |doi= }}
* {{cite journal | vauthors = Hegde R, Srinivasula SM, Datta P, Madesh M, Wassell R, Zhang Z, Cheong N, Nejmeh J, Fernandes-Alnemri T, Hoshino S, Alnemri ES | title = The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein | journal = The Journal of Biological Chemistry | volume = 278 | issue = 40 | pages = 38699–706 | date = Oct 2003 | pmid = 12865429 | doi = 10.1074/jbc.M303179200 }}
*{{cite journal  | author=Loftus BJ, Kim UJ, Sneddon VP, ''et al.'' |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295-308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927 }}
* {{cite journal | vauthors = Janzen DM, Geballe AP | title = The effect of eukaryotic release factor depletion on translation termination in human cell lines | journal = Nucleic Acids Research | volume = 32 | issue = 15 | pages = 4491–502 | year = 2004 | pmid = 15326224 | pmc = 516063 | doi = 10.1093/nar/gkh791 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Le Roy F, Salehzada T, Bisbal C, Dougherty JP, Peltz SW | title = A newly discovered function for RNase L in regulating translation termination | journal = Nature Structural & Molecular Biology | volume = 12 | issue = 6 | pages = 505–12 | date = Jun 2005 | pmid = 15908960 | doi = 10.1038/nsmb944 }}
*{{cite journal | author=Cosson B, Berkova N, Couturier A, ''et al.'' |title=Poly(A)-binding protein and eRF3 are associated in vivo in human and Xenopus cells. |journal=Biol. Cell |volume=94 |issue= 4-5 |pages= 205-16 |year= 2003 |pmid= 12489690 |doi= }}
* {{cite journal | vauthors = Brito M, Malta-Vacas J, Carmona B, Aires C, Costa P, Martins AP, Ramos S, Conde AR, Monteiro C | title = Polyglycine expansions in eRF3/GSPT1 are associated with gastric cancer susceptibility | journal = Carcinogenesis | volume = 26 | issue = 12 | pages = 2046–9 | date = Dec 2005 | pmid = 15987717 | doi = 10.1093/carcin/bgi168 }}
*{{cite journal | author=Hegde R, Srinivasula SM, Datta P, ''et al.'' |title=The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 38699-706 |year= 2003 |pmid= 12865429 |doi= 10.1074/jbc.M303179200 }}
* {{cite journal | vauthors = Chauvin C, Salhi S, Le Goff C, Viranaicken W, Diop D, Jean-Jean O | title = Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation | journal = Molecular and Cellular Biology | volume = 25 | issue = 14 | pages = 5801–11 | date = Jul 2005 | pmid = 15987998 | pmc = 1168810 | doi = 10.1128/MCB.25.14.5801-5811.2005 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Kashima I, Yamashita A, Izumi N, Kataoka N, Morishita R, Hoshino S, Ohno M, Dreyfuss G, Ohno S | title = Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay | journal = Genes & Development | volume = 20 | issue = 3 | pages = 355–67 | date = Feb 2006 | pmid = 16452507 | pmc = 1361706 | doi = 10.1101/gad.1389006 }}
*{{cite journal | author=Janzen DM, Geballe AP |title=The effect of eukaryotic release factor depletion on translation termination in human cell lines. |journal=Nucleic Acids Res. |volume=32 |issue= 15 |pages= 4491-502 |year= 2004 |pmid= 15326224 |doi= 10.1093/nar/gkh791 }}
* {{cite journal | vauthors = Tompkins V, Hagen J, Zediak VP, Quelle DE | title = Identification of novel ARF binding proteins by two-hybrid screening | journal = Cell Cycle | volume = 5 | issue = 6 | pages = 641–6 | date = Mar 2006 | pmid = 16582619 | doi = 10.4161/cc.5.6.2560 }}
*{{cite journal | author=Le Roy F, Salehzada T, Bisbal C, ''et al.'' |title=A newly discovered function for RNase L in regulating translation termination. |journal=Nat. Struct. Mol. Biol. |volume=12 |issue= 6 |pages= 505-12 |year= 2005 |pmid= 15908960 |doi= 10.1038/nsmb944 }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | date = May 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Brito M, Malta-Vacas J, Carmona B, ''et al.'' |title=Polyglycine expansions in eRF3/GSPT1 are associated with gastric cancer susceptibility. |journal=Carcinogenesis |volume=26 |issue= 12 |pages= 2046-9 |year= 2006 |pmid= 15987717 |doi= 10.1093/carcin/bgi168 }}
* {{cite journal | vauthors = Chauvin C, Salhi S, Jean-Jean O | title = Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway | journal = Molecular and Cellular Biology | volume = 27 | issue = 16 | pages = 5619–29 | date = Aug 2007 | pmid = 17562865 | pmc = 1952125 | doi = 10.1128/MCB.00035-07 }}
*{{cite journal | author=Chauvin C, Salhi S, Le Goff C, ''et al.'' |title=Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation. |journal=Mol. Cell. Biol. |volume=25 |issue= 14 |pages= 5801-11 |year= 2005 |pmid= 15987998 |doi= 10.1128/MCB.25.14.5801-5811.2005 }}
*{{cite journal  | author=Kashima I, Yamashita A, Izumi N, ''et al.'' |title=Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. |journal=Genes Dev. |volume=20 |issue= 3 |pages= 355-67 |year= 2006 |pmid= 16452507 |doi= 10.1101/gad.1389006 }}
*{{cite journal  | author=Tompkins V, Hagen J, Zediak VP, Quelle DE |title=Identification of novel ARF binding proteins by two-hybrid screening. |journal=Cell Cycle |volume=5 |issue= 6 |pages= 641-6 |year= 2006 |pmid= 16582619 |doi=  }}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal  | author=Chauvin C, Salhi S, Jean-Jean O |title=Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway. |journal=Mol. Cell. Biol. |volume=27 |issue= 16 |pages= 5619-29 |year= 2007 |pmid= 17562865 |doi= 10.1128/MCB.00035-07 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{gene-16-stub}}
{{WikiDoc Sources}}

Latest revision as of 09:07, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Eukaryotic peptide chain release factor GTP-binding subunit ERF3A is an enzyme that in humans is encoded by the GSPT1 gene.[1][2][3]

Interactions

GSPT1 has been shown to interact with BIRC2.[4]

References

  1. ↑ Hoshino S, Miyazawa H, Enomoto T, Hanaoka F, Kikuchi Y, Kikuchi A, Ui M (Dec 1989). "A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells". The EMBO Journal. 8 (12): 3807–14. PMC 402068. PMID 2511002.
  2. ↑ Lee JA, Park JE, Lee DH, Park SG, Myung PK, Park BC, Cho S (Feb 2008). "G1 to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1". Oncogene. 27 (9): 1297–305. doi:10.1038/sj.onc.1210740. PMID 17700517.
  3. ↑ "Entrez Gene: GSPT1 G1 to S phase transition 1".
  4. ↑ Hegde R, Srinivasula SM, Datta P, Madesh M, Wassell R, Zhang Z, Cheong N, Nejmeh J, Fernandes-Alnemri T, Hoshino S, Alnemri ES (Oct 2003). "The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein". The Journal of Biological Chemistry. 278 (40): 38699–706. doi:10.1074/jbc.M303179200. PMID 12865429.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=GSPT1&oldid=1417322"